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SOX6 (SRY-box transcription factor 6)

Identity

Alias (NCBI)HSSOX6
SOXD
TOLCAS
HGNC (Hugo) SOX6
HGNC Previous nameSRY (sex determining region Y)-box 6
 SRY-box 6
LocusID (NCBI) 55553
Atlas_Id 46348
Location 11p15.2  [Link to chromosome band 11p15]
Location_base_pair Starts at 15966449 and ends at 16476388 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
SOX6 (11p15.2) / BCYRN1 (Xq13.1)SOX6 (11p15.2) / DDOST (1p36.12)SOX6 (11p15.2) / DGKH (13q14.11)
SOX6 (11p15.2) / GALNT18 (11p15.3)SOX6 (11p15.2) / HTRA1 (10q26.13)SOX6 (11p15.2) / PTPRJ (11p11.2)
SOX6 (11p15.2) / SOX6 (11p15.2)SOX6 11p15.2 GALNTL4SOX6 11p15.2 / PTPRJ 11p11.2

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



External links

 

Nomenclature
HGNC (Hugo)SOX6   16421
Cards
Entrez_Gene (NCBI)SOX6    SRY-box transcription factor 6
AliasesHSSOX6; SOXD; TOLCAS
GeneCards (Weizmann)SOX6
Ensembl hg19 (Hinxton)ENSG00000110693 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000110693 [Gene_View]  ENSG00000110693 [Sequence]  chr11:15966449-16476388 [Contig_View]  SOX6 [Vega]
ICGC DataPortalENSG00000110693
TCGA cBioPortalSOX6
AceView (NCBI)SOX6
Genatlas (Paris)SOX6
SOURCE (Princeton)SOX6
Genetics Home Reference (NIH)SOX6
Genomic and cartography
GoldenPath hg38 (UCSC)SOX6  -     chr11:15966449-16476388 -  11p15.2   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)SOX6  -     11p15.2   [Description]    (hg19-Feb_2009)
GoldenPathSOX6 - 11p15.2 [CytoView hg19]  SOX6 - 11p15.2 [CytoView hg38]
ImmunoBaseENSG00000110693
Genome Data Viewer NCBISOX6 [Mapview hg19]  
OMIM607257   618971   
Gene and transcription
Genbank (Entrez)AF309034 AK021785 AK097455 AK310506 AL136780
RefSeq transcript (Entrez)NM_001145811 NM_001145819 NM_001367872 NM_001367873 NM_017508 NM_033326
Consensus coding sequences : CCDS (NCBI)SOX6
Gene ExpressionSOX6 [ NCBI-GEO ]   SOX6 [ EBI - ARRAY_EXPRESS ]   SOX6 [ SEEK ]   SOX6 [ MEM ]
Gene Expression Viewer (FireBrowse)SOX6 [ Firebrowse - Broad ]
GenevisibleExpression of SOX6 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)55553
GTEX Portal (Tissue expression)SOX6
Human Protein AtlasENSG00000110693-SOX6 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP35712   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP35712  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP35712
PhosPhoSitePlusP35712
Domaine pattern : Prosite (Expaxy)HMG_BOX_2 (PS50118)   
Domains : Interpro (EBI)HMG_box_dom    HMG_box_dom_sf    SOX-6   
Domain families : Pfam (Sanger)HMG_box (PF00505)   
Domain families : Pfam (NCBI)pfam00505   
Domain families : Smart (EMBL)HMG (SM00398)  
Conserved Domain (NCBI)SOX6
SuperfamilyP35712
AlphaFold pdb e-kbP35712   
Human Protein Atlas [tissue]ENSG00000110693-SOX6 [tissue]
HPRD06267
Protein Interaction databases
DIP (DOE-UCLA)P35712
IntAct (EBI)P35712
BioGRIDSOX6
STRING (EMBL)SOX6
ZODIACSOX6
Ontologies - Pathways
QuickGOP35712
Ontology : AmiGOchromatin  transcription cis-regulatory region binding  RNA polymerase II cis-regulatory region sequence-specific DNA binding  DNA-binding transcription factor activity, RNA polymerase II-specific  DNA-binding transcription factor activity, RNA polymerase II-specific  DNA-binding transcription repressor activity  cartilage condensation  chondrocyte differentiation  DNA binding  DNA-binding transcription factor activity  DNA-binding transcription factor activity  protein binding  nucleus  nucleus  nucleus  nucleus  nucleoplasm  nucleoplasm  regulation of transcription, DNA-templated  regulation of transcription by RNA polymerase II  central nervous system development  brain development  muscle organ development  spinal cord oligodendrocyte cell differentiation  positive regulation of chondrocyte differentiation  positive regulation of chondrocyte differentiation  protein homodimerization activity  cell fate commitment  negative regulation of transcription, DNA-templated  cartilage development  positive regulation of cartilage development  cellular response to transforming growth factor beta stimulus  negative regulation of cardiac muscle cell differentiation  positive regulation of mesenchymal stem cell differentiation  
Ontology : EGO-EBIchromatin  transcription cis-regulatory region binding  RNA polymerase II cis-regulatory region sequence-specific DNA binding  DNA-binding transcription factor activity, RNA polymerase II-specific  DNA-binding transcription factor activity, RNA polymerase II-specific  DNA-binding transcription repressor activity  cartilage condensation  chondrocyte differentiation  DNA binding  DNA-binding transcription factor activity  DNA-binding transcription factor activity  protein binding  nucleus  nucleus  nucleus  nucleus  nucleoplasm  nucleoplasm  regulation of transcription, DNA-templated  regulation of transcription by RNA polymerase II  central nervous system development  brain development  muscle organ development  spinal cord oligodendrocyte cell differentiation  positive regulation of chondrocyte differentiation  positive regulation of chondrocyte differentiation  protein homodimerization activity  cell fate commitment  negative regulation of transcription, DNA-templated  cartilage development  positive regulation of cartilage development  cellular response to transforming growth factor beta stimulus  negative regulation of cardiac muscle cell differentiation  positive regulation of mesenchymal stem cell differentiation  
NDEx NetworkSOX6
Atlas of Cancer Signalling NetworkSOX6
Wikipedia pathwaysSOX6
Orthology - Evolution
OrthoDB55553
GeneTree (enSembl)ENSG00000110693
Phylogenetic Trees/Animal Genes : TreeFamSOX6
Homologs : HomoloGeneSOX6
Homology/Alignments : Family Browser (UCSC)SOX6
Gene fusions - Rearrangements
Fusion : MitelmanSOX6/GALNT18 [11p15.2/11p15.3]  
Fusion : MitelmanSOX6/PTPRJ [11p15.2/11p11.2]  
Fusion : QuiverSOX6
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerSOX6 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)SOX6
dbVarSOX6
ClinVarSOX6
MonarchSOX6
1000_GenomesSOX6 
Exome Variant ServerSOX6
GNOMAD BrowserENSG00000110693
Varsome BrowserSOX6
ACMGSOX6 variants
VarityP35712
Genomic Variants (DGV)SOX6 [DGVbeta]
DECIPHERSOX6 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisSOX6 
Mutations
ICGC Data PortalSOX6 
TCGA Data PortalSOX6 
Broad Tumor PortalSOX6
OASIS PortalSOX6 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICSOX6  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DSOX6
Mutations and Diseases : HGMDSOX6
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaSOX6
DgiDB (Drug Gene Interaction Database)SOX6
DoCM (Curated mutations)SOX6
CIViC (Clinical Interpretations of Variants in Cancer)SOX6
Cancer3DSOX6
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM607257    618971   
Orphanet
DisGeNETSOX6
MedgenSOX6
Genetic Testing Registry SOX6
NextProtP35712 [Medical]
GENETestsSOX6
Target ValidationSOX6
Huge Navigator SOX6 [HugePedia]
ClinGenSOX6 (curated)
Clinical trials, drugs, therapy
MyCancerGenomeSOX6
Protein Interactions : CTDSOX6
Pharm GKB GenePA38137
PharosP35712
Clinical trialSOX6
Miscellaneous
canSAR (ICR)SOX6
HarmonizomeSOX6
DataMed IndexSOX6
Probes
Litterature
PubMed90 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXSOX6
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Oct 4 15:32:41 CEST 2021

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