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SP1 (Sp1 transcription factor)

Identity

Other alias-
HGNC (Hugo) SP1
LocusID (NCBI) 6667
Atlas_Id 43949
Location 12q13.13  [Link to chromosome band 12q13]
Location_base_pair Starts at 53380195 and ends at 53416442 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
CLRN3 (10q26.2) / SP1 (12q13.13)SP1 (12q13.13) / QRICH1 (3p21.31)SP1 (12q13.13) / SP1 (12q13.13)
SP1 (12q13.13) / TUBB (6p21.33)UBAP1 (9p13.3) / SP1 (12q13.13)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)SP1   11205
Cards
Entrez_Gene (NCBI)SP1  6667  Sp1 transcription factor
Aliases
GeneCards (Weizmann)SP1
Ensembl hg19 (Hinxton)ENSG00000185591 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000185591 [Gene_View]  ENSG00000185591 [Sequence]  chr12:53380195-53416442 [Contig_View]  SP1 [Vega]
ICGC DataPortalENSG00000185591
TCGA cBioPortalSP1
AceView (NCBI)SP1
Genatlas (Paris)SP1
WikiGenes6667
SOURCE (Princeton)SP1
Genetics Home Reference (NIH)SP1
Genomic and cartography
GoldenPath hg38 (UCSC)SP1  -     chr12:53380195-53416442 +  12q13.13   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)SP1  -     12q13.13   [Description]    (hg19-Feb_2009)
EnsemblSP1 - 12q13.13 [CytoView hg19]  SP1 - 12q13.13 [CytoView hg38]
Mapping of homologs : NCBISP1 [Mapview hg19]  SP1 [Mapview hg38]
OMIM189906   
Gene and transcription
Genbank (Entrez)AB209678 AF252284 AF255682 AI282745 AI561005
RefSeq transcript (Entrez)NM_001251825 NM_003109 NM_138473
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)SP1
Cluster EST : UnigeneHs.649191 [ NCBI ]
CGAP (NCI)Hs.649191
Alternative Splicing GalleryENSG00000185591
Gene ExpressionSP1 [ NCBI-GEO ]   SP1 [ EBI - ARRAY_EXPRESS ]   SP1 [ SEEK ]   SP1 [ MEM ]
Gene Expression Viewer (FireBrowse)SP1 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)6667
GTEX Portal (Tissue expression)SP1
Human Protein AtlasENSG00000185591-SP1 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP08047   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP08047  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP08047
Splice isoforms : SwissVarP08047
PhosPhoSitePlusP08047
Domaine pattern : Prosite (Expaxy)ZINC_FINGER_C2H2_1 (PS00028)    ZINC_FINGER_C2H2_2 (PS50157)   
Domains : Interpro (EBI)SP1    Znf_C2H2_sf    Znf_C2H2_type   
Domain families : Pfam (Sanger)
Domain families : Pfam (NCBI)
Domain families : Smart (EMBL)ZnF_C2H2 (SM00355)  
Conserved Domain (NCBI)SP1
DMDM Disease mutations6667
Blocks (Seattle)SP1
PDB (SRS)1SP1    1SP2    1VA1    1VA2    1VA3   
PDB (PDBSum)1SP1    1SP2    1VA1    1VA2    1VA3   
PDB (IMB)1SP1    1SP2    1VA1    1VA2    1VA3   
PDB (RSDB)1SP1    1SP2    1VA1    1VA2    1VA3   
Structural Biology KnowledgeBase1SP1    1SP2    1VA1    1VA2    1VA3   
SCOP (Structural Classification of Proteins)1SP1    1SP2    1VA1    1VA2    1VA3   
CATH (Classification of proteins structures)1SP1    1SP2    1VA1    1VA2    1VA3   
SuperfamilyP08047
Human Protein Atlas [tissue]ENSG00000185591-SP1 [tissue]
Peptide AtlasP08047
HPRD01796
IPIIPI00465152   IPI00916684   
Protein Interaction databases
DIP (DOE-UCLA)P08047
IntAct (EBI)P08047
FunCoupENSG00000185591
BioGRIDSP1
STRING (EMBL)SP1
ZODIACSP1
Ontologies - Pathways
QuickGOP08047
Ontology : AmiGOnuclear chromatin  RNA polymerase II regulatory region sequence-specific DNA binding  RNA polymerase II proximal promoter sequence-specific DNA binding  RNA polymerase II proximal promoter sequence-specific DNA binding  DNA-binding transcription factor activity, RNA polymerase II-specific  DNA-binding transcription factor activity, RNA polymerase II-specific  DNA-binding transcription factor activity, RNA polymerase II-specific  transcription factor activity, RNA polymerase II proximal promoter sequence-specific DNA binding  proximal promoter sequence-specific DNA binding  proximal promoter DNA-binding transcription activator activity, RNA polymerase II-specific  RNA polymerase II repressing transcription factor binding  DNA binding  double-stranded DNA binding  DNA-binding transcription factor activity  protein binding  nucleus  nucleus  nucleoplasm  nucleoplasm  cytoplasm  regulation of transcription, DNA-templated  regulation of transcription by RNA polymerase II  protein C-terminus binding  transcription factor binding  positive regulation of gene expression  viral process  transcriptional repressor complex  cellular response to insulin stimulus  protein-DNA complex  response to hydroperoxide  histone acetyltransferase binding  snRNA transcription by RNA polymerase II  protein homodimerization activity  histone deacetylase binding  bHLH transcription factor binding  positive regulation of blood vessel endothelial cell migration  sequence-specific DNA binding  positive regulation by host of viral transcription  transcription regulatory region DNA binding  regulation of cholesterol biosynthetic process  positive regulation of angiogenesis  positive regulation of transcription, DNA-templated  positive regulation of transcription by RNA polymerase II  positive regulation of transcription by RNA polymerase II  positive regulation of transcription by RNA polymerase II  positive regulation of transcription by RNA polymerase II  metal ion binding  rhythmic process  repressing transcription factor binding  HMG box domain binding  regulation of phenotypic switching by transcription from RNA polymerase II promoter  positive regulation of hydrogen sulfide biosynthetic process  positive regulation of vascular endothelial cell proliferation  
Ontology : EGO-EBInuclear chromatin  RNA polymerase II regulatory region sequence-specific DNA binding  RNA polymerase II proximal promoter sequence-specific DNA binding  RNA polymerase II proximal promoter sequence-specific DNA binding  DNA-binding transcription factor activity, RNA polymerase II-specific  DNA-binding transcription factor activity, RNA polymerase II-specific  DNA-binding transcription factor activity, RNA polymerase II-specific  transcription factor activity, RNA polymerase II proximal promoter sequence-specific DNA binding  proximal promoter sequence-specific DNA binding  proximal promoter DNA-binding transcription activator activity, RNA polymerase II-specific  RNA polymerase II repressing transcription factor binding  DNA binding  double-stranded DNA binding  DNA-binding transcription factor activity  protein binding  nucleus  nucleus  nucleoplasm  nucleoplasm  cytoplasm  regulation of transcription, DNA-templated  regulation of transcription by RNA polymerase II  protein C-terminus binding  transcription factor binding  positive regulation of gene expression  viral process  transcriptional repressor complex  cellular response to insulin stimulus  protein-DNA complex  response to hydroperoxide  histone acetyltransferase binding  snRNA transcription by RNA polymerase II  protein homodimerization activity  histone deacetylase binding  bHLH transcription factor binding  positive regulation of blood vessel endothelial cell migration  sequence-specific DNA binding  positive regulation by host of viral transcription  transcription regulatory region DNA binding  regulation of cholesterol biosynthetic process  positive regulation of angiogenesis  positive regulation of transcription, DNA-templated  positive regulation of transcription by RNA polymerase II  positive regulation of transcription by RNA polymerase II  positive regulation of transcription by RNA polymerase II  positive regulation of transcription by RNA polymerase II  metal ion binding  rhythmic process  repressing transcription factor binding  HMG box domain binding  regulation of phenotypic switching by transcription from RNA polymerase II promoter  positive regulation of hydrogen sulfide biosynthetic process  positive regulation of vascular endothelial cell proliferation  
Pathways : KEGGTGF-beta signaling pathway    Estrogen signaling pathway    Huntington's disease    Transcriptional misregulation in cancer   
NDEx NetworkSP1
Atlas of Cancer Signalling NetworkSP1
Wikipedia pathwaysSP1
Orthology - Evolution
OrthoDB6667
GeneTree (enSembl)ENSG00000185591
Phylogenetic Trees/Animal Genes : TreeFamSP1
HOVERGENP08047
HOGENOMP08047
Homologs : HomoloGeneSP1
Homology/Alignments : Family Browser (UCSC)SP1
Gene fusions - Rearrangements
Fusion : QuiverSP1
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerSP1 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)SP1
dbVarSP1
ClinVarSP1
1000_GenomesSP1 
Exome Variant ServerSP1
ExAC (Exome Aggregation Consortium)ENSG00000185591
GNOMAD BrowserENSG00000185591
Varsome BrowserSP1
Genetic variants : HAPMAP6667
Genomic Variants (DGV)SP1 [DGVbeta]
DECIPHERSP1 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisSP1 
Mutations
ICGC Data PortalSP1 
TCGA Data PortalSP1 
Broad Tumor PortalSP1
OASIS PortalSP1 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICSP1  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDSP1
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch SP1
DgiDB (Drug Gene Interaction Database)SP1
DoCM (Curated mutations)SP1 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)SP1 (select a term)
intoGenSP1
Cancer3DSP1(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM189906   
Orphanet
DisGeNETSP1
MedgenSP1
Genetic Testing Registry SP1
NextProtP08047 [Medical]
TSGene6667
GENETestsSP1
Target ValidationSP1
Huge Navigator SP1 [HugePedia]
snp3D : Map Gene to Disease6667
BioCentury BCIQSP1
ClinGenSP1
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD6667
Chemical/Pharm GKB GenePA36042
Clinical trialSP1
Miscellaneous
canSAR (ICR)SP1 (select the gene name)
Probes
Litterature
PubMed499 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineSP1
EVEXSP1
GoPubMedSP1
iHOPSP1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Tue Nov 6 11:41:16 CET 2018

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