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SORCS3 (sortilin-related VPS10 domain containing receptor 3)

Identity

Alias_namessortilin-related VPS10 domain containing receptor 3
Alias_symbol (synonym)KIAA1059
SORCS
Other alias
HGNC (Hugo) SORCS3
LocusID (NCBI) 22986
Atlas_Id 74073
Location 10q25.1  [Link to chromosome band 10q25]
Location_base_pair Starts at 106400859 and ends at 107025000 bp from pter ( according to hg19-Feb_2009)
Fusion genes
(updated 2016)
ARHGAP12 (10p11.22) / SORCS3 (10q25.1)SORCS3 (10q25.1) / REC8 (14q12)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)SORCS3   16699
Cards
Entrez_Gene (NCBI)SORCS3  22986  sortilin-related VPS10 domain containing receptor 3
AliasesSORCS
GeneCards (Weizmann)SORCS3
Ensembl hg19 (Hinxton)ENSG00000156395 [Gene_View]  chr10:106400859-107025000 [Contig_View]  SORCS3 [Vega]
Ensembl hg38 (Hinxton)ENSG00000156395 [Gene_View]  chr10:106400859-107025000 [Contig_View]  SORCS3 [Vega]
ICGC DataPortalENSG00000156395
TCGA cBioPortalSORCS3
AceView (NCBI)SORCS3
Genatlas (Paris)SORCS3
WikiGenes22986
SOURCE (Princeton)SORCS3
Genetics Home Reference (NIH)SORCS3
Genomic and cartography
GoldenPath hg19 (UCSC)SORCS3  -     chr10:106400859-107025000 +  10q25.1   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)SORCS3  -     10q25.1   [Description]    (hg38-Dec_2013)
EnsemblSORCS3 - 10q25.1 [CytoView hg19]  SORCS3 - 10q25.1 [CytoView hg38]
Mapping of homologs : NCBISORCS3 [Mapview hg19]  SORCS3 [Mapview hg38]
OMIM606285   
Gene and transcription
Genbank (Entrez)AB028982 AK303009 BC045754 BC117417
RefSeq transcript (Entrez)NM_014978
RefSeq genomic (Entrez)NC_000010 NC_018921 NT_030059 NW_004929376
Consensus coding sequences : CCDS (NCBI)SORCS3
Cluster EST : UnigeneHs.671950 [ NCBI ]
CGAP (NCI)Hs.671950
Alternative Splicing GalleryENSG00000156395
Gene ExpressionSORCS3 [ NCBI-GEO ]   SORCS3 [ EBI - ARRAY_EXPRESS ]   SORCS3 [ SEEK ]   SORCS3 [ MEM ]
Gene Expression Viewer (FireBrowse)SORCS3 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)22986
GTEX Portal (Tissue expression)SORCS3
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9UPU3   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9UPU3  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9UPU3
Splice isoforms : SwissVarQ9UPU3
PhosPhoSitePlusQ9UPU3
Domaine pattern : Prosite (Expaxy)PKD (PS50093)   
Domains : Interpro (EBI)PKD_dom    VPS10   
Domain families : Pfam (Sanger)PKD (PF00801)   
Domain families : Pfam (NCBI)pfam00801   
Domain families : Smart (EMBL)VPS10 (SM00602)  
Conserved Domain (NCBI)SORCS3
DMDM Disease mutations22986
Blocks (Seattle)SORCS3
SuperfamilyQ9UPU3
Human Protein AtlasENSG00000156395
Peptide AtlasQ9UPU3
HPRD12100
IPIIPI00010381   IPI01010218   IPI00555937   
Protein Interaction databases
DIP (DOE-UCLA)Q9UPU3
IntAct (EBI)Q9UPU3
FunCoupENSG00000156395
BioGRIDSORCS3
STRING (EMBL)SORCS3
ZODIACSORCS3
Ontologies - Pathways
QuickGOQ9UPU3
Ontology : AmiGOneuropeptide signaling pathway  learning  memory  neuropeptide receptor activity  membrane  integral component of membrane  neuronal postsynaptic density  regulation of long term synaptic depression  
Ontology : EGO-EBIneuropeptide signaling pathway  learning  memory  neuropeptide receptor activity  membrane  integral component of membrane  neuronal postsynaptic density  regulation of long term synaptic depression  
NDEx NetworkSORCS3
Atlas of Cancer Signalling NetworkSORCS3
Wikipedia pathwaysSORCS3
Orthology - Evolution
OrthoDB22986
GeneTree (enSembl)ENSG00000156395
Phylogenetic Trees/Animal Genes : TreeFamSORCS3
HOVERGENQ9UPU3
HOGENOMQ9UPU3
Homologs : HomoloGeneSORCS3
Homology/Alignments : Family Browser (UCSC)SORCS3
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerSORCS3 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)SORCS3
dbVarSORCS3
ClinVarSORCS3
1000_GenomesSORCS3 
Exome Variant ServerSORCS3
ExAC (Exome Aggregation Consortium)SORCS3 (select the gene name)
Genetic variants : HAPMAP22986
Genomic Variants (DGV)SORCS3 [DGVbeta]
DECIPHER (Syndromes)10:106400859-107025000  ENSG00000156395
CONAN: Copy Number AnalysisSORCS3 
Mutations
ICGC Data PortalSORCS3 
TCGA Data PortalSORCS3 
Broad Tumor PortalSORCS3
OASIS PortalSORCS3 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICSORCS3  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDSORCS3
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch SORCS3
DgiDB (Drug Gene Interaction Database)SORCS3
DoCM (Curated mutations)SORCS3 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)SORCS3 (select a term)
intoGenSORCS3
Cancer3DSORCS3(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM606285   
Orphanet
MedgenSORCS3
Genetic Testing Registry SORCS3
NextProtQ9UPU3 [Medical]
TSGene22986
GENETestsSORCS3
Huge Navigator SORCS3 [HugePedia]
snp3D : Map Gene to Disease22986
BioCentury BCIQSORCS3
ClinGenSORCS3
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD22986
Chemical/Pharm GKB GenePA134949387
Clinical trialSORCS3
Miscellaneous
canSAR (ICR)SORCS3 (select the gene name)
Probes
Litterature
PubMed12 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineSORCS3
EVEXSORCS3
GoPubMedSORCS3
iHOPSORCS3
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Tue Mar 14 12:46:10 CET 2017

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