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SOST (sclerostin)

Identity

Other namesCDD
SOST1
VBCH
HGNC (Hugo) SOST
LocusID (NCBI) 50964
Atlas_Id 50789
Location 17q21.31  [Link to chromosome band 17q21]
Location_base_pair Starts at 41831099 and ends at 41836156 bp from pter ( according to hg19-Feb_2009)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)SOST   13771
Cards
Entrez_Gene (NCBI)SOST  50964  sclerostin
AliasesCDD; SOST1; VBCH
GeneCards (Weizmann)SOST
Ensembl hg19 (Hinxton)ENSG00000167941 [Gene_View]  chr17:41831099-41836156 [Contig_View]  SOST [Vega]
Ensembl hg38 (Hinxton)ENSG00000167941 [Gene_View]  chr17:41831099-41836156 [Contig_View]  SOST [Vega]
ICGC DataPortalENSG00000167941
TCGA cBioPortalSOST
AceView (NCBI)SOST
Genatlas (Paris)SOST
WikiGenes50964
SOURCE (Princeton)SOST
Genomic and cartography
GoldenPath hg19 (UCSC)SOST  -     chr17:41831099-41836156 -  17q21.31   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)SOST  -     17q21.31   [Description]    (hg38-Dec_2013)
EnsemblSOST - 17q21.31 [CytoView hg19]  SOST - 17q21.31 [CytoView hg38]
Mapping of homologs : NCBISOST [Mapview hg19]  SOST [Mapview hg38]
OMIM122860   239100   269500   605740   
Gene and transcription
Genbank (Entrez)AF170491 AF184211 AF326739 AF331844 AY358203
RefSeq transcript (Entrez)NM_025237
RefSeq genomic (Entrez)NC_000017 NC_018928 NG_008078 NT_010783 NW_004929407
Consensus coding sequences : CCDS (NCBI)SOST
Cluster EST : UnigeneHs.349204 [ NCBI ]
CGAP (NCI)Hs.349204
Alternative Splicing GalleryENSG00000167941
Gene ExpressionSOST [ NCBI-GEO ]   SOST [ EBI - ARRAY_EXPRESS ]   SOST [ SEEK ]   SOST [ MEM ]
Gene Expression Viewer (FireBrowse)SOST [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)50964
GTEX Portal (Tissue expression)SOST
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9BQB4 (Uniprot)
NextProtQ9BQB4  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9BQB4
Splice isoforms : SwissVarQ9BQB4 (Swissvar)
PhosPhoSitePlusQ9BQB4
Domains : Interpro (EBI)Sclerostin/SOSTDC1    SOST   
Domain families : Pfam (Sanger)Sclerostin (PF05463)   
Domain families : Pfam (NCBI)pfam05463   
DMDM Disease mutations50964
Blocks (Seattle)SOST
PDB (SRS)2K8P    3SOV   
PDB (PDBSum)2K8P    3SOV   
PDB (IMB)2K8P    3SOV   
PDB (RSDB)2K8P    3SOV   
Structural Biology KnowledgeBase2K8P    3SOV   
SCOP (Structural Classification of Proteins)2K8P    3SOV   
CATH (Classification of proteins structures)2K8P    3SOV   
SuperfamilyQ9BQB4
Human Protein AtlasENSG00000167941
Peptide AtlasQ9BQB4
HPRD05762
IPIIPI00019272   IPI00410101   IPI00384900   IPI00385104   
Protein Interaction databases
DIP (DOE-UCLA)Q9BQB4
IntAct (EBI)Q9BQB4
FunCoupENSG00000167941
BioGRIDSOST
STRING (EMBL)SOST
ZODIACSOST
Ontologies - Pathways
QuickGOQ9BQB4
Ontology : AmiGOossification  protein binding  extracellular region  proteinaceous extracellular matrix  extracellular space  Golgi apparatus  transcription factor binding  heparin binding  response to mechanical stimulus  Wnt signaling pathway  negative regulation of ossification  negative regulation of BMP signaling pathway  extracellular matrix  negative regulation of protein complex assembly  positive regulation of transcription, DNA-templated  cellular response to parathyroid hormone stimulus  negative regulation of canonical Wnt signaling pathway  negative regulation of canonical Wnt signaling pathway  negative regulation of Wnt signaling pathway involved in dorsal/ventral axis specification  
Ontology : EGO-EBIossification  protein binding  extracellular region  proteinaceous extracellular matrix  extracellular space  Golgi apparatus  transcription factor binding  heparin binding  response to mechanical stimulus  Wnt signaling pathway  negative regulation of ossification  negative regulation of BMP signaling pathway  extracellular matrix  negative regulation of protein complex assembly  positive regulation of transcription, DNA-templated  cellular response to parathyroid hormone stimulus  negative regulation of canonical Wnt signaling pathway  negative regulation of canonical Wnt signaling pathway  negative regulation of Wnt signaling pathway involved in dorsal/ventral axis specification  
Pathways : KEGGWnt signaling pathway   
NDEx Network
Atlas of Cancer Signalling NetworkSOST
Wikipedia pathwaysSOST
Orthology - Evolution
OrthoDB50964
GeneTree (enSembl)ENSG00000167941
Phylogenetic Trees/Animal Genes : TreeFamSOST
Homologs : HomoloGeneSOST
Homology/Alignments : Family Browser (UCSC)SOST
Gene fusions - Rearrangements
Polymorphisms : SNP, variants
NCBI Variation ViewerSOST [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)SOST
dbVarSOST
ClinVarSOST
1000_GenomesSOST 
Exome Variant ServerSOST
ExAC (Exome Aggregation Consortium)SOST (select the gene name)
Genetic variants : HAPMAP50964
Genomic Variants (DGV)SOST [DGVbeta]
Mutations
ICGC Data PortalSOST 
TCGA Data PortalSOST 
Broad Tumor PortalSOST
OASIS PortalSOST [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICSOST 
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
BioMutasearch SOST
DgiDB (Drug Gene Interaction Database)SOST
DoCM (Curated mutations)SOST (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)SOST (select a term)
intoGenSOST
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] 
Diseases
DECIPHER (Syndromes)17:41831099-41836156  ENSG00000167941
CONAN: Copy Number AnalysisSOST 
Mutations and Diseases : HGMDSOST
OMIM122860    239100    269500    605740   
MedgenSOST
Genetic Testing Registry SOST
NextProtQ9BQB4 [Medical]
TSGene50964
GENETestsSOST
Huge Navigator SOST [HugePedia]
snp3D : Map Gene to Disease50964
BioCentury BCIQSOST
ClinGenSOST
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD50964
Chemical/Pharm GKB GenePA37809
Clinical trialSOST
Miscellaneous
canSAR (ICR)SOST (select the gene name)
Probes
Litterature
PubMed181 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineSOST
EVEXSOST
GoPubMedSOST
iHOPSOST
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Tue Aug 9 19:21:32 CEST 2016

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