SORBS3 (sorbin and SH3 domain containing 3)

2010-07-01  

Identity

HGNC
SORBS3
LOCATION
8p21.3
LOCUSID
10174
ALIAS
SCAM-1,SCAM1,SH3D4
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 10174
MIM: 610795
HGNC: 30907
Ensembl: ENSG00000120896

Variants:

dbSNP: 10174
ClinVar: 10174
TCGA: ENSG00000120896
COSMIC: SORBS3

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000120896ENST00000240123O60504
ENSG00000120896ENST00000517500E7EQH0
ENSG00000120896ENST00000517962H0YAZ3
ENSG00000120896ENST00000520563H0YAU6
ENSG00000120896ENST00000522721E5RIA0
ENSG00000120896ENST00000523348H0YB51
ENSG00000120896ENST00000523900E5RJP2
ENSG00000120896ENST00000523965O60504

Expression (GTEx)

0
50
100
150
200
250
300
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Muscle contractionREACTOMER-HSA-397014
Smooth Muscle ContractionREACTOMER-HSA-445355

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
157347362005Vinexin beta interacts with the non-phosphorylated AF-1 domain of retinoid receptor gamma (RARgamma) and represses RARgamma-mediated transcription.20
203619632010Crucial role of vinexin for keratinocyte migration in vitro and epidermal wound healing in vivo.15
192944872009Interaction of a multi-domain adaptor protein, vinexin, with a Rho-effector, Rhotekin.14
151843912004Extracellular signal-regulated kinase activated by epidermal growth factor and cell adhesion interacts with and phosphorylates vinexin.11
169231192006Vinexin beta regulates the phosphorylation of epidermal growth factor receptor on the cell surface.8
273118822016Chromosome 8p tumor suppressor genes SH2D4A and SORBS3 cooperate to inhibit interleukin-6 signaling in hepatocellular carcinoma.8
174860602007Essential roles of ERK-mediated phosphorylation of vinexin in cell spreading, migration and anchorage-independent growth.7
274370342016Next-generation sequencing methylation profiling of subjects with obesity identifies novel gene changes.7
125103802002[A novel adaptor protein family regulating cytoskeletal organization and signal transduction--Vinexin, CAP/ponsin, ArgBP2].3
259725352015Vinexin β Interacts with Hepatitis C Virus NS5A, Modulating Its Hyperphosphorylation To Regulate Viral Propagation.3

Citation

Dessen P

SORBS3 (sorbin and SH3 domain containing 3)

Atlas Genet Cytogenet Oncol Haematol. 2010-07-01

Online version: http://atlasgeneticsoncology.org/gene/51545/sorbs3