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SOST (sclerostin)

Identity

Other namesCDD
VBCH
HGNC (Hugo) SOST
LocusID (NCBI) 50964
Location 17q21.31
Location_base_pair Starts at 41831099 and ends at 41836156 bp from pter ( according to hg19-Feb_2009)
Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

External links

Nomenclature
HGNC (Hugo)SOST   13771
Cards
Entrez_Gene (NCBI)SOST  50964  sclerostin
GeneCards (Weizmann)SOST
Ensembl (Hinxton)ENSG00000167941 [Gene_View]  chr17:41831099-41836156 [Contig_View]  SOST [Vega]
AceView (NCBI)SOST
Genatlas (Paris)SOST
WikiGenes50964
SOURCE (Princeton)NM_025237
Genomic and cartography
GoldenPath (UCSC)SOST  -  17q21.31   chr17:41831099-41836156 -  17q21.31   [Description]    (hg19-Feb_2009)
EnsemblSOST - 17q21.31 [CytoView]
Mapping of homologs : NCBISOST [Mapview]
OMIM122860   239100   269500   605740   
Gene and transcription
Genbank (Entrez)AF170491 AF184211 AF326739 AF331844 AY358203
RefSeq transcript (Entrez)NM_025237
RefSeq genomic (Entrez)AC_000149 NC_000017 NC_018928 NG_008078 NT_010783 NW_001838437 NW_004929407
Consensus coding sequences : CCDS (NCBI)SOST
Cluster EST : UnigeneHs.349204 [ NCBI ]
CGAP (NCI)Hs.349204
Alternative Splicing : Fast-db (Paris)GSHG0013444
Alternative Splicing GalleryENSG00000167941
Gene ExpressionSOST [ NCBI-GEO ]     SOST [ SEEK ]   SOST [ MEM ]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9BQB4 (Uniprot)
NextProtQ9BQB4  [Medical]
With graphics : InterProQ9BQB4
Splice isoforms : SwissVarQ9BQB4 (Swissvar)
Domaine pattern : Prosite (Expaxy)CTCK_1 (PS01185)    CTCK_2 (PS01225)   
Domains : Interpro (EBI)Sclerostin/SOSTDC1    SOST   
Related proteins : CluSTrQ9BQB4
Domain families : Pfam (Sanger)Sclerostin (PF05463)   
Domain families : Pfam (NCBI)pfam05463   
DMDM Disease mutations50964
Blocks (Seattle)Q9BQB4
PDB (SRS)2K8P   
PDB (PDBSum)2K8P   
PDB (IMB)2K8P   
PDB (RSDB)2K8P   
Human Protein AtlasENSG00000167941
Peptide AtlasQ9BQB4
HPRD05762
IPIIPI00019272   IPI00410101   IPI00384900   IPI00385104   
Protein Interaction databases
DIP (DOE-UCLA)Q9BQB4
IntAct (EBI)Q9BQB4
FunCoupENSG00000167941
BioGRIDSOST
InParanoidQ9BQB4
Interologous Interaction database Q9BQB4
IntegromeDBSOST
STRING (EMBL)SOST
Ontologies - Pathways
Ontology : AmiGOossification  protein binding  proteinaceous extracellular matrix  extracellular space  Golgi apparatus  transcription factor binding  heparin binding  response to mechanical stimulus  Wnt receptor signaling pathway  negative regulation of ossification  negative regulation of BMP signaling pathway  extracellular matrix  negative regulation of protein complex assembly  positive regulation of transcription, DNA-dependent  cellular response to parathyroid hormone stimulus  negative regulation of canonical Wnt receptor signaling pathway  negative regulation of Wnt receptor signaling pathway involved in dorsal/ventral axis specification  
Ontology : EGO-EBIossification  protein binding  proteinaceous extracellular matrix  extracellular space  Golgi apparatus  transcription factor binding  heparin binding  response to mechanical stimulus  Wnt receptor signaling pathway  negative regulation of ossification  negative regulation of BMP signaling pathway  extracellular matrix  negative regulation of protein complex assembly  positive regulation of transcription, DNA-dependent  cellular response to parathyroid hormone stimulus  negative regulation of canonical Wnt receptor signaling pathway  negative regulation of Wnt receptor signaling pathway involved in dorsal/ventral axis specification  
Pathways : KEGGWnt signaling pathway   
REACTOMESOST
Protein Interaction DatabaseSOST
Wikipedia pathwaysSOST
Gene fusion - rearrangments
Polymorphisms : SNP, mutations, diseases
SNP Single Nucleotide Polymorphism (NCBI)SOST
SNP (GeneSNP Utah)SOST
SNP : HGBaseSOST
Genetic variants : HAPMAPSOST
1000_GenomesSOST 
ICGC programENSG00000167941 
Somatic Mutations in Cancer : COSMICSOST 
CONAN: Copy Number AnalysisSOST 
Mutations and Diseases : HGMDSOST
OMIM122860    239100    269500    605740   
GENETestsSOST
Disease Genetic AssociationSOST
Huge Navigator SOST [HugePedia]  SOST [HugeCancerGEM]
Genomic VariantsSOST  SOST [DGVbeta]
Exome VariantSOST
dbVarSOST
ClinVarSOST
snp3D : Map Gene to Disease50964
General knowledge
Homologs : HomoloGeneSOST
Homology/Alignments : Family Browser (UCSC)SOST
Phylogenetic Trees/Animal Genes : TreeFamSOST
Chemical/Protein Interactions : CTD50964
Chemical/Pharm GKB GenePA37809
Clinical trialSOST
Cancer Resource (Charite)ENSG00000167941
Other databases
Probes
Litterature
PubMed112 Pubmed reference(s) in Entrez
CoreMineSOST
iHOPSOST
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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Contributor(s)

Written09-2002Dessen P, Le Minor S
Updated12-2013Dessen P

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Fri Apr 18 16:44:14 CEST 2014

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