Atlas of Genetics and Cytogenetics in Oncology and Haematology

Home   Genes   Leukemias   Solid Tumors   Cancer-Prone   Deep Insight   Case Reports   Journals  Portal   Teaching   
X Y 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 NA

SP3 (Sp3 transcription factor)

Identity

Alias (NCBI)SPR2
HGNC (Hugo) SP3
HGNC Alias symbSPR-2
LocusID (NCBI) 6670
Atlas_Id 44016
Location 2q31.1  [Link to chromosome band 2q31]
Location_base_pair Starts at 173906459 and ends at 173965702 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)		Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
CDKL4 (2p22.1)::SP3 (2q31.1)EFHD2 (1p36.21)::SP3 (2q31.1)EWSR1 (22q12.2)::SP3 (2q31.1)
SP3 (2q31.1)::AFTPH (2p14)SP3 (2q31.1)::GPR155 (2q31.1)SP3 (2q31.1)::OLA1 (2q31.1)
SP3 (2q31.1)::PTK2 (8q24.3)SP3 (2q31.1)::STK39 (2q24.3)SP3 (2q31.1)::TRPM3 (9q21.12)
EWSR1 22q12.2::SP3 2q31.1SP3 2q31.1::GPR155 2q31.1SP3 2q31.1::OLA1 2q31.1
SP3 2q31.1::STK39 2q24.3

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

External links

 

Nomenclature
HGNC (Hugo)SP3   11208
Cards
Entrez_Gene (NCBI)SP3    Sp3 transcription factor
AliasesSPR2
GeneCards (Weizmann)SP3
Ensembl hg19 (Hinxton)ENSG00000172845 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000172845 [Gene_View]  ENSG00000172845 [Sequence]  chr2:173906459-173965702 [Contig_View]  SP3 [Vega]
ICGC DataPortalENSG00000172845
TCGA cBioPortalSP3
AceView (NCBI)SP3
Genatlas (Paris)SP3
SOURCE (Princeton)SP3
Genetics Home Reference (NIH)SP3
Genomic and cartography
GoldenPath hg38 (UCSC)SP3  -     chr2:173906459-173965702 -  2q31.1   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)SP3  -     2q31.1   [Description]    (hg19-Feb_2009)
GoldenPathSP3 - 2q31.1 [CytoView hg19]  SP3 - 2q31.1 [CytoView hg38]
ImmunoBaseENSG00000172845
Genome Data Viewer NCBISP3 [Mapview hg19]  
OMIM601804   
Gene and transcription
Genbank (Entrez)AA706229 AB209334 AJ310752 AJ430844 AK304199
RefSeq transcript (Entrez)NM_001017371 NM_001172712 NM_003111
Consensus coding sequences : CCDS (NCBI)SP3
Gene ExpressionSP3 [ NCBI-GEO ]   SP3 [ EBI - ARRAY_EXPRESS ]   SP3 [ SEEK ]   SP3 [ MEM ]
Gene Expression Viewer (FireBrowse)SP3 [ Firebrowse - Broad ]
GenevisibleExpression of SP3 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)6670
GTEX Portal (Tissue expression)SP3
Human Protein AtlasENSG00000172845-SP3 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ02447   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ02447  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ02447
PhosPhoSitePlusQ02447
Domaine pattern : Prosite (Expaxy)ZINC_FINGER_C2H2_1 (PS00028)    ZINC_FINGER_C2H2_2 (PS50157)   
Domains : Interpro (EBI)SP3    Znf_C2H2_sf    Znf_C2H2_type   
Domain families : Pfam (Sanger)zf-C2H2 (PF00096)   
Domain families : Pfam (NCBI)pfam00096   
Domain families : Smart (EMBL)ZnF_C2H2 (SM00355)  
Conserved Domain (NCBI)SP3
SuperfamilyQ02447
AlphaFold pdb e-kbQ02447   
Human Protein Atlas [tissue]ENSG00000172845-SP3 [tissue]
HPRD03483
Protein Interaction databases
DIP (DOE-UCLA)Q02447
IntAct (EBI)Q02447
BioGRIDSP3
STRING (EMBL)SP3
ZODIACSP3
Ontologies - Pathways
QuickGOQ02447
Ontology : AmiGOnegative regulation of transcription by RNA polymerase II  chromatin  RNA polymerase II transcription regulatory region sequence-specific DNA binding  RNA polymerase II cis-regulatory region sequence-specific DNA binding  DNA-binding transcription factor activity, RNA polymerase II-specific  DNA-binding transcription factor activity, RNA polymerase II-specific  cis-regulatory region sequence-specific DNA binding  DNA-binding transcription repressor activity, RNA polymerase II-specific  ossification  natural killer cell differentiation  trophectodermal cell differentiation  liver development  embryonic placenta development  chromatin binding  protein binding  nucleus  nucleoplasm  regulation of transcription, DNA-templated  regulation of transcription by RNA polymerase II  PML body  transcription repressor complex  B cell differentiation  T cell differentiation  megakaryocyte differentiation  monocyte differentiation  lung development  granulocyte differentiation  protein-DNA complex  enucleate erythrocyte differentiation  negative regulation of transcription, DNA-templated  negative regulation of transcription, DNA-templated  positive regulation of transcription, DNA-templated  positive regulation of transcription, DNA-templated  positive regulation of transcription by RNA polymerase II  positive regulation of transcription by RNA polymerase II  metal ion binding  embryonic camera-type eye morphogenesis  embryonic skeletal system development  embryonic process involved in female pregnancy  definitive hemopoiesis  RNA polymerase II-specific DNA-binding transcription factor binding  sequence-specific double-stranded DNA binding  
Ontology : EGO-EBInegative regulation of transcription by RNA polymerase II  chromatin  RNA polymerase II transcription regulatory region sequence-specific DNA binding  RNA polymerase II cis-regulatory region sequence-specific DNA binding  DNA-binding transcription factor activity, RNA polymerase II-specific  DNA-binding transcription factor activity, RNA polymerase II-specific  cis-regulatory region sequence-specific DNA binding  DNA-binding transcription repressor activity, RNA polymerase II-specific  ossification  natural killer cell differentiation  trophectodermal cell differentiation  liver development  embryonic placenta development  chromatin binding  protein binding  nucleus  nucleoplasm  regulation of transcription, DNA-templated  regulation of transcription by RNA polymerase II  PML body  transcription repressor complex  B cell differentiation  T cell differentiation  megakaryocyte differentiation  monocyte differentiation  lung development  granulocyte differentiation  protein-DNA complex  enucleate erythrocyte differentiation  negative regulation of transcription, DNA-templated  negative regulation of transcription, DNA-templated  positive regulation of transcription, DNA-templated  positive regulation of transcription, DNA-templated  positive regulation of transcription by RNA polymerase II  positive regulation of transcription by RNA polymerase II  metal ion binding  embryonic camera-type eye morphogenesis  embryonic skeletal system development  embryonic process involved in female pregnancy  definitive hemopoiesis  RNA polymerase II-specific DNA-binding transcription factor binding  sequence-specific double-stranded DNA binding  
Pathways : BIOCARTABIOCARTA_TERTPATHWAY    BIOCARTA_TERCPATHWAY    BIOCARTA_CALCINEURINPATHWAY   
NDEx NetworkSP3
Atlas of Cancer Signalling NetworkSP3
Wikipedia pathwaysSP3
Orthology - Evolution
OrthoDB6670
GeneTree (enSembl)ENSG00000172845
Phylogenetic Trees/Animal Genes : TreeFamSP3
Homologs : HomoloGeneSP3
Homology/Alignments : Family Browser (UCSC)SP3
Gene fusions - Rearrangements
Fusion : MitelmanEWSR1::SP3 [22q12.2/2q31.1]  
Fusion : MitelmanSP3::GPR155 [2q31.1/2q31.1]  
Fusion : MitelmanSP3::OLA1 [2q31.1/2q31.1]  
Fusion : MitelmanSP3::PTK2 [2q31.1/8q24.3]  
Fusion : MitelmanSP3::STK39 [2q31.1/2q24.3]  
Fusion : QuiverSP3
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerSP3 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)SP3
dbVarSP3
ClinVarSP3
MonarchSP3
1000_GenomesSP3 
Exome Variant ServerSP3
GNOMAD BrowserENSG00000172845
Varsome BrowserSP3
ACMGSP3 variants
VarityQ02447
Genomic Variants (DGV)SP3 [DGVbeta]
DECIPHERSP3 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisSP3 
Mutations
ICGC Data PortalSP3 
TCGA Data PortalSP3 
Broad Tumor PortalSP3
OASIS PortalSP3 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICSP3  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DSP3
Mutations and Diseases : HGMDSP3
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaSP3
DgiDB (Drug Gene Interaction Database)SP3
DoCM (Curated mutations)SP3
CIViC (Clinical Interpretations of Variants in Cancer)SP3
Cancer3DSP3
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM601804   
Orphanet
DisGeNETSP3
MedgenSP3
Genetic Testing Registry SP3
NextProtQ02447 [Medical]
GENETestsSP3
Target ValidationSP3
Huge Navigator SP3 [HugePedia]
ClinGenSP3
Clinical trials, drugs, therapy
MyCancerGenomeSP3
Protein Interactions : CTDSP3
Pharm GKB GenePA36045
PharosQ02447
Clinical trialSP3
Miscellaneous
canSAR (ICR)SP3
HarmonizomeSP3
ARCHS4SP3
DataMed IndexSP3
Probes
Litterature
PubMed217 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXSP3
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Thu Jan 20 13:00:21 CET 2022
Home   Genes   Leukemias   Solid Tumors   Cancer-Prone   Deep Insight   Case Reports   Journals  Portal   Teaching   

For comments and suggestions or contributions, please contact us

jlhuret@AtlasGeneticsOncology.org.