SORD (sorbitol dehydrogenase)

2010-08-01  

Identity

HGNC
LOCATION
15q21.1
LOCUSID
ALIAS
HEL-S-95n,RDH,SDH,SORD1,SORDD,XDH
FUSION GENES

Other Information

Locus ID:

NCBI: 6652
MIM: 182500
HGNC: 11184
Ensembl: ENSG00000140263

Variants:

dbSNP: 6652
ClinVar: 6652
TCGA: ENSG00000140263
COSMIC: SORD

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000140263ENST00000267814Q00796
ENSG00000140263ENST00000558789Q00796
ENSG00000140263ENST00000559230H0YKB3

Expression (GTEx)

0
50
100
150

Pathways

PathwaySourceExternal ID
Pentose and glucuronate interconversionsKEGGko00040
Fructose and mannose metabolismKEGGko00051
Pentose and glucuronate interconversionsKEGGhsa00040
Fructose and mannose metabolismKEGGhsa00051
Metabolic pathwaysKEGGhsa01100
Glucuronate pathway (uronate pathway)KEGGM00014
Glucuronate pathway (uronate pathway)KEGGhsa_M00014
MetabolismREACTOMER-HSA-1430728
Metabolism of carbohydratesREACTOMER-HSA-71387
Fructose metabolismREACTOMER-HSA-5652084
Fructose biosynthesisREACTOMER-HSA-5652227
Catabolism of glucuronate to xylulose-5-phosphateREACTOMER-HSA-5661270

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
206286242010Evaluation of candidate stromal epithelial cross-talk genes identifies association between risk of serous ovarian cancer and TERT, a cancer susceptibility "hot-spot".29
245674192014Sorbitol dehydrogenase overexpression and other aspects of dysregulated protein expression in human precancerous colorectal neoplasms: a quantitative proteomics study.17
149652272004Sorbitol dehydrogenase: structure, function and ligand design.12
194237112009ZAC1 is up-regulated by hypertonicity and decreases sorbitol dehydrogenase expression, allowing accumulation of sorbitol in kidney cells.6
203728352010Sorbitol dehydrogenase expression is regulated by androgens in the human prostate.6
276280632016Osmotic expression of aldose reductase in retinal pigment epithelial cells: involvement of NFAT5.5
173435682007Catalytic mechanism of Zn2+-dependent polyol dehydrogenases: kinetic comparison of sheep liver sorbitol dehydrogenase with wild-type and Glu154-->Cys forms of yeast xylitol dehydrogenase.4
238509722013Association study of sorbitol dehydrogenase -888G>C polymorphism with type 2 diabetic retinopathy in Caucasian-Brazilians.3
234521822013Aldo-keto reductase and sorbitol dehydrogenase enzymes in Egyptian diabetic patients with and without proliferative diabetic retinopathy.1
125957252003Expression, purification and preliminary crystallographic analysis of human sorbitol dehydrogenase.0

Citation

Dessen P

SORD (sorbitol dehydrogenase)

Atlas Genet Cytogenet Oncol Haematol. 2010-08-01

Online version: http://atlasgeneticsoncology.org/gene/51608/sord