| Nomenclature |
|---|
| HGNC (Hugo) | SOX8 11203 |
| Cards |
|---|
| Entrez_Gene (NCBI) | SOX8 30812 SRY-box 8 |
| Aliases | |
| GeneCards (Weizmann) | SOX8 |
| Ensembl hg19 (Hinxton) | ENSG00000005513 [Gene_View] |
| Ensembl hg38 (Hinxton) | ENSG00000005513 [Gene_View] ENSG00000005513 [Sequence] chr16:981808-986979 [Contig_View] SOX8 [Vega] |
| ICGC DataPortal | ENSG00000005513 |
| TCGA cBioPortal | SOX8 |
| AceView (NCBI) | SOX8 |
| Genatlas (Paris) | SOX8 |
| WikiGenes | 30812 |
| SOURCE (Princeton) | SOX8 |
| Genetics Home Reference (NIH) | SOX8 |
| Genomic and cartography |
|---|
| GoldenPath hg38 (UCSC) | SOX8 - chr16:981808-986979 + 8p23.1 [Description] (hg38-Dec_2013) |
| GoldenPath hg19 (UCSC) | SOX8 - 8p23.1 [Description] (hg19-Feb_2009) |
| Ensembl | SOX8 - 8p23.1 [CytoView hg19] SOX8 - 8p23.1 [CytoView hg38] |
| Mapping of homologs : NCBI | SOX8 [Mapview hg19] SOX8 [Mapview hg38] |
| OMIM | 605923 |
| Gene and transcription |
|---|
| Genbank (Entrez) | AF164104 AF226675 AK024491 BC031797 |
| RefSeq transcript (Entrez) | NM_014587 |
| RefSeq genomic (Entrez) | |
| Consensus coding sequences : CCDS (NCBI) | SOX8 |
| Cluster EST : Unigene | Hs.243678 [ NCBI ] |
| CGAP (NCI) | Hs.243678 |
| Alternative Splicing Gallery | ENSG00000005513 |
| Gene Expression | SOX8 [ NCBI-GEO ] SOX8 [ EBI - ARRAY_EXPRESS ]
SOX8 [ SEEK ] SOX8 [ MEM ] |
| Gene Expression Viewer (FireBrowse) | SOX8 [ Firebrowse - Broad ] |
| SOURCE (Princeton) | Expression in : [Datasets] [Normal Tissue Atlas] [carcinoma Classsification] [NCI60] |
| Genevestigator | Expression in : [tissues] [cell-lines] [cancer] [perturbations] |
| BioGPS (Tissue expression) | 30812 |
| GTEX Portal (Tissue expression) | SOX8 |
| Human Protein Atlas | ENSG00000005513-SOX8 [pathology] [cell] [tissue] |
| Protein : pattern, domain, 3D structure |
|---|
| UniProt/SwissProt | P57073 [function] [subcellular_location] [family_and_domains] [pathology_and_biotech] [ptm_processing] [expression] [interaction] |
| NextProt | P57073 [Sequence] [Exons] [Medical] [Publications] |
| With graphics : InterPro | P57073 |
| Splice isoforms : SwissVar | P57073 |
| PhosPhoSitePlus | P57073 |
| Domaine pattern : Prosite (Expaxy) | HMG_BOX_2 (PS50118) |
| Domains : Interpro (EBI) | HMG_box_dom HMG_box_dom_sf SOX-8 Sox_N |
| Domain families : Pfam (Sanger) | HMG_box (PF00505) Sox_N (PF12444) |
| Domain families : Pfam (NCBI) | pfam00505 pfam12444 |
| Domain families : Smart (EMBL) | HMG (SM00398) |
| Conserved Domain (NCBI) | SOX8 |
| DMDM Disease mutations | 30812 |
| Blocks (Seattle) | SOX8 |
| Superfamily | P57073 |
| Human Protein Atlas [tissue] | ENSG00000005513-SOX8 [tissue] |
| Peptide Atlas | P57073 |
| HPRD | 16175 |
| IPI | IPI00299069 IPI00386303 |
| Protein Interaction databases |
|---|
| DIP (DOE-UCLA) | P57073 |
| IntAct (EBI) | P57073 |
| FunCoup | ENSG00000005513 |
| BioGRID | SOX8 |
| STRING (EMBL) | SOX8 |
| ZODIAC | SOX8 |
| Ontologies - Pathways |
|---|
| QuickGO | P57073 |
| Ontology : AmiGO | negative regulation of transcription by RNA polymerase II RNA polymerase II core promoter sequence-specific DNA binding RNA polymerase II transcription factor activity, sequence-specific DNA binding RNA polymerase II transcription factor activity, sequence-specific DNA binding RNA polymerase II transcription factor activity, sequence-specific DNA binding transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding osteoblast differentiation in utero embryonic development neural crest cell migration morphogenesis of an epithelium DNA binding nucleus nucleus cytoplasm transcription, DNA-templated signal transduction spermatogenesis central nervous system development peripheral nervous system development peripheral nervous system development transcription factor binding male gonad development regulation of hormone levels positive regulation of gliogenesis neural crest cell development positive regulation of osteoblast proliferation skeletal muscle cell differentiation negative regulation of apoptotic process nuclear transcription factor complex cell fate commitment fat cell differentiation negative regulation of myoblast differentiation negative regulation of transcription, DNA-templated positive regulation of transcription, DNA-templated positive regulation of transcription by RNA polymerase II positive regulation of transcription by RNA polymerase II negative regulation of photoreceptor cell differentiation protein heterodimerization activity cell maturation enteric nervous system development enteric nervous system development oligodendrocyte differentiation oligodendrocyte differentiation Sertoli cell development astrocyte fate commitment retina development in camera-type eye retinal rod cell differentiation adipose tissue development morphogenesis of a branching epithelium renal vesicle induction ureter morphogenesis metanephric nephron tubule formation positive regulation of kidney development positive regulation of branching involved in ureteric bud morphogenesis |
| Ontology : EGO-EBI | negative regulation of transcription by RNA polymerase II RNA polymerase II core promoter sequence-specific DNA binding RNA polymerase II transcription factor activity, sequence-specific DNA binding RNA polymerase II transcription factor activity, sequence-specific DNA binding RNA polymerase II transcription factor activity, sequence-specific DNA binding transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding osteoblast differentiation in utero embryonic development neural crest cell migration morphogenesis of an epithelium DNA binding nucleus nucleus cytoplasm transcription, DNA-templated signal transduction spermatogenesis central nervous system development peripheral nervous system development peripheral nervous system development transcription factor binding male gonad development regulation of hormone levels positive regulation of gliogenesis neural crest cell development positive regulation of osteoblast proliferation skeletal muscle cell differentiation negative regulation of apoptotic process nuclear transcription factor complex cell fate commitment fat cell differentiation negative regulation of myoblast differentiation negative regulation of transcription, DNA-templated positive regulation of transcription, DNA-templated positive regulation of transcription by RNA polymerase II positive regulation of transcription by RNA polymerase II negative regulation of photoreceptor cell differentiation protein heterodimerization activity cell maturation enteric nervous system development enteric nervous system development oligodendrocyte differentiation oligodendrocyte differentiation Sertoli cell development astrocyte fate commitment retina development in camera-type eye retinal rod cell differentiation adipose tissue development morphogenesis of a branching epithelium renal vesicle induction ureter morphogenesis metanephric nephron tubule formation positive regulation of kidney development positive regulation of branching involved in ureteric bud morphogenesis |
| NDEx Network | SOX8 |
| Atlas of Cancer Signalling Network | SOX8 |
| Wikipedia pathways | SOX8 |
| Orthology - Evolution |
|---|
| OrthoDB | 30812 |
| GeneTree (enSembl) | ENSG00000005513 |
| Phylogenetic Trees/Animal Genes : TreeFam | SOX8 |
| HOVERGEN | P57073 |
| HOGENOM | P57073 |
| Homologs : HomoloGene | SOX8 |
| Homology/Alignments : Family Browser (UCSC) | SOX8 |
| Gene fusions - Rearrangements |
|---|
| Fusion : Quiver | SOX8 |
| Polymorphisms : SNP and Copy number variants |
|---|
| NCBI Variation Viewer | SOX8 [hg38] |
| dbSNP Single Nucleotide Polymorphism (NCBI) | SOX8 |
| dbVar | SOX8 |
| ClinVar | SOX8 |
| 1000_Genomes | SOX8 |
| Exome Variant Server | SOX8 |
| ExAC (Exome Aggregation Consortium) | ENSG00000005513 |
| GNOMAD Browser | ENSG00000005513 |
| Varsome Browser | SOX8 |
| Genetic variants : HAPMAP | 30812 |
| Genomic Variants (DGV) | SOX8 [DGVbeta] |
| DECIPHER | SOX8 [patients] [syndromes] [variants] [genes] |
| CONAN: Copy Number Analysis | SOX8 |
| Mutations |
|---|
| ICGC Data Portal | SOX8 |
| TCGA Data Portal | SOX8 |
| Broad Tumor Portal | SOX8 |
| OASIS Portal | SOX8 [ Somatic mutations - Copy number] |
| Somatic Mutations in Cancer : COSMIC | SOX8 [overview] [genome browser] [tissue] [distribution] |
| Mutations and Diseases : HGMD | SOX8 |
| LOVD (Leiden Open Variation Database) | Whole genome datasets |
| LOVD (Leiden Open Variation Database) | LOVD - Leiden Open Variation Database |
| LOVD (Leiden Open Variation Database) | LOVD 3.0 shared installation |
| BioMuta | search SOX8 |
| DgiDB (Drug Gene Interaction Database) | SOX8 |
| DoCM (Curated mutations) | SOX8 (select the gene name) |
| CIViC (Clinical Interpretations of Variants in Cancer) | SOX8 (select a term) |
| intoGen | SOX8 |
| Cancer3D | SOX8(select the gene name) |
| Impact of mutations | [PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser] |
| Diseases |
|---|
| OMIM | 605923 |
| Orphanet | |
| DisGeNET | SOX8 |
| Medgen | SOX8 |
| Genetic Testing Registry | SOX8
|
| NextProt | P57073 [Medical] |
| TSGene | 30812 |
| GENETests | SOX8 |
| Target Validation | SOX8 |
| Huge Navigator |
SOX8 [HugePedia] |
| snp3D : Map Gene to Disease | 30812 |
| BioCentury BCIQ | SOX8 |
| ClinGen | SOX8 (curated) |
| Clinical trials, drugs, therapy |
|---|
| Chemical/Protein Interactions : CTD | 30812 |
| Chemical/Pharm GKB Gene | PA36040 |
| Clinical trial | SOX8 |
| Miscellaneous |
|---|
| canSAR (ICR) | SOX8 (select the gene name) |
| Probes |
|---|
| Litterature |
|---|
| PubMed | 24 Pubmed reference(s) in Entrez |
| GeneRIFs | Gene References Into Functions (Entrez) |
| CoreMine | SOX8 |
| EVEX | SOX8 |
| GoPubMed | SOX8 |
| iHOP | SOX8 |
