Atlas of Genetics and Cytogenetics in Oncology and Haematology


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SOS1 (SOS Ras/Rac guanine nucleotide exchange factor 1)

Identity

Other namesGF1
GGF1
GINGF
HGF
NS4
HGNC (Hugo) SOS1
LocusID (NCBI) 6654
Atlas_Id 42355
Location 2p22.1
Location_base_pair Starts at 39208690 and ends at 39347604 bp from pter ( according to hg19-Feb_2009)
Fusion genes
(updated 2016)
DHX57 (2p22.1) / SOS1 (2p22.1)P4HB (17q25.3) / SOS1 (2p22.1)RBM8A (1q21.1) / SOS1 (2p22.1)
SOS1 (2p22.1) / ADCY3 (2p23.3)SOS1 (2p22.1) / MAP4K3 (2p22.1)SOS1 (2p22.1) / SOS1 (2p22.1)
DHX57 2p22.1 / SOS1 2p22.1P4HB 17q25.3 / SOS1 2p22.1SOS1 2p22.1 / MAP4K3 2p22.1

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


Other Cancer prone implicated (Data extracted from papers in the Atlas) [ 1 ]
  Noonan syndrome

External links

Nomenclature
HGNC (Hugo)SOS1   11187
Cards
Entrez_Gene (NCBI)SOS1  6654  SOS Ras/Rac guanine nucleotide exchange factor 1
GeneCards (Weizmann)SOS1
Ensembl hg19 (Hinxton)ENSG00000115904 [Gene_View]  chr2:39208690-39347604 [Contig_View]  SOS1 [Vega]
Ensembl hg38 (Hinxton)ENSG00000115904 [Gene_View]  chr2:39208690-39347604 [Contig_View]  SOS1 [Vega]
ICGC DataPortalENSG00000115904
TCGA cBioPortalSOS1
AceView (NCBI)SOS1
Genatlas (Paris)SOS1
WikiGenes6654
SOURCE (Princeton)SOS1
Genomic and cartography
GoldenPath hg19 (UCSC)SOS1  -     chr2:39208690-39347604 -  2p22.1   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)SOS1  -     2p22.1   [Description]    (hg38-Dec_2013)
EnsemblSOS1 - 2p22.1 [CytoView hg19]  SOS1 - 2p22.1 [CytoView hg38]
Mapping of homologs : NCBISOS1 [Mapview hg19]  SOS1 [Mapview hg38]
OMIM135300   182530   610733   
Gene and transcription
Genbank (Entrez)AB209140 AK290228 AK301960 AL833457 AV702692
RefSeq transcript (Entrez)NM_005633
RefSeq genomic (Entrez)NC_000002 NC_018913 NG_007530 NT_022184 NW_004929300
Consensus coding sequences : CCDS (NCBI)SOS1
Cluster EST : UnigeneHs.732497 [ NCBI ]
CGAP (NCI)Hs.732497
Alternative Splicing : Fast-db (Paris)GSHG0017567
Alternative Splicing GalleryENSG00000115904
Gene ExpressionSOS1 [ NCBI-GEO ]   SOS1 [ EBI - ARRAY_EXPRESS ]   SOS1 [ SEEK ]   SOS1 [ MEM ]
Gene Expression Viewer (FireBrowse)SOS1 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
BioGPS (Tissue expression)6654
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ07889 (Uniprot)
NextProtQ07889  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ07889
Splice isoforms : SwissVarQ07889 (Swissvar)
PhosPhoSitePlusQ07889
Domaine pattern : Prosite (Expaxy)DH_2 (PS50010)    PH_DOMAIN (PS50003)    RASGEF (PS00720)    RASGEF_CAT (PS50009)    RASGEF_NTER (PS50212)   
Domains : Interpro (EBI)DH-domain    Histone-fold    Histone_H2A/H2B/H3    PH_dom-like    PH_domain    Ras-like_Gua-exchang_fac_N    Ras_G-nucl-exch_fac_CS    Ras_GEF_dom    RASGEF_cat_dom   
Domain families : Pfam (Sanger)Histone (PF00125)    PH (PF00169)    RasGEF (PF00617)    RasGEF_N (PF00618)    RhoGEF (PF00621)   
Domain families : Pfam (NCBI)pfam00125    pfam00169    pfam00617    pfam00618    pfam00621   
Domain families : Smart (EMBL)PH (SM00233)  RasGEF (SM00147)  RasGEFN (SM00229)  RhoGEF (SM00325)  
DMDM Disease mutations6654
Blocks (Seattle)SOS1
PDB (SRS)1AWE    1BKD    1DBH    1NVU    1NVV    1NVW    1NVX    1Q9C    1XD2    1XD4    1XDV    2II0    3KSY    4NYI    4NYJ    4NYM    4URU    4URV    4URW    4URX    4URY    4URZ    4US0    4US1    4US2   
PDB (PDBSum)1AWE    1BKD    1DBH    1NVU    1NVV    1NVW    1NVX    1Q9C    1XD2    1XD4    1XDV    2II0    3KSY    4NYI    4NYJ    4NYM    4URU    4URV    4URW    4URX    4URY    4URZ    4US0    4US1    4US2   
PDB (IMB)1AWE    1BKD    1DBH    1NVU    1NVV    1NVW    1NVX    1Q9C    1XD2    1XD4    1XDV    2II0    3KSY    4NYI    4NYJ    4NYM    4URU    4URV    4URW    4URX    4URY    4URZ    4US0    4US1    4US2   
PDB (RSDB)1AWE    1BKD    1DBH    1NVU    1NVV    1NVW    1NVX    1Q9C    1XD2    1XD4    1XDV    2II0    3KSY    4NYI    4NYJ    4NYM    4URU    4URV    4URW    4URX    4URY    4URZ    4US0    4US1    4US2   
Structural Biology KnowledgeBase1AWE    1BKD    1DBH    1NVU    1NVV    1NVW    1NVX    1Q9C    1XD2    1XD4    1XDV    2II0    3KSY    4NYI    4NYJ    4NYM    4URU    4URV    4URW    4URX    4URY    4URZ    4US0    4US1    4US2   
SCOP (Structural Classification of Proteins)1AWE    1BKD    1DBH    1NVU    1NVV    1NVW    1NVX    1Q9C    1XD2    1XD4    1XDV    2II0    3KSY    4NYI    4NYJ    4NYM    4URU    4URV    4URW    4URX    4URY    4URZ    4US0    4US1    4US2   
CATH (Classification of proteins structures)1AWE    1BKD    1DBH    1NVU    1NVV    1NVW    1NVX    1Q9C    1XD2    1XD4    1XDV    2II0    3KSY    4NYI    4NYJ    4NYM    4URU    4URV    4URW    4URX    4URY    4URZ    4US0    4US1    4US2   
SuperfamilyQ07889
Human Protein AtlasENSG00000115904
Peptide AtlasQ07889
HPRD01681
IPIIPI00020131   IPI00873613   IPI01010500   IPI00917204   
Protein Interaction databases
DIP (DOE-UCLA)Q07889
IntAct (EBI)Q07889
FunCoupENSG00000115904
BioGRIDSOS1
STRING (EMBL)SOS1
ZODIACSOS1
Ontologies - Pathways
QuickGOQ07889
Ontology : AmiGOMAPK cascade  B cell homeostasis  hair follicle development  cardiac atrium morphogenesis  pericardium morphogenesis  DNA binding  guanyl-nucleotide exchange factor activity  Ras guanyl-nucleotide exchange factor activity  Ras guanyl-nucleotide exchange factor activity  Rho guanyl-nucleotide exchange factor activity  GTPase activator activity  protein binding  cytosol  plasma membrane  signal transduction  epidermal growth factor receptor signaling pathway  Ras protein signal transduction  vitellogenesis  axon guidance  insulin receptor signaling pathway  postsynaptic density  SH3 domain binding  regulation of T cell differentiation in thymus  regulation of Rho protein signal transduction  multicellular organism growth  Fc-epsilon receptor signaling pathway  ERBB2 signaling pathway  regulation of T cell proliferation  neuronal cell body  positive regulation of apoptotic process  positive regulation of GTPase activity  positive regulation of GTPase activity  positive regulation of GTPase activity  positive regulation of epidermal growth factor receptor signaling pathway  protein heterodimerization activity  neurotrophin TRK receptor signaling pathway  blood vessel morphogenesis  leukocyte migration  regulation of small GTPase mediated signal transduction  positive regulation of small GTPase mediated signal transduction  palate development  eyelid development in camera-type eye  heart trabecula morphogenesis  midbrain morphogenesis  regulation of pro-B cell differentiation  
Ontology : EGO-EBIMAPK cascade  B cell homeostasis  hair follicle development  cardiac atrium morphogenesis  pericardium morphogenesis  DNA binding  guanyl-nucleotide exchange factor activity  Ras guanyl-nucleotide exchange factor activity  Ras guanyl-nucleotide exchange factor activity  Rho guanyl-nucleotide exchange factor activity  GTPase activator activity  protein binding  cytosol  plasma membrane  signal transduction  epidermal growth factor receptor signaling pathway  Ras protein signal transduction  vitellogenesis  axon guidance  insulin receptor signaling pathway  postsynaptic density  SH3 domain binding  regulation of T cell differentiation in thymus  regulation of Rho protein signal transduction  multicellular organism growth  Fc-epsilon receptor signaling pathway  ERBB2 signaling pathway  regulation of T cell proliferation  neuronal cell body  positive regulation of apoptotic process  positive regulation of GTPase activity  positive regulation of GTPase activity  positive regulation of GTPase activity  positive regulation of epidermal growth factor receptor signaling pathway  protein heterodimerization activity  neurotrophin TRK receptor signaling pathway  blood vessel morphogenesis  leukocyte migration  regulation of small GTPase mediated signal transduction  positive regulation of small GTPase mediated signal transduction  palate development  eyelid development in camera-type eye  heart trabecula morphogenesis  midbrain morphogenesis  regulation of pro-B cell differentiation  
Pathways : BIOCARTAInsulin Signaling Pathway [Genes]    Links between Pyk2 and Map Kinases [Genes]    Trka Receptor Signaling Pathway [Genes]    EGF Signaling Pathway [Genes]    Inhibition of Cellular Proliferation by Gleevec [Genes]    PTEN dependent cell cycle arrest and apoptosis [Genes]    Transcription factor CREB and its extracellular signals [Genes]    T Cell Receptor Signaling Pathway [Genes]    Multiple antiapoptotic pathways from IGF-1R signaling lead to BAD phosphorylation [Genes]    IL 2 signaling pathway [Genes]    IL-2 Receptor Beta Chain in T cell Activation [Genes]    IL 3 signaling pathway [Genes]    Integrin Signaling Pathway [Genes]    Signaling of Hepatocyte Growth Factor Receptor [Genes]    Role of ERBB2 in Signal Transduction and Oncology [Genes]    Trefoil Factors Initiate Mucosal Healing [Genes]    Angiotensin II mediated activation of JNK Pathway via Pyk2 dependent signaling [Genes]    IL 6 signaling pathway [Genes]    BCR Signaling Pathway [Genes]    EPO Signaling Pathway [Genes]    Erk1/Erk2 Mapk Signaling pathway [Genes]    Growth Hormone Signaling Pathway [Genes]    Nerve growth factor pathway (NGF) [Genes]    PDGF Signaling Pathway [Genes]    Sprouty regulation of tyrosine kinase signals [Genes]    Calcium Signaling by HBx of Hepatitis B virus [Genes]    TPO Signaling Pathway [Genes]    Bioactive Peptide Induced Signaling Pathway [Genes]    Fc Epsilon Receptor I Signaling in Mast Cells [Genes]    IGF-1 Signaling Pathway [Genes]   
Pathways : KEGGMAPK signaling pathway    ErbB signaling pathway    Ras signaling pathway    Chemokine signaling pathway    FoxO signaling pathway    PI3K-Akt signaling pathway    Dorso-ventral axis formation    Focal adhesion    Gap junction    Jak-STAT signaling pathway    Natural killer cell mediated cytotoxicity    T cell receptor signaling pathway    B cell receptor signaling pathway    Fc epsilon RI signaling pathway    Neurotrophin signaling pathway    Regulation of actin cytoskeleton    Insulin signaling pathway    GnRH signaling pathway    Estrogen signaling pathway    Prolactin signaling pathway    Alcoholism    Hepatitis C    Pathways in cancer    Proteoglycans in cancer    MicroRNAs in cancer    Renal cell carcinoma    Endometrial cancer    Glioma    Prostate cancer    Chronic myeloid leukemia    Acute myeloid leukemia    Non-small cell lung cancer   
NDEx Network
Atlas of Cancer Signalling NetworkSOS1
Wikipedia pathwaysSOS1
Orthology - Evolution
OrthoDB6654
GeneTree (enSembl)ENSG00000115904
Phylogenetic Trees/Animal Genes : TreeFamSOS1
Homologs : HomoloGeneSOS1
Homology/Alignments : Family Browser (UCSC)SOS1
Gene fusions - Rearrangements
Fusion: TCGADHX57 2p22.1 SOS1 2p22.1 BRCA
Fusion: TCGAP4HB 17q25.3 SOS1 2p22.1 LGG
Fusion: TCGASOS1 2p22.1 MAP4K3 2p22.1 THCA
Polymorphisms : SNP, variants
NCBI Variation ViewerSOS1 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)SOS1
dbVarSOS1
ClinVarSOS1
1000_GenomesSOS1 
Exome Variant ServerSOS1
ExAC (Exome Aggregation Consortium)SOS1 (select the gene name)
SNP (GeneSNP Utah)SOS1
SNP : HGBaseSOS1
Genetic variants : HAPMAPSOS1
Genomic Variants (DGV)SOS1 [DGVbeta]
Mutations
ICGC Data PortalSOS1 
TCGA Data PortalSOS1 
Broad Tumor PortalSOS1
OASIS PortalSOS1 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICSOS1 
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
LOVD (Leiden Open Variation Database)Mendelian genes
BioMutasearch SOS1
DgiDB (Drug Gene Interaction Database)SOS1
DoCM (Curated mutations)SOS1 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)SOS1 (select a term)
intoGenSOS1
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] 
Diseases
DECIPHER (Syndromes)2:39208690-39347604
CONAN: Copy Number AnalysisSOS1 
Mutations and Diseases : HGMDSOS1
OMIM135300    182530    610733   
MedgenSOS1
Genetic Testing Registry SOS1
NextProtQ07889 [Medical]
TSGene6654
GENETestsSOS1
Huge Navigator SOS1 [HugePedia]  SOS1 [HugeCancerGEM]
snp3D : Map Gene to Disease6654
BioCentury BCIQSOS1
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD6654
Chemical/Pharm GKB GenePA36024
Clinical trialSOS1
Miscellaneous
canSAR (ICR)SOS1 (select the gene name)
Probes
Litterature
PubMed200 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineSOS1
GoPubMedSOS1
iHOPSOS1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Sat Apr 16 18:05:17 CEST 2016

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