Atlas of Genetics and Cytogenetics in Oncology and Haematology


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SORBS3 (sorbin and SH3 domain containing 3)

Identity

Alias (NCBI)SCAM-1
SCAM1
SH3D4
HGNC (Hugo) SORBS3
HGNC Alias symbSCAM-1
SH3D4
vinexin
LocusID (NCBI) 10174
Atlas_Id 51545
Location 8p21.3  [Link to chromosome band 8p21]
Location_base_pair Starts at 22551927 and ends at 22575788 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
CCAR2 (8p21.3) / SORBS3 (8p21.3)EFHC1 (6p12.2) / SORBS3 (8p21.3)SORBS3 (8p21.3) / SEPT4 (17q22)
TUSC3 (8p22) / SORBS3 (8p21.3)TUSC3 8p22 / SORBS3 8p21.3

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



External links

 

Nomenclature
HGNC (Hugo)SORBS3   30907
Cards
Entrez_Gene (NCBI)SORBS3    sorbin and SH3 domain containing 3
AliasesSCAM-1; SCAM1; SH3D4
GeneCards (Weizmann)SORBS3
Ensembl hg19 (Hinxton)ENSG00000120896 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000120896 [Gene_View]  ENSG00000120896 [Sequence]  chr8:22551927-22575788 [Contig_View]  SORBS3 [Vega]
ICGC DataPortalENSG00000120896
TCGA cBioPortalSORBS3
AceView (NCBI)SORBS3
Genatlas (Paris)SORBS3
SOURCE (Princeton)SORBS3
Genetics Home Reference (NIH)SORBS3
Genomic and cartography
GoldenPath hg38 (UCSC)SORBS3  -     chr8:22551927-22575788 +  8p21.3   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)SORBS3  -     8p21.3   [Description]    (hg19-Feb_2009)
GoldenPathSORBS3 - 8p21.3 [CytoView hg19]  SORBS3 - 8p21.3 [CytoView hg38]
ImmunoBaseENSG00000120896
Genome Data Viewer NCBISORBS3 [Mapview hg19]  
OMIM610795   
Gene and transcription
Genbank (Entrez)AF037261 AF064807 AK301196 AK303950 BC004314
RefSeq transcript (Entrez)NM_001018003 NM_005775
Consensus coding sequences : CCDS (NCBI)SORBS3
Gene ExpressionSORBS3 [ NCBI-GEO ]   SORBS3 [ EBI - ARRAY_EXPRESS ]   SORBS3 [ SEEK ]   SORBS3 [ MEM ]
Gene Expression Viewer (FireBrowse)SORBS3 [ Firebrowse - Broad ]
GenevisibleExpression of SORBS3 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)10174
GTEX Portal (Tissue expression)SORBS3
Human Protein AtlasENSG00000120896-SORBS3 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtO60504   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtO60504  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProO60504
PhosPhoSitePlusO60504
Domaine pattern : Prosite (Expaxy)SH3 (PS50002)    SOHO (PS50831)   
Domains : Interpro (EBI)SH3-like_dom_sf    SH3_domain    SoHo_dom    Vinexin    Vinexin_SH3_1    Vinexin_SH3_2    Vinexin_SH3_3   
Domain families : Pfam (Sanger)SH3_1 (PF00018)    SH3_9 (PF14604)    Sorb (PF02208)   
Domain families : Pfam (NCBI)pfam00018    pfam14604    pfam02208   
Domain families : Smart (EMBL)SH3 (SM00326)  Sorb (SM00459)  
Conserved Domain (NCBI)SORBS3
PDB (RSDB)2CT3    2DLM    2NWM    2YUP   
PDB Europe2CT3    2DLM    2NWM    2YUP   
PDB (PDBSum)2CT3    2DLM    2NWM    2YUP   
PDB (IMB)2CT3    2DLM    2NWM    2YUP   
Structural Biology KnowledgeBase2CT3    2DLM    2NWM    2YUP   
SCOP (Structural Classification of Proteins)2CT3    2DLM    2NWM    2YUP   
CATH (Classification of proteins structures)2CT3    2DLM    2NWM    2YUP   
SuperfamilyO60504
AlphaFold pdb e-kbO60504   
Human Protein Atlas [tissue]ENSG00000120896-SORBS3 [tissue]
HPRD11535
Protein Interaction databases
DIP (DOE-UCLA)O60504
IntAct (EBI)O60504
BioGRIDSORBS3
STRING (EMBL)SORBS3
ZODIACSORBS3
Ontologies - Pathways
QuickGOO60504
Ontology : AmiGOnegative regulation of transcription by RNA polymerase II  structural constituent of cytoskeleton  protein binding  nucleus  cytosol  cytoskeleton  focal adhesion  focal adhesion  muscle contraction  actin filament organization  cell adhesion  vinculin binding  cell-substrate adhesion  positive regulation of MAPK cascade  positive regulation of cytoskeleton organization  positive regulation of stress fiber assembly  
Ontology : EGO-EBInegative regulation of transcription by RNA polymerase II  structural constituent of cytoskeleton  protein binding  nucleus  cytosol  cytoskeleton  focal adhesion  focal adhesion  muscle contraction  actin filament organization  cell adhesion  vinculin binding  cell-substrate adhesion  positive regulation of MAPK cascade  positive regulation of cytoskeleton organization  positive regulation of stress fiber assembly  
NDEx NetworkSORBS3
Atlas of Cancer Signalling NetworkSORBS3
Wikipedia pathwaysSORBS3
Orthology - Evolution
OrthoDB10174
GeneTree (enSembl)ENSG00000120896
Phylogenetic Trees/Animal Genes : TreeFamSORBS3
Homologs : HomoloGeneSORBS3
Homology/Alignments : Family Browser (UCSC)SORBS3
Gene fusions - Rearrangements
Fusion : MitelmanCCAR2/SORBS3 [8p21.3/8p21.3]  
Fusion : MitelmanTUSC3/SORBS3 [8p22/8p21.3]  
Fusion : QuiverSORBS3
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerSORBS3 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)SORBS3
dbVarSORBS3
ClinVarSORBS3
MonarchSORBS3
1000_GenomesSORBS3 
Exome Variant ServerSORBS3
GNOMAD BrowserENSG00000120896
Varsome BrowserSORBS3
ACMGSORBS3 variants
VarityO60504
Genomic Variants (DGV)SORBS3 [DGVbeta]
DECIPHERSORBS3 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisSORBS3 
Mutations
ICGC Data PortalSORBS3 
TCGA Data PortalSORBS3 
Broad Tumor PortalSORBS3
OASIS PortalSORBS3 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICSORBS3  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DSORBS3
Mutations and Diseases : HGMDSORBS3
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaSORBS3
DgiDB (Drug Gene Interaction Database)SORBS3
DoCM (Curated mutations)SORBS3
CIViC (Clinical Interpretations of Variants in Cancer)SORBS3
Cancer3DSORBS3
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM610795   
Orphanet
DisGeNETSORBS3
MedgenSORBS3
Genetic Testing Registry SORBS3
NextProtO60504 [Medical]
GENETestsSORBS3
Target ValidationSORBS3
Huge Navigator SORBS3 [HugePedia]
ClinGenSORBS3
Clinical trials, drugs, therapy
MyCancerGenomeSORBS3
Protein Interactions : CTDSORBS3
Pharm GKB GenePA128394570
PharosO60504
Clinical trialSORBS3
Miscellaneous
canSAR (ICR)SORBS3
HarmonizomeSORBS3
DataMed IndexSORBS3
Probes
Litterature
PubMed49 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXSORBS3
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Oct 4 15:32:37 CEST 2021

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