Atlas of Genetics and Cytogenetics in Oncology and Haematology


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SPAG9 (sperm associated antigen 9)

Identity

Alias_symbol (synonym)HSS
SYD1
KIAA0516
MGC14967
MGC74461
MGC117291
JLP
PHET
HLC4
PIG6
FLJ13450
FLJ14006
FLJ26141
FLJ34602
CT89
Other aliasHLC-6
HLC6
JIP-4
JIP4
HGNC (Hugo) SPAG9
LocusID (NCBI) 9043
Atlas_Id 43500
Location 17q21.33  [Link to chromosome band 17q21]
Location_base_pair Starts at 50962174 and ends at 51120865 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
ACSF2 (17q21.33) / SPAG9 (17q21.33)LRRC59 (17q21.33) / SPAG9 (17q21.33)MKS1 (17q22) / SPAG9 (17q21.33)
NGFR (17q21.33) / SPAG9 (17q21.33)SPAG9 (17q21.33) / CLYBL (13q32.3)SPAG9 (17q21.33) / FAM117A (17q21.33)
SPAG9 (17q21.33) / JAK2 (9p24.1)SPAG9 (17q21.33) / LRRC59 (17q21.33)SPAG9 (17q21.33) / MBTD1 (17q21.33)
SPAG9 (17q21.33) / NGFR (17q21.33)SPAG9 (17q21.33) / PARP6 (15q23)SPAG9 (17q21.33) / PCMT1 (6q25.1)
SPAG9 (17q21.33) / RHBDD1 (2q36.3)SPAG9 (17q21.33) / SKAP1 (17q21.32)SPAG9 (17q21.33) / SPAG9 (17q21.33)
SPAG9 (17q21.33) / TSN (2q14.3)SPAG9 (17q21.33) / VIM (10p13)TANC2 (17q23.2) / SPAG9 (17q21.33)
ACSF2 17q21.33 / SPAG9 17q21.33LRRC59 17q21.33 / SPAG9 17q21.33MKS1 17q22 / SPAG9 17q21.33
SPAG9 17q21.33 / CLYBL 13q32.3SPAG9 17q21.33 / FAM117A 17q21.33SPAG9 17q21.33 / MBTD1 17q21.33
SPAG9 17q21.33 / PCMT1 6q25.1SPAG9 17q21.33 / SKAP1 17q21.32TANC2 17q23.2 / SPAG9 17q21.33

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)SPAG9   14524
Cards
Entrez_Gene (NCBI)SPAG9  9043  sperm associated antigen 9
AliasesCT89; HLC-6; HLC4; HLC6; 
JIP-4; JIP4; JLP; PHET; PIG6
GeneCards (Weizmann)SPAG9
Ensembl hg19 (Hinxton)ENSG00000008294 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000008294 [Gene_View]  chr17:50962174-51120865 [Contig_View]  SPAG9 [Vega]
ICGC DataPortalENSG00000008294
TCGA cBioPortalSPAG9
AceView (NCBI)SPAG9
Genatlas (Paris)SPAG9
WikiGenes9043
SOURCE (Princeton)SPAG9
Genetics Home Reference (NIH)SPAG9
Genomic and cartography
GoldenPath hg38 (UCSC)SPAG9  -     chr17:50962174-51120865 -  17q21.33   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)SPAG9  -     17q21.33   [Description]    (hg19-Feb_2009)
EnsemblSPAG9 - 17q21.33 [CytoView hg19]  SPAG9 - 17q21.33 [CytoView hg38]
Mapping of homologs : NCBISPAG9 [Mapview hg19]  SPAG9 [Mapview hg38]
OMIM605430   
Gene and transcription
Genbank (Entrez)AB011088 AF327452 AF542172 AK023512 AK024068
RefSeq transcript (Entrez)NM_001130527 NM_001130528 NM_001251971 NM_003971 NM_172345
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)SPAG9
Cluster EST : UnigeneHs.463439 [ NCBI ]
CGAP (NCI)Hs.463439
Alternative Splicing GalleryENSG00000008294
Gene ExpressionSPAG9 [ NCBI-GEO ]   SPAG9 [ EBI - ARRAY_EXPRESS ]   SPAG9 [ SEEK ]   SPAG9 [ MEM ]
Gene Expression Viewer (FireBrowse)SPAG9 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)9043
GTEX Portal (Tissue expression)SPAG9
Protein : pattern, domain, 3D structure
UniProt/SwissProtO60271   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtO60271  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProO60271
Splice isoforms : SwissVarO60271
PhosPhoSitePlusO60271
Domaine pattern : Prosite (Expaxy)RH1 (PS51776)    RH2 (PS51777)   
Domains : Interpro (EBI)JIP_LZII    JNK/Rab-associated_protein-1_N    WD40/YVTN_repeat-like_dom    WD40_repeat_dom   
Domain families : Pfam (Sanger)JIP_LZII (PF16471)    Jnk-SapK_ap_N (PF09744)   
Domain families : Pfam (NCBI)pfam16471    pfam09744   
Conserved Domain (NCBI)SPAG9
DMDM Disease mutations9043
Blocks (Seattle)SPAG9
PDB (SRS)2W83   
PDB (PDBSum)2W83   
PDB (IMB)2W83   
PDB (RSDB)2W83   
Structural Biology KnowledgeBase2W83   
SCOP (Structural Classification of Proteins)2W83   
CATH (Classification of proteins structures)2W83   
SuperfamilyO60271
Human Protein AtlasENSG00000008294
Peptide AtlasO60271
HPRD10398
IPIIPI00744648   IPI00384432   IPI00879552   IPI00479676   IPI00744288   IPI00303397   IPI00748244   IPI00748833   IPI01018638   IPI00385301   IPI00218097   IPI00745406   IPI01011459   IPI00965149   IPI00976669   IPI00984866   
Protein Interaction databases
DIP (DOE-UCLA)O60271
IntAct (EBI)O60271
FunCoupENSG00000008294
BioGRIDSPAG9
STRING (EMBL)SPAG9
ZODIACSPAG9
Ontologies - Pathways
QuickGOO60271
Ontology : AmiGOacrosomal vesicle  MAP-kinase scaffold activity  protein binding  cytoplasm  microtubule organizing center  cytosol  cytosol  activation of JUN kinase activity  spermatogenesis  JUN kinase binding  integral component of membrane  kinesin binding  receptor signaling complex scaffold activity  positive regulation of cell migration  retrograde transport, endosome to Golgi  positive regulation of neuron differentiation  mitogen-activated protein kinase p38 binding  perinuclear region of cytoplasm  striated muscle cell differentiation  positive regulation of muscle cell differentiation  protein homooligomerization  extracellular exosome  negative regulation of protein homodimerization activity  
Ontology : EGO-EBIacrosomal vesicle  MAP-kinase scaffold activity  protein binding  cytoplasm  microtubule organizing center  cytosol  cytosol  activation of JUN kinase activity  spermatogenesis  JUN kinase binding  integral component of membrane  kinesin binding  receptor signaling complex scaffold activity  positive regulation of cell migration  retrograde transport, endosome to Golgi  positive regulation of neuron differentiation  mitogen-activated protein kinase p38 binding  perinuclear region of cytoplasm  striated muscle cell differentiation  positive regulation of muscle cell differentiation  protein homooligomerization  extracellular exosome  negative regulation of protein homodimerization activity  
NDEx NetworkSPAG9
Atlas of Cancer Signalling NetworkSPAG9
Wikipedia pathwaysSPAG9
Orthology - Evolution
OrthoDB9043
GeneTree (enSembl)ENSG00000008294
Phylogenetic Trees/Animal Genes : TreeFamSPAG9
HOVERGENO60271
HOGENOMO60271
Homologs : HomoloGeneSPAG9
Homology/Alignments : Family Browser (UCSC)SPAG9
Gene fusions - Rearrangements
Fusion : MitelmanACSF2/SPAG9 [17q21.33/17q21.33]  [t(17;17)(q21;q21)]  
Fusion : MitelmanLRRC59/SPAG9 [17q21.33/17q21.33]  [t(17;17)(q21;q21)]  
Fusion : MitelmanMKS1/SPAG9 [17q22/17q21.33]  [t(17;17)(q21;q22)]  
Fusion : MitelmanSPAG9/CLYBL [17q21.33/13q32.3]  [t(13;17)(q32;q21)]  
Fusion : MitelmanSPAG9/FAM117A [17q21.33/17q21.33]  [t(17;17)(q21;q21)]  
Fusion : MitelmanSPAG9/JAK2 [17q21.33/9p24.1]  [t(9;17)(p24;q21)]  
Fusion : MitelmanSPAG9/MBTD1 [17q21.33/17q21.33]  [t(17;17)(q21;q21)]  
Fusion : MitelmanSPAG9/PCMT1 [17q21.33/6q25.1]  [t(6;17)(q25;q21)]  
Fusion : MitelmanSPAG9/SKAP1 [17q21.33/17q21.32]  [t(17;17)(q21;q21)]  
Fusion : MitelmanTANC2/SPAG9 [17q23.2/17q21.33]  [t(17;17)(q21;q23)]  
Fusion: TCGAACSF2 17q21.33 SPAG9 17q21.33 BRCA
Fusion: TCGALRRC59 17q21.33 SPAG9 17q21.33 BRCA
Fusion: TCGAMKS1 17q22 SPAG9 17q21.33 BRCA
Fusion: TCGASPAG9 17q21.33 CLYBL 13q32.3 LGG
Fusion: TCGASPAG9 17q21.33 FAM117A 17q21.33 BRCA
Fusion: TCGASPAG9 17q21.33 MBTD1 17q21.33 OV
Fusion: TCGASPAG9 17q21.33 PCMT1 6q25.1 BLCA
Fusion: TCGASPAG9 17q21.33 SKAP1 17q21.32 BRCA
Fusion: TCGATANC2 17q23.2 SPAG9 17q21.33 LUAD
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerSPAG9 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)SPAG9
dbVarSPAG9
ClinVarSPAG9
1000_GenomesSPAG9 
Exome Variant ServerSPAG9
ExAC (Exome Aggregation Consortium)SPAG9 (select the gene name)
Genetic variants : HAPMAP9043
Genomic Variants (DGV)SPAG9 [DGVbeta]
DECIPHERSPAG9 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisSPAG9 
Mutations
ICGC Data PortalSPAG9 
TCGA Data PortalSPAG9 
Broad Tumor PortalSPAG9
OASIS PortalSPAG9 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICSPAG9  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDSPAG9
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch SPAG9
DgiDB (Drug Gene Interaction Database)SPAG9
DoCM (Curated mutations)SPAG9 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)SPAG9 (select a term)
intoGenSPAG9
Cancer3DSPAG9(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM605430   
Orphanet
MedgenSPAG9
Genetic Testing Registry SPAG9
NextProtO60271 [Medical]
TSGene9043
GENETestsSPAG9
Target ValidationSPAG9
Huge Navigator SPAG9 [HugePedia]
snp3D : Map Gene to Disease9043
BioCentury BCIQSPAG9
ClinGenSPAG9
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD9043
Chemical/Pharm GKB GenePA37890
Clinical trialSPAG9
Miscellaneous
canSAR (ICR)SPAG9 (select the gene name)
Probes
Litterature
PubMed69 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineSPAG9
EVEXSPAG9
GoPubMedSPAG9
iHOPSPAG9
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Mon Sep 18 14:08:15 CEST 2017

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