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SORCS2 (sortilin related VPS10 domain containing receptor 2)

Identity

Alias (NCBI)-
HGNC (Hugo) SORCS2
HGNC Alias symbKIAA1329
HGNC Previous namesortilin-related VPS10 domain containing receptor 2
LocusID (NCBI) 57537
Atlas_Id 74072
Location 4p16.1  [Link to chromosome band 4p16]
Location_base_pair Starts at 7192647 and ends at 7742837 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
CRTC1 (19p13.11) / SORCS2 (4p16.1)RSPH14 (22q11.22) / SORCS2 (4p16.1)SORCS2 (4p16.1) / SH3TC1 (4p16.1)
SORCS2 (4p16.1) / SPSB1 (1p36.22)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 1 ]
  SORCS2/SH3TC1 (4p16)


External links

Nomenclature
HGNC (Hugo)SORCS2   16698
Cards
Entrez_Gene (NCBI)SORCS2  57537  sortilin related VPS10 domain containing receptor 2
Aliases
GeneCards (Weizmann)SORCS2
Ensembl hg19 (Hinxton)ENSG00000184985 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000184985 [Gene_View]  ENSG00000184985 [Sequence]  chr4:7192647-7742837 [Contig_View]  SORCS2 [Vega]
ICGC DataPortalENSG00000184985
TCGA cBioPortalSORCS2
AceView (NCBI)SORCS2
Genatlas (Paris)SORCS2
WikiGenes57537
SOURCE (Princeton)SORCS2
Genetics Home Reference (NIH)SORCS2
Genomic and cartography
GoldenPath hg38 (UCSC)SORCS2  -     chr4:7192647-7742837 +  4p16.1   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)SORCS2  -     4p16.1   [Description]    (hg19-Feb_2009)
GoldenPathSORCS2 - 4p16.1 [CytoView hg19]  SORCS2 - 4p16.1 [CytoView hg38]
ImmunoBaseENSG00000184985
genome Data Viewer NCBISORCS2 [Mapview hg19]  
OMIM606284   
Gene and transcription
Genbank (Entrez)AB037750 AF286190 AI206155 AK295629 BC035257
RefSeq transcript (Entrez)NM_020777
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)SORCS2
Alternative Splicing GalleryENSG00000184985
Gene ExpressionSORCS2 [ NCBI-GEO ]   SORCS2 [ EBI - ARRAY_EXPRESS ]   SORCS2 [ SEEK ]   SORCS2 [ MEM ]
Gene Expression Viewer (FireBrowse)SORCS2 [ Firebrowse - Broad ]
GenevisibleExpression of SORCS2 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)57537
GTEX Portal (Tissue expression)SORCS2
Human Protein AtlasENSG00000184985-SORCS2 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ96PQ0   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ96PQ0  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ96PQ0
Splice isoforms : SwissVarQ96PQ0
PhosPhoSitePlusQ96PQ0
Domaine pattern : Prosite (Expaxy)PKD (PS50093)   
Domains : Interpro (EBI)Ig-like_fold    PKD/Chitinase_dom    PKD_dom    PKD_dom_sf    Sortilin_C    Sortilin_N    VPS10    WD40/YVTN_repeat-like_dom_sf   
Domain families : Pfam (Sanger)PKD (PF00801)    Sortilin-Vps10 (PF15902)    Sortilin_C (PF15901)   
Domain families : Pfam (NCBI)pfam00801    pfam15902    pfam15901   
Domain families : Smart (EMBL)PKD (SM00089)  VPS10 (SM00602)  
Conserved Domain (NCBI)SORCS2
DMDM Disease mutations57537
Blocks (Seattle)SORCS2
PDB (RSDB)1WGO   
PDB Europe1WGO   
PDB (PDBSum)1WGO   
PDB (IMB)1WGO   
Structural Biology KnowledgeBase1WGO   
SCOP (Structural Classification of Proteins)1WGO   
CATH (Classification of proteins structures)1WGO   
SuperfamilyQ96PQ0
Human Protein Atlas [tissue]ENSG00000184985-SORCS2 [tissue]
Peptide AtlasQ96PQ0
HPRD12099
IPIIPI00044600   IPI00903209   
Protein Interaction databases
DIP (DOE-UCLA)Q96PQ0
IntAct (EBI)Q96PQ0
FunCoupENSG00000184985
BioGRIDSORCS2
STRING (EMBL)SORCS2
ZODIACSORCS2
Ontologies - Pathways
QuickGOQ96PQ0
Ontology : AmiGOintegral component of plasma membrane  intracellular protein transport  neuropeptide signaling pathway  neuropeptide receptor activity  postsynaptic density  membrane  integral component of membrane  cell junction  cytoplasmic vesicle membrane  early endosome membrane  dendritic spine  perikaryon  postsynaptic membrane  recycling endosome membrane  long-term synaptic depression  
Ontology : EGO-EBIintegral component of plasma membrane  intracellular protein transport  neuropeptide signaling pathway  neuropeptide receptor activity  postsynaptic density  membrane  integral component of membrane  cell junction  cytoplasmic vesicle membrane  early endosome membrane  dendritic spine  perikaryon  postsynaptic membrane  recycling endosome membrane  long-term synaptic depression  
NDEx NetworkSORCS2
Atlas of Cancer Signalling NetworkSORCS2
Wikipedia pathwaysSORCS2
Orthology - Evolution
OrthoDB57537
GeneTree (enSembl)ENSG00000184985
Phylogenetic Trees/Animal Genes : TreeFamSORCS2
HOGENOMQ96PQ0
Homologs : HomoloGeneSORCS2
Homology/Alignments : Family Browser (UCSC)SORCS2
Gene fusions - Rearrangements
Fusion : QuiverSORCS2
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerSORCS2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)SORCS2
dbVarSORCS2
ClinVarSORCS2
1000_GenomesSORCS2 
Exome Variant ServerSORCS2
GNOMAD BrowserENSG00000184985
Varsome BrowserSORCS2
Genetic variants : HAPMAP57537
Genomic Variants (DGV)SORCS2 [DGVbeta]
DECIPHERSORCS2 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisSORCS2 
Mutations
ICGC Data PortalSORCS2 
TCGA Data PortalSORCS2 
Broad Tumor PortalSORCS2
OASIS PortalSORCS2 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICSORCS2  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DSORCS2
Mutations and Diseases : HGMDSORCS2
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch SORCS2
DgiDB (Drug Gene Interaction Database)SORCS2
DoCM (Curated mutations)SORCS2 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)SORCS2 (select a term)
intoGenSORCS2
Cancer3DSORCS2(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM606284   
Orphanet
DisGeNETSORCS2
MedgenSORCS2
Genetic Testing Registry SORCS2
NextProtQ96PQ0 [Medical]
TSGene57537
GENETestsSORCS2
Target ValidationSORCS2
Huge Navigator SORCS2 [HugePedia]
snp3D : Map Gene to Disease57537
BioCentury BCIQSORCS2
ClinGenSORCS2
Clinical trials, drugs, therapy
Protein Interactions : CTD57537
Pharm GKB GenePA134902026
Clinical trialSORCS2
Miscellaneous
canSAR (ICR)SORCS2 (select the gene name)
HarmonizomeSORCS2
DataMed IndexSORCS2
Probes
Litterature
PubMed19 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineSORCS2
EVEXSORCS2
GoPubMedSORCS2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

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indexed on : Sat Aug 22 19:36:33 CEST 2020

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