SOX17 (SRY-box transcription factor 17)

2008-07-01  

Identity

HGNC
SOX17
LOCATION
8q11.23
LOCUSID
64321
ALIAS
VUR3

Other Information

Locus ID:

NCBI: 64321
MIM: 610928
HGNC: 18122
Ensembl: ENSG00000164736

Variants:

dbSNP: 64321
ClinVar: 64321
TCGA: ENSG00000164736
COSMIC: SOX17

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000164736ENST00000297316Q9H6I2

Expression (GTEx)

0
10
20
30
40
50
60
70
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Wnt signaling pathwayKEGGko04310
Wnt signaling pathwayKEGGhsa04310
Signal TransductionREACTOMER-HSA-162582
Signaling by WntREACTOMER-HSA-195721
TCF dependent signaling in response to WNTREACTOMER-HSA-201681
Deactivation of the beta-catenin transactivating complexREACTOMER-HSA-3769402

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
255431522015SOX17 is a critical specifier of human primordial germ cell fate.162
203641372010Genome-wide association study of intracranial aneurysm identifies three new risk loci.90
184137432008Epigenetic inactivation of the canonical Wnt antagonist SRY-box containing gene 17 in colorectal cancer.72
186822402008Establishment of endoderm progenitors by SOX transcription factor expression in human embryonic stem cells.71
296509612018Identification of rare sequence variation underlying heritable pulmonary arterial hypertension.55
207169542010SOX17 antagonizes WNT/β-catenin signaling pathway in hepatocellular carcinoma.54
213625732011Targeting SOX17 in human embryonic stem cells creates unique strategies for isolating and analyzing developing endoderm.47
197363172009Interplay of Oct4 with Sox2 and Sox17: a molecular switch from stem cell pluripotency to specifying a cardiac fate.41
229619612012Genome-wide association study of intracranial aneurysms confirms role of Anril and SOX17 in disease risk.41
219572542011SRY-box containing gene 17 regulates the Wnt/β-catenin signaling pathway in oligodendrocyte progenitor cells.39

Citation

Dessen P

SOX17 (SRY-box transcription factor 17)

Atlas Genet Cytogenet Oncol Haematol. 2008-07-01

Online version: http://atlasgeneticsoncology.org/gene/50199/sox17