Atlas of Genetics and Cytogenetics in Oncology and Haematology


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SORBS1 (sorbin and SH3 domain containing 1)

Identity

Alias (NCBI)CAP
FLAF2
R85FL
SH3D5
SH3P12
SORB1
HGNC (Hugo) SORBS1
HGNC Alias symbFLJ12406
CAP
sh3p12
ponsin
KIAA1296
HGNC Alias namec-Cbl-associated protein
HGNC Previous nameSH3D5
HGNC Previous nameSH3-domain protein 5 (ponsin)
LocusID (NCBI) 10580
Atlas_Id 57478
Location 10q24.1  [Link to chromosome band 10q24]
Location_base_pair Starts at 95311773 and ends at 95561371 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
AKIRIN1 (1p34.3) / SORBS1 (10q24.1)GNG4 (1q42.3) / SORBS1 (10q24.1)LLGL2 (17q25.1) / SORBS1 (10q24.1)
MKI67 (10q26.2) / SORBS1 (10q24.1)MSC (8q13.3) / SORBS1 (10q24.1)PDLIM1 (10q23.33) / SORBS1 (10q24.1)
PRICKLE1 (12q12) / SORBS1 (10q24.1)SORBS1 (10q24.1) / IMMP2L (7q31.1)SORBS1 (10q24.1) / MIAT (22q12.1)
SORBS1 (10q24.1) / SORBS1 (10q24.1)SORBS1 (10q24.1) / SPOP (17q21.33)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 1 ]
  PDLIM1/SORBS1 (10q24)


External links

Nomenclature
HGNC (Hugo)SORBS1   14565
Cards
Entrez_Gene (NCBI)SORBS1    sorbin and SH3 domain containing 1
AliasesCAP; FLAF2; R85FL; SH3D5; 
SH3P12; SORB1
GeneCards (Weizmann)SORBS1
Ensembl hg19 (Hinxton)ENSG00000095637 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000095637 [Gene_View]  ENSG00000095637 [Sequence]  chr10:95311773-95561371 [Contig_View]  SORBS1 [Vega]
ICGC DataPortalENSG00000095637
TCGA cBioPortalSORBS1
AceView (NCBI)SORBS1
Genatlas (Paris)SORBS1
SOURCE (Princeton)SORBS1
Genetics Home Reference (NIH)SORBS1
Genomic and cartography
GoldenPath hg38 (UCSC)SORBS1  -     chr10:95311773-95561371 -  10q24.1   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)SORBS1  -     10q24.1   [Description]    (hg19-Feb_2009)
GoldenPathSORBS1 - 10q24.1 [CytoView hg19]  SORBS1 - 10q24.1 [CytoView hg38]
ImmunoBaseENSG00000095637
genome Data Viewer NCBISORBS1 [Mapview hg19]  
OMIM605264   
Gene and transcription
Genbank (Entrez)AB037717 AF136380 AF136381 AF330623 AF330624
RefSeq transcript (Entrez)NM_001034954 NM_001034955 NM_001034956 NM_001034957 NM_001290294 NM_001290295 NM_001290296 NM_001290297 NM_001290298 NM_001377197 NM_001377198 NM_001377199 NM_001377200 NM_001377201 NM_001377202 NM_001377203 NM_001377204 NM_001377205 NM_001377206 NM_001377207 NM_001377208 NM_001377209 NM_001384447 NM_001384448 NM_001384449 NM_001384450 NM_001384451 NM_001384452 NM_001384453 NM_001384454 NM_001384455 NM_001384456 NM_001384457 NM_001384458 NM_001384459 NM_001384460 NM_001384461 NM_001384462 NM_001384463 NM_001384464 NM_001384465 NM_006434 NM_015385 NM_024991
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)SORBS1
Alternative Splicing GalleryENSG00000095637
Gene ExpressionSORBS1 [ NCBI-GEO ]   SORBS1 [ EBI - ARRAY_EXPRESS ]   SORBS1 [ SEEK ]   SORBS1 [ MEM ]
Gene Expression Viewer (FireBrowse)SORBS1 [ Firebrowse - Broad ]
GenevisibleExpression of SORBS1 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)10580
GTEX Portal (Tissue expression)SORBS1
Human Protein AtlasENSG00000095637-SORBS1 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9BX66   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9BX66  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9BX66
Splice isoforms : SwissVarQ9BX66
PhosPhoSitePlusQ9BX66
Domaine pattern : Prosite (Expaxy)SH3 (PS50002)    SOHO (PS50831)   
Domains : Interpro (EBI)SH3-like_dom_sf    SH3_domain    SoHo_dom    SORBS1_SH3    SORBS1_SH3_1    SORBS1_SH3_2   
Domain families : Pfam (Sanger)SH3_1 (PF00018)    SH3_2 (PF07653)    SH3_9 (PF14604)    Sorb (PF02208)   
Domain families : Pfam (NCBI)pfam00018    pfam07653    pfam14604    pfam02208   
Domain families : Smart (EMBL)SH3 (SM00326)  Sorb (SM00459)  
Conserved Domain (NCBI)SORBS1
Blocks (Seattle)SORBS1
PDB (RSDB)2DL3    2ECZ    2LJ0    2LJ1    2MOX    2O2W    2O31    2O9S    2O9V    4LN2    4LNP   
PDB Europe2DL3    2ECZ    2LJ0    2LJ1    2MOX    2O2W    2O31    2O9S    2O9V    4LN2    4LNP   
PDB (PDBSum)2DL3    2ECZ    2LJ0    2LJ1    2MOX    2O2W    2O31    2O9S    2O9V    4LN2    4LNP   
PDB (IMB)2DL3    2ECZ    2LJ0    2LJ1    2MOX    2O2W    2O31    2O9S    2O9V    4LN2    4LNP   
Structural Biology KnowledgeBase2DL3    2ECZ    2LJ0    2LJ1    2MOX    2O2W    2O31    2O9S    2O9V    4LN2    4LNP   
SCOP (Structural Classification of Proteins)2DL3    2ECZ    2LJ0    2LJ1    2MOX    2O2W    2O31    2O9S    2O9V    4LN2    4LNP   
CATH (Classification of proteins structures)2DL3    2ECZ    2LJ0    2LJ1    2MOX    2O2W    2O31    2O9S    2O9V    4LN2    4LNP   
SuperfamilyQ9BX66
Human Protein Atlas [tissue]ENSG00000095637-SORBS1 [tissue]
Peptide AtlasQ9BX66
IPIIPI00186452   IPI00807389   IPI01018230   IPI00010555   IPI00010554   IPI00454950   IPI00454951   IPI00334908   IPI00383430   IPI00064591   IPI00002491   IPI00654848   IPI00426075   IPI00306791   IPI00979864   
Protein Interaction databases
DIP (DOE-UCLA)Q9BX66
IntAct (EBI)Q9BX66
BioGRIDSORBS1
STRING (EMBL)SORBS1
ZODIACSORBS1
Ontologies - Pathways
QuickGOQ9BX66
Ontology : AmiGOstress fiber  actin binding  insulin receptor binding  protein binding  nucleus  centrosome  cytosol  cytosol  insulin receptor complex  adherens junction  zonula adherens  focal adhesion  muscle contraction  cell-matrix adhesion  cytoskeletal protein binding  insulin receptor signaling pathway  nuclear matrix  cell-substrate junction  receptor signaling complex scaffold activity  cellular response to insulin stimulus  stress fiber assembly  membrane raft  positive regulation of glycogen biosynthetic process  positive regulation of glucose import  positive regulation of insulin receptor signaling pathway  positive regulation of lipid biosynthetic process  focal adhesion assembly  positive regulation of protein localization to plasma membrane  
Ontology : EGO-EBIstress fiber  actin binding  insulin receptor binding  protein binding  nucleus  centrosome  cytosol  cytosol  insulin receptor complex  adherens junction  zonula adherens  focal adhesion  muscle contraction  cell-matrix adhesion  cytoskeletal protein binding  insulin receptor signaling pathway  nuclear matrix  cell-substrate junction  receptor signaling complex scaffold activity  cellular response to insulin stimulus  stress fiber assembly  membrane raft  positive regulation of glycogen biosynthetic process  positive regulation of glucose import  positive regulation of insulin receptor signaling pathway  positive regulation of lipid biosynthetic process  focal adhesion assembly  positive regulation of protein localization to plasma membrane  
Pathways : KEGGPPAR signaling pathway    Adherens junction    Insulin signaling pathway   
NDEx NetworkSORBS1
Atlas of Cancer Signalling NetworkSORBS1
Wikipedia pathwaysSORBS1
Orthology - Evolution
OrthoDB10580
GeneTree (enSembl)ENSG00000095637
Phylogenetic Trees/Animal Genes : TreeFamSORBS1
HOGENOMQ9BX66
Homologs : HomoloGeneSORBS1
Homology/Alignments : Family Browser (UCSC)SORBS1
Gene fusions - Rearrangements
Fusion : QuiverSORBS1
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerSORBS1 [hg38]
dbVarSORBS1
ClinVarSORBS1
MonarchSORBS1
1000_GenomesSORBS1 
Exome Variant ServerSORBS1
GNOMAD BrowserENSG00000095637
Varsome BrowserSORBS1
Genomic Variants (DGV)SORBS1 [DGVbeta]
DECIPHERSORBS1 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisSORBS1 
Mutations
ICGC Data PortalSORBS1 
TCGA Data PortalSORBS1 
Broad Tumor PortalSORBS1
OASIS PortalSORBS1 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICSORBS1  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DSORBS1
Mutations and Diseases : HGMDSORBS1
BioMutasearch SORBS1
DgiDB (Drug Gene Interaction Database)SORBS1
DoCM (Curated mutations)SORBS1 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)SORBS1 (select a term)
intoGenSORBS1
Cancer3DSORBS1(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM605264   
Orphanet
DisGeNETSORBS1
MedgenSORBS1
Genetic Testing Registry SORBS1
NextProtQ9BX66 [Medical]
GENETestsSORBS1
Target ValidationSORBS1
Huge Navigator SORBS1 [HugePedia]
ClinGenSORBS1
Clinical trials, drugs, therapy
MyCancerGenomeSORBS1
Protein Interactions : CTD
Pharm GKB GenePA37899
PharosQ9BX66
Clinical trialSORBS1
Miscellaneous
canSAR (ICR)SORBS1 (select the gene name)
HarmonizomeSORBS1
DataMed IndexSORBS1
Probes
Litterature
PubMed79 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXSORBS1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Fri Jan 1 18:38:43 CET 2021

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