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SOST (sclerostin)

Identity

Alias (NCBI)CDD
DAND6
SOST1
VBCH
HGNC (Hugo) SOST
HGNC Alias symbVBCH
DAND6
HGNC Previous namesclerosteosis
LocusID (NCBI) 50964
Atlas_Id 50789
Location 17q21.31  [Link to chromosome band 17q21]
Location_base_pair Starts at 43753738 and ends at 43758791 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



External links

 

Nomenclature
HGNC (Hugo)SOST   13771
Cards
Entrez_Gene (NCBI)SOST    sclerostin
AliasesCDD; DAND6; SOST1; VBCH
GeneCards (Weizmann)SOST
Ensembl hg19 (Hinxton)ENSG00000167941 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000167941 [Gene_View]  ENSG00000167941 [Sequence]  chr17:43753738-43758791 [Contig_View]  SOST [Vega]
ICGC DataPortalENSG00000167941
TCGA cBioPortalSOST
AceView (NCBI)SOST
Genatlas (Paris)SOST
SOURCE (Princeton)SOST
Genetics Home Reference (NIH)SOST
Genomic and cartography
GoldenPath hg38 (UCSC)SOST  -     chr17:43753738-43758791 -  17q21.31   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)SOST  -     17q21.31   [Description]    (hg19-Feb_2009)
GoldenPathSOST - 17q21.31 [CytoView hg19]  SOST - 17q21.31 [CytoView hg38]
ImmunoBaseENSG00000167941
Genome Data Viewer NCBISOST [Mapview hg19]  
OMIM122860   269500   605740   
Gene and transcription
Genbank (Entrez)AF170491 AF184211 AF326739 AF331844 AY358203
RefSeq transcript (Entrez)NM_025237
Consensus coding sequences : CCDS (NCBI)SOST
Gene ExpressionSOST [ NCBI-GEO ]   SOST [ EBI - ARRAY_EXPRESS ]   SOST [ SEEK ]   SOST [ MEM ]
Gene Expression Viewer (FireBrowse)SOST [ Firebrowse - Broad ]
GenevisibleExpression of SOST in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)50964
GTEX Portal (Tissue expression)SOST
Human Protein AtlasENSG00000167941-SOST [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9BQB4   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9BQB4  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9BQB4
PhosPhoSitePlusQ9BQB4
Domains : Interpro (EBI)Cys_knot_C    Cystine-knot_cytokine    Sclerostin/SOSTDC1    SOST   
Domain families : Pfam (Sanger)Sclerostin (PF05463)   
Domain families : Pfam (NCBI)pfam05463   
Domain families : Smart (EMBL)CT (SM00041)  
Conserved Domain (NCBI)SOST
PDB (RSDB)2K8P    3SOV    6L6R   
PDB Europe2K8P    3SOV    6L6R   
PDB (PDBSum)2K8P    3SOV    6L6R   
PDB (IMB)2K8P    3SOV    6L6R   
Structural Biology KnowledgeBase2K8P    3SOV    6L6R   
SCOP (Structural Classification of Proteins)2K8P    3SOV    6L6R   
CATH (Classification of proteins structures)2K8P    3SOV    6L6R   
SuperfamilyQ9BQB4
AlphaFold pdb e-kbQ9BQB4   
Human Protein Atlas [tissue]ENSG00000167941-SOST [tissue]
HPRD05762
Protein Interaction databases
DIP (DOE-UCLA)Q9BQB4
IntAct (EBI)Q9BQB4
BioGRIDSOST
STRING (EMBL)SOST
ZODIACSOST
Ontologies - Pathways
QuickGOQ9BQB4
Ontology : AmiGOossification  protein binding  extracellular region  extracellular space  Golgi apparatus  transcription factor binding  heparin binding  response to mechanical stimulus  Wnt signaling pathway  negative regulation of Wnt signaling pathway  negative regulation of ossification  negative regulation of BMP signaling pathway  negative regulation of BMP signaling pathway  negative regulation of protein-containing complex assembly  protein-containing complex  BMP binding  positive regulation of transcription, DNA-templated  collagen-containing extracellular matrix  cellular response to parathyroid hormone stimulus  negative regulation of canonical Wnt signaling pathway  negative regulation of canonical Wnt signaling pathway  
Ontology : EGO-EBIossification  protein binding  extracellular region  extracellular space  Golgi apparatus  transcription factor binding  heparin binding  response to mechanical stimulus  Wnt signaling pathway  negative regulation of Wnt signaling pathway  negative regulation of ossification  negative regulation of BMP signaling pathway  negative regulation of BMP signaling pathway  negative regulation of protein-containing complex assembly  protein-containing complex  BMP binding  positive regulation of transcription, DNA-templated  collagen-containing extracellular matrix  cellular response to parathyroid hormone stimulus  negative regulation of canonical Wnt signaling pathway  negative regulation of canonical Wnt signaling pathway  
Pathways : KEGGWnt signaling pathway   
NDEx NetworkSOST
Atlas of Cancer Signalling NetworkSOST
Wikipedia pathwaysSOST
Orthology - Evolution
OrthoDB50964
GeneTree (enSembl)ENSG00000167941
Phylogenetic Trees/Animal Genes : TreeFamSOST
Homologs : HomoloGeneSOST
Homology/Alignments : Family Browser (UCSC)SOST
Gene fusions - Rearrangements
Fusion : QuiverSOST
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerSOST [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)SOST
dbVarSOST
ClinVarSOST
MonarchSOST
1000_GenomesSOST 
Exome Variant ServerSOST
GNOMAD BrowserENSG00000167941
Varsome BrowserSOST
ACMGSOST variants
VarityQ9BQB4
Genomic Variants (DGV)SOST [DGVbeta]
DECIPHERSOST [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisSOST 
Mutations
ICGC Data PortalSOST 
TCGA Data PortalSOST 
Broad Tumor PortalSOST
OASIS PortalSOST [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICSOST  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DSOST
Mutations and Diseases : HGMDSOST
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaSOST
DgiDB (Drug Gene Interaction Database)SOST
DoCM (Curated mutations)SOST
CIViC (Clinical Interpretations of Variants in Cancer)SOST
Cancer3DSOST
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM122860    269500    605740   
Orphanet1680    3010    2819   
DisGeNETSOST
MedgenSOST
Genetic Testing Registry SOST
NextProtQ9BQB4 [Medical]
GENETestsSOST
Target ValidationSOST
Huge Navigator SOST [HugePedia]
ClinGenSOST (curated)
Clinical trials, drugs, therapy
MyCancerGenomeSOST
Protein Interactions : CTDSOST
Pharm GKB GenePA37809
PharosQ9BQB4
Clinical trialSOST
Miscellaneous
canSAR (ICR)SOST
HarmonizomeSOST
DataMed IndexSOST
Probes
Litterature
PubMed289 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXSOST
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Oct 4 15:32:38 CEST 2021

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