SP7 (Sp7 transcription factor)

2011-02-01  

Identity

HGNC
SP7
LOCATION
12q13.13
LOCUSID
121340
ALIAS
OI11,OI12,OSX,osterix

Other Information

Locus ID:

NCBI: 121340
MIM: 606633
HGNC: 17321
Ensembl: ENSG00000170374

Variants:

dbSNP: 121340
ClinVar: 121340
TCGA: ENSG00000170374
COSMIC: SP7

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000170374ENST00000303846Q8TDD2
ENSG00000170374ENST00000536324Q8TDD2
ENSG00000170374ENST00000537210A0A024RAY8
ENSG00000170374ENST00000547755F8VV67

Expression (GTEx)

0
1
2
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
190792622009New sequence variants associated with bone mineral density.123
218808932011MiR-637 maintains the balance between adipocytes and osteoblasts by directly targeting Osterix.66
199271242010Regulation of the osteoblast-specific transcription factor Osterix by NO66, a Jumonji family histone demethylase.65
238274572013MicroRNA expression profiling of human bone marrow mesenchymal stem cells during osteogenic differentiation reveals Osterix regulation by miR-31.63
228693682012Osterix regulates calcification and degradation of chondrogenic matrices through matrix metalloproteinase 13 (MMP13) expression in association with transcription factor Runx2 during endochondral ossification.42
224672002012miR-93/Sp7 function loop mediates osteoblast mineralization.32
126743322003Telomerase accelerates osteogenesis of bone marrow stromal stem cells by upregulation of CBFA1, osterix, and osteocalcin.27
218984062012The transcription factor osterix (SP7) regulates BMP6-induced human osteoblast differentiation.23
251227692014Mitogen-activated protein kinase (MAPK)-regulated interactions between Osterix and Runx2 are critical for the transcriptional osteogenic program.23
231598762013Osterix induces Col1a1 gene expression through binding to Sp1 sites in the bone enhancer and proximal promoter regions.22

Citation

Dessen P

SP7 (Sp7 transcription factor)

Atlas Genet Cytogenet Oncol Haematol. 2011-02-01

Online version: http://atlasgeneticsoncology.org/gene/52051/sp7