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SPAG5 (sperm associated antigen 5)

Identity

Alias (NCBI)DEEPEST
MAP126
hMAP126
HGNC (Hugo) SPAG5
HGNC Alias symbDEEPEST
MAP126
hMAP126
HGNC Alias namemitotic spindle coiled-coil related protein
 astrin
 mitotic spindle associated protein p126
LocusID (NCBI) 10615
Atlas_Id 54948
Location 17q11.2  [Link to chromosome band 17q11]
Location_base_pair Starts at 28577574 and ends at 28599025 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
CDC42BPB (14q32.32) / SPAG5 (17q11.2)PIGS (17q11.2) / SPAG5 (17q11.2)PPM1E (17q22) / SPAG5 (17q11.2)
SPAG5 (17q11.2) / BLMH (17q11.2)SPAG5 (17q11.2) / SLC47A1 (17p11.2)SPAG5 (17q11.2) / SPAG5 (17q11.2)
PIGS 17q11.2 / SPAG5 17q11.2PPM1E 17q22 / SPAG5 17q11.2SPAG5 17q11.2 / BLMH 17q11.2
SPAG5 17q11.2 / SLC47A1 17p11.2

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



External links

 

Nomenclature
HGNC (Hugo)SPAG5   13452
Cards
Entrez_Gene (NCBI)SPAG5    sperm associated antigen 5
AliasesDEEPEST; MAP126; hMAP126
GeneCards (Weizmann)SPAG5
Ensembl hg19 (Hinxton)ENSG00000076382 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000076382 [Gene_View]  ENSG00000076382 [Sequence]  chr17:28577574-28599025 [Contig_View]  SPAG5 [Vega]
ICGC DataPortalENSG00000076382
TCGA cBioPortalSPAG5
AceView (NCBI)SPAG5
Genatlas (Paris)SPAG5
SOURCE (Princeton)SPAG5
Genetics Home Reference (NIH)SPAG5
Genomic and cartography
GoldenPath hg38 (UCSC)SPAG5  -     chr17:28577574-28599025 -  17q11.2   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)SPAG5  -     17q11.2   [Description]    (hg19-Feb_2009)
GoldenPathSPAG5 - 17q11.2 [CytoView hg19]  SPAG5 - 17q11.2 [CytoView hg38]
ImmunoBaseENSG00000076382
Genome Data Viewer NCBISPAG5 [Mapview hg19]  
OMIM615562   
Gene and transcription
Genbank (Entrez)AF063308 AF345347 AF399910 AK025725 AK292398
RefSeq transcript (Entrez)NM_006461
Consensus coding sequences : CCDS (NCBI)SPAG5
Gene ExpressionSPAG5 [ NCBI-GEO ]   SPAG5 [ EBI - ARRAY_EXPRESS ]   SPAG5 [ SEEK ]   SPAG5 [ MEM ]
Gene Expression Viewer (FireBrowse)SPAG5 [ Firebrowse - Broad ]
GenevisibleExpression of SPAG5 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)10615
GTEX Portal (Tissue expression)SPAG5
Human Protein AtlasENSG00000076382-SPAG5 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ96R06   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ96R06  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ96R06
PhosPhoSitePlusQ96R06
Domains : Interpro (EBI)Astrin   
Domain families : Pfam (Sanger)
Domain families : Pfam (NCBI)
Conserved Domain (NCBI)SPAG5
SuperfamilyQ96R06
AlphaFold pdb e-kbQ96R06   
Human Protein Atlas [tissue]ENSG00000076382-SPAG5 [tissue]
HPRD10246
Protein Interaction databases
DIP (DOE-UCLA)Q96R06
IntAct (EBI)Q96R06
BioGRIDSPAG5
STRING (EMBL)SPAG5
ZODIACSPAG5
Ontologies - Pathways
QuickGOQ96R06
Ontology : AmiGOmitotic sister chromatid segregation  kinetochore  protein binding  cytoplasm  cytosol  spindle organization  chromosome segregation  microtubule binding  nuclear body  midbody  positive regulation of intracellular transport  centriolar satellite  ciliary rootlet  microtubule plus-end  ciliary basal body  establishment of spindle orientation  cell division  regulation of attachment of spindle microtubules to kinetochore  protein localization to centrosome  mitotic spindle  regulation of metaphase plate congression  mitotic spindle pole  positive regulation of spindle assembly  
Ontology : EGO-EBImitotic sister chromatid segregation  kinetochore  protein binding  cytoplasm  cytosol  spindle organization  chromosome segregation  microtubule binding  nuclear body  midbody  positive regulation of intracellular transport  centriolar satellite  ciliary rootlet  microtubule plus-end  ciliary basal body  establishment of spindle orientation  cell division  regulation of attachment of spindle microtubules to kinetochore  protein localization to centrosome  mitotic spindle  regulation of metaphase plate congression  mitotic spindle pole  positive regulation of spindle assembly  
NDEx NetworkSPAG5
Atlas of Cancer Signalling NetworkSPAG5
Wikipedia pathwaysSPAG5
Orthology - Evolution
OrthoDB10615
GeneTree (enSembl)ENSG00000076382
Phylogenetic Trees/Animal Genes : TreeFamSPAG5
Homologs : HomoloGeneSPAG5
Homology/Alignments : Family Browser (UCSC)SPAG5
Gene fusions - Rearrangements
Fusion : MitelmanPIGS/SPAG5 [17q11.2/17q11.2]  
Fusion : MitelmanPPM1E/SPAG5 [17q22/17q11.2]  
Fusion : MitelmanSPAG5/BLMH [17q11.2/17q11.2]  
Fusion : MitelmanSPAG5/SLC47A1 [17q11.2/17p11.2]  
Fusion : QuiverSPAG5
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerSPAG5 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)SPAG5
dbVarSPAG5
ClinVarSPAG5
MonarchSPAG5
1000_GenomesSPAG5 
Exome Variant ServerSPAG5
GNOMAD BrowserENSG00000076382
Varsome BrowserSPAG5
ACMGSPAG5 variants
VarityQ96R06
Genomic Variants (DGV)SPAG5 [DGVbeta]
DECIPHERSPAG5 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisSPAG5 
Mutations
ICGC Data PortalSPAG5 
TCGA Data PortalSPAG5 
Broad Tumor PortalSPAG5
OASIS PortalSPAG5 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICSPAG5  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DSPAG5
Mutations and Diseases : HGMDSPAG5
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaSPAG5
DgiDB (Drug Gene Interaction Database)SPAG5
DoCM (Curated mutations)SPAG5
CIViC (Clinical Interpretations of Variants in Cancer)SPAG5
Cancer3DSPAG5
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM615562   
Orphanet
DisGeNETSPAG5
MedgenSPAG5
Genetic Testing Registry SPAG5
NextProtQ96R06 [Medical]
GENETestsSPAG5
Target ValidationSPAG5
Huge Navigator SPAG5 [HugePedia]
ClinGenSPAG5
Clinical trials, drugs, therapy
MyCancerGenomeSPAG5
Protein Interactions : CTDSPAG5
Pharm GKB GenePA134868542
PharosQ96R06
Clinical trialSPAG5
Miscellaneous
canSAR (ICR)SPAG5
HarmonizomeSPAG5
DataMed IndexSPAG5
Probes
Litterature
PubMed81 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXSPAG5
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Oct 4 15:32:45 CEST 2021

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