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SOSTDC1 (sclerostin domain containing 1)

Identity

Alias (NCBI)CDA019
DAND7
ECTODIN
USAG1
HGNC (Hugo) SOSTDC1
HGNC Alias symbDKFZp564D206
USAG1
DAND7
HGNC Alias nameectodin
 wise
LocusID (NCBI) 25928
Atlas_Id 50503
Location 7p21.2  [Link to chromosome band 7p21]
Location_base_pair Starts at 16461481 and ends at 16465738 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
SOSTDC1 (7p21.1) / SOSTDC1 (7p21.1)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



External links

 

Nomenclature
HGNC (Hugo)SOSTDC1   21748
Cards
Entrez_Gene (NCBI)SOSTDC1    sclerostin domain containing 1
AliasesCDA019; DAND7; ECTODIN; USAG1
GeneCards (Weizmann)SOSTDC1
Ensembl hg19 (Hinxton)ENSG00000171243 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000171243 [Gene_View]  ENSG00000171243 [Sequence]  chr7:16461481-16465738 [Contig_View]  SOSTDC1 [Vega]
ICGC DataPortalENSG00000171243
TCGA cBioPortalSOSTDC1
AceView (NCBI)SOSTDC1
Genatlas (Paris)SOSTDC1
SOURCE (Princeton)SOSTDC1
Genetics Home Reference (NIH)SOSTDC1
Genomic and cartography
GoldenPath hg38 (UCSC)SOSTDC1  -     chr7:16461481-16465738 -  7p21.2   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)SOSTDC1  -     7p21.2   [Description]    (hg19-Feb_2009)
GoldenPathSOSTDC1 - 7p21.2 [CytoView hg19]  SOSTDC1 - 7p21.2 [CytoView hg38]
ImmunoBaseENSG00000171243
Genome Data Viewer NCBISOSTDC1 [Mapview hg19]  
OMIM609675   
Gene and transcription
Genbank (Entrez)AB059270 AF361494 AI540640 AI927000 AK093408
RefSeq transcript (Entrez)NM_015464
Consensus coding sequences : CCDS (NCBI)SOSTDC1
Gene ExpressionSOSTDC1 [ NCBI-GEO ]   SOSTDC1 [ EBI - ARRAY_EXPRESS ]   SOSTDC1 [ SEEK ]   SOSTDC1 [ MEM ]
Gene Expression Viewer (FireBrowse)SOSTDC1 [ Firebrowse - Broad ]
GenevisibleExpression of SOSTDC1 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)25928
GTEX Portal (Tissue expression)SOSTDC1
Human Protein AtlasENSG00000171243-SOSTDC1 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ6X4U4   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ6X4U4  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ6X4U4
PhosPhoSitePlusQ6X4U4
Domaine pattern : Prosite (Expaxy)CTCK_2 (PS01225)   
Domains : Interpro (EBI)Cys_knot_C    Cystine-knot_cytokine    Sclerostin/SOSTDC1   
Domain families : Pfam (Sanger)Sclerostin (PF05463)   
Domain families : Pfam (NCBI)pfam05463   
Conserved Domain (NCBI)SOSTDC1
SuperfamilyQ6X4U4
AlphaFold pdb e-kbQ6X4U4   
Human Protein Atlas [tissue]ENSG00000171243-SOSTDC1 [tissue]
HPRD15417
Protein Interaction databases
DIP (DOE-UCLA)Q6X4U4
IntAct (EBI)Q6X4U4
BioGRIDSOSTDC1
STRING (EMBL)SOSTDC1
ZODIACSOSTDC1
Ontologies - Pathways
QuickGOQ6X4U4
Ontology : AmiGOextracellular space  extracellular space  pattern specification process  negative regulation of cell fate commitment  Wnt signaling pathway  negative regulation of Wnt signaling pathway  negative regulation of Wnt signaling pathway  BMP signaling pathway  negative regulation of BMP signaling pathway  negative regulation of BMP signaling pathway  hair follicle morphogenesis  BMP binding  BMP binding  odontogenesis of dentin-containing tooth  negative regulation of myoblast differentiation  mammary gland bud morphogenesis  negative regulation of canonical Wnt signaling pathway  BMP receptor activity  negative regulation of determination of dorsal identity  
Ontology : EGO-EBIextracellular space  extracellular space  pattern specification process  negative regulation of cell fate commitment  Wnt signaling pathway  negative regulation of Wnt signaling pathway  negative regulation of Wnt signaling pathway  BMP signaling pathway  negative regulation of BMP signaling pathway  negative regulation of BMP signaling pathway  hair follicle morphogenesis  BMP binding  BMP binding  odontogenesis of dentin-containing tooth  negative regulation of myoblast differentiation  mammary gland bud morphogenesis  negative regulation of canonical Wnt signaling pathway  BMP receptor activity  negative regulation of determination of dorsal identity  
NDEx NetworkSOSTDC1
Atlas of Cancer Signalling NetworkSOSTDC1
Wikipedia pathwaysSOSTDC1
Orthology - Evolution
OrthoDB25928
GeneTree (enSembl)ENSG00000171243
Phylogenetic Trees/Animal Genes : TreeFamSOSTDC1
Homologs : HomoloGeneSOSTDC1
Homology/Alignments : Family Browser (UCSC)SOSTDC1
Gene fusions - Rearrangements
Fusion : QuiverSOSTDC1
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerSOSTDC1 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)SOSTDC1
dbVarSOSTDC1
ClinVarSOSTDC1
MonarchSOSTDC1
1000_GenomesSOSTDC1 
Exome Variant ServerSOSTDC1
GNOMAD BrowserENSG00000171243
Varsome BrowserSOSTDC1
ACMGSOSTDC1 variants
VarityQ6X4U4
Genomic Variants (DGV)SOSTDC1 [DGVbeta]
DECIPHERSOSTDC1 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisSOSTDC1 
Mutations
ICGC Data PortalSOSTDC1 
TCGA Data PortalSOSTDC1 
Broad Tumor PortalSOSTDC1
OASIS PortalSOSTDC1 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICSOSTDC1  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DSOSTDC1
Mutations and Diseases : HGMDSOSTDC1
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaSOSTDC1
DgiDB (Drug Gene Interaction Database)SOSTDC1
DoCM (Curated mutations)SOSTDC1
CIViC (Clinical Interpretations of Variants in Cancer)SOSTDC1
Cancer3DSOSTDC1
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM609675   
Orphanet
DisGeNETSOSTDC1
MedgenSOSTDC1
Genetic Testing Registry SOSTDC1
NextProtQ6X4U4 [Medical]
GENETestsSOSTDC1
Target ValidationSOSTDC1
Huge Navigator SOSTDC1 [HugePedia]
ClinGenSOSTDC1
Clinical trials, drugs, therapy
MyCancerGenomeSOSTDC1
Protein Interactions : CTDSOSTDC1
Pharm GKB GenePA134937603
PharosQ6X4U4
Clinical trialSOSTDC1
Miscellaneous
canSAR (ICR)SOSTDC1
HarmonizomeSOSTDC1
DataMed IndexSOSTDC1
Probes
Litterature
PubMed30 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXSOSTDC1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Oct 4 15:32:38 CEST 2021

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