| Nomenclature |
|---|
| HGNC (Hugo) | SOX6 16421 |
| Cards |
|---|
| Entrez_Gene (NCBI) | SOX6 SRY-box transcription factor 6 |
| Aliases | HSSOX6; SOXD; TOLCAS |
| GeneCards (Weizmann) | SOX6 |
| Ensembl hg19 (Hinxton) | ENSG00000110693 [Gene_View] |
| Ensembl hg38 (Hinxton) | ENSG00000110693 [Gene_View] ENSG00000110693 [Sequence] chr11:15966449-16476388 [Contig_View] SOX6 [Vega] |
| ICGC DataPortal | ENSG00000110693 |
| TCGA cBioPortal | SOX6 |
| AceView (NCBI) | SOX6 |
| Genatlas (Paris) | SOX6 |
| SOURCE (Princeton) | SOX6 |
| Genetics Home Reference (NIH) | SOX6 |
| Genomic and cartography |
|---|
| GoldenPath hg38 (UCSC) | SOX6 - chr11:15966449-16476388 - 11p15.2 [Description] (hg38-Dec_2013) |
| GoldenPath hg19 (UCSC) | SOX6 - 11p15.2 [Description] (hg19-Feb_2009) |
| GoldenPath | SOX6 - 11p15.2 [CytoView hg19] SOX6 - 11p15.2 [CytoView hg38] |
| ImmunoBase | ENSG00000110693 |
| Genome Data Viewer NCBI | SOX6 [Mapview hg19] |
| OMIM | 607257 618971 |
| Gene and transcription |
|---|
| Genbank (Entrez) | AF309034 AK021785 AK097455 AK310506 AL136780 |
| RefSeq transcript (Entrez) | NM_001145811 NM_001145819 NM_001367872 NM_001367873 NM_017508 NM_033326 |
| Consensus coding sequences : CCDS (NCBI) | SOX6 |
| Gene Expression | SOX6 [ NCBI-GEO ] SOX6 [ EBI - ARRAY_EXPRESS ]
SOX6 [ SEEK ] SOX6 [ MEM ] |
| Gene Expression Viewer (FireBrowse) | SOX6 [ Firebrowse - Broad ] |
| Genevisible | Expression of SOX6 in : [tissues] [cell-lines] [cancer] [perturbations] |
| BioGPS (Tissue expression) | 55553 |
| GTEX Portal (Tissue expression) | SOX6 |
| Human Protein Atlas | ENSG00000110693-SOX6 [pathology] [cell] [tissue] |
| Protein : pattern, domain, 3D structure |
|---|
| UniProt/SwissProt | P35712 [function] [subcellular_location] [family_and_domains] [pathology_and_biotech] [ptm_processing] [expression] [interaction] |
| NextProt | P35712 [Sequence] [Exons] [Medical] [Publications] |
| With graphics : InterPro | P35712 |
| PhosPhoSitePlus | P35712 |
| Domaine pattern : Prosite (Expaxy) | HMG_BOX_2 (PS50118) |
| Domains : Interpro (EBI) | HMG_box_dom HMG_box_dom_sf SOX-6 |
| Domain families : Pfam (Sanger) | HMG_box (PF00505) |
| Domain families : Pfam (NCBI) | pfam00505 |
| Domain families : Smart (EMBL) | HMG (SM00398) |
| Conserved Domain (NCBI) | SOX6 |
| Superfamily | P35712 |
| AlphaFold pdb e-kb | P35712 |
| Human Protein Atlas [tissue] | ENSG00000110693-SOX6 [tissue] |
| HPRD | 06267 |
| Protein Interaction databases |
|---|
| DIP (DOE-UCLA) | P35712 |
| IntAct (EBI) | P35712 |
| BioGRID | SOX6 |
| STRING (EMBL) | SOX6 |
| ZODIAC | SOX6 |
| Ontologies - Pathways |
|---|
| QuickGO | P35712 |
| Ontology : AmiGO | chromatin transcription cis-regulatory region binding RNA polymerase II cis-regulatory region sequence-specific DNA binding DNA-binding transcription factor activity, RNA polymerase II-specific DNA-binding transcription factor activity, RNA polymerase II-specific DNA-binding transcription repressor activity cartilage condensation chondrocyte differentiation DNA binding DNA-binding transcription factor activity DNA-binding transcription factor activity protein binding nucleus nucleus nucleus nucleus nucleoplasm nucleoplasm regulation of transcription, DNA-templated regulation of transcription by RNA polymerase II central nervous system development brain development muscle organ development spinal cord oligodendrocyte cell differentiation positive regulation of chondrocyte differentiation positive regulation of chondrocyte differentiation protein homodimerization activity cell fate commitment negative regulation of transcription, DNA-templated cartilage development positive regulation of cartilage development cellular response to transforming growth factor beta stimulus negative regulation of cardiac muscle cell differentiation positive regulation of mesenchymal stem cell differentiation |
| Ontology : EGO-EBI | chromatin transcription cis-regulatory region binding RNA polymerase II cis-regulatory region sequence-specific DNA binding DNA-binding transcription factor activity, RNA polymerase II-specific DNA-binding transcription factor activity, RNA polymerase II-specific DNA-binding transcription repressor activity cartilage condensation chondrocyte differentiation DNA binding DNA-binding transcription factor activity DNA-binding transcription factor activity protein binding nucleus nucleus nucleus nucleus nucleoplasm nucleoplasm regulation of transcription, DNA-templated regulation of transcription by RNA polymerase II central nervous system development brain development muscle organ development spinal cord oligodendrocyte cell differentiation positive regulation of chondrocyte differentiation positive regulation of chondrocyte differentiation protein homodimerization activity cell fate commitment negative regulation of transcription, DNA-templated cartilage development positive regulation of cartilage development cellular response to transforming growth factor beta stimulus negative regulation of cardiac muscle cell differentiation positive regulation of mesenchymal stem cell differentiation |
| NDEx Network | SOX6 |
| Atlas of Cancer Signalling Network | SOX6 |
| Wikipedia pathways | SOX6 |
| Orthology - Evolution |
|---|
| OrthoDB | 55553 |
| GeneTree (enSembl) | ENSG00000110693 |
| Phylogenetic Trees/Animal Genes : TreeFam | SOX6 |
| Homologs : HomoloGene | SOX6 |
| Homology/Alignments : Family Browser (UCSC) | SOX6 |
| Gene fusions - Rearrangements |
|---|
| Fusion : Mitelman | SOX6/GALNT18 [11p15.2/11p15.3] |
| Fusion : Mitelman | SOX6/PTPRJ [11p15.2/11p11.2] |
| Fusion : Quiver | SOX6 |
| Polymorphisms : SNP and Copy number variants |
|---|
| NCBI Variation Viewer | SOX6 [hg38] |
| dbSNP Single Nucleotide Polymorphism (NCBI) | SOX6 |
| dbVar | SOX6 |
| ClinVar | SOX6 |
| Monarch | SOX6 |
| 1000_Genomes | SOX6 |
| Exome Variant Server | SOX6 |
| GNOMAD Browser | ENSG00000110693 |
| Varsome Browser | SOX6 |
| ACMG | SOX6 variants |
| Varity | P35712 |
| Genomic Variants (DGV) | SOX6 [DGVbeta] |
| DECIPHER | SOX6 [patients] [syndromes] [variants] [genes] |
| CONAN: Copy Number Analysis | SOX6 |
| Mutations |
|---|
| ICGC Data Portal | SOX6 |
| TCGA Data Portal | SOX6 |
| Broad Tumor Portal | SOX6 |
| OASIS Portal | SOX6 [ Somatic mutations - Copy number] |
| Somatic Mutations in Cancer : COSMIC | SOX6 [overview] [genome browser] [tissue] [distribution] |
| Somatic Mutations in Cancer : COSMIC3D | SOX6 |
| Mutations and Diseases : HGMD | SOX6 |
| LOVD (Leiden Open Variation Database) | [gene] [transcripts] [variants] |
| BioMuta | SOX6 |
| DgiDB (Drug Gene Interaction Database) | SOX6 |
| DoCM (Curated mutations) | SOX6 |
| CIViC (Clinical Interpretations of Variants in Cancer) | SOX6 |
| Cancer3D | SOX6 |
| Impact of mutations | [PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser] |
| Diseases |
|---|
| OMIM | 607257 618971 |
| Orphanet | |
| DisGeNET | SOX6 |
| Medgen | SOX6 |
| Genetic Testing Registry | SOX6
|
| NextProt | P35712 [Medical] |
| GENETests | SOX6 |
| Target Validation | SOX6 |
| Huge Navigator |
SOX6 [HugePedia] |
| ClinGen | SOX6 (curated) |
| Clinical trials, drugs, therapy |
|---|
| MyCancerGenome | SOX6 |
| Protein Interactions : CTD | SOX6 |
| Pharm GKB Gene | PA38137 |
| Pharos | P35712 |
| Clinical trial | SOX6 |
| Miscellaneous |
|---|
| canSAR (ICR) | SOX6 |
| Harmonizome | SOX6 |
| DataMed Index | SOX6 |
| Probes |
|---|
| Litterature |
|---|
| PubMed | 90 Pubmed reference(s) in Entrez |
| GeneRIFs | Gene References Into Functions (Entrez) |
| EVEX | SOX6 |
