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SORD (sorbitol dehydrogenase)

Identity

Other aliasHEL-S-95n
SORD1
HGNC (Hugo) SORD
LocusID (NCBI) 6652
Atlas_Id 51608
Location 15q21.1  [Link to chromosome band 15q21]
Location_base_pair Starts at 45023104 and ends at 45075089 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
CASC4 (15q15.3) / SORD (15q21.1)SPG11 (15q21.1) / SORD (15q21.1)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 1 ]
  Lung: Translocations in Small Cell Carcinoma


External links

Nomenclature
HGNC (Hugo)SORD   11184
Cards
Entrez_Gene (NCBI)SORD  6652  sorbitol dehydrogenase
AliasesHEL-S-95n; SORD1
GeneCards (Weizmann)SORD
Ensembl hg19 (Hinxton)ENSG00000140263 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000140263 [Gene_View]  chr15:45023104-45075089 [Contig_View]  SORD [Vega]
ICGC DataPortalENSG00000140263
TCGA cBioPortalSORD
AceView (NCBI)SORD
Genatlas (Paris)SORD
WikiGenes6652
SOURCE (Princeton)SORD
Genetics Home Reference (NIH)SORD
Genomic and cartography
GoldenPath hg38 (UCSC)SORD  -     chr15:45023104-45075089 +  15q21.1   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)SORD  -     15q21.1   [Description]    (hg19-Feb_2009)
EnsemblSORD - 15q21.1 [CytoView hg19]  SORD - 15q21.1 [CytoView hg38]
Mapping of homologs : NCBISORD [Mapview hg19]  SORD [Mapview hg38]
OMIM182500   
Gene and transcription
Genbank (Entrez)AK090738 AK295656 AK296574 AK309672 AK312444
RefSeq transcript (Entrez)NM_003104
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)SORD
Cluster EST : UnigeneHs.878 [ NCBI ]
CGAP (NCI)Hs.878
Alternative Splicing GalleryENSG00000140263
Gene ExpressionSORD [ NCBI-GEO ]   SORD [ EBI - ARRAY_EXPRESS ]   SORD [ SEEK ]   SORD [ MEM ]
Gene Expression Viewer (FireBrowse)SORD [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)6652
GTEX Portal (Tissue expression)SORD
Human Protein AtlasENSG00000140263-SORD [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ00796   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ00796  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ00796
Splice isoforms : SwissVarQ00796
Catalytic activity : Enzyme1.1.1.14 [ Enzyme-Expasy ]   1.1.1.141.1.1.14 [ IntEnz-EBI ]   1.1.1.14 [ BRENDA ]   1.1.1.14 [ KEGG ]   
PhosPhoSitePlusQ00796
Domaine pattern : Prosite (Expaxy)ADH_ZINC (PS00059)   
Domains : Interpro (EBI)ADH_C    ADH_N    ADH_Zn_CS    GroES-like    NAD(P)-bd_dom    PKS_ER   
Domain families : Pfam (Sanger)ADH_N (PF08240)    ADH_zinc_N (PF00107)   
Domain families : Pfam (NCBI)pfam08240    pfam00107   
Domain families : Smart (EMBL)PKS_ER (SM00829)  
Conserved Domain (NCBI)SORD
DMDM Disease mutations6652
Blocks (Seattle)SORD
PDB (SRS)1PL6    1PL7    1PL8   
PDB (PDBSum)1PL6    1PL7    1PL8   
PDB (IMB)1PL6    1PL7    1PL8   
PDB (RSDB)1PL6    1PL7    1PL8   
Structural Biology KnowledgeBase1PL6    1PL7    1PL8   
SCOP (Structural Classification of Proteins)1PL6    1PL7    1PL8   
CATH (Classification of proteins structures)1PL6    1PL7    1PL8   
SuperfamilyQ00796
Human Protein Atlas [tissue]ENSG00000140263-SORD [tissue]
Peptide AtlasQ00796
HPRD01679
IPIIPI00216057   
Protein Interaction databases
DIP (DOE-UCLA)Q00796
IntAct (EBI)Q00796
FunCoupENSG00000140263
BioGRIDSORD
STRING (EMBL)SORD
ZODIACSORD
Ontologies - Pathways
QuickGOQ00796
Ontology : AmiGOL-iditol 2-dehydrogenase activity  L-iditol 2-dehydrogenase activity  L-iditol 2-dehydrogenase activity  extracellular space  cytosol  glucose metabolic process  sorbitol catabolic process  response to osmotic stress  zinc ion binding  zinc ion binding  response to hormone  membrane  glucuronate catabolic process to xylulose 5-phosphate  carbohydrate binding  flagellated sperm motility  flagellated sperm motility  motile cilium  response to nutrient levels  mitochondrial membrane  response to drug  identical protein binding  fructose biosynthetic process  fructose biosynthetic process  D-xylulose reductase activity  response to cadmium ion  response to copper ion  L-xylitol catabolic process  L-xylitol metabolic process  NAD binding  oxidation-reduction process  extracellular exosome  
Ontology : EGO-EBIL-iditol 2-dehydrogenase activity  L-iditol 2-dehydrogenase activity  L-iditol 2-dehydrogenase activity  extracellular space  cytosol  glucose metabolic process  sorbitol catabolic process  response to osmotic stress  zinc ion binding  zinc ion binding  response to hormone  membrane  glucuronate catabolic process to xylulose 5-phosphate  carbohydrate binding  flagellated sperm motility  flagellated sperm motility  motile cilium  response to nutrient levels  mitochondrial membrane  response to drug  identical protein binding  fructose biosynthetic process  fructose biosynthetic process  D-xylulose reductase activity  response to cadmium ion  response to copper ion  L-xylitol catabolic process  L-xylitol metabolic process  NAD binding  oxidation-reduction process  extracellular exosome  
Pathways : KEGGFructose and mannose metabolism   
NDEx NetworkSORD
Atlas of Cancer Signalling NetworkSORD
Wikipedia pathwaysSORD
Orthology - Evolution
OrthoDB6652
GeneTree (enSembl)ENSG00000140263
Phylogenetic Trees/Animal Genes : TreeFamSORD
HOVERGENQ00796
HOGENOMQ00796
Homologs : HomoloGeneSORD
Homology/Alignments : Family Browser (UCSC)SORD
Gene fusions - Rearrangements
Fusion : MitelmanSPG11/SORD [15q21.1/15q21.1]  [t(15;15)(q21;q21)]  
Tumor Fusion PortalSORD
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerSORD [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)SORD
dbVarSORD
ClinVarSORD
1000_GenomesSORD 
Exome Variant ServerSORD
ExAC (Exome Aggregation Consortium)ENSG00000140263
GNOMAD BrowserENSG00000140263
Genetic variants : HAPMAP6652
Genomic Variants (DGV)SORD [DGVbeta]
DECIPHERSORD [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisSORD 
Mutations
ICGC Data PortalSORD 
TCGA Data PortalSORD 
Broad Tumor PortalSORD
OASIS PortalSORD [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICSORD  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDSORD
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch SORD
DgiDB (Drug Gene Interaction Database)SORD
DoCM (Curated mutations)SORD (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)SORD (select a term)
intoGenSORD
Cancer3DSORD(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM182500   
Orphanet
DisGeNETSORD
MedgenSORD
Genetic Testing Registry SORD
NextProtQ00796 [Medical]
TSGene6652
GENETestsSORD
Target ValidationSORD
Huge Navigator SORD [HugePedia]
snp3D : Map Gene to Disease6652
BioCentury BCIQSORD
ClinGenSORD
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD6652
Chemical/Pharm GKB GenePA36021
Clinical trialSORD
Miscellaneous
canSAR (ICR)SORD (select the gene name)
Probes
Litterature
PubMed44 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineSORD
EVEXSORD
GoPubMedSORD
iHOPSORD
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Tue Nov 21 14:35:59 CET 2017

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