SOX18 (SRY-box transcription factor 18)

2012-01-01  

Identity

HGNC
LOCATION
20q13.33
LOCUSID
ALIAS
HLTRS,HLTS

Other Information

Locus ID:

NCBI: 54345
MIM: 601618
HGNC: 11194
Ensembl: ENSG00000203883

Variants:

dbSNP: 54345
ClinVar: 54345
TCGA: ENSG00000203883
COSMIC: SOX18

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000203883ENST00000340356P35713

Expression (GTEx)

0
10
20
30
40
50
60
70
80

References

Pubmed IDYearTitleCitations
127407612003Mutations in the transcription factor gene SOX18 underlie recessive and dominant forms of hypotrichosis-lymphedema-telangiectasia.89
180655212008SOX-18 controls endothelial-specific claudin-5 gene expression and barrier function.30
185649202008HGF and MET mutations in primary and secondary lymphedema.25
168829432006Effect of disrupted SOX18 transcription factor function on tumor growth, vascularization, and endothelial development.22
185649212008Candidate gene analysis in primary lymphedema.16
253101932015Prognostic significance of SOX18 expression in non-small cell lung cancer.13
161795962005Transcription factor SOX18 is expressed in human coronary atherosclerotic lesions and regulates DNA synthesis and vascular cell growth.12
294084812018MiR-7-5p functions as a tumor suppressor by targeting SOX18 in pancreatic ductal adenocarcinoma.12
240652152013Impact of SOX18 expression in cancer cells and vessels on the outcome of invasive ductal breast carcinoma.11
263961732015Silencing NKD2 by promoter region hypermethylation promotes gastric cancer invasion and metastasis by up-regulating SOX18 in human gastric cancer.11

Citation

Dessen P

SOX18 (SRY-box transcription factor 18)

Atlas Genet Cytogenet Oncol Haematol. 2012-01-01

Online version: http://atlasgeneticsoncology.org/gene/52574/sox18