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SP140 (SP140 nuclear body protein)

Identity

Alias_symbol (synonym)LYSP100-B
LYSP100-A
Other aliasLYSP100
HGNC (Hugo) SP140
LocusID (NCBI) 11262
Atlas_Id 74086
Location 2q37.1  [Link to chromosome band 2q37]
Location_base_pair Starts at 231090445 and ends at 231103791 bp from pter ( according to hg19-Feb_2009)
Fusion genes
(updated 2016)
DGKD (2q37.1) / SP140 (2q37.1)SP140 (2q37.1) / DGKI (7q33)SP140 (2q37.1) / REPS1 (6q24.1)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)SP140   17133
Cards
Entrez_Gene (NCBI)SP140  11262  SP140 nuclear body protein
AliasesLYSP100; LYSP100-A; LYSP100-B
GeneCards (Weizmann)SP140
Ensembl hg19 (Hinxton)ENSG00000079263 [Gene_View]  chr2:231090445-231103791 [Contig_View]  SP140 [Vega]
Ensembl hg38 (Hinxton)ENSG00000079263 [Gene_View]  chr2:231090445-231103791 [Contig_View]  SP140 [Vega]
ICGC DataPortalENSG00000079263
TCGA cBioPortalSP140
AceView (NCBI)SP140
Genatlas (Paris)SP140
WikiGenes11262
SOURCE (Princeton)SP140
Genetics Home Reference (NIH)SP140
Genomic and cartography
GoldenPath hg19 (UCSC)SP140  -     chr2:231090445-231103791 +  2q37.1   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)SP140  -     2q37.1   [Description]    (hg38-Dec_2013)
EnsemblSP140 - 2q37.1 [CytoView hg19]  SP140 - 2q37.1 [CytoView hg38]
Mapping of homologs : NCBISP140 [Mapview hg19]  SP140 [Mapview hg38]
OMIM608602   
Gene and transcription
Genbank (Entrez)AA741304 AK301267 AK301317 BC038091 BC054890
RefSeq transcript (Entrez)NM_001005176 NM_001278451 NM_001278452 NM_001278453 NM_007237
RefSeq genomic (Entrez)NC_000002 NC_018913 NT_005403 NW_004929305
Consensus coding sequences : CCDS (NCBI)SP140
Cluster EST : UnigeneHs.632549 [ NCBI ]
CGAP (NCI)Hs.632549
Alternative Splicing GalleryENSG00000079263
Gene ExpressionSP140 [ NCBI-GEO ]   SP140 [ EBI - ARRAY_EXPRESS ]   SP140 [ SEEK ]   SP140 [ MEM ]
Gene Expression Viewer (FireBrowse)SP140 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)11262
GTEX Portal (Tissue expression)SP140
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ13342   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ13342  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ13342
Splice isoforms : SwissVarQ13342
PhosPhoSitePlusQ13342
Domaine pattern : Prosite (Expaxy)BROMODOMAIN_2 (PS50014)    HSR (PS51414)    SAND (PS50864)    ZF_PHD_1 (PS01359)    ZF_PHD_2 (PS50016)   
Domains : Interpro (EBI)Bromodomain    HSR_dom    SAND_dom    SAND_dom-like    SP140    Zinc_finger_PHD-type_CS    Znf_FYVE_PHD    Znf_PHD    Znf_PHD-finger    Znf_RING/FYVE/PHD   
Domain families : Pfam (Sanger)Bromodomain (PF00439)    PHD (PF00628)    SAND (PF01342)    Sp100 (PF03172)   
Domain families : Pfam (NCBI)pfam00439    pfam00628    pfam01342    pfam03172   
Domain families : Smart (EMBL)BROMO (SM00297)  PHD (SM00249)  SAND (SM00258)  
Conserved Domain (NCBI)SP140
DMDM Disease mutations11262
Blocks (Seattle)SP140
PDB (SRS)2MD7    2MD8   
PDB (PDBSum)2MD7    2MD8   
PDB (IMB)2MD7    2MD8   
PDB (RSDB)2MD7    2MD8   
Structural Biology KnowledgeBase2MD7    2MD8   
SCOP (Structural Classification of Proteins)2MD7    2MD8   
CATH (Classification of proteins structures)2MD7    2MD8   
SuperfamilyQ13342
Human Protein AtlasENSG00000079263
Peptide AtlasQ13342
HPRD09780
IPIIPI00219535   IPI00219536   IPI00908574   IPI00908789   IPI01011082   IPI00981123   IPI00012793   IPI00431685   IPI01025902   IPI00784584   
Protein Interaction databases
DIP (DOE-UCLA)Q13342
IntAct (EBI)Q13342
FunCoupENSG00000079263
BioGRIDSP140
STRING (EMBL)SP140
ZODIACSP140
Ontologies - Pathways
QuickGOQ13342
Ontology : AmiGODNA binding  chromatin binding  sequence-specific DNA binding transcription factor activity  protein binding  nucleus  nuclear envelope  nucleoplasm  cytoplasm  chromatin remodeling  regulation of transcription, DNA-templated  defense response  zinc ion binding  PML body  
Ontology : EGO-EBIDNA binding  chromatin binding  sequence-specific DNA binding transcription factor activity  protein binding  nucleus  nuclear envelope  nucleoplasm  cytoplasm  chromatin remodeling  regulation of transcription, DNA-templated  defense response  zinc ion binding  PML body  
NDEx NetworkSP140
Atlas of Cancer Signalling NetworkSP140
Wikipedia pathwaysSP140
Orthology - Evolution
OrthoDB11262
GeneTree (enSembl)ENSG00000079263
Phylogenetic Trees/Animal Genes : TreeFamSP140
HOVERGENQ13342
HOGENOMQ13342
Homologs : HomoloGeneSP140
Homology/Alignments : Family Browser (UCSC)SP140
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerSP140 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)SP140
dbVarSP140
ClinVarSP140
1000_GenomesSP140 
Exome Variant ServerSP140
ExAC (Exome Aggregation Consortium)SP140 (select the gene name)
Genetic variants : HAPMAP11262
Genomic Variants (DGV)SP140 [DGVbeta]
DECIPHER (Syndromes)2:231090445-231103791  ENSG00000079263
CONAN: Copy Number AnalysisSP140 
Mutations
ICGC Data PortalSP140 
TCGA Data PortalSP140 
Broad Tumor PortalSP140
OASIS PortalSP140 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICSP140  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDSP140
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch SP140
DgiDB (Drug Gene Interaction Database)SP140
DoCM (Curated mutations)SP140 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)SP140 (select a term)
intoGenSP140
Cancer3DSP140(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM608602   
Orphanet
MedgenSP140
Genetic Testing Registry SP140
NextProtQ13342 [Medical]
TSGene11262
GENETestsSP140
Huge Navigator SP140 [HugePedia]
snp3D : Map Gene to Disease11262
BioCentury BCIQSP140
ClinGenSP140
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD11262
Chemical/Pharm GKB GenePA38205
Clinical trialSP140
Miscellaneous
canSAR (ICR)SP140 (select the gene name)
Probes
Litterature
PubMed19 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineSP140
EVEXSP140
GoPubMedSP140
iHOPSP140
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Tue Mar 14 12:46:12 CET 2017

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