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SOX8 (SRY-box 8)

Identity

Alias_namesSRY (sex determining region Y)-box 8
SRY box 8
Other alias-
HGNC (Hugo) SOX8
LocusID (NCBI) 30812
Atlas_Id 50907
Location 16p13.3  [Link to chromosome band 16p13]
Location_base_pair Starts at 981808 and ends at 986979 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
RPL3 (22q13.1) / SOX8 (16p13.3)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)SOX8   11203
Cards
Entrez_Gene (NCBI)SOX8  30812  SRY-box 8
Aliases
GeneCards (Weizmann)SOX8
Ensembl hg19 (Hinxton)ENSG00000005513 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000005513 [Gene_View]  chr16:981808-986979 [Contig_View]  SOX8 [Vega]
ICGC DataPortalENSG00000005513
TCGA cBioPortalSOX8
AceView (NCBI)SOX8
Genatlas (Paris)SOX8
WikiGenes30812
SOURCE (Princeton)SOX8
Genetics Home Reference (NIH)SOX8
Genomic and cartography
GoldenPath hg38 (UCSC)SOX8  -     chr16:981808-986979 +  16p13.3   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)SOX8  -     16p13.3   [Description]    (hg19-Feb_2009)
EnsemblSOX8 - 16p13.3 [CytoView hg19]  SOX8 - 16p13.3 [CytoView hg38]
Mapping of homologs : NCBISOX8 [Mapview hg19]  SOX8 [Mapview hg38]
OMIM605923   
Gene and transcription
Genbank (Entrez)AF164104 AF226675 AK024491 BC031797
RefSeq transcript (Entrez)NM_014587
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)SOX8
Cluster EST : UnigeneHs.243678 [ NCBI ]
CGAP (NCI)Hs.243678
Alternative Splicing GalleryENSG00000005513
Gene ExpressionSOX8 [ NCBI-GEO ]   SOX8 [ EBI - ARRAY_EXPRESS ]   SOX8 [ SEEK ]   SOX8 [ MEM ]
Gene Expression Viewer (FireBrowse)SOX8 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)30812
GTEX Portal (Tissue expression)SOX8
Protein : pattern, domain, 3D structure
UniProt/SwissProtP57073   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP57073  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP57073
Splice isoforms : SwissVarP57073
PhosPhoSitePlusP57073
Domaine pattern : Prosite (Expaxy)HMG_BOX_2 (PS50118)   
Domains : Interpro (EBI)HMG_box_dom    SOX-8    Sox_N   
Domain families : Pfam (Sanger)HMG_box (PF00505)    Sox_N (PF12444)   
Domain families : Pfam (NCBI)pfam00505    pfam12444   
Domain families : Smart (EMBL)HMG (SM00398)  
Conserved Domain (NCBI)SOX8
DMDM Disease mutations30812
Blocks (Seattle)SOX8
SuperfamilyP57073
Human Protein AtlasENSG00000005513
Peptide AtlasP57073
HPRD16175
IPIIPI00299069   IPI00386303   
Protein Interaction databases
DIP (DOE-UCLA)P57073
IntAct (EBI)P57073
FunCoupENSG00000005513
BioGRIDSOX8
STRING (EMBL)SOX8
ZODIACSOX8
Ontologies - Pathways
QuickGOP57073
Ontology : AmiGORNA polymerase II core promoter sequence-specific DNA binding  RNA polymerase II transcription factor activity, sequence-specific DNA binding  osteoblast differentiation  in utero embryonic development  neural crest cell migration  DNA binding  nucleus  nucleus  cytoplasm  transcription, DNA-templated  signal transduction  spermatogenesis  peripheral nervous system development  transcription factor binding  male gonad development  regulation of hormone levels  positive regulation of gliogenesis  positive regulation of osteoblast proliferation  skeletal muscle cell differentiation  negative regulation of apoptotic process  nuclear transcription factor complex  cell fate commitment  fat cell differentiation  negative regulation of myoblast differentiation  negative regulation of transcription, DNA-templated  positive regulation of transcription, DNA-templated  positive regulation of transcription from RNA polymerase II promoter  negative regulation of photoreceptor cell differentiation  protein heterodimerization activity  cell maturation  enteric nervous system development  oligodendrocyte differentiation  Sertoli cell development  astrocyte fate commitment  retina development in camera-type eye  retinal rod cell differentiation  adipose tissue development  morphogenesis of a branching epithelium  renal vesicle induction  ureter morphogenesis  metanephric nephron tubule formation  positive regulation of kidney development  positive regulation of branching involved in ureteric bud morphogenesis  
Ontology : EGO-EBIRNA polymerase II core promoter sequence-specific DNA binding  RNA polymerase II transcription factor activity, sequence-specific DNA binding  osteoblast differentiation  in utero embryonic development  neural crest cell migration  DNA binding  nucleus  nucleus  cytoplasm  transcription, DNA-templated  signal transduction  spermatogenesis  peripheral nervous system development  transcription factor binding  male gonad development  regulation of hormone levels  positive regulation of gliogenesis  positive regulation of osteoblast proliferation  skeletal muscle cell differentiation  negative regulation of apoptotic process  nuclear transcription factor complex  cell fate commitment  fat cell differentiation  negative regulation of myoblast differentiation  negative regulation of transcription, DNA-templated  positive regulation of transcription, DNA-templated  positive regulation of transcription from RNA polymerase II promoter  negative regulation of photoreceptor cell differentiation  protein heterodimerization activity  cell maturation  enteric nervous system development  oligodendrocyte differentiation  Sertoli cell development  astrocyte fate commitment  retina development in camera-type eye  retinal rod cell differentiation  adipose tissue development  morphogenesis of a branching epithelium  renal vesicle induction  ureter morphogenesis  metanephric nephron tubule formation  positive regulation of kidney development  positive regulation of branching involved in ureteric bud morphogenesis  
NDEx NetworkSOX8
Atlas of Cancer Signalling NetworkSOX8
Wikipedia pathwaysSOX8
Orthology - Evolution
OrthoDB30812
GeneTree (enSembl)ENSG00000005513
Phylogenetic Trees/Animal Genes : TreeFamSOX8
HOVERGENP57073
HOGENOMP57073
Homologs : HomoloGeneSOX8
Homology/Alignments : Family Browser (UCSC)SOX8
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerSOX8 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)SOX8
dbVarSOX8
ClinVarSOX8
1000_GenomesSOX8 
Exome Variant ServerSOX8
ExAC (Exome Aggregation Consortium)SOX8 (select the gene name)
Genetic variants : HAPMAP30812
Genomic Variants (DGV)SOX8 [DGVbeta]
DECIPHERSOX8 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisSOX8 
Mutations
ICGC Data PortalSOX8 
TCGA Data PortalSOX8 
Broad Tumor PortalSOX8
OASIS PortalSOX8 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICSOX8  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDSOX8
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch SOX8
DgiDB (Drug Gene Interaction Database)SOX8
DoCM (Curated mutations)SOX8 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)SOX8 (select a term)
intoGenSOX8
Cancer3DSOX8(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM605923   
Orphanet
MedgenSOX8
Genetic Testing Registry SOX8
NextProtP57073 [Medical]
TSGene30812
GENETestsSOX8
Target ValidationSOX8
Huge Navigator SOX8 [HugePedia]
snp3D : Map Gene to Disease30812
BioCentury BCIQSOX8
ClinGenSOX8 (curated)
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD30812
Chemical/Pharm GKB GenePA36040
Clinical trialSOX8
Miscellaneous
canSAR (ICR)SOX8 (select the gene name)
Probes
Litterature
PubMed24 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineSOX8
EVEXSOX8
GoPubMedSOX8
iHOPSOX8
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Sep 25 19:32:32 CEST 2017

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