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SORBS3 (sorbin and SH3 domain containing 3)

Identity

Alias_symbol (synonym)SCAM-1
SH3D4
vinexin
Other aliasSCAM1
HGNC (Hugo) SORBS3
LocusID (NCBI) 10174
Atlas_Id 51545
Location 8p21.3  [Link to chromosome band 8p21]
Location_base_pair Starts at 22565666 and ends at 22575495 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
CCAR2 (8p21.3) / SORBS3 (8p21.3)EFHC1 (6p12.2) / SORBS3 (8p21.3)SORBS3 (8p21.3) / SEPT4 (17q22)
TUSC3 (8p22) / SORBS3 (8p21.3)TUSC3 8p22 / SORBS3 8p21.3

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)SORBS3   30907
Cards
Entrez_Gene (NCBI)SORBS3  10174  sorbin and SH3 domain containing 3
AliasesSCAM-1; SCAM1; SH3D4
GeneCards (Weizmann)SORBS3
Ensembl hg19 (Hinxton)ENSG00000120896 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000120896 [Gene_View]  chr8:22565666-22575495 [Contig_View]  SORBS3 [Vega]
ICGC DataPortalENSG00000120896
TCGA cBioPortalSORBS3
AceView (NCBI)SORBS3
Genatlas (Paris)SORBS3
WikiGenes10174
SOURCE (Princeton)SORBS3
Genetics Home Reference (NIH)SORBS3
Genomic and cartography
GoldenPath hg38 (UCSC)SORBS3  -     chr8:22565666-22575495 +  8p21.3   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)SORBS3  -     8p21.3   [Description]    (hg19-Feb_2009)
EnsemblSORBS3 - 8p21.3 [CytoView hg19]  SORBS3 - 8p21.3 [CytoView hg38]
Mapping of homologs : NCBISORBS3 [Mapview hg19]  SORBS3 [Mapview hg38]
OMIM610795   
Gene and transcription
Genbank (Entrez)AF037261 AF064807 AK301196 AK303950 BC004314
RefSeq transcript (Entrez)NM_001018003 NM_005775
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)SORBS3
Cluster EST : UnigeneHs.528572 [ NCBI ]
CGAP (NCI)Hs.528572
Alternative Splicing GalleryENSG00000120896
Gene ExpressionSORBS3 [ NCBI-GEO ]   SORBS3 [ EBI - ARRAY_EXPRESS ]   SORBS3 [ SEEK ]   SORBS3 [ MEM ]
Gene Expression Viewer (FireBrowse)SORBS3 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)10174
GTEX Portal (Tissue expression)SORBS3
Protein : pattern, domain, 3D structure
UniProt/SwissProtO60504   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtO60504  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProO60504
Splice isoforms : SwissVarO60504
PhosPhoSitePlusO60504
Domaine pattern : Prosite (Expaxy)SH3 (PS50002)    SOHO (PS50831)   
Domains : Interpro (EBI)SH3_domain    SoHo_dom    Vinexin   
Domain families : Pfam (Sanger)SH3_1 (PF00018)    SH3_9 (PF14604)    Sorb (PF02208)   
Domain families : Pfam (NCBI)pfam00018    pfam14604    pfam02208   
Domain families : Smart (EMBL)SH3 (SM00326)  Sorb (SM00459)  
Conserved Domain (NCBI)SORBS3
DMDM Disease mutations10174
Blocks (Seattle)SORBS3
PDB (SRS)2CT3    2DLM    2NWM    2YUP   
PDB (PDBSum)2CT3    2DLM    2NWM    2YUP   
PDB (IMB)2CT3    2DLM    2NWM    2YUP   
PDB (RSDB)2CT3    2DLM    2NWM    2YUP   
Structural Biology KnowledgeBase2CT3    2DLM    2NWM    2YUP   
SCOP (Structural Classification of Proteins)2CT3    2DLM    2NWM    2YUP   
CATH (Classification of proteins structures)2CT3    2DLM    2NWM    2YUP   
SuperfamilyO60504
Human Protein AtlasENSG00000120896
Peptide AtlasO60504
HPRD11535
IPIIPI00419847   IPI00939882   IPI00604452   IPI00910304   IPI00984081   IPI00973936   IPI00979513   IPI01026355   IPI00975945   IPI00981430   IPI00977889   IPI00978357   IPI00980834   IPI00980097   
Protein Interaction databases
DIP (DOE-UCLA)O60504
IntAct (EBI)O60504
FunCoupENSG00000120896
BioGRIDSORBS3
STRING (EMBL)SORBS3
ZODIACSORBS3
Ontologies - Pathways
QuickGOO60504
Ontology : AmiGOnegative regulation of transcription from RNA polymerase II promoter  structural constituent of cytoskeleton  protein binding  nucleus  cytosol  cytoskeleton  focal adhesion  focal adhesion  muscle contraction  actin filament organization  cell adhesion  transcription factor binding  vinculin binding  cell-substrate adhesion  positive regulation of MAPK cascade  positive regulation of cytoskeleton organization  positive regulation of stress fiber assembly  
Ontology : EGO-EBInegative regulation of transcription from RNA polymerase II promoter  structural constituent of cytoskeleton  protein binding  nucleus  cytosol  cytoskeleton  focal adhesion  focal adhesion  muscle contraction  actin filament organization  cell adhesion  transcription factor binding  vinculin binding  cell-substrate adhesion  positive regulation of MAPK cascade  positive regulation of cytoskeleton organization  positive regulation of stress fiber assembly  
NDEx NetworkSORBS3
Atlas of Cancer Signalling NetworkSORBS3
Wikipedia pathwaysSORBS3
Orthology - Evolution
OrthoDB10174
GeneTree (enSembl)ENSG00000120896
Phylogenetic Trees/Animal Genes : TreeFamSORBS3
HOVERGENO60504
HOGENOMO60504
Homologs : HomoloGeneSORBS3
Homology/Alignments : Family Browser (UCSC)SORBS3
Gene fusions - Rearrangements
Fusion : MitelmanCCAR2/SORBS3 [8p21.3/8p21.3]  [t(8;8)(p21;p21)]  
Fusion : MitelmanTUSC3/SORBS3 [8p22/8p21.3]  [t(8;8)(p21;p22)]  
Fusion: TCGATUSC3 8p22 SORBS3 8p21.3 BRCA
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerSORBS3 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)SORBS3
dbVarSORBS3
ClinVarSORBS3
1000_GenomesSORBS3 
Exome Variant ServerSORBS3
ExAC (Exome Aggregation Consortium)SORBS3 (select the gene name)
Genetic variants : HAPMAP10174
Genomic Variants (DGV)SORBS3 [DGVbeta]
DECIPHERSORBS3 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisSORBS3 
Mutations
ICGC Data PortalSORBS3 
TCGA Data PortalSORBS3 
Broad Tumor PortalSORBS3
OASIS PortalSORBS3 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICSORBS3  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDSORBS3
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch SORBS3
DgiDB (Drug Gene Interaction Database)SORBS3
DoCM (Curated mutations)SORBS3 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)SORBS3 (select a term)
intoGenSORBS3
Cancer3DSORBS3(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM610795   
Orphanet
MedgenSORBS3
Genetic Testing Registry SORBS3
NextProtO60504 [Medical]
TSGene10174
GENETestsSORBS3
Target ValidationSORBS3
Huge Navigator SORBS3 [HugePedia]
snp3D : Map Gene to Disease10174
BioCentury BCIQSORBS3
ClinGenSORBS3
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD10174
Chemical/Pharm GKB GenePA128394570
Clinical trialSORBS3
Miscellaneous
canSAR (ICR)SORBS3 (select the gene name)
Probes
Litterature
PubMed39 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineSORBS3
EVEXSORBS3
GoPubMedSORBS3
iHOPSORBS3
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Wed Jun 7 12:56:52 CEST 2017

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