| Nomenclature |
|---|
| HGNC (Hugo) | SOX6 16421 |
| Cards |
|---|
| Entrez_Gene (NCBI) | SOX6 55553 SRY-box transcription factor 6 |
| Aliases | HSSOX6; SOXD |
| GeneCards (Weizmann) | SOX6 |
| Ensembl hg19 (Hinxton) | ENSG00000110693 [Gene_View] |
| Ensembl hg38 (Hinxton) | ENSG00000110693 [Gene_View] ENSG00000110693 [Sequence] chr11:15966449-16476388 [Contig_View] SOX6 [Vega] |
| ICGC DataPortal | ENSG00000110693 |
| TCGA cBioPortal | SOX6 |
| AceView (NCBI) | SOX6 |
| Genatlas (Paris) | SOX6 |
| WikiGenes | 55553 |
| SOURCE (Princeton) | SOX6 |
| Genetics Home Reference (NIH) | SOX6 |
| Genomic and cartography |
|---|
| GoldenPath hg38 (UCSC) | SOX6 - chr11:15966449-16476388 - 11p15.2 [Description] (hg38-Dec_2013) |
| GoldenPath hg19 (UCSC) | SOX6 - 11p15.2 [Description] (hg19-Feb_2009) |
| GoldenPath | SOX6 - 11p15.2 [CytoView hg19] SOX6 - 11p15.2 [CytoView hg38] |
| ImmunoBase | ENSG00000110693 |
| Mapping of homologs : NCBI | SOX6 [Mapview hg19] SOX6 [Mapview hg38] |
| OMIM | 607257 |
| Gene and transcription |
|---|
| Genbank (Entrez) | AF309034 AK021785 AK097455 AK310506 AL136780 |
| RefSeq transcript (Entrez) | NM_001145811 NM_001145819 NM_001367872 NM_001367873 NM_017508 NM_033326 |
| RefSeq genomic (Entrez) | |
| Consensus coding sequences : CCDS (NCBI) | SOX6 |
| Alternative Splicing Gallery | ENSG00000110693 |
| Gene Expression | SOX6 [ NCBI-GEO ] SOX6 [ EBI - ARRAY_EXPRESS ]
SOX6 [ SEEK ] SOX6 [ MEM ] |
| Gene Expression Viewer (FireBrowse) | SOX6 [ Firebrowse - Broad ] |
| SOURCE (Princeton) | Expression in : [Datasets] [Normal Tissue Atlas] [carcinoma Classsification] [NCI60] |
| Genevestigator | Expression in : [tissues] [cell-lines] [cancer] [perturbations] |
| BioGPS (Tissue expression) | 55553 |
| GTEX Portal (Tissue expression) | SOX6 |
| Human Protein Atlas | ENSG00000110693-SOX6 [pathology] [cell] [tissue] |
| Protein : pattern, domain, 3D structure |
|---|
| UniProt/SwissProt | P35712 [function] [subcellular_location] [family_and_domains] [pathology_and_biotech] [ptm_processing] [expression] [interaction] |
| NextProt | P35712 [Sequence] [Exons] [Medical] [Publications] |
| With graphics : InterPro | P35712 |
| Splice isoforms : SwissVar | P35712 |
| PhosPhoSitePlus | P35712 |
| Domaine pattern : Prosite (Expaxy) | HMG_BOX_2 (PS50118) |
| Domains : Interpro (EBI) | HMG_box_dom HMG_box_dom_sf SOX-5/6 |
| Domain families : Pfam (Sanger) | HMG_box (PF00505) |
| Domain families : Pfam (NCBI) | pfam00505 |
| Domain families : Smart (EMBL) | HMG (SM00398) |
| Conserved Domain (NCBI) | SOX6 |
| DMDM Disease mutations | 55553 |
| Blocks (Seattle) | SOX6 |
| Superfamily | P35712 |
| Human Protein Atlas [tissue] | ENSG00000110693-SOX6 [tissue] |
| Peptide Atlas | P35712 |
| HPRD | 06267 |
| IPI | IPI00872738 IPI00218631 IPI00926649 IPI00641980 IPI00981950 IPI00984293 IPI00981612 IPI00984623 |
| Protein Interaction databases |
|---|
| DIP (DOE-UCLA) | P35712 |
| IntAct (EBI) | P35712 |
| FunCoup | ENSG00000110693 |
| BioGRID | SOX6 |
| STRING (EMBL) | SOX6 |
| ZODIAC | SOX6 |
| Ontologies - Pathways |
|---|
| QuickGO | P35712 |
| Ontology : AmiGO | negative regulation of transcription by RNA polymerase II nuclear chromatin cell morphogenesis RNA polymerase II proximal promoter sequence-specific DNA binding DNA-binding transcription factor activity, RNA polymerase II-specific DNA-binding transcription factor activity, RNA polymerase II-specific DNA-binding transcription factor activity, RNA polymerase II-specific DNA-binding transcription repressor activity, RNA polymerase II-specific in utero embryonic development DNA binding DNA-binding transcription factor activity protein binding nucleus nucleus nucleoplasm nucleoplasm regulation of transcription, DNA-templated muscle organ development post-embryonic development gene silencing oligodendrocyte cell fate specification positive regulation of chondrocyte differentiation positive regulation of chondrocyte differentiation cell fate commitment negative regulation of transcription, DNA-templated positive regulation of transcription by RNA polymerase II protein heterodimerization activity astrocyte differentiation erythrocyte development cartilage development cardiac muscle cell differentiation positive regulation of cartilage development cellular response to transforming growth factor beta stimulus negative regulation of cardiac muscle cell differentiation positive regulation of mesenchymal stem cell differentiation |
| Ontology : EGO-EBI | negative regulation of transcription by RNA polymerase II nuclear chromatin cell morphogenesis RNA polymerase II proximal promoter sequence-specific DNA binding DNA-binding transcription factor activity, RNA polymerase II-specific DNA-binding transcription factor activity, RNA polymerase II-specific DNA-binding transcription factor activity, RNA polymerase II-specific DNA-binding transcription repressor activity, RNA polymerase II-specific in utero embryonic development DNA binding DNA-binding transcription factor activity protein binding nucleus nucleus nucleoplasm nucleoplasm regulation of transcription, DNA-templated muscle organ development post-embryonic development gene silencing oligodendrocyte cell fate specification positive regulation of chondrocyte differentiation positive regulation of chondrocyte differentiation cell fate commitment negative regulation of transcription, DNA-templated positive regulation of transcription by RNA polymerase II protein heterodimerization activity astrocyte differentiation erythrocyte development cartilage development cardiac muscle cell differentiation positive regulation of cartilage development cellular response to transforming growth factor beta stimulus negative regulation of cardiac muscle cell differentiation positive regulation of mesenchymal stem cell differentiation |
| NDEx Network | SOX6 |
| Atlas of Cancer Signalling Network | SOX6 |
| Wikipedia pathways | SOX6 |
| Orthology - Evolution |
|---|
| OrthoDB | 55553 |
| GeneTree (enSembl) | ENSG00000110693 |
| Phylogenetic Trees/Animal Genes : TreeFam | SOX6 |
| HOGENOM | P35712 |
| Homologs : HomoloGene | SOX6 |
| Homology/Alignments : Family Browser (UCSC) | SOX6 |
| Gene fusions - Rearrangements |
|---|
| Fusion : Mitelman | SOX6/GALNT18 [11p15.2/11p15.3] |
| Fusion : Mitelman | SOX6/PTPRJ [11p15.2/11p11.2] [t(11;11)(p11;p15)] |
| Fusion Portal | SOX6 11p15.2 GALNTL4 BRCA |
| Fusion Portal | SOX6 11p15.2 PTPRJ 11p11.2 LGG |
| Fusion : Quiver | SOX6 |
| Polymorphisms : SNP and Copy number variants |
|---|
| NCBI Variation Viewer | SOX6 [hg38] |
| dbSNP Single Nucleotide Polymorphism (NCBI) | SOX6 |
| dbVar | SOX6 |
| ClinVar | SOX6 |
| 1000_Genomes | SOX6 |
| Exome Variant Server | SOX6 |
| ExAC (Exome Aggregation Consortium) | ENSG00000110693 |
| GNOMAD Browser | ENSG00000110693 |
| Varsome Browser | SOX6 |
| Genetic variants : HAPMAP | 55553 |
| Genomic Variants (DGV) | SOX6 [DGVbeta] |
| DECIPHER | SOX6 [patients] [syndromes] [variants] [genes] |
| CONAN: Copy Number Analysis | SOX6 |
| Mutations |
|---|
| ICGC Data Portal | SOX6 |
| TCGA Data Portal | SOX6 |
| Broad Tumor Portal | SOX6 |
| OASIS Portal | SOX6 [ Somatic mutations - Copy number] |
| Somatic Mutations in Cancer : COSMIC | SOX6 [overview] [genome browser] [tissue] [distribution] |
| Somatic Mutations in Cancer : COSMIC3D | SOX6 |
| Mutations and Diseases : HGMD | SOX6 |
| LOVD (Leiden Open Variation Database) | Whole genome datasets |
| LOVD (Leiden Open Variation Database) | LOVD - Leiden Open Variation Database |
| LOVD (Leiden Open Variation Database) | LOVD 3.0 shared installation |
| BioMuta | search SOX6 |
| DgiDB (Drug Gene Interaction Database) | SOX6 |
| DoCM (Curated mutations) | SOX6 (select the gene name) |
| CIViC (Clinical Interpretations of Variants in Cancer) | SOX6 (select a term) |
| intoGen | SOX6 |
| Cancer3D | SOX6(select the gene name) |
| Impact of mutations | [PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser] |
| Diseases |
|---|
| OMIM | 607257 |
| Orphanet | |
| DisGeNET | SOX6 |
| Medgen | SOX6 |
| Genetic Testing Registry | SOX6
|
| NextProt | P35712 [Medical] |
| TSGene | 55553 |
| GENETests | SOX6 |
| Target Validation | SOX6 |
| Huge Navigator |
SOX6 [HugePedia] |
| snp3D : Map Gene to Disease | 55553 |
| BioCentury BCIQ | SOX6 |
| ClinGen | SOX6 (curated) |
| Clinical trials, drugs, therapy |
|---|
| Chemical/Protein Interactions : CTD | 55553 |
| Chemical/Pharm GKB Gene | PA38137 |
| Clinical trial | SOX6 |
| Miscellaneous |
|---|
| canSAR (ICR) | SOX6 (select the gene name) |
| Harmonizome | SOX6 |
| DataMed Index | SOX6 |
| Probes |
|---|
| Litterature |
|---|
| PubMed | 77 Pubmed reference(s) in Entrez |
| GeneRIFs | Gene References Into Functions (Entrez) |
| CoreMine | SOX6 |
| EVEX | SOX6 |
| GoPubMed | SOX6 |
| iHOP | SOX6 |
