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SOCS7 (suppressor of cytokine signaling 7)

Identity

Alias_symbol (synonym)NAP4
NCKAP4
Other alias
HGNC (Hugo) SOCS7
LocusID (NCBI) 30837
Atlas_Id 51649
Location 17q12  [Link to chromosome band 17q12]
Location_base_pair Starts at 38352124 and ends at 38405593 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
ITPR1 (3p26.1) / SOCS7 (17q12)SOCS7 (17q12) / BDNF (11p14.1)SOCS7 (17q12) / FLOT2 (17q11.2)
SOCS7 (17q12) / PHACTR1 (6p24.1)SOCS7 (17q12) / RSF1 (11q14.1)SOCS7 (17q12) / SOCS7 (17q12)
SOCS7 (17q12) / SRCIN1 (17q12)SOCS7 17q12 / FLOT2 17q11.2SOCS7 17q12 / PHACTR1 6p24.1
SOCS7 17q12 / RSF1 11q14.1SOCS7 17q12 / SRCIN1 17q12

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)SOCS7   29846
Cards
Entrez_Gene (NCBI)SOCS7  30837  suppressor of cytokine signaling 7
AliasesNAP4; NCKAP4
GeneCards (Weizmann)geneka2ds.org/cgi-bin/carddisp.pl?gene=SOCS7 TARGET=Genecards>SOCS7
Ensembl hg19 (Hinxton)ENSG00000274211 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000274211 [Gene_View]  chr17:38352124-38405593 [Contig_View]  SOCS7 [Vega]
ICGC DataPortalENSG00000274211
TCGA cBioPortalSOCS7
AceView (NCBI)SOCS7
Genatlas (Paris)SOCS7
WikiGenes30837
SOURCE (Princeton)SOCS7
Genetics Home Reference (NIH)SOCS7
Genomic and cartography
GoldenPath hg38 (UCSC)SOCS7  -     chr17:38352124-38405593 +  17q12   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)SOCS7  -     17q12   [Description]    (hg19-Feb_2009)
EnsemblSOCS7 - 17q12 [CytoView hg19]  SOCS7 - 17q12 [CytoView hg38]
Mapping of homologs : NCBISOCS7 [Mapview hg19]  SOCS7 [Mapview hg38]
OMIM608788   
Gene and transcription
Genbank (Entrez)AA233668 AB005216 AI223248 AK094338 AW613025
RefSeq transcript (Entrez)NM_014598
RefSeq genomic (Entrez)NC_000017 NC_018928 NT_187614
Consensus coding sequences : CCDS (NCBI)SOCS7
Cluster EST : UnigeneHs.514132 [ NCBI ]
CGAP (NCI)Hs.514132
Alternative Splicing GalleryENSG00000274211
Gene ExpressionSOCS7 [ NCBI-GEO ]   SOCS7 [ EBI - ARRAY_EXPRESS ]   SOCS7 [ SEEK ]   SOCS7 [ MEM ]
Gene Expression Viewer (FireBrowse)SOCS7 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)30837
GTEX Portal (Tissue expression)SOCS7
Human Protein AtlasENSG00000274211-SOCS7 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtO14512   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtO14512  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProO14512
Splice isoforms : SwissVarO14512
PhosPhoSitePlusO14512
Domaine pattern : Prosite (Expaxy)SH2 (PS500p1)    SOCS (PS50225)   
Domains : Interpro (EBI)SH2    SOCS7    SOCS_box   
Domain families : Pfam (Sanger)SH2 (PF00017)    SOCS_box (PF07525)   
Domain families : Pfam (NCBI)pfam00017    pfam07525   
Domain families : Smart (EMBL)SH2 (SM00252)  SOCS (SM00253)  SOCS_box (SM00969)  
Conserved Domain (NCBI)SOCS7
DMDM Disease mutations30837
Blocks (Seattle)SOCS7
SuperfamilyO14512
Human Protein Atlas [tissue]ENSG00000274211-SOCS7 [tissue]
Peptide AtlasO14512
HPRD12299
IPIIPI00022329   IPI00873574   IPI00807330   
Protein Interaction databases
DIP (DOE-UCLA)O14512
IntAct (EBI)O14512
FunCoupENSG00000274211
BioGRIDSOCS7
STRING (EMBL)SOCS7
ZODIACSOCS7
Ontologies - Pathways
QuickGOO14512
Ontology : AmiGOprotein kinase inhibitor activity  protein binding  nucleus  cytoplasm  cytosol  plasma membrane  negative regulation of protein kinase activity  biological_process  insulin receptor signaling pathway  protein ubiquitination  SH3 domain binding  cytokine-mediated signaling pathway  layer formation in cerebral cortex  radial glia guided migration of Purkinje cell  intracellular signal transduction  regulation of growth  fat cell differentiation  negative regulation of JAK-STAT cascade  
Ontology : EGO-EBIprotein kinase inhibitor activity  protein binding  nucleus  cytoplasm  cytosol  plasma membrane  negative regulation of protein kinase activity  biological_process  insulin receptor signaling pathway  protein ubiquitination  SH3 domain binding  cytokine-mediated signaling pathway  layer formation in cerebral cortex  radial glia guided migration of Purkinje cell  intracellular signal transduction  regulation of growth  fat cell differentiation  negative regulation of JAK-STAT cascade  
Pathways : KEGGJak-STAT signaling pathway    Prolactin signaling pathway   
NDEx NetworkSOCS7
Atlas of Cancer Signalling NetworkSOCS7
Wikipedia pathwaysSOCS7
Orthology - Evolution
OrthoDB30837
GeneTree (enSembl)ENSG00000274211
Phylogenetic Trees/Animal Genes : TreeFamSOCS7
HOVERGENO14512
HOGENOMO14512
Homologs : HomoloGeneSOCS7
Homology/Alignments : Family Browser (UCSC)SOCS7
Gene fusions - Rearrangements
Fusion : MitelmanSOCS7/FLOT2 [17q12/17q11.2]  
Fusion : MitelmanSOCS7/PHACTR1 [17q12/6p24.1]  [t(6;17)(p24;q12)]  
Fusion : MitelmanSOCS7/RSF1 [17q12/11q14.1]  [t(11;17)(q14;q12)]  
Fusion: TCGASOCS7 17q12 FLOT2 17q11.2 BRCA
Fusion: TCGASOCS7 17q12 PHACTR1 6p24.1 BRCA
Fusion: TCGASOCS7 17q12 RSF1 11q14.1 LUAD
Fusion: TCGASOCS7 17q12 SRCIN1 17q12 BRCA
Fusion: Tumor Portal SOCS7
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerSOCS7 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)SOCS7
dbVarSOCS7
ClinVarSOCS7
1000_GenomesSOCS7 
Exome Variant ServerSOCS7
ExAC (Exome Aggregation Consortium)ENSG00000274211
GNOMAD BrowserENSG00000274211
Genetic variants : HAPMAP30837
Genomic Variants (DGV)SOCS7 [DGVbeta]
DECIPHERSOCS7 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisSOCS7 
Mutations
ICGC Data PortalSOCS7 
TCGA Data PortalSOCS7 
Broad Tumor PortalSOCS7
OASIS PortalSOCS7 [ Somatic mutations - Copy number]
Mutations and Diseases : HGMDSOCS7
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch SOCS7
DgiDB (Drug Gene Interaction Database)SOCS7
DoCM (Curated mutations)SOCS7 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)SOCS7 (select a term)
intoGenSOCS7
Cancer3DSOCS7(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM608788   
Orphanet
MedgenSOCS7
Genetic Testing Registry SOCS7
NextProtO14512 [Medical]
TSGene30837
GENETestsSOCS7
Target ValidationSOCS7
Huge Navigator SOCS7 [HugePedia]
snp3D : Map Gene to Disease30837
BioCentury BCIQSOCS7
ClinGenSOCS7
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD30837
Chemical/Pharm GKB GenePA164742488
Clinical trialSOCS7
Miscellaneous
canSAR (ICR)SOCS7 (select the gene name)
Probes
Litterature
PubMed31 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineSOCS7
EVEXSOCS7
GoPubMedSOCS7
iHOPSOCS7
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Thu Nov 9 13:12:07 CET 2017

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