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SPACA3 (sperm acrosome associated 3)

Identity

Alias (NCBI)ALLP17
CT54
LYC3
LYZC
LYZL3
SLLP1
HGNC (Hugo) SPACA3
HGNC Alias symbALLP17
SLLP1
LYC3
LYZL3
CT54
HGNC Alias namecancer/testis antigen 54
 sperm lyzozyme-like acrosomal protein 1
LocusID (NCBI) 124912
Atlas_Id 46382
Location 17q11.2  [Link to chromosome band 17q11]
Location_base_pair Starts at 32991847 and ends at 32997877 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
ADCY2 (5p15.31) / SPACA3 (17q11.2)PHC3 (3q26.2) / SPACA3 (17q11.2)USP22 (17p11.2) / SPACA3 (17q11.2)
USP22 17p11.2 / SPACA3 17q11.2

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



External links

 

Nomenclature
HGNC (Hugo)SPACA3   16260
Cards
Entrez_Gene (NCBI)SPACA3    sperm acrosome associated 3
AliasesALLP17; CT54; LYC3; LYZC; 
LYZL3; SLLP1
GeneCards (Weizmann)SPACA3
Ensembl hg19 (Hinxton)ENSG00000141316 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000141316 [Gene_View]  ENSG00000141316 [Sequence]  chr17:32991847-32997877 [Contig_View]  SPACA3 [Vega]
ICGC DataPortalENSG00000141316
TCGA cBioPortalSPACA3
AceView (NCBI)SPACA3
Genatlas (Paris)SPACA3
SOURCE (Princeton)SPACA3
Genetics Home Reference (NIH)SPACA3
Genomic and cartography
GoldenPath hg38 (UCSC)SPACA3  -     chr17:32991847-32997877 +  17q11.2   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)SPACA3  -     17q11.2   [Description]    (hg19-Feb_2009)
GoldenPathSPACA3 - 17q11.2 [CytoView hg19]  SPACA3 - 17q11.2 [CytoView hg38]
ImmunoBaseENSG00000141316
Genome Data Viewer NCBISPACA3 [Mapview hg19]  
OMIM612749   
Gene and transcription
Genbank (Entrez)AF216311 AY358653 BC029867 BC100886 BC100887
RefSeq transcript (Entrez)NM_001317225 NM_001317226 NM_173847
Consensus coding sequences : CCDS (NCBI)SPACA3
Gene ExpressionSPACA3 [ NCBI-GEO ]   SPACA3 [ EBI - ARRAY_EXPRESS ]   SPACA3 [ SEEK ]   SPACA3 [ MEM ]
Gene Expression Viewer (FireBrowse)SPACA3 [ Firebrowse - Broad ]
GenevisibleExpression of SPACA3 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)124912
GTEX Portal (Tissue expression)SPACA3
Human Protein AtlasENSG00000141316-SPACA3 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ8IXA5   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ8IXA5  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ8IXA5
PhosPhoSitePlusQ8IXA5
Domaine pattern : Prosite (Expaxy)GLYCOSYL_HYDROL_F22_1 (PS00128)    GLYCOSYL_HYDROL_F22_2 (PS51348)   
Domains : Interpro (EBI)Glyco_hydro_22    Glyco_hydro_22_CS    Glyco_hydro_22_lys    Lysozyme-like_dom_sf    LYZL3   
Domain families : Pfam (Sanger)Lys (PF00062)   
Domain families : Pfam (NCBI)pfam00062   
Domain families : Smart (EMBL)LYZ1 (SM00263)  
Conserved Domain (NCBI)SPACA3
SuperfamilyQ8IXA5
AlphaFold pdb e-kbQ8IXA5   
Human Protein Atlas [tissue]ENSG00000141316-SPACA3 [tissue]
HPRD15420
Protein Interaction databases
DIP (DOE-UCLA)Q8IXA5
IntAct (EBI)Q8IXA5
BioGRIDSPACA3
STRING (EMBL)SPACA3
ZODIACSPACA3
Ontologies - Pathways
QuickGOQ8IXA5
Ontology : AmiGOacrosomal vesicle  acrosomal membrane  lysozyme activity  protein binding  extracellular region  fusion of sperm to egg plasma membrane involved in single fertilization  fusion of sperm to egg plasma membrane involved in single fertilization  integral component of membrane  secretory granule  sperm-egg recognition  sperm flagellum  monocyte activation  positive regulation of macrophage activation  acrosomal matrix  positive regulation of phagocytosis  
Ontology : EGO-EBIacrosomal vesicle  acrosomal membrane  lysozyme activity  protein binding  extracellular region  fusion of sperm to egg plasma membrane involved in single fertilization  fusion of sperm to egg plasma membrane involved in single fertilization  integral component of membrane  secretory granule  sperm-egg recognition  sperm flagellum  monocyte activation  positive regulation of macrophage activation  acrosomal matrix  positive regulation of phagocytosis  
NDEx NetworkSPACA3
Atlas of Cancer Signalling NetworkSPACA3
Wikipedia pathwaysSPACA3
Orthology - Evolution
OrthoDB124912
GeneTree (enSembl)ENSG00000141316
Phylogenetic Trees/Animal Genes : TreeFamSPACA3
Homologs : HomoloGeneSPACA3
Homology/Alignments : Family Browser (UCSC)SPACA3
Gene fusions - Rearrangements
Fusion : MitelmanUSP22/SPACA3 [17p11.2/17q11.2]  
Fusion : QuiverSPACA3
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerSPACA3 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)SPACA3
dbVarSPACA3
ClinVarSPACA3
MonarchSPACA3
1000_GenomesSPACA3 
Exome Variant ServerSPACA3
GNOMAD BrowserENSG00000141316
Varsome BrowserSPACA3
ACMGSPACA3 variants
VarityQ8IXA5
Genomic Variants (DGV)SPACA3 [DGVbeta]
DECIPHERSPACA3 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisSPACA3 
Mutations
ICGC Data PortalSPACA3 
TCGA Data PortalSPACA3 
Broad Tumor PortalSPACA3
OASIS PortalSPACA3 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICSPACA3  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DSPACA3
Mutations and Diseases : HGMDSPACA3
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaSPACA3
DgiDB (Drug Gene Interaction Database)SPACA3
DoCM (Curated mutations)SPACA3
CIViC (Clinical Interpretations of Variants in Cancer)SPACA3
Cancer3DSPACA3
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM612749   
Orphanet
DisGeNETSPACA3
MedgenSPACA3
Genetic Testing Registry SPACA3
NextProtQ8IXA5 [Medical]
GENETestsSPACA3
Target ValidationSPACA3
Huge Navigator SPACA3 [HugePedia]
ClinGenSPACA3
Clinical trials, drugs, therapy
MyCancerGenomeSPACA3
Protein Interactions : CTDSPACA3
Pharm GKB GenePA38101
PharosQ8IXA5
Clinical trialSPACA3
Miscellaneous
canSAR (ICR)SPACA3
HarmonizomeSPACA3
DataMed IndexSPACA3
Probes
Litterature
PubMed13 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXSPACA3
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Oct 4 15:32:44 CEST 2021

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