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SORCS2 (sortilin-related VPS10 domain containing receptor 2)

Identity

Alias_namessortilin-related VPS10 domain containing receptor 2
Alias_symbol (synonym)KIAA1329
Other alias-
HGNC (Hugo) SORCS2
LocusID (NCBI) 57537
Atlas_Id 74072
Location 4p16.1  [Link to chromosome band 4p16]
Location_base_pair Starts at 7194374 and ends at 7744564 bp from pter ( according to hg19-Feb_2009)
Fusion genes
(updated 2016)
CRTC1 (19p13.11) / SORCS2 (4p16.1)RSPH14 (22q11.22) / SORCS2 (4p16.1)SORCS2 (4p16.1) / SH3TC1 (4p16.1)
SORCS2 (4p16.1) / SPSB1 (1p36.22)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)SORCS2   16698
Cards
Entrez_Gene (NCBI)SORCS2  57537  sortilin-related VPS10 domain containing receptor 2
Aliases
GeneCards (Weizmann)SORCS2
Ensembl hg19 (Hinxton)ENSG00000184985 [Gene_View]  chr4:7194374-7744564 [Contig_View]  SORCS2 [Vega]
Ensembl hg38 (Hinxton)ENSG00000184985 [Gene_View]  chr4:7194374-7744564 [Contig_View]  SORCS2 [Vega]
ICGC DataPortalENSG00000184985
TCGA cBioPortalSORCS2
AceView (NCBI)SORCS2
Genatlas (Paris)SORCS2
WikiGenes57537
SOURCE (Princeton)SORCS2
Genetics Home Reference (NIH)SORCS2
Genomic and cartography
GoldenPath hg19 (UCSC)SORCS2  -     chr4:7194374-7744564 +  4p16.1   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)SORCS2  -     4p16.1   [Description]    (hg38-Dec_2013)
EnsemblSORCS2 - 4p16.1 [CytoView hg19]  SORCS2 - 4p16.1 [CytoView hg38]
Mapping of homologs : NCBISORCS2 [Mapview hg19]  SORCS2 [Mapview hg38]
OMIM606284   
Gene and transcription
Genbank (Entrez)AB037750 AF286190 AI206155 AK295629 BC035257
RefSeq transcript (Entrez)NM_020777
RefSeq genomic (Entrez)NC_000004 NC_018915 NT_006051 NW_004929314
Consensus coding sequences : CCDS (NCBI)SORCS2
Cluster EST : UnigeneHs.479099 [ NCBI ]
CGAP (NCI)Hs.479099
Alternative Splicing GalleryENSG00000184985
Gene ExpressionSORCS2 [ NCBI-GEO ]   SORCS2 [ EBI - ARRAY_EXPRESS ]   SORCS2 [ SEEK ]   SORCS2 [ MEM ]
Gene Expression Viewer (FireBrowse)SORCS2 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)57537
GTEX Portal (Tissue expression)SORCS2
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ96PQ0   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ96PQ0  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ96PQ0
Splice isoforms : SwissVarQ96PQ0
PhosPhoSitePlusQ96PQ0
Domaine pattern : Prosite (Expaxy)PKD (PS50093)   
Domains : Interpro (EBI)PKD/Chitinase_dom    PKD_dom    VPS10   
Domain families : Pfam (Sanger)PKD (PF00801)   
Domain families : Pfam (NCBI)pfam00801   
Domain families : Smart (EMBL)PKD (SM00089)  VPS10 (SM00602)  
Conserved Domain (NCBI)SORCS2
DMDM Disease mutations57537
Blocks (Seattle)SORCS2
PDB (SRS)1WGO   
PDB (PDBSum)1WGO   
PDB (IMB)1WGO   
PDB (RSDB)1WGO   
Structural Biology KnowledgeBase1WGO   
SCOP (Structural Classification of Proteins)1WGO   
CATH (Classification of proteins structures)1WGO   
SuperfamilyQ96PQ0
Human Protein AtlasENSG00000184985
Peptide AtlasQ96PQ0
HPRD12099
IPIIPI00044600   IPI00903209   
Protein Interaction databases
DIP (DOE-UCLA)Q96PQ0
IntAct (EBI)Q96PQ0
FunCoupENSG00000184985
BioGRIDSORCS2
STRING (EMBL)SORCS2
ZODIACSORCS2
Ontologies - Pathways
QuickGOQ96PQ0
Ontology : AmiGOneuropeptide signaling pathway  neuropeptide receptor activity  membrane  integral component of membrane  
Ontology : EGO-EBIneuropeptide signaling pathway  neuropeptide receptor activity  membrane  integral component of membrane  
NDEx NetworkSORCS2
Atlas of Cancer Signalling NetworkSORCS2
Wikipedia pathwaysSORCS2
Orthology - Evolution
OrthoDB57537
GeneTree (enSembl)ENSG00000184985
Phylogenetic Trees/Animal Genes : TreeFamSORCS2
HOVERGENQ96PQ0
HOGENOMQ96PQ0
Homologs : HomoloGeneSORCS2
Homology/Alignments : Family Browser (UCSC)SORCS2
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerSORCS2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)SORCS2
dbVarSORCS2
ClinVarSORCS2
1000_GenomesSORCS2 
Exome Variant ServerSORCS2
ExAC (Exome Aggregation Consortium)SORCS2 (select the gene name)
Genetic variants : HAPMAP57537
Genomic Variants (DGV)SORCS2 [DGVbeta]
DECIPHER (Syndromes)4:7194374-7744564  ENSG00000184985
CONAN: Copy Number AnalysisSORCS2 
Mutations
ICGC Data PortalSORCS2 
TCGA Data PortalSORCS2 
Broad Tumor PortalSORCS2
OASIS PortalSORCS2 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICSORCS2  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDSORCS2
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch SORCS2
DgiDB (Drug Gene Interaction Database)SORCS2
DoCM (Curated mutations)SORCS2 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)SORCS2 (select a term)
intoGenSORCS2
Cancer3DSORCS2(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM606284   
Orphanet
MedgenSORCS2
Genetic Testing Registry SORCS2
NextProtQ96PQ0 [Medical]
TSGene57537
GENETestsSORCS2
Huge Navigator SORCS2 [HugePedia]
snp3D : Map Gene to Disease57537
BioCentury BCIQSORCS2
ClinGenSORCS2
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD57537
Chemical/Pharm GKB GenePA134902026
Clinical trialSORCS2
Miscellaneous
canSAR (ICR)SORCS2 (select the gene name)
Probes
Litterature
PubMed13 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineSORCS2
EVEXSORCS2
GoPubMedSORCS2
iHOPSORCS2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Tue Mar 14 12:46:09 CET 2017

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