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SOS2 (SOS Ras/Rho guanine nucleotide exchange factor 2)

Identity

Alias_namesson of sevenless (Drosophilia) homolog 2
son of sevenless homolog 2 (Drosophila)
Other aliasNS9
SOS-2
HGNC (Hugo) SOS2
LocusID (NCBI) 6655
Atlas_Id 42356
Location 14q21.3  [Link to chromosome band 14q21]
Location_base_pair Starts at 50117121 and ends at 50231693 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
AFTPH (2p14) / SOS2 (14q21.3)NEMF (14q21.3) / SOS2 (14q21.3)PRPF40A (2q23.3) / SOS2 (14q21.3)
RASSF3 (12q14.2) / SOS2 (14q21.3)SOS2 (14q21.3) / NRXN3 (14q31.1)SOS2 (14q21.3) / PRPF40A (2q23.3)
SOS2 (14q21.3) / SOS2 (14q21.3)NEMF 14q21.3 / SOS2 14q21.3SOS2 14q21.3 / NRXN3 14q31.1

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 2 ]
  t(14;14)(q21;q21) NEMF/SOS2
t(14;14)(q21;q24) SOS2/NRXN3


External links

Nomenclature
HGNC (Hugo)SOS2   11188
Cards
Entrez_Gene (NCBI)SOS2  6655  SOS Ras/Rho guanine nucleotide exchange factor 2
AliasesNS9; SOS-2
GeneCards (Weizmann)SOS2
Ensembl hg19 (Hinxton)ENSG00000100485 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000100485 [Gene_View]  ENSG00000100485 [Sequence]  chr14:50117121-50231693 [Contig_View]  SOS2 [Vega]
ICGC DataPortalENSG00000100485
TCGA cBioPortalSOS2
AceView (NCBI)SOS2
Genatlas (Paris)SOS2
WikiGenes6655
SOURCE (Princeton)SOS2
Genetics Home Reference (NIH)SOS2
Genomic and cartography
GoldenPath hg38 (UCSC)SOS2  -     chr14:50117121-50231693 -  14q21.3   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)SOS2  -     14q21.3   [Description]    (hg19-Feb_2009)
EnsemblSOS2 - 14q21.3 [CytoView hg19]  SOS2 - 14q21.3 [CytoView hg38]
Mapping of homologs : NCBISOS2 [Mapview hg19]  SOS2 [Mapview hg38]
OMIM601247   616559   
Gene and transcription
Genbank (Entrez)AB209277 AI419975 AK295868 AK302825 AK308978
RefSeq transcript (Entrez)NM_006939
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)SOS2
Cluster EST : UnigeneHs.291533 [ NCBI ]
CGAP (NCI)Hs.291533
Alternative Splicing GalleryENSG00000100485
Gene ExpressionSOS2 [ NCBI-GEO ]   SOS2 [ EBI - ARRAY_EXPRESS ]   SOS2 [ SEEK ]   SOS2 [ MEM ]
Gene Expression Viewer (FireBrowse)SOS2 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)6655
GTEX Portal (Tissue expression)SOS2
Human Protein AtlasENSG00000100485-SOS2 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ07890   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ07890  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ07890
Splice isoforms : SwissVarQ07890
PhosPhoSitePlusQ07890
Domaine pattern : Prosite (Expaxy)DH_2 (PS50010)    PH_DOMAIN (PS50003)    RASGEF (PS00720)    RASGEF_CAT (PS50009)    RASGEF_NTER (PS50212)   
Domains : Interpro (EBI)DH-domain    Histone-fold    Histone_H2A/H2B/H3    PH_dom-like    PH_domain    Ras-like_Gua-exchang_fac_N    Ras_G-nucl-exch_fac_CS    Ras_GEF_dom    RASGEF_cat_dom   
Domain families : Pfam (Sanger)Histone (PF00125)    PH (PF00169)    RasGEF (PF00617)    RasGEF_N (PF00618)    RhoGEF (PF00621)   
Domain families : Pfam (NCBI)pfam00125    pfam00169    pfam00617    pfam00618    pfam00621   
Domain families : Smart (EMBL)PH (SM00233)  RasGEF (SM00147)  RasGEFN (SM00229)  RhoGEF (SM00325)  
Conserved Domain (NCBI)SOS2
DMDM Disease mutations6655
Blocks (Seattle)SOS2
SuperfamilyQ07890
Human Protein Atlas [tissue]ENSG00000100485-SOS2 [tissue]
Peptide AtlasQ07890
HPRD03149
IPIIPI00020134   IPI01009360   IPI01025046   
Protein Interaction databases
DIP (DOE-UCLA)Q07890
IntAct (EBI)Q07890
FunCoupENSG00000100485
BioGRIDSOS2
STRING (EMBL)SOS2
ZODIACSOS2
Ontologies - Pathways
QuickGOQ07890
Ontology : AmiGODNA binding  guanyl-nucleotide exchange factor activity  Rho guanyl-nucleotide exchange factor activity  protein binding  cytosol  G-protein coupled receptor signaling pathway  small GTPase mediated signal transduction  regulation of Rho protein signal transduction  positive regulation of apoptotic process  protein heterodimerization activity  regulation of small GTPase mediated signal transduction  positive regulation of small GTPase mediated signal transduction  regulation of molecular function  
Ontology : EGO-EBIDNA binding  guanyl-nucleotide exchange factor activity  Rho guanyl-nucleotide exchange factor activity  protein binding  cytosol  G-protein coupled receptor signaling pathway  small GTPase mediated signal transduction  regulation of Rho protein signal transduction  positive regulation of apoptotic process  protein heterodimerization activity  regulation of small GTPase mediated signal transduction  positive regulation of small GTPase mediated signal transduction  regulation of molecular function  
Pathways : KEGGJak-STAT signaling pathway    T cell receptor signaling pathway    Colorectal cancer    Insulin signaling pathway    Fc epsilon RI signaling pathway    Regulation of actin cytoskeleton    Natural killer cell mediated cytotoxicity    Gap junction    Dorso-ventral axis formation    GnRH signaling pathway    Focal adhesion    MAPK signaling pathway   
NDEx NetworkSOS2
Atlas of Cancer Signalling NetworkSOS2
Wikipedia pathwaysSOS2
Orthology - Evolution
OrthoDB6655
GeneTree (enSembl)ENSG00000100485
Phylogenetic Trees/Animal Genes : TreeFamSOS2
HOVERGENQ07890
HOGENOMQ07890
Homologs : HomoloGeneSOS2
Homology/Alignments : Family Browser (UCSC)SOS2
Gene fusions - Rearrangements
Fusion : MitelmanNEMF/SOS2 [14q21.3/14q21.3]  [t(14;14)(q21;q21)]  
Fusion : MitelmanSOS2/NRXN3 [14q21.3/14q31.1]  [t(14;14)(q21;q24)]  
Fusion PortalNEMF 14q21.3 SOS2 14q21.3 BRCA LUAD
Fusion PortalSOS2 14q21.3 NRXN3 14q31.1 SKCM
Fusion : QuiverSOS2
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerSOS2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)SOS2
dbVarSOS2
ClinVarSOS2
1000_GenomesSOS2 
Exome Variant ServerSOS2
ExAC (Exome Aggregation Consortium)ENSG00000100485
GNOMAD BrowserENSG00000100485
Genetic variants : HAPMAP6655
Genomic Variants (DGV)SOS2 [DGVbeta]
DECIPHERSOS2 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisSOS2 
Mutations
ICGC Data PortalSOS2 
TCGA Data PortalSOS2 
Broad Tumor PortalSOS2
OASIS PortalSOS2 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICSOS2  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDSOS2
intOGen PortalSOS2
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch SOS2
DgiDB (Drug Gene Interaction Database)SOS2
DoCM (Curated mutations)SOS2 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)SOS2 (select a term)
intoGenSOS2
Cancer3DSOS2(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM601247    616559   
Orphanet206   
DisGeNETSOS2
MedgenSOS2
Genetic Testing Registry SOS2
NextProtQ07890 [Medical]
TSGene6655
GENETestsSOS2
Target ValidationSOS2
Huge Navigator SOS2 [HugePedia]
snp3D : Map Gene to Disease6655
BioCentury BCIQSOS2
ClinGenSOS2
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD6655
Chemical/Pharm GKB GenePA36025
Clinical trialSOS2
Miscellaneous
canSAR (ICR)SOS2 (select the gene name)
Probes
Litterature
PubMed45 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineSOS2
EVEXSOS2
GoPubMedSOS2
iHOPSOS2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Fri Jun 22 16:51:11 CEST 2018

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