SP3 (Sp3 transcription factor)

2007-02-01  

Identity

HGNC
LOCATION
2q31.1
LOCUSID
ALIAS
SPR2
FUSION GENES

Other Information

Locus ID:

NCBI: 6670
MIM: 601804
HGNC: 11208
Ensembl: ENSG00000172845

Variants:

dbSNP: 6670
ClinVar: 6670
TCGA: ENSG00000172845
COSMIC: SP3

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000172845ENST00000310015Q02447
ENSG00000172845ENST00000416195H0Y7L6
ENSG00000172845ENST00000418194H0Y6K5
ENSG00000172845ENST00000650743A0A494C0Z6
ENSG00000172845ENST00000651846A0A494C1G8
ENSG00000172845ENST00000652005A0A494C070

Expression (GTEx)

0
10
20
30
40
50
60

Pathways

PathwaySourceExternal ID
Metabolism of proteinsREACTOMER-HSA-392499
Post-translational protein modificationREACTOMER-HSA-597592
SUMOylationREACTOMER-HSA-2990846
SUMO E3 ligases SUMOylate target proteinsREACTOMER-HSA-3108232
SUMOylation of transcription factorsREACTOMER-HSA-3232118

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
205386072010Inhibition of NFkappaB and pancreatic cancer cell and tumor growth by curcumin is dependent on specificity protein down-regulation.80
185939362008Curcumin decreases specificity protein expression in bladder cancer cells.67
172974702007Tumor suppressor Pdcd4 inhibits invasion/intravasation and regulates urokinase receptor (u-PAR) gene expression via Sp-transcription factors.63
121514072002Sp1 and Sp3 recruit histone deacetylase to repress transcription of human telomerase reverse transcriptase (hTERT) promoter in normal human somatic cells.62
125094262003Oxidative stress regulates vascular endothelial growth factor-A gene transcription through Sp1- and Sp3-dependent activation of two proximal GC-rich promoter elements.56
128377482003Acetylated sp3 is a transcriptional activator.43
180657602008Interleukin-6 (IL-6) and/or soluble IL-6 receptor down-regulation of human type II collagen gene expression in articular chondrocytes requires a decrease of Sp1.Sp3 ratio and of the binding activity of both factors to the COL2A1 promoter.43
176166682007EGFR activation results in enhanced cyclooxygenase-2 expression through p38 mitogen-activated protein kinase-dependent activation of the Sp1/Sp3 transcription factors in human gliomas.40
183489862008The proinflammatory cytokine, interleukin-6, up-regulates calcium-sensing receptor gene transcription via Stat1/3 and Sp1/3.39
185225352008The human receptor tyrosine kinase Axl gene--promoter characterization and regulation of constitutive expression by Sp1, Sp3 and CpG methylation.39

Citation

Dessen P

SP3 (Sp3 transcription factor)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/44016/sp3