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SOD1 (superoxide dismutase 1, soluble)

Identity

Other namesALS
ALS1
IPOA
SOD
hSod1
homodimer
HGNC (Hugo) SOD1
LocusID (NCBI) 6647
Location 21q22.11
Location_base_pair Starts at 33031935 and ends at 33041243 bp from pter ( according to hg19-Feb_2009)
Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

External links

Nomenclature
HGNC (Hugo)SOD1   11179
Cards
Entrez_Gene (NCBI)SOD1  6647  superoxide dismutase 1, soluble
GeneCards (Weizmann)SOD1
Ensembl (Hinxton)ENSG00000142168 [Gene_View]  chr21:33031935-33041243 [Contig_View]  SOD1 [Vega]
AceView (NCBI)SOD1
Genatlas (Paris)SOD1
WikiGenes6647
SOURCE (Princeton)NM_000454
Genomic and cartography
GoldenPath (UCSC)SOD1  -  21q22.11   chr21:33031935-33041243 +  21q22.11   [Description]    (hg19-Feb_2009)
EnsemblSOD1 - 21q22.11 [CytoView]
Mapping of homologs : NCBISOD1 [Mapview]
OMIM105400   147450   
Gene and transcription
Genbank (Entrez)AK312116 AV756797 AY049787 AY450286 BC001034
RefSeq transcript (Entrez)NM_000454
RefSeq genomic (Entrez)AC_000153 NC_000021 NC_018932 NG_008689 NT_011512 NW_001838706 NW_004929426
Consensus coding sequences : CCDS (NCBI)SOD1
Cluster EST : UnigeneHs.443914 [ NCBI ]
CGAP (NCI)Hs.443914
Alternative Splicing : Fast-db (Paris)GSHG0019409
Alternative Splicing GalleryENSG00000142168
Gene ExpressionSOD1 [ NCBI-GEO ]     SOD1 [ SEEK ]   SOD1 [ MEM ]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP00441 (Uniprot)
NextProtP00441  [Medical]
With graphics : InterProP00441
Splice isoforms : SwissVarP00441 (Swissvar)
Catalytic activity : Enzyme1.15.1.1 [ Enzyme-Expasy ]   1.15.1.11.15.1.1 [ IntEnz-EBI ]   1.15.1.1 [ BRENDA ]   1.15.1.1 [ KEGG ]   
Domaine pattern : Prosite (Expaxy)SOD_CU_ZN_1 (PS00087)    SOD_CU_ZN_2 (PS00332)   
Domains : Interpro (EBI)SOD_Cu/Zn_/chaperone    SOD_Cu/Zn_BS    SOD_Cu_Zn_dom   
Related proteins : CluSTrP00441
Domain families : Pfam (Sanger)Sod_Cu (PF00080)   
Domain families : Pfam (NCBI)pfam00080   
DMDM Disease mutations6647
Blocks (Seattle)P00441
PDB (SRS)1AZV    1BA9    1DSW    1FUN    1HL4    1HL5    1KMG    1L3N    1MFM    1N18    1N19    1OEZ    1OZT    1OZU    1P1V    1PTZ    1PU0    1RK7    1SOS    1SPD    1UXL    1UXM    2AF2    2C9S    2C9U    2C9V    2GBT    2GBU    2GBV    2LU5    2NNX    2R27    2V0A    2VR6    2VR7    2VR8    2WKO    2WYT    2WYZ    2WZ0    2WZ5    2WZ6    2XJK    2XJL    2ZKW    2ZKX    2ZKY    3CQP    3CQQ    3ECU    3ECV    3ECW    3GQF    3GTV    3GZO    3GZP    3GZQ    3H2P    3H2Q    3HFF    3K91    3KH3    3KH4    3LTV    3QQD    3RE0    3T5W    4A7G    4A7Q    4A7S    4A7T    4A7U    4A7V    4B3E    4BCY    4BCZ    4BD4    4SOD   
PDB (PDBSum)1AZV    1BA9    1DSW    1FUN    1HL4    1HL5    1KMG    1L3N    1MFM    1N18    1N19    1OEZ    1OZT    1OZU    1P1V    1PTZ    1PU0    1RK7    1SOS    1SPD    1UXL    1UXM    2AF2    2C9S    2C9U    2C9V    2GBT    2GBU    2GBV    2LU5    2NNX    2R27    2V0A    2VR6    2VR7    2VR8    2WKO    2WYT    2WYZ    2WZ0    2WZ5    2WZ6    2XJK    2XJL    2ZKW    2ZKX    2ZKY    3CQP    3CQQ    3ECU    3ECV    3ECW    3GQF    3GTV    3GZO    3GZP    3GZQ    3H2P    3H2Q    3HFF    3K91    3KH3    3KH4    3LTV    3QQD    3RE0    3T5W    4A7G    4A7Q    4A7S    4A7T    4A7U    4A7V    4B3E    4BCY    4BCZ    4BD4    4SOD   
PDB (IMB)1AZV    1BA9    1DSW    1FUN    1HL4    1HL5    1KMG    1L3N    1MFM    1N18    1N19    1OEZ    1OZT    1OZU    1P1V    1PTZ    1PU0    1RK7    1SOS    1SPD    1UXL    1UXM    2AF2    2C9S    2C9U    2C9V    2GBT    2GBU    2GBV    2LU5    2NNX    2R27    2V0A    2VR6    2VR7    2VR8    2WKO    2WYT    2WYZ    2WZ0    2WZ5    2WZ6    2XJK    2XJL    2ZKW    2ZKX    2ZKY    3CQP    3CQQ    3ECU    3ECV    3ECW    3GQF    3GTV    3GZO    3GZP    3GZQ    3H2P    3H2Q    3HFF    3K91    3KH3    3KH4    3LTV    3QQD    3RE0    3T5W    4A7G    4A7Q    4A7S    4A7T    4A7U    4A7V    4B3E    4BCY    4BCZ    4BD4    4SOD   
PDB (RSDB)1AZV    1BA9    1DSW    1FUN    1HL4    1HL5    1KMG    1L3N    1MFM    1N18    1N19    1OEZ    1OZT    1OZU    1P1V    1PTZ    1PU0    1RK7    1SOS    1SPD    1UXL    1UXM    2AF2    2C9S    2C9U    2C9V    2GBT    2GBU    2GBV    2LU5    2NNX    2R27    2V0A    2VR6    2VR7    2VR8    2WKO    2WYT    2WYZ    2WZ0    2WZ5    2WZ6    2XJK    2XJL    2ZKW    2ZKX    2ZKY    3CQP    3CQQ    3ECU    3ECV    3ECW    3GQF    3GTV    3GZO    3GZP    3GZQ    3H2P    3H2Q    3HFF    3K91    3KH3    3KH4    3LTV    3QQD    3RE0    3T5W    4A7G    4A7Q    4A7S    4A7T    4A7U    4A7V    4B3E    4BCY    4BCZ    4BD4    4SOD   
Human Protein AtlasENSG00000142168
Peptide AtlasP00441
HPRD00937
IPIIPI00218733   IPI01011706   IPI00789078   
Protein Interaction databases
DIP (DOE-UCLA)P00441
IntAct (EBI)P00441
FunCoupENSG00000142168
BioGRIDSOD1
InParanoidP00441
Interologous Interaction database P00441
IntegromeDBSOD1
STRING (EMBL)SOD1
Ontologies - Pathways
Ontology : AmiGOactivation of MAPK activity  response to superoxide  ovarian follicle development  positive regulation of cytokine production  placenta development  retina homeostasis  response to amphetamine  myeloid cell homeostasis  platelet degranulation  superoxide dismutase activity  copper ion binding  protein binding  extracellular region  extracellular space  nucleus  nucleolus  cytoplasm  mitochondrion  mitochondrial matrix  peroxisome  peroxisome  cytosol  cytosol  plasma membrane  double-strand break repair  apoptotic DNA fragmentation  glutathione metabolic process  superoxide metabolic process  superoxide metabolic process  cellular iron ion homeostasis  spermatogenesis  embryo implantation  embryo implantation  cell aging  blood coagulation  sensory perception of sound  locomotory behavior  anterograde axon cargo transport  retrograde axon cargo transport  regulation of blood pressure  zinc ion binding  response to heat  response to organic substance  transmission of nerve impulse  removal of superoxide radicals  removal of superoxide radicals  platelet activation  protein phosphatase 2B binding  extracellular matrix  cytoplasmic vesicle  response to nutrient levels  peripheral nervous system myelin maintenance  regulation of Rac GTPase activity  dendrite cytoplasm  positive regulation of superoxide anion generation  regulation of T cell differentiation in thymus  regulation of multicellular organism growth  response to drug  response to hydrogen peroxide  superoxide anion generation  identical protein binding  protein homodimerization activity  neuronal cell body  positive regulation of apoptotic process  positive regulation of catalytic activity  protein complex  negative regulation of neuron apoptotic process  response to ethanol  negative regulation of cholesterol biosynthetic process  regulation of protein kinase activity  regulation of organ growth  response to copper ion  muscle cell cellular homeostasis  Rac GTPase binding  thymus development  response to axon injury  hydrogen peroxide biosynthetic process  hydrogen peroxide biosynthetic process  chaperone binding  regulation of mitochondrial membrane potential  heart contraction  neurofilament cytoskeleton organization  relaxation of vascular smooth muscle  auditory receptor cell stereocilium organization  positive regulation of intrinsic apoptotic signaling pathway in response to oxidative stress  
Ontology : EGO-EBIactivation of MAPK activity  response to superoxide  ovarian follicle development  positive regulation of cytokine production  placenta development  retina homeostasis  response to amphetamine  myeloid cell homeostasis  platelet degranulation  superoxide dismutase activity  copper ion binding  protein binding  extracellular region  extracellular space  nucleus  nucleolus  cytoplasm  mitochondrion  mitochondrial matrix  peroxisome  peroxisome  cytosol  cytosol  plasma membrane  double-strand break repair  apoptotic DNA fragmentation  glutathione metabolic process  superoxide metabolic process  superoxide metabolic process  cellular iron ion homeostasis  spermatogenesis  embryo implantation  embryo implantation  cell aging  blood coagulation  sensory perception of sound  locomotory behavior  anterograde axon cargo transport  retrograde axon cargo transport  regulation of blood pressure  zinc ion binding  response to heat  response to organic substance  transmission of nerve impulse  removal of superoxide radicals  removal of superoxide radicals  platelet activation  protein phosphatase 2B binding  extracellular matrix  cytoplasmic vesicle  response to nutrient levels  peripheral nervous system myelin maintenance  regulation of Rac GTPase activity  dendrite cytoplasm  positive regulation of superoxide anion generation  regulation of T cell differentiation in thymus  regulation of multicellular organism growth  response to drug  response to hydrogen peroxide  superoxide anion generation  identical protein binding  protein homodimerization activity  neuronal cell body  positive regulation of apoptotic process  positive regulation of catalytic activity  protein complex  negative regulation of neuron apoptotic process  response to ethanol  negative regulation of cholesterol biosynthetic process  regulation of protein kinase activity  regulation of organ growth  response to copper ion  muscle cell cellular homeostasis  Rac GTPase binding  thymus development  response to axon injury  hydrogen peroxide biosynthetic process  hydrogen peroxide biosynthetic process  chaperone binding  regulation of mitochondrial membrane potential  heart contraction  neurofilament cytoskeleton organization  relaxation of vascular smooth muscle  auditory receptor cell stereocilium organization  positive regulation of intrinsic apoptotic signaling pathway in response to oxidative stress  
Pathways : BIOCARTACardiac Protection Against ROS [Genes]    Free Radical Induced Apoptosis [Genes]    The IGF-1 Receptor and Longevity [Genes]   
Pathways : KEGGPeroxisome    Amyotrophic lateral sclerosis (ALS)    Huntington's disease    Prion diseases   
REACTOMESOD1
Protein Interaction DatabaseSOD1
Wikipedia pathwaysSOD1
Gene fusion - rearrangments
Polymorphisms : SNP, mutations, diseases
SNP Single Nucleotide Polymorphism (NCBI)SOD1
SNP (GeneSNP Utah)SOD1
SNP : HGBaseSOD1
Genetic variants : HAPMAPSOD1
1000_GenomesSOD1 
ICGC programENSG00000142168 
Somatic Mutations in Cancer : COSMICSOD1 
CONAN: Copy Number AnalysisSOD1 
Mutations and Diseases : HGMDSOD1
OMIM105400    147450   
GENETestsSOD1
Disease Genetic AssociationSOD1
Huge Navigator SOD1 [HugePedia]  SOD1 [HugeCancerGEM]
Genomic VariantsSOD1  SOD1 [DGVbeta]
Exome VariantSOD1
dbVarSOD1
ClinVarSOD1
snp3D : Map Gene to Disease6647
General knowledge
Homologs : HomoloGeneSOD1
Homology/Alignments : Family Browser (UCSC)SOD1
Phylogenetic Trees/Animal Genes : TreeFamSOD1
Chemical/Protein Interactions : CTD6647
Chemical/Pharm GKB GenePA334
Clinical trialSOD1
Cancer Resource (Charite)ENSG00000142168
Other databases
Probes
Litterature
PubMed499 Pubmed reference(s) in Entrez
CoreMineSOD1
iHOPSOD1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

Contributor(s)

Written09-2002Dessen P, Le Minor S
Updated12-2013Dessen P

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Fri Apr 18 17:09:11 CEST 2014

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