SOX6 (SRY-box transcription factor 6)

2007-02-01  

Identity

HGNC
LOCATION
11p15.2
LOCUSID
ALIAS
HSSOX6,SOXD,TOLCAS
FUSION GENES

Other Information

Locus ID:

NCBI: 55553
MIM: 607257
HGNC: 16421
Ensembl: ENSG00000110693

Variants:

dbSNP: 55553
ClinVar: 55553
TCGA: ENSG00000110693
COSMIC: SOX6

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000110693ENST00000316399P35712
ENSG00000110693ENST00000396356P35712
ENSG00000110693ENST00000526673E9PN02
ENSG00000110693ENST00000527619P35712
ENSG00000110693ENST00000528252P35712
ENSG00000110693ENST00000528429P35712
ENSG00000110693ENST00000529469E9PQ67
ENSG00000110693ENST00000530378E9PQ78
ENSG00000110693ENST00000533411E9PQL4
ENSG00000110693ENST00000655819P35712

Expression (GTEx)

0
1
2
3
4
5
6
7
8
9
10

Pathways

PathwaySourceExternal ID
Signal TransductionREACTOMER-HSA-162582
Signaling by WntREACTOMER-HSA-195721
TCF dependent signaling in response to WNTREACTOMER-HSA-201681
Deactivation of the beta-catenin transactivating complexREACTOMER-HSA-3769402

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
203953652010Transcriptional silencing of {gamma}-globin by BCL11A involves long-range interactions and cooperation with SOX6.147
197096292009The cell-intrinsic requirement of Sox6 for cortical interneuron development.95
205489442010An integration of genome-wide association study and gene expression profiling to prioritize the discovery of novel susceptibility Loci for osteoporosis-related traits.90
199131212009Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.85
192400612009Coeliac disease-associated risk variants in TNFAIP3 and REL implicate altered NF-kappaB signalling.75
203796142010Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.62
197142492009Powerful bivariate genome-wide association analyses suggest the SOX6 gene influencing both obesity and osteoporosis phenotypes in males.42
197142492009Powerful bivariate genome-wide association analyses suggest the SOX6 gene influencing both obesity and osteoporosis phenotypes in males.42
250236492014Mir-208 promotes cell proliferation by repressing SOX6 expression in human esophageal squamous cell carcinoma.32
225470662012L-Sox5 and Sox6 proteins enhance chondrogenic miR-140 microRNA expression by strengthening dimeric Sox9 activity.27

Citation

Dessen P

SOX6 (SRY-box transcription factor 6)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/46348/sox6