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SORCS3 (sortilin related VPS10 domain containing receptor 3)

Identity

Alias (NCBI)SORCS
HGNC (Hugo) SORCS3
HGNC Alias symbKIAA1059
SORCS
HGNC Previous namesortilin-related VPS10 domain containing receptor 3
LocusID (NCBI) 22986
Atlas_Id 74073
Location 10q25.1  [Link to chromosome band 10q25]
Location_base_pair Starts at 104641290 and ends at 105265242 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
ARHGAP12 (10p11.22) / SORCS3 (10q25.1)SORCS3 (10q25.1) / REC8 (14q12)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



External links

 

Nomenclature
HGNC (Hugo)SORCS3   16699
Cards
Entrez_Gene (NCBI)SORCS3    sortilin related VPS10 domain containing receptor 3
AliasesSORCS
GeneCards (Weizmann)SORCS3
Ensembl hg19 (Hinxton)ENSG00000156395 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000156395 [Gene_View]  ENSG00000156395 [Sequence]  chr10:104641290-105265242 [Contig_View]  SORCS3 [Vega]
ICGC DataPortalENSG00000156395
TCGA cBioPortalSORCS3
AceView (NCBI)SORCS3
Genatlas (Paris)SORCS3
SOURCE (Princeton)SORCS3
Genetics Home Reference (NIH)SORCS3
Genomic and cartography
GoldenPath hg38 (UCSC)SORCS3  -     chr10:104641290-105265242 +  10q25.1   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)SORCS3  -     10q25.1   [Description]    (hg19-Feb_2009)
GoldenPathSORCS3 - 10q25.1 [CytoView hg19]  SORCS3 - 10q25.1 [CytoView hg38]
ImmunoBaseENSG00000156395
Genome Data Viewer NCBISORCS3 [Mapview hg19]  
OMIM606285   
Gene and transcription
Genbank (Entrez)AB028982 AK303009 BC045754 BC117417
RefSeq transcript (Entrez)NM_014978
Consensus coding sequences : CCDS (NCBI)SORCS3
Gene ExpressionSORCS3 [ NCBI-GEO ]   SORCS3 [ EBI - ARRAY_EXPRESS ]   SORCS3 [ SEEK ]   SORCS3 [ MEM ]
Gene Expression Viewer (FireBrowse)SORCS3 [ Firebrowse - Broad ]
GenevisibleExpression of SORCS3 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)22986
GTEX Portal (Tissue expression)SORCS3
Human Protein AtlasENSG00000156395-SORCS3 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9UPU3   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9UPU3  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9UPU3
PhosPhoSitePlusQ9UPU3
Domaine pattern : Prosite (Expaxy)PKD (PS50093)   
Domains : Interpro (EBI)Ig-like_fold    PKD_dom    PKD_dom_sf    Sortilin_C    Sortilin_N    VPS10    WD40/YVTN_repeat-like_dom_sf   
Domain families : Pfam (Sanger)PKD (PF00801)    Sortilin-Vps10 (PF15902)    Sortilin_C (PF15901)   
Domain families : Pfam (NCBI)pfam00801    pfam15902    pfam15901   
Domain families : Smart (EMBL)VPS10 (SM00602)  
Conserved Domain (NCBI)SORCS3
SuperfamilyQ9UPU3
AlphaFold pdb e-kbQ9UPU3   
Human Protein Atlas [tissue]ENSG00000156395-SORCS3 [tissue]
HPRD12100
Protein Interaction databases
DIP (DOE-UCLA)Q9UPU3
IntAct (EBI)Q9UPU3
BioGRIDSORCS3
STRING (EMBL)SORCS3
ZODIACSORCS3
Ontologies - Pathways
QuickGOQ9UPU3
Ontology : AmiGOprotein binding  neuropeptide signaling pathway  learning  memory  neuropeptide receptor activity  membrane  integral component of membrane  glutamatergic synapse  integral component of postsynaptic density membrane  regulation of long-term synaptic depression  
Ontology : EGO-EBIprotein binding  neuropeptide signaling pathway  learning  memory  neuropeptide receptor activity  membrane  integral component of membrane  glutamatergic synapse  integral component of postsynaptic density membrane  regulation of long-term synaptic depression  
NDEx NetworkSORCS3
Atlas of Cancer Signalling NetworkSORCS3
Wikipedia pathwaysSORCS3
Orthology - Evolution
OrthoDB22986
GeneTree (enSembl)ENSG00000156395
Phylogenetic Trees/Animal Genes : TreeFamSORCS3
Homologs : HomoloGeneSORCS3
Homology/Alignments : Family Browser (UCSC)SORCS3
Gene fusions - Rearrangements
Fusion : QuiverSORCS3
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerSORCS3 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)SORCS3
dbVarSORCS3
ClinVarSORCS3
MonarchSORCS3
1000_GenomesSORCS3 
Exome Variant ServerSORCS3
GNOMAD BrowserENSG00000156395
Varsome BrowserSORCS3
ACMGSORCS3 variants
VarityQ9UPU3
Genomic Variants (DGV)SORCS3 [DGVbeta]
DECIPHERSORCS3 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisSORCS3 
Mutations
ICGC Data PortalSORCS3 
TCGA Data PortalSORCS3 
Broad Tumor PortalSORCS3
OASIS PortalSORCS3 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICSORCS3  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DSORCS3
Mutations and Diseases : HGMDSORCS3
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaSORCS3
DgiDB (Drug Gene Interaction Database)SORCS3
DoCM (Curated mutations)SORCS3
CIViC (Clinical Interpretations of Variants in Cancer)SORCS3
Cancer3DSORCS3
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM606285   
Orphanet
DisGeNETSORCS3
MedgenSORCS3
Genetic Testing Registry SORCS3
NextProtQ9UPU3 [Medical]
GENETestsSORCS3
Target ValidationSORCS3
Huge Navigator SORCS3 [HugePedia]
ClinGenSORCS3
Clinical trials, drugs, therapy
MyCancerGenomeSORCS3
Protein Interactions : CTDSORCS3
Pharm GKB GenePA134949387
PharosQ9UPU3
Clinical trialSORCS3
Miscellaneous
canSAR (ICR)SORCS3
HarmonizomeSORCS3
DataMed IndexSORCS3
Probes
Litterature
PubMed17 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXSORCS3
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Oct 4 16:23:40 CEST 2021

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