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SOS1 (SOS Ras/Rac guanine nucleotide exchange factor 1)

Identity

Alias (NCBI)GF1
GGF1
GINGF
HGF
NS4
SOS-1
HGNC (Hugo) SOS1
HGNC Alias symbHGF
GF1
HGNC Previous nameGINGF
HGNC Previous namegingival fibromatosis, hereditary, 1
 son of sevenless homolog 1 (Drosophila)
LocusID (NCBI) 6654
Atlas_Id 42355
Location 2p22.1  [Link to chromosome band 2p22]
Location_base_pair Starts at 38981549 and ends at 39120463 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
DHX57 (2p22.1) / SOS1 (2p22.1)P4HB (17q25.3) / SOS1 (2p22.1)RBM8A (1q21.1) / SOS1 (2p22.1)
SOS1 (2p22.1) / ADCY3 (2p23.3)SOS1 (2p22.1) / MAP4K3 (2p22.1)SOS1 (2p22.1) / SOS1 (2p22.1)
DHX57 2p22.1 / SOS1 2p22.1P4HB 17q25.3 / SOS1 2p22.1SOS1 2p22.1 / MAP4K3 2p22.1

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



Other Cancer prone implicated (Data extracted from papers in the Atlas) [ 1 ]
  Noonan syndrome


External links

 

Nomenclature
HGNC (Hugo)SOS1   11187
LRG (Locus Reference Genomic)LRG_754
Cards
Entrez_Gene (NCBI)SOS1    SOS Ras/Rac guanine nucleotide exchange factor 1
AliasesGF1; GGF1; GINGF; HGF; 
NS4; SOS-1
GeneCards (Weizmann)SOS1
Ensembl hg19 (Hinxton)ENSG00000115904 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000115904 [Gene_View]  ENSG00000115904 [Sequence]  chr2:38981549-39120463 [Contig_View]  SOS1 [Vega]
ICGC DataPortalENSG00000115904
TCGA cBioPortalSOS1
AceView (NCBI)SOS1
Genatlas (Paris)SOS1
SOURCE (Princeton)SOS1
Genetics Home Reference (NIH)SOS1
Genomic and cartography
GoldenPath hg38 (UCSC)SOS1  -     chr2:38981549-39120463 -  2p22.1   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)SOS1  -     2p22.1   [Description]    (hg19-Feb_2009)
GoldenPathSOS1 - 2p22.1 [CytoView hg19]  SOS1 - 2p22.1 [CytoView hg38]
ImmunoBaseENSG00000115904
Genome Data Viewer NCBISOS1 [Mapview hg19]  
OMIM135300   182530   610733   
Gene and transcription
Genbank (Entrez)AB209140 AK290228 AK301960 AL833457 AV702692
RefSeq transcript (Entrez)NM_001382394 NM_001382395 NM_005633
Consensus coding sequences : CCDS (NCBI)SOS1
Gene ExpressionSOS1 [ NCBI-GEO ]   SOS1 [ EBI - ARRAY_EXPRESS ]   SOS1 [ SEEK ]   SOS1 [ MEM ]
Gene Expression Viewer (FireBrowse)SOS1 [ Firebrowse - Broad ]
GenevisibleExpression of SOS1 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)6654
GTEX Portal (Tissue expression)SOS1
Human Protein AtlasENSG00000115904-SOS1 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ07889   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ07889  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ07889
PhosPhoSitePlusQ07889
Domaine pattern : Prosite (Expaxy)DH_2 (PS50010)    PH_DOMAIN (PS50003)    RASGEF (PS00720)    RASGEF_CAT (PS50009)    RASGEF_NTER (PS50212)   
Domains : Interpro (EBI)DBL_dom_sf    DH-domain    Histone-fold    Histone_H2A/H2B/H3    PH-like_dom_sf    PH_domain    Ras-like_GEF    Ras-like_Gua-exchang_fac_N    Ras_G-nucl-exch_fac_CS    Ras_GEF_dom_sf    RASGEF_cat_dom    RASGEF_cat_dom_sf   
Domain families : Pfam (Sanger)Histone (PF00125)    PH (PF00169)    RasGEF (PF00617)    RasGEF_N (PF00618)    RhoGEF (PF00621)   
Domain families : Pfam (NCBI)pfam00125    pfam00169    pfam00617    pfam00618    pfam00621   
Domain families : Smart (EMBL)PH (SM00233)  RasGEF (SM00147)  RasGEFN (SM00229)  RhoGEF (SM00325)  
Conserved Domain (NCBI)SOS1
PDB (RSDB)1AWE    1BKD    1DBH    1NVU    1NVV    1NVW    1NVX    1Q9C    1XD2    1XD4    1XDV    2II0    3KSY    4NYI    4NYJ    4NYM    4URU    4URV    4URW    4URX    4URY    4URZ    4US0    4US1    4US2    5OVD    5OVE    5OVF    5OVG    5OVH    5OVI    5WFO    5WFP    5WFQ    5WFR    6BVI    6BVJ    6BVK    6BVL    6BVM    6CUO    6CUP    6CUR    6D55    6D56    6D59    6D5E    6D5G    6D5H    6D5J    6D5L    6D5M    6D5V    6D5W    6EPL    6EPM    6EPN    6EPO    6EPP    6F08    6SCM    6SFR    6V94    6V9F    6V9J    6V9L    6V9M    6V9N    6Y44   
PDB Europe1AWE    1BKD    1DBH    1NVU    1NVV    1NVW    1NVX    1Q9C    1XD2    1XD4    1XDV    2II0    3KSY    4NYI    4NYJ    4NYM    4URU    4URV    4URW    4URX    4URY    4URZ    4US0    4US1    4US2    5OVD    5OVE    5OVF    5OVG    5OVH    5OVI    5WFO    5WFP    5WFQ    5WFR    6BVI    6BVJ    6BVK    6BVL    6BVM    6CUO    6CUP    6CUR    6D55    6D56    6D59    6D5E    6D5G    6D5H    6D5J    6D5L    6D5M    6D5V    6D5W    6EPL    6EPM    6EPN    6EPO    6EPP    6F08    6SCM    6SFR    6V94    6V9F    6V9J    6V9L    6V9M    6V9N    6Y44   
PDB (PDBSum)1AWE    1BKD    1DBH    1NVU    1NVV    1NVW    1NVX    1Q9C    1XD2    1XD4    1XDV    2II0    3KSY    4NYI    4NYJ    4NYM    4URU    4URV    4URW    4URX    4URY    4URZ    4US0    4US1    4US2    5OVD    5OVE    5OVF    5OVG    5OVH    5OVI    5WFO    5WFP    5WFQ    5WFR    6BVI    6BVJ    6BVK    6BVL    6BVM    6CUO    6CUP    6CUR    6D55    6D56    6D59    6D5E    6D5G    6D5H    6D5J    6D5L    6D5M    6D5V    6D5W    6EPL    6EPM    6EPN    6EPO    6EPP    6F08    6SCM    6SFR    6V94    6V9F    6V9J    6V9L    6V9M    6V9N    6Y44   
PDB (IMB)1AWE    1BKD    1DBH    1NVU    1NVV    1NVW    1NVX    1Q9C    1XD2    1XD4    1XDV    2II0    3KSY    4NYI    4NYJ    4NYM    4URU    4URV    4URW    4URX    4URY    4URZ    4US0    4US1    4US2    5OVD    5OVE    5OVF    5OVG    5OVH    5OVI    5WFO    5WFP    5WFQ    5WFR    6BVI    6BVJ    6BVK    6BVL    6BVM    6CUO    6CUP    6CUR    6D55    6D56    6D59    6D5E    6D5G    6D5H    6D5J    6D5L    6D5M    6D5V    6D5W    6EPL    6EPM    6EPN    6EPO    6EPP    6F08    6SCM    6SFR    6V94    6V9F    6V9J    6V9L    6V9M    6V9N    6Y44   
Structural Biology KnowledgeBase1AWE    1BKD    1DBH    1NVU    1NVV    1NVW    1NVX    1Q9C    1XD2    1XD4    1XDV    2II0    3KSY    4NYI    4NYJ    4NYM    4URU    4URV    4URW    4URX    4URY    4URZ    4US0    4US1    4US2    5OVD    5OVE    5OVF    5OVG    5OVH    5OVI    5WFO    5WFP    5WFQ    5WFR    6BVI    6BVJ    6BVK    6BVL    6BVM    6CUO    6CUP    6CUR    6D55    6D56    6D59    6D5E    6D5G    6D5H    6D5J    6D5L    6D5M    6D5V    6D5W    6EPL    6EPM    6EPN    6EPO    6EPP    6F08    6SCM    6SFR    6V94    6V9F    6V9J    6V9L    6V9M    6V9N    6Y44   
SCOP (Structural Classification of Proteins)1AWE    1BKD    1DBH    1NVU    1NVV    1NVW    1NVX    1Q9C    1XD2    1XD4    1XDV    2II0    3KSY    4NYI    4NYJ    4NYM    4URU    4URV    4URW    4URX    4URY    4URZ    4US0    4US1    4US2    5OVD    5OVE    5OVF    5OVG    5OVH    5OVI    5WFO    5WFP    5WFQ    5WFR    6BVI    6BVJ    6BVK    6BVL    6BVM    6CUO    6CUP    6CUR    6D55    6D56    6D59    6D5E    6D5G    6D5H    6D5J    6D5L    6D5M    6D5V    6D5W    6EPL    6EPM    6EPN    6EPO    6EPP    6F08    6SCM    6SFR    6V94    6V9F    6V9J    6V9L    6V9M    6V9N    6Y44   
CATH (Classification of proteins structures)1AWE    1BKD    1DBH    1NVU    1NVV    1NVW    1NVX    1Q9C    1XD2    1XD4    1XDV    2II0    3KSY    4NYI    4NYJ    4NYM    4URU    4URV    4URW    4URX    4URY    4URZ    4US0    4US1    4US2    5OVD    5OVE    5OVF    5OVG    5OVH    5OVI    5WFO    5WFP    5WFQ    5WFR    6BVI    6BVJ    6BVK    6BVL    6BVM    6CUO    6CUP    6CUR    6D55    6D56    6D59    6D5E    6D5G    6D5H    6D5J    6D5L    6D5M    6D5V    6D5W    6EPL    6EPM    6EPN    6EPO    6EPP    6F08    6SCM    6SFR    6V94    6V9F    6V9J    6V9L    6V9M    6V9N    6Y44   
SuperfamilyQ07889
AlphaFold pdb e-kbQ07889   
Human Protein Atlas [tissue]ENSG00000115904-SOS1 [tissue]
HPRD01681
Protein Interaction databases
DIP (DOE-UCLA)Q07889
IntAct (EBI)Q07889
BioGRIDSOS1
STRING (EMBL)SOS1
ZODIACSOS1
Ontologies - Pathways
QuickGOQ07889
Ontology : AmiGOMAPK cascade  B cell homeostasis  hair follicle development  cardiac atrium morphogenesis  pericardium morphogenesis  DNA binding  guanyl-nucleotide exchange factor activity  GTPase activator activity  protein binding  cytoplasm  cytosol  plasma membrane  signal transduction  epidermal growth factor receptor signaling pathway  G protein-coupled receptor signaling pathway  Ras protein signal transduction  vitellogenesis  axon guidance  insulin receptor signaling pathway  postsynaptic density  SH3 domain binding  cytokine-mediated signaling pathway  regulation of T cell differentiation in thymus  multicellular organism growth  Fc-epsilon receptor signaling pathway  ERBB2 signaling pathway  regulation of T cell proliferation  neuronal cell body  positive regulation of apoptotic process  positive regulation of epidermal growth factor receptor signaling pathway  protein heterodimerization activity  neurotrophin TRK receptor signaling pathway  blood vessel morphogenesis  regulation of catalytic activity  leukocyte migration  regulation of small GTPase mediated signal transduction  positive regulation of small GTPase mediated signal transduction  roof of mouth development  eyelid development in camera-type eye  heart trabecula morphogenesis  midbrain morphogenesis  regulation of pro-B cell differentiation  
Ontology : EGO-EBIMAPK cascade  B cell homeostasis  hair follicle development  cardiac atrium morphogenesis  pericardium morphogenesis  DNA binding  guanyl-nucleotide exchange factor activity  GTPase activator activity  protein binding  cytoplasm  cytosol  plasma membrane  signal transduction  epidermal growth factor receptor signaling pathway  G protein-coupled receptor signaling pathway  Ras protein signal transduction  vitellogenesis  axon guidance  insulin receptor signaling pathway  postsynaptic density  SH3 domain binding  cytokine-mediated signaling pathway  regulation of T cell differentiation in thymus  multicellular organism growth  Fc-epsilon receptor signaling pathway  ERBB2 signaling pathway  regulation of T cell proliferation  neuronal cell body  positive regulation of apoptotic process  positive regulation of epidermal growth factor receptor signaling pathway  protein heterodimerization activity  neurotrophin TRK receptor signaling pathway  blood vessel morphogenesis  regulation of catalytic activity  leukocyte migration  regulation of small GTPase mediated signal transduction  positive regulation of small GTPase mediated signal transduction  roof of mouth development  eyelid development in camera-type eye  heart trabecula morphogenesis  midbrain morphogenesis  regulation of pro-B cell differentiation  
Pathways : BIOCARTAInsulin Signaling Pathway [Genes]    Links between Pyk2 and Map Kinases [Genes]    Trka Receptor Signaling Pathway [Genes]    EGF Signaling Pathway [Genes]    Inhibition of Cellular Proliferation by Gleevec [Genes]    PTEN dependent cell cycle arrest and apoptosis [Genes]    Transcription factor CREB and its extracellular signals [Genes]    T Cell Receptor Signaling Pathway [Genes]    Multiple antiapoptotic pathways from IGF-1R signaling lead to BAD phosphorylation [Genes]    IL 2 signaling pathway [Genes]    IL-2 Receptor Beta Chain in T cell Activation [Genes]    IL 3 signaling pathway [Genes]    Integrin Signaling Pathway [Genes]    Signaling of Hepatocyte Growth Factor Receptor [Genes]    Role of ERBB2 in Signal Transduction and Oncology [Genes]    Trefoil Factors Initiate Mucosal Healing [Genes]    Angiotensin II mediated activation of JNK Pathway via Pyk2 dependent signaling [Genes]    IL 6 signaling pathway [Genes]    BCR Signaling Pathway [Genes]    EPO Signaling Pathway [Genes]    Erk1/Erk2 Mapk Signaling pathway [Genes]    Growth Hormone Signaling Pathway [Genes]    Nerve growth factor pathway (NGF) [Genes]    PDGF Signaling Pathway [Genes]    Sprouty regulation of tyrosine kinase signals [Genes]    Calcium Signaling by HBx of Hepatitis B virus [Genes]    TPO Signaling Pathway [Genes]    Bioactive Peptide Induced Signaling Pathway [Genes]    Fc Epsilon Receptor I Signaling in Mast Cells [Genes]    IGF-1 Signaling Pathway [Genes]   
Pathways : KEGGMAPK signaling pathway    ErbB signaling pathway    Ras signaling pathway    Chemokine signaling pathway    FoxO signaling pathway    PI3K-Akt signaling pathway    Dorso-ventral axis formation    Focal adhesion    Gap junction    Jak-STAT signaling pathway    Natural killer cell mediated cytotoxicity    T cell receptor signaling pathway    B cell receptor signaling pathway    Fc epsilon RI signaling pathway    Neurotrophin signaling pathway    Regulation of actin cytoskeleton    Insulin signaling pathway    GnRH signaling pathway    Estrogen signaling pathway    Prolactin signaling pathway    Alcoholism    Hepatitis C    Pathways in cancer    Proteoglycans in cancer    MicroRNAs in cancer    Renal cell carcinoma    Endometrial cancer    Glioma    Prostate cancer    Chronic myeloid leukemia    Acute myeloid leukemia    Non-small cell lung cancer   
NDEx NetworkSOS1
Atlas of Cancer Signalling NetworkSOS1
Wikipedia pathwaysSOS1
Orthology - Evolution
OrthoDB6654
GeneTree (enSembl)ENSG00000115904
Phylogenetic Trees/Animal Genes : TreeFamSOS1
Homologs : HomoloGeneSOS1
Homology/Alignments : Family Browser (UCSC)SOS1
Gene fusions - Rearrangements
Fusion : MitelmanDHX57/SOS1 [2p22.1/2p22.1]  
Fusion : MitelmanP4HB/SOS1 [17q25.3/2p22.1]  
Fusion : MitelmanSOS1/MAP4K3 [2p22.1/2p22.1]  
Fusion : QuiverSOS1
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerSOS1 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)SOS1
dbVarSOS1
ClinVarSOS1
MonarchSOS1
1000_GenomesSOS1 
Exome Variant ServerSOS1
GNOMAD BrowserENSG00000115904
Varsome BrowserSOS1
ACMGSOS1 variants
VarityQ07889
Genomic Variants (DGV)SOS1 [DGVbeta]
DECIPHERSOS1 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisSOS1 
Mutations
ICGC Data PortalSOS1 
TCGA Data PortalSOS1 
Broad Tumor PortalSOS1
OASIS PortalSOS1 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICSOS1  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DSOS1
Mutations and Diseases : HGMDSOS1
intOGen PortalSOS1
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaSOS1
DgiDB (Drug Gene Interaction Database)SOS1
DoCM (Curated mutations)SOS1
CIViC (Clinical Interpretations of Variants in Cancer)SOS1
Cancer3DSOS1
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM135300    182530    610733   
Orphanet206    1955   
DisGeNETSOS1
MedgenSOS1
Genetic Testing Registry SOS1
NextProtQ07889 [Medical]
GENETestsSOS1
Target ValidationSOS1
Huge Navigator SOS1 [HugePedia]
ClinGenSOS1 (curated)
Clinical trials, drugs, therapy
MyCancerGenomeSOS1
Protein Interactions : CTDSOS1
Pharm GKB GenePA36024
Pharm GKB PathwaysPA162356267   PA165980050   
PharosQ07889
Clinical trialSOS1
Miscellaneous
canSAR (ICR)SOS1
HarmonizomeSOS1
DataMed IndexSOS1
Probes
Litterature
PubMed254 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXSOS1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Oct 4 15:32:38 CEST 2021

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