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SOS1 (son of sevenless homolog 1 (Drosophila))

Identity

Other namesGF1
GGF1
GINGF
HGF
NS4
HGNC (Hugo) SOS1
LocusID (NCBI) 6654
Location 2p22.1
Location_base_pair Starts at 39208690 and ends at 39347604 bp from pter ( according to hg19-Feb_2009)
Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

External links

Nomenclature
HGNC (Hugo)SOS1   11187
Cards
Entrez_Gene (NCBI)SOS1  6654  son of sevenless homolog 1 (Drosophila)
GeneCards (Weizmann)SOS1
Ensembl (Hinxton)ENSG00000115904 [Gene_View]  chr2:39208690-39347604 [Contig_View]  SOS1 [Vega]
AceView (NCBI)SOS1
Genatlas (Paris)SOS1
WikiGenes6654
SOURCE (Princeton)NM_005633
Genomic and cartography
GoldenPath (UCSC)SOS1  -  2p22.1   chr2:39208690-39347604 -  2p22.1   [Description]    (hg19-Feb_2009)
EnsemblSOS1 - 2p22.1 [CytoView]
Mapping of homologs : NCBISOS1 [Mapview]
OMIM135300   163955   182530   610733   
Gene and transcription
Genbank (Entrez)AB209140 AK290228 AK301960 AL833457 AV702692
RefSeq transcript (Entrez)NM_005633
RefSeq genomic (Entrez)AC_000134 NC_000002 NC_018913 NG_007530 NT_022184 NW_001838769 NW_004929300
Consensus coding sequences : CCDS (NCBI)SOS1
Cluster EST : UnigeneHs.732497 [ NCBI ]
CGAP (NCI)Hs.732497
Alternative Splicing : Fast-db (Paris)GSHG0017567
Alternative Splicing GalleryENSG00000115904
Gene ExpressionSOS1 [ NCBI-GEO ]     SOS1 [ SEEK ]   SOS1 [ MEM ]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ07889 (Uniprot)
NextProtQ07889  [Medical]
With graphics : InterProQ07889
Splice isoforms : SwissVarQ07889 (Swissvar)
Domaine pattern : Prosite (Expaxy)DH_1 (PS00741)    DH_2 (PS50010)    PH_DOMAIN (PS50003)    RASGEF (PS00720)    RASGEF_CAT (PS50009)    RASGEF_NTER (PS50212)   
Domains : Interpro (EBI)DH-domain    Histone-fold    Histone_core_D    PH_like_dom    Pleckstrin_homology    Ras-like_Gua-exchang_fac_N    Ras_G-nucl-exch_fac_CS    Ras_GEF    Ras_GEF_dom    RasGRF_CDC25   
Related proteins : CluSTrQ07889
Domain families : Pfam (Sanger)Histone (PF00125)    PH (PF00169)    RasGEF (PF00617)    RasGEF_N (PF00618)    RhoGEF (PF00621)   
Domain families : Pfam (NCBI)pfam00125    pfam00169    pfam00617    pfam00618    pfam00621   
Domain families : Smart (EMBL)PH (SM00233)  RasGEF (SM00147)  RasGEFN (SM00229)  RhoGEF (SM00325)  
DMDM Disease mutations6654
Blocks (Seattle)Q07889
PDB (SRS)1AWE    1BKD    1DBH    1NVU    1NVV    1NVW    1NVX    1Q9C    1XD2    1XD4    1XDV    2II0    3KSY   
PDB (PDBSum)1AWE    1BKD    1DBH    1NVU    1NVV    1NVW    1NVX    1Q9C    1XD2    1XD4    1XDV    2II0    3KSY   
PDB (IMB)1AWE    1BKD    1DBH    1NVU    1NVV    1NVW    1NVX    1Q9C    1XD2    1XD4    1XDV    2II0    3KSY   
PDB (RSDB)1AWE    1BKD    1DBH    1NVU    1NVV    1NVW    1NVX    1Q9C    1XD2    1XD4    1XDV    2II0    3KSY   
Human Protein AtlasENSG00000115904
Peptide AtlasQ07889
HPRD01681
IPIIPI00020131   IPI00873613   IPI01010500   IPI00917204   
Protein Interaction databases
DIP (DOE-UCLA)Q07889
IntAct (EBI)Q07889
FunCoupENSG00000115904
BioGRIDSOS1
InParanoidQ07889
Interologous Interaction database Q07889
IntegromeDBSOS1
STRING (EMBL)SOS1
Ontologies - Pathways
Ontology : AmiGODNA binding  Ras guanyl-nucleotide exchange factor activity  Ras guanyl-nucleotide exchange factor activity  Rho guanyl-nucleotide exchange factor activity  Rho GTPase activator activity  protein binding  phospholipid binding  cytosol  plasma membrane  signal transduction  epidermal growth factor receptor signaling pathway  small GTPase mediated signal transduction  Ras protein signal transduction  axon guidance  blood coagulation  insulin receptor signaling pathway  fibroblast growth factor receptor signaling pathway  platelet activation  positive regulation of Rho GTPase activity  Fc-epsilon receptor signaling pathway  positive regulation of apoptotic process  innate immune response  protein heterodimerization activity  neurotrophin TRK receptor signaling pathway  leukocyte migration  regulation of small GTPase mediated signal transduction  apoptotic signaling pathway  
Ontology : EGO-EBIDNA binding  Ras guanyl-nucleotide exchange factor activity  Ras guanyl-nucleotide exchange factor activity  Rho guanyl-nucleotide exchange factor activity  Rho GTPase activator activity  protein binding  phospholipid binding  cytosol  plasma membrane  signal transduction  epidermal growth factor receptor signaling pathway  small GTPase mediated signal transduction  Ras protein signal transduction  axon guidance  blood coagulation  insulin receptor signaling pathway  fibroblast growth factor receptor signaling pathway  platelet activation  positive regulation of Rho GTPase activity  Fc-epsilon receptor signaling pathway  positive regulation of apoptotic process  innate immune response  protein heterodimerization activity  neurotrophin TRK receptor signaling pathway  leukocyte migration  regulation of small GTPase mediated signal transduction  apoptotic signaling pathway  
Pathways : BIOCARTAInsulin Signaling Pathway [Genes]    Links between Pyk2 and Map Kinases [Genes]    Trka Receptor Signaling Pathway [Genes]    EGF Signaling Pathway [Genes]    Inhibition of Cellular Proliferation by Gleevec [Genes]    PTEN dependent cell cycle arrest and apoptosis [Genes]    Transcription factor CREB and its extracellular signals [Genes]    T Cell Receptor Signaling Pathway [Genes]    Multiple antiapoptotic pathways from IGF-1R signaling lead to BAD phosphorylation [Genes]    IL 2 signaling pathway [Genes]    IL-2 Receptor Beta Chain in T cell Activation [Genes]    IL 3 signaling pathway [Genes]    Integrin Signaling Pathway [Genes]    Signaling of Hepatocyte Growth Factor Receptor [Genes]    Role of ERBB2 in Signal Transduction and Oncology [Genes]    Trefoil Factors Initiate Mucosal Healing [Genes]    Angiotensin II mediated activation of JNK Pathway via Pyk2 dependent signaling [Genes]    IL 6 signaling pathway [Genes]    BCR Signaling Pathway [Genes]    EPO Signaling Pathway [Genes]    Erk1/Erk2 Mapk Signaling pathway [Genes]    Growth Hormone Signaling Pathway [Genes]    Nerve growth factor pathway (NGF) [Genes]    PDGF Signaling Pathway [Genes]    Sprouty regulation of tyrosine kinase signals [Genes]    Calcium Signaling by HBx of Hepatitis B virus [Genes]    TPO Signaling Pathway [Genes]    Bioactive Peptide Induced Signaling Pathway [Genes]    Fc Epsilon Receptor I Signaling in Mast Cells [Genes]    IGF-1 Signaling Pathway [Genes]   
Pathways : KEGGMAPK signaling pathway    ErbB signaling pathway    Ras signaling pathway    Chemokine signaling pathway    FoxO signaling pathway    PI3K-Akt signaling pathway    Dorso-ventral axis formation    Focal adhesion    Gap junction    Jak-STAT signaling pathway    Natural killer cell mediated cytotoxicity    T cell receptor signaling pathway    B cell receptor signaling pathway    Fc epsilon RI signaling pathway    Neurotrophin signaling pathway    Regulation of actin cytoskeleton    Insulin signaling pathway    GnRH signaling pathway    Estrogen signaling pathway    Prolactin signaling pathway    Alcoholism    Hepatitis C    Pathways in cancer    Proteoglycans in cancer    MicroRNAs in cancer    Renal cell carcinoma    Endometrial cancer    Glioma    Prostate cancer    Chronic myeloid leukemia    Acute myeloid leukemia    Non-small cell lung cancer   
REACTOMESOS1
Protein Interaction DatabaseSOS1
Wikipedia pathwaysSOS1
Gene fusion - rearrangments
Polymorphisms : SNP, mutations, diseases
SNP Single Nucleotide Polymorphism (NCBI)SOS1
SNP (GeneSNP Utah)SOS1
SNP : HGBaseSOS1
Genetic variants : HAPMAPSOS1
1000_GenomesSOS1 
ICGC programENSG00000115904 
Somatic Mutations in Cancer : COSMICSOS1 
CONAN: Copy Number AnalysisSOS1 
Mutations and Diseases : HGMDSOS1
OMIM135300    163955    182530    610733   
GENETestsSOS1
Disease Genetic AssociationSOS1
Huge Navigator SOS1 [HugePedia]  SOS1 [HugeCancerGEM]
Genomic VariantsSOS1  SOS1 [DGVbeta]
Exome VariantSOS1
dbVarSOS1
ClinVarSOS1
snp3D : Map Gene to Disease6654
General knowledge
Homologs : HomoloGeneSOS1
Homology/Alignments : Family Browser (UCSC)SOS1
Phylogenetic Trees/Animal Genes : TreeFamSOS1
Chemical/Protein Interactions : CTD6654
Chemical/Pharm GKB GenePA36024
Clinical trialSOS1
Cancer Resource (Charite)ENSG00000115904
Other databases
Probes
Litterature
PubMed170 Pubmed reference(s) in Entrez
CoreMineSOS1
iHOPSOS1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

Contributor(s)

Written09-2002Dessen P, Le Minor S
Updated12-2013Dessen P

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Fri Apr 18 17:15:53 CEST 2014

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