SOSTDC1 (sclerostin domain containing 1)

2008-12-01 Affiliation

Identity

HGNC

SOSTDC1

LOCATION

7p21.2

LOCUSID

25928

ALIAS

CDA019,DAND7,ECTODIN,USAG1

FUSION GENES

Show Gene Fusions

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 25928
MIM: 609675
HGNC: 21748
Ensembl: ENSG00000171243

Variants:

dbSNP: 25928
ClinVar: 25928
TCGA: ENSG00000171243
COSMIC: SOSTDC1

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000171243	ENST00000307068	Q6X4U4
ENSG00000171243	ENST00000307068	A4D125
ENSG00000171243	ENST00000396652	Q6X4U4

Expression (GTEx)

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

References

Pubmed ID	Year	Title	Citations
14623234	2003	Identification of a secreted BMP antagonist, ectodin, integrating BMP, FGF, and SHH signals from the tooth enamel knot.	75
15020244	2004	USAG-1: a bone morphogenetic protein antagonist abundantly expressed in the kidney.	45
25858146	2015	Hepcidin regulation in prostate and its disruption in prostate cancer.	43
18032587	2008	A human bone morphogenetic protein antagonist is down-regulated in renal cancer.	24
26378658	2015	Down-regulation of SOSTDC1 promotes thyroid cancer cell proliferation via regulating cyclin A2 and cyclin E2.	18
21113658	2011	SOSTDC1 differentially modulates Smad and beta-catenin activation and is down-regulated in breast cancer.	17
21221677	2011	Contribution of the sclerostin domain-containing protein 1 (SOSTDC1) gene to normal variation of peak bone mineral density in Chinese women and men.	10
23830730	2013	SOSTDC1 down-regulation of expression involves CpG methylation and is a potential prognostic marker in gastric cancer.	10
19760604	2009	Two candidate tumor suppressor genes, MEOX2 and SOSTDC1, identified in a 7p21 homozygous deletion region in a Wilms tumor.	9
21080955	2010	Loss of heterozygosity and SOSTDC1 in adult and pediatric renal tumors.	9

Citation

Dessen P

SOSTDC1 (sclerostin domain containing 1)

Atlas Genet Cytogenet Oncol Haematol. 2008-12-01

Online version: http://atlasgeneticsoncology.org/gene/50503/sostdc1