Atlas of Genetics and Cytogenetics in Oncology and Haematology


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SORCS1 (sortilin related VPS10 domain containing receptor 1)

Identity

Alias_namessortilin-related VPS10 domain containing receptor 1
Alias_symbol (synonym)sorCS1
Other aliashSorCS
HGNC (Hugo) SORCS1
LocusID (NCBI) 114815
Atlas_Id 54655
Location 10q25.1  [Link to chromosome band 10q25]
Location_base_pair Starts at 108333421 and ends at 108924466 bp from pter ( according to hg19-Feb_2009)
Fusion genes
(updated 2016)
ACTR3C (7q36.1) / SORCS1 (10q25.1)FIP1L1 (4q12) / SORCS1 (10q25.1)FIP1L1 4q12 / SORCS1 10q25.1

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 1 ]
  Lung: Translocations in Squamous Cell Carcinoma


External links

Nomenclature
HGNC (Hugo)SORCS1   16697
Cards
Entrez_Gene (NCBI)SORCS1  114815  sortilin related VPS10 domain containing receptor 1
AliaseshSorCS
GeneCards (Weizmann)SORCS1
Ensembl hg19 (Hinxton)ENSG00000108018 [Gene_View]  chr10:108333421-108924466 [Contig_View]  SORCS1 [Vega]
Ensembl hg38 (Hinxton)ENSG00000108018 [Gene_View]  chr10:108333421-108924466 [Contig_View]  SORCS1 [Vega]
ICGC DataPortalENSG00000108018
TCGA cBioPortalSORCS1
AceView (NCBI)SORCS1
Genatlas (Paris)SORCS1
WikiGenes114815
SOURCE (Princeton)SORCS1
Genetics Home Reference (NIH)SORCS1
Genomic and cartography
GoldenPath hg19 (UCSC)SORCS1  -     chr10:108333421-108924466 -  10q25.1   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)SORCS1  -     10q25.1   [Description]    (hg38-Dec_2013)
EnsemblSORCS1 - 10q25.1 [CytoView hg19]  SORCS1 - 10q25.1 [CytoView hg38]
Mapping of homologs : NCBISORCS1 [Mapview hg19]  SORCS1 [Mapview hg38]
OMIM606283   
Gene and transcription
Genbank (Entrez)AB209142 AF284756 AK074581 AK123752 AK125464
RefSeq transcript (Entrez)NM_001013031 NM_001206569 NM_001206570 NM_001206571 NM_001206572 NM_052918
RefSeq genomic (Entrez)NC_000010 NC_018921 NG_029120 NT_030059 NW_004929376
Consensus coding sequences : CCDS (NCBI)SORCS1
Cluster EST : UnigeneHs.591915 [ NCBI ]
CGAP (NCI)Hs.591915
Alternative Splicing GalleryENSG00000108018
Gene ExpressionSORCS1 [ NCBI-GEO ]   SORCS1 [ EBI - ARRAY_EXPRESS ]   SORCS1 [ SEEK ]   SORCS1 [ MEM ]
Gene Expression Viewer (FireBrowse)SORCS1 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)114815
GTEX Portal (Tissue expression)SORCS1
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ8WY21   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ8WY21  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ8WY21
Splice isoforms : SwissVarQ8WY21
PhosPhoSitePlusQ8WY21
Domaine pattern : Prosite (Expaxy)PKD (PS50093)   
Domains : Interpro (EBI)PKD/Chitinase_dom    PKD_dom    Sortilin_C    Sortilin_N    VPS10   
Domain families : Pfam (Sanger)PKD (PF00801)    Sortilin-Vps10 (PF15902)    Sortilin_C (PF15901)   
Domain families : Pfam (NCBI)pfam00801    pfam15902    pfam15901   
Domain families : Smart (EMBL)PKD (SM00089)  VPS10 (SM00602)  
Conserved Domain (NCBI)SORCS1
DMDM Disease mutations114815
Blocks (Seattle)SORCS1
SuperfamilyQ8WY21
Human Protein AtlasENSG00000108018
Peptide AtlasQ8WY21
HPRD12098
IPIIPI00103597   IPI00412910   IPI00644354   IPI00644454   IPI01018203   IPI01018218   
Protein Interaction databases
DIP (DOE-UCLA)Q8WY21
IntAct (EBI)Q8WY21
FunCoupENSG00000108018
BioGRIDSORCS1
STRING (EMBL)SORCS1
ZODIACSORCS1
Ontologies - Pathways
QuickGOQ8WY21
Ontology : AmiGOprotein binding  neuropeptide signaling pathway  neuropeptide receptor activity  membrane  integral component of membrane  
Ontology : EGO-EBIprotein binding  neuropeptide signaling pathway  neuropeptide receptor activity  membrane  integral component of membrane  
NDEx NetworkSORCS1
Atlas of Cancer Signalling NetworkSORCS1
Wikipedia pathwaysSORCS1
Orthology - Evolution
OrthoDB114815
GeneTree (enSembl)ENSG00000108018
Phylogenetic Trees/Animal Genes : TreeFamSORCS1
HOVERGENQ8WY21
HOGENOMQ8WY21
Homologs : HomoloGeneSORCS1
Homology/Alignments : Family Browser (UCSC)SORCS1
Gene fusions - Rearrangements
Fusion : MitelmanACTR3C/SORCS1 [7q36.1/10q25.1]  [t(7;10)(q36;q25)]  
Fusion : MitelmanFIP1L1/SORCS1 [4q12/10q25.1]  [t(4;10)(q12;q25)]  
Fusion: TCGAFIP1L1 4q12 SORCS1 10q25.1 LUAD
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerSORCS1 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)SORCS1
dbVarSORCS1
ClinVarSORCS1
1000_GenomesSORCS1 
Exome Variant ServerSORCS1
ExAC (Exome Aggregation Consortium)SORCS1 (select the gene name)
Genetic variants : HAPMAP114815
Genomic Variants (DGV)SORCS1 [DGVbeta]
DECIPHER (Syndromes)10:108333421-108924466  ENSG00000108018
CONAN: Copy Number AnalysisSORCS1 
Mutations
ICGC Data PortalSORCS1 
TCGA Data PortalSORCS1 
Broad Tumor PortalSORCS1
OASIS PortalSORCS1 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICSORCS1  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDSORCS1
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch SORCS1
DgiDB (Drug Gene Interaction Database)SORCS1
DoCM (Curated mutations)SORCS1 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)SORCS1 (select a term)
intoGenSORCS1
Cancer3DSORCS1(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM606283   
Orphanet
MedgenSORCS1
Genetic Testing Registry SORCS1
NextProtQ8WY21 [Medical]
TSGene114815
GENETestsSORCS1
Huge Navigator SORCS1 [HugePedia]
snp3D : Map Gene to Disease114815
BioCentury BCIQSORCS1
ClinGenSORCS1
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD114815
Chemical/Pharm GKB GenePA134861284
Clinical trialSORCS1
Miscellaneous
canSAR (ICR)SORCS1 (select the gene name)
Probes
Litterature
PubMed30 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineSORCS1
EVEXSORCS1
GoPubMedSORCS1
iHOPSORCS1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Tue Mar 14 13:28:38 CET 2017

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