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SOX12 (SRY-box 12)

Identity

Alias_namesSOX22
SRY (sex determining region Y)-box 22
SRY (sex determining region Y)-box 12
SRY box 12
Other alias
HGNC (Hugo) SOX12
LocusID (NCBI) 6666
Atlas_Id 55336
Location 20p13  [Link to chromosome band 20p13]
Location_base_pair Starts at 325571 and ends at 330228 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
HLA-DPA1 (6p21.32) / SOX12 (20p13)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)SOX12   11198
Cards
Entrez_Gene (NCBI)SOX12  6666  SRY-box 12
AliasesSOX22
GeneCards (Weizmann)SOX12
Ensembl hg19 (Hinxton)ENSG00000177732 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000177732 [Gene_View]  ENSG00000177732 [Sequence]  chr20:325571-330228 [Contig_View]  SOX12 [Vega]
ICGC DataPortalENSG00000177732
TCGA cBioPortalSOX12
AceView (NCBI)SOX12
Genatlas (Paris)SOX12
WikiGenes6666
SOURCE (Princeton)SOX12
Genetics Home Reference (NIH)SOX12
Genomic and cartography
GoldenPath hg38 (UCSC)SOX12  -     chr20:325571-330228 +  20p13   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)SOX12  -     20p13   [Description]    (hg19-Feb_2009)
EnsemblSOX12 - 20p13 [CytoView hg19]  SOX12 - 20p13 [CytoView hg38]
Mapping of homologs : NCBISOX12 [Mapview hg19]  SOX12 [Mapview hg38]
OMIM601947   
Gene and transcription
Genbank (Entrez)AA322870 AW296348 BC028103 BC067361 BF530163
RefSeq transcript (Entrez)NM_006943
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)SOX12
Cluster EST : UnigeneHs.745058 [ NCBI ]
CGAP (NCI)Hs.745058
Alternative Splicing GalleryENSG00000177732
Gene ExpressionSOX12 [ NCBI-GEO ]   SOX12 [ EBI - ARRAY_EXPRESS ]   SOX12 [ SEEK ]   SOX12 [ MEM ]
Gene Expression Viewer (FireBrowse)SOX12 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)6666
GTEX Portal (Tissue expression)SOX12
Human Protein AtlasENSG00000177732-SOX12 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtO15370   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtO15370  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProO15370
Splice isoforms : SwissVarO15370
PhosPhoSitePlusO15370
Domaine pattern : Prosite (Expaxy)HMG_BOX_2 (PS50118)   
Domains : Interpro (EBI)HMG_box_dom    HMG_box_dom_sf    SOX-11/4    SOX-12   
Domain families : Pfam (Sanger)HMG_box (PF00505)   
Domain families : Pfam (NCBI)pfam00505   
Domain families : Smart (EMBL)HMG (SM00398)  
Conserved Domain (NCBI)SOX12
DMDM Disease mutations6666
Blocks (Seattle)SOX12
SuperfamilyO15370
Human Protein Atlas [tissue]ENSG00000177732-SOX12 [tissue]
Peptide AtlasO15370
HPRD09056
IPIIPI00006180   
Protein Interaction databases
DIP (DOE-UCLA)O15370
IntAct (EBI)O15370
FunCoupENSG00000177732
BioGRIDSOX12
STRING (EMBL)SOX12
ZODIACSOX12
Ontologies - Pathways
QuickGOO15370
Ontology : AmiGOtranscription regulatory region sequence-specific DNA binding  DNA-binding transcription factor activity, RNA polymerase II-specific  DNA-binding transcription factor activity, RNA polymerase II-specific  DNA-binding transcription factor activity, RNA polymerase II-specific  DNA-binding transcription factor activity, RNA polymerase II-specific  proximal promoter DNA-binding transcription activator activity, RNA polymerase II-specific  proximal promoter DNA-binding transcription activator activity, RNA polymerase II-specific  DNA binding  transcription coactivator activity  cellular_component  nucleus  nucleoplasm  regulation of transcription, DNA-templated  regulation of transcription by RNA polymerase II  spinal cord development  cell differentiation  protein-DNA complex  nuclear transcription factor complex  cell fate commitment  positive regulation of transcription by RNA polymerase II  positive regulation of transcription by RNA polymerase II  protein-DNA complex assembly  
Ontology : EGO-EBItranscription regulatory region sequence-specific DNA binding  DNA-binding transcription factor activity, RNA polymerase II-specific  DNA-binding transcription factor activity, RNA polymerase II-specific  DNA-binding transcription factor activity, RNA polymerase II-specific  DNA-binding transcription factor activity, RNA polymerase II-specific  proximal promoter DNA-binding transcription activator activity, RNA polymerase II-specific  proximal promoter DNA-binding transcription activator activity, RNA polymerase II-specific  DNA binding  transcription coactivator activity  cellular_component  nucleus  nucleoplasm  regulation of transcription, DNA-templated  regulation of transcription by RNA polymerase II  spinal cord development  cell differentiation  protein-DNA complex  nuclear transcription factor complex  cell fate commitment  positive regulation of transcription by RNA polymerase II  positive regulation of transcription by RNA polymerase II  protein-DNA complex assembly  
NDEx NetworkSOX12
Atlas of Cancer Signalling NetworkSOX12
Wikipedia pathwaysSOX12
Orthology - Evolution
OrthoDB6666
GeneTree (enSembl)ENSG00000177732
Phylogenetic Trees/Animal Genes : TreeFamSOX12
HOVERGENO15370
HOGENOMO15370
Homologs : HomoloGeneSOX12
Homology/Alignments : Family Browser (UCSC)SOX12
Gene fusions - Rearrangements
Fusion : QuiverSOX12
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerSOX12 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)SOX12
dbVarSOX12
ClinVarSOX12
1000_GenomesSOX12 
Exome Variant ServerSOX12
ExAC (Exome Aggregation Consortium)ENSG00000177732
GNOMAD BrowserENSG00000177732
Varsome BrowserSOX12
Genetic variants : HAPMAP6666
Genomic Variants (DGV)SOX12 [DGVbeta]
DECIPHERSOX12 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisSOX12 
Mutations
ICGC Data PortalSOX12 
TCGA Data PortalSOX12 
Broad Tumor PortalSOX12
OASIS PortalSOX12 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICSOX12  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDSOX12
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch SOX12
DgiDB (Drug Gene Interaction Database)SOX12
DoCM (Curated mutations)SOX12 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)SOX12 (select a term)
intoGenSOX12
Cancer3DSOX12(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM601947   
Orphanet
DisGeNETSOX12
MedgenSOX12
Genetic Testing Registry SOX12
NextProtO15370 [Medical]
TSGene6666
GENETestsSOX12
Target ValidationSOX12
Huge Navigator SOX12 [HugePedia]
snp3D : Map Gene to Disease6666
BioCentury BCIQSOX12
ClinGenSOX12
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD6666
Chemical/Pharm GKB GenePA36035
Clinical trialSOX12
Miscellaneous
canSAR (ICR)SOX12 (select the gene name)
Probes
Litterature
PubMed20 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineSOX12
EVEXSOX12
GoPubMedSOX12
iHOPSOX12
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Tue Nov 6 11:41:10 CET 2018

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