SP1 (Sp1 transcription factor)

2007-02-01 Affiliation

Identity

HGNC

SP1

LOCATION

12q13.13

LOCUSID

6667

ALIAS

FUSION GENES

Show Gene Fusions

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 6667
MIM: 189906
HGNC: 11205
Ensembl: ENSG00000185591

Variants:

dbSNP: 6667
ClinVar: 6667
TCGA: ENSG00000185591
COSMIC: SP1

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000185591	ENST00000327443	P08047
ENSG00000185591	ENST00000426431	P08047
ENSG00000185591	ENST00000548560	H3BVI2
ENSG00000185591	ENST00000551969	H3BUU5

Expression (GTEx)

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
TGF-beta signaling pathway	KEGG	ko04350
Huntington's disease	KEGG	ko05016
TGF-beta signaling pathway	KEGG	hsa04350
Huntington's disease	KEGG	hsa05016
Transcriptional misregulation in cancer	KEGG	ko05202
Transcriptional misregulation in cancer	KEGG	hsa05202
Estrogen signaling pathway	KEGG	hsa04915
Estrogen signaling pathway	KEGG	ko04915
Choline metabolism in cancer	KEGG	hsa05231
Choline metabolism in cancer	KEGG	ko05231
Signal Transduction	REACTOME	R-HSA-162582
Signaling by TGF-beta Receptor Complex	REACTOME	R-HSA-170834
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer	REACTOME	R-HSA-2173793
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription	REACTOME	R-HSA-2173796
Gene Expression	REACTOME	R-HSA-74160
Generic Transcription Pathway	REACTOME	R-HSA-212436
Metabolism	REACTOME	R-HSA-1430728
Metabolism of lipids and lipoproteins	REACTOME	R-HSA-556833
Fatty acid, triacylglycerol, and ketone body metabolism	REACTOME	R-HSA-535734
Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)	REACTOME	R-HSA-400206
PPARA activates gene expression	REACTOME	R-HSA-1989781
Regulation of cholesterol biosynthesis by SREBP (SREBF)	REACTOME	R-HSA-1655829
Activation of gene expression by SREBF (SREBP)	REACTOME	R-HSA-2426168
Cellular responses to stress	REACTOME	R-HSA-2262752
Cellular Senescence	REACTOME	R-HSA-2559583
Oncogene Induced Senescence	REACTOME	R-HSA-2559585
RNA polymerase II transcribes snRNA genes	REACTOME	R-HSA-6807505
Endocrine resistance	KEGG	ko01522
Endocrine resistance	KEGG	hsa01522
Breast cancer	KEGG	ko05224
Breast cancer	KEGG	hsa05224
Mitophagy - animal	KEGG	ko04137
Mitophagy - animal	KEGG	hsa04137

Protein levels (Protein atlas)

Not detected

Low

Medium

High

PharmGKB

Entity ID	Name	Type	Evidence	Association	PK	PD	PMIDs
PA134992438	CAMK1D	Gene	Pathway	associated
PA24684	AKT1	Gene	Pathway	associated
PA24685	AKT2	Gene	Pathway	associated
PA24686	AKT3	Gene	Pathway	associated
PA26048	CAMK1	Gene	Pathway	associated
PA26049	CAMK1G	Gene	Pathway	associated
PA283	MAPK8	Gene	Pathway	associated
PA30616	MAPK1	Gene	Pathway	associated
PA30622	MAPK3	Gene	Pathway	associated
PA337	STAT3	Gene	Pathway	associated
PA33759	PRKCA	Gene	Pathway	associated
PA33761	PRKCB	Gene	Pathway	associated
PA33766	PRKCG	Gene	Pathway	associated
PA338	STAT5A	Gene	Pathway	associated
PA36183	STAT1	Gene	Pathway	associated
PA36184	STAT2	Gene	Pathway	associated
PA36185	STAT4	Gene	Pathway	associated
PA36186	STAT5B	Gene	Pathway	associated
PA443886	Diabetes Mellitus	Disease	ClinicalAnnotation	associated	PK	PD	24853734
PA443890	Diabetes Mellitus, Type 2	Disease	ClinicalAnnotation	associated	PK	PD	24853734, 29352482
PA450395	metformin	Chemical	ClinicalAnnotation	associated	PK	PD	24853734, 29352482
PA90	CAMK2A	Gene	Pathway	associated
PA91	CAMK2B	Gene	Pathway	associated
PA92	CAMK2D	Gene	Pathway	associated
PA93	CAMK2G	Gene	Pathway	associated

References

Pubmed ID	Year	Title	Citations
11988536	2002	Sp1 and TAFII130 transcriptional activity disrupted in early Huntington's disease.	204
17670825	2007	c-Myc and Sp1 contribute to proviral latency by recruiting histone deacetylase 1 to the human immunodeficiency virus type 1 promoter.	110
25393971	2015	Sp1 and the 'hallmarks of cancer'.	108
25728677	2015	SP1-induced upregulation of the long noncoding RNA TINCR regulates cell proliferation and apoptosis by affecting KLF2 mRNA stability in gastric cancer.	98
18654640	2008	Genome-wide occupancy of SREBP1 and its partners NFY and SP1 reveals novel functional roles and combinatorial regulation of distinct classes of genes.	95
18812468	2009	Central role of Sp1-regulated CD39 in hypoxia/ischemia protection.	90
12228247	2002	Endoglin expression is regulated by transcriptional cooperation between the hypoxia and transforming growth factor-beta pathways.	89
15367601	2004	Latency-associated nuclear antigen of Kaposi's sarcoma-associated herpesvirus up-regulates transcription of human telomerase reverse transcriptase promoter through interaction with transcription factor Sp1.	80
20538607	2010	Inhibition of NFkappaB and pancreatic cancer cell and tumor growth by curcumin is dependent on specificity protein down-regulation.	80
21822301	2012	MicroRNA-335 acts as a metastasis suppressor in gastric cancer by targeting Bcl-w and specificity protein 1.	76

Citation

Dessen P

SP1 (Sp1 transcription factor)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/43949/sp1