Atlas of Genetics and Cytogenetics in Oncology and Haematology


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SPACA3 (sperm acrosome associated 3)

Identity

Alias_symbol (synonym)ALLP17
SLLP1
LYC3
LYZL3
CT54
Other aliasLYZC
HGNC (Hugo) SPACA3
LocusID (NCBI) 124912
Atlas_Id 46382
Location 17q11.2  [Link to chromosome band 17q11]
Location_base_pair Starts at 31319869 and ends at 31324895 bp from pter ( according to hg19-Feb_2009)
Fusion genes
(updated 2016)
ADCY2 (5p15.31) / SPACA3 (17q11.2)PHC3 (3q26.2) / SPACA3 (17q11.2)USP22 (17p11.2) / SPACA3 (17q11.2)
USP22 17p11.2 / SPACA3 17q11.2

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)SPACA3   16260
Cards
Entrez_Gene (NCBI)SPACA3  124912  sperm acrosome associated 3
AliasesALLP17; CT54; LYC3; LYZC; 
LYZL3; SLLP1
GeneCards (Weizmann)SPACA3
Ensembl hg19 (Hinxton)ENSG00000141316 [Gene_View]  chr17:31319869-31324895 [Contig_View]  SPACA3 [Vega]
Ensembl hg38 (Hinxton)ENSG00000141316 [Gene_View]  chr17:31319869-31324895 [Contig_View]  SPACA3 [Vega]
ICGC DataPortalENSG00000141316
TCGA cBioPortalSPACA3
AceView (NCBI)SPACA3
Genatlas (Paris)SPACA3
WikiGenes124912
SOURCE (Princeton)SPACA3
Genetics Home Reference (NIH)SPACA3
Genomic and cartography
GoldenPath hg19 (UCSC)SPACA3  -     chr17:31319869-31324895 +  17q11.2   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)SPACA3  -     17q11.2   [Description]    (hg38-Dec_2013)
EnsemblSPACA3 - 17q11.2 [CytoView hg19]  SPACA3 - 17q11.2 [CytoView hg38]
Mapping of homologs : NCBISPACA3 [Mapview hg19]  SPACA3 [Mapview hg38]
OMIM612749   
Gene and transcription
Genbank (Entrez)AF216311 AY358653 BC029867 BC100886 BC100887
RefSeq transcript (Entrez)NM_001317225 NM_001317226 NM_173847
RefSeq genomic (Entrez)NC_000017 NC_018928 NT_010783 NW_004929407
Consensus coding sequences : CCDS (NCBI)SPACA3
Cluster EST : UnigeneHs.434112 [ NCBI ]
CGAP (NCI)Hs.434112
Alternative Splicing GalleryENSG00000141316
Gene ExpressionSPACA3 [ NCBI-GEO ]   SPACA3 [ EBI - ARRAY_EXPRESS ]   SPACA3 [ SEEK ]   SPACA3 [ MEM ]
Gene Expression Viewer (FireBrowse)SPACA3 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)124912
GTEX Portal (Tissue expression)SPACA3
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ8IXA5   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ8IXA5  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ8IXA5
Splice isoforms : SwissVarQ8IXA5
PhosPhoSitePlusQ8IXA5
Domaine pattern : Prosite (Expaxy)LACTALBUMIN_LYSOZYME_1 (PS00128)    LACTALBUMIN_LYSOZYME_2 (PS51348)   
Domains : Interpro (EBI)Glyco_hydro_22    Glyco_hydro_22_CS    Glyco_hydro_22_lys    Lysozyme-like_dom    LYZL3   
Domain families : Pfam (Sanger)Lys (PF00062)   
Domain families : Pfam (NCBI)pfam00062   
Domain families : Smart (EMBL)LYZ1 (SM00263)  
Conserved Domain (NCBI)SPACA3
DMDM Disease mutations124912
Blocks (Seattle)SPACA3
SuperfamilyQ8IXA5
Human Protein AtlasENSG00000141316
Peptide AtlasQ8IXA5
HPRD15420
IPIIPI00217482   IPI00953057   IPI00790426   IPI00791096   
Protein Interaction databases
DIP (DOE-UCLA)Q8IXA5
IntAct (EBI)Q8IXA5
FunCoupENSG00000141316
BioGRIDSPACA3
STRING (EMBL)SPACA3
ZODIACSPACA3
Ontologies - Pathways
QuickGOQ8IXA5
Ontology : AmiGOacrosomal membrane  lysozyme activity  protein binding  extracellular region  lysosome  peptidoglycan catabolic process  response to virus  integral component of membrane  cell wall macromolecule catabolic process  secretory granule  sperm-egg recognition  monocyte activation  positive regulation of macrophage activation  positive regulation of phagocytosis  defense response to Gram-positive bacterium  
Ontology : EGO-EBIacrosomal membrane  lysozyme activity  protein binding  extracellular region  lysosome  peptidoglycan catabolic process  response to virus  integral component of membrane  cell wall macromolecule catabolic process  secretory granule  sperm-egg recognition  monocyte activation  positive regulation of macrophage activation  positive regulation of phagocytosis  defense response to Gram-positive bacterium  
NDEx NetworkSPACA3
Atlas of Cancer Signalling NetworkSPACA3
Wikipedia pathwaysSPACA3
Orthology - Evolution
OrthoDB124912
GeneTree (enSembl)ENSG00000141316
Phylogenetic Trees/Animal Genes : TreeFamSPACA3
HOVERGENQ8IXA5
HOGENOMQ8IXA5
Homologs : HomoloGeneSPACA3
Homology/Alignments : Family Browser (UCSC)SPACA3
Gene fusions - Rearrangements
Fusion : MitelmanUSP22/SPACA3 [17p11.2/17q11.2]  [t(17;17)(p11;q11)]  
Fusion: TCGAUSP22 17p11.2 SPACA3 17q11.2 BRCA
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerSPACA3 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)SPACA3
dbVarSPACA3
ClinVarSPACA3
1000_GenomesSPACA3 
Exome Variant ServerSPACA3
ExAC (Exome Aggregation Consortium)SPACA3 (select the gene name)
Genetic variants : HAPMAP124912
Genomic Variants (DGV)SPACA3 [DGVbeta]
DECIPHER (Syndromes)17:31319869-31324895  ENSG00000141316
CONAN: Copy Number AnalysisSPACA3 
Mutations
ICGC Data PortalSPACA3 
TCGA Data PortalSPACA3 
Broad Tumor PortalSPACA3
OASIS PortalSPACA3 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICSPACA3  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDSPACA3
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch SPACA3
DgiDB (Drug Gene Interaction Database)SPACA3
DoCM (Curated mutations)SPACA3 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)SPACA3 (select a term)
intoGenSPACA3
Cancer3DSPACA3(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM612749   
Orphanet
MedgenSPACA3
Genetic Testing Registry SPACA3
NextProtQ8IXA5 [Medical]
TSGene124912
GENETestsSPACA3
Huge Navigator SPACA3 [HugePedia]
snp3D : Map Gene to Disease124912
BioCentury BCIQSPACA3
ClinGenSPACA3
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD124912
Chemical/Pharm GKB GenePA38101
Clinical trialSPACA3
Miscellaneous
canSAR (ICR)SPACA3 (select the gene name)
Probes
Litterature
PubMed14 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineSPACA3
EVEXSPACA3
GoPubMedSPACA3
iHOPSPACA3
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Thu Mar 30 15:20:30 CEST 2017

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