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SP2 (Sp2 transcription factor)

Identity

Alias (NCBI)-
HGNC (Hugo) SP2
HGNC Alias symbKIAA0048
LocusID (NCBI) 6668
Atlas_Id 54936
Location 17q21.32  [Link to chromosome band 17q21]
Location_base_pair Starts at 47896236 and ends at 47928957 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
ANK3 (10q21.2) / SP2 (17q21.32)SP2 (17q21.32) / SP2 (17q21.32)ANK3 10q21.2 / SP2 17q21.32

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



Other Leukemias implicated (Data extracted from papers in the Atlas) [ 1 ]
  t(9;17)(p13;q21) PAX5/SP2


External links

 

Nomenclature
HGNC (Hugo)SP2   11207
Cards
Entrez_Gene (NCBI)SP2    Sp2 transcription factor
Aliases
GeneCards (Weizmann)SP2
Ensembl hg19 (Hinxton)ENSG00000167182 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000167182 [Gene_View]  ENSG00000167182 [Sequence]  chr17:47896236-47928957 [Contig_View]  SP2 [Vega]
ICGC DataPortalENSG00000167182
TCGA cBioPortalSP2
AceView (NCBI)SP2
Genatlas (Paris)SP2
SOURCE (Princeton)SP2
Genetics Home Reference (NIH)SP2
Genomic and cartography
GoldenPath hg38 (UCSC)SP2  -     chr17:47896236-47928957 +  17q21.32   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)SP2  -     17q21.32   [Description]    (hg19-Feb_2009)
GoldenPathSP2 - 17q21.32 [CytoView hg19]  SP2 - 17q21.32 [CytoView hg38]
ImmunoBaseENSG00000167182
Genome Data Viewer NCBISP2 [Mapview hg19]  
OMIM601801   
Gene and transcription
Genbank (Entrez)AK097532 BC005914 BC016680 BC033814 D28588
RefSeq transcript (Entrez)NM_003110
Consensus coding sequences : CCDS (NCBI)SP2
Gene ExpressionSP2 [ NCBI-GEO ]   SP2 [ EBI - ARRAY_EXPRESS ]   SP2 [ SEEK ]   SP2 [ MEM ]
Gene Expression Viewer (FireBrowse)SP2 [ Firebrowse - Broad ]
GenevisibleExpression of SP2 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)6668
GTEX Portal (Tissue expression)SP2
Human Protein AtlasENSG00000167182-SP2 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ02086   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ02086  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ02086
PhosPhoSitePlusQ02086
Domaine pattern : Prosite (Expaxy)ZINC_FINGER_C2H2_1 (PS00028)    ZINC_FINGER_C2H2_2 (PS50157)   
Domains : Interpro (EBI)SP2_TF    Znf_C2H2_sf    Znf_C2H2_type   
Domain families : Pfam (Sanger)zf-C2H2 (PF00096)   
Domain families : Pfam (NCBI)pfam00096   
Domain families : Smart (EMBL)ZnF_C2H2 (SM00355)  
Conserved Domain (NCBI)SP2
SuperfamilyQ02086
AlphaFold pdb e-kbQ02086   
Human Protein Atlas [tissue]ENSG00000167182-SP2 [tissue]
HPRD03481
Protein Interaction databases
DIP (DOE-UCLA)Q02086
IntAct (EBI)Q02086
BioGRIDSP2
STRING (EMBL)SP2
ZODIACSP2
Ontologies - Pathways
QuickGOQ02086
Ontology : AmiGOnegative regulation of transcription by RNA polymerase II  chromatin  RNA polymerase II cis-regulatory region sequence-specific DNA binding  RNA polymerase II cis-regulatory region sequence-specific DNA binding  DNA-binding transcription factor activity, RNA polymerase II-specific  DNA-binding transcription factor activity, RNA polymerase II-specific  DNA-binding transcription repressor activity, RNA polymerase II-specific  protein binding  nucleoplasm  regulation of transcription by RNA polymerase II  immune response  multicellular organism growth  histone deacetylase binding  metal ion binding  sequence-specific double-stranded DNA binding  
Ontology : EGO-EBInegative regulation of transcription by RNA polymerase II  chromatin  RNA polymerase II cis-regulatory region sequence-specific DNA binding  RNA polymerase II cis-regulatory region sequence-specific DNA binding  DNA-binding transcription factor activity, RNA polymerase II-specific  DNA-binding transcription factor activity, RNA polymerase II-specific  DNA-binding transcription repressor activity, RNA polymerase II-specific  protein binding  nucleoplasm  regulation of transcription by RNA polymerase II  immune response  multicellular organism growth  histone deacetylase binding  metal ion binding  sequence-specific double-stranded DNA binding  
NDEx NetworkSP2
Atlas of Cancer Signalling NetworkSP2
Wikipedia pathwaysSP2
Orthology - Evolution
OrthoDB6668
GeneTree (enSembl)ENSG00000167182
Phylogenetic Trees/Animal Genes : TreeFamSP2
Homologs : HomoloGeneSP2
Homology/Alignments : Family Browser (UCSC)SP2
Gene fusions - Rearrangements
Fusion : MitelmanANK3/SP2 [10q21.2/17q21.32]  
Fusion : QuiverSP2
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerSP2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)SP2
dbVarSP2
ClinVarSP2
MonarchSP2
1000_GenomesSP2 
Exome Variant ServerSP2
GNOMAD BrowserENSG00000167182
Varsome BrowserSP2
ACMGSP2 variants
VarityQ02086
Genomic Variants (DGV)SP2 [DGVbeta]
DECIPHERSP2 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisSP2 
Mutations
ICGC Data PortalSP2 
TCGA Data PortalSP2 
Broad Tumor PortalSP2
OASIS PortalSP2 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICSP2  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DSP2
Mutations and Diseases : HGMDSP2
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaSP2
DgiDB (Drug Gene Interaction Database)SP2
DoCM (Curated mutations)SP2
CIViC (Clinical Interpretations of Variants in Cancer)SP2
Cancer3DSP2
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM601801   
Orphanet
DisGeNETSP2
MedgenSP2
Genetic Testing Registry SP2
NextProtQ02086 [Medical]
GENETestsSP2
Target ValidationSP2
Huge Navigator SP2 [HugePedia]
ClinGenSP2
Clinical trials, drugs, therapy
MyCancerGenomeSP2
Protein Interactions : CTDSP2
Pharm GKB GenePA36044
PharosQ02086
Clinical trialSP2
Miscellaneous
canSAR (ICR)SP2
HarmonizomeSP2
DataMed IndexSP2
Probes
Litterature
PubMed40 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXSP2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Oct 4 15:32:43 CEST 2021

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