SPARCL1 (SPARC like 1)

2003-05-01  

Identity

HGNC
SPARCL1
LOCATION
4q22.1
LOCUSID
8404
ALIAS
MAST
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 8404
MIM: 606041
HGNC: 11220
Ensembl: ENSG00000152583

Variants:

dbSNP: 8404
ClinVar: 8404
TCGA: ENSG00000152583
COSMIC: SPARCL1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000152583ENST00000282470Q14515
ENSG00000152583ENST00000282470A0A024RDE1
ENSG00000152583ENST00000418378Q14515
ENSG00000152583ENST00000418378A0A024RDE1
ENSG00000152583ENST00000434434C9JJR8
ENSG00000152583ENST00000458304E7EU82
ENSG00000152583ENST00000503414Q14515
ENSG00000152583ENST00000509407E9PC64
ENSG00000152583ENST00000512317D6RA29
ENSG00000152583ENST00000535835F5H331
ENSG00000152583ENST00000541496F5H1Y9
ENSG00000152583ENST00000543631F5H4Y3

Expression (GTEx)

0
500
1000
1500
2000
2500
3000
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
183840592008Association analysis of schizophrenia on 18 genes involved in neuronal migration: MDGA1 as a new susceptibility gene.44
198345352009Sequential use of transcriptional profiling, expression quantitative trait mapping, and gene association implicates MMP20 in human kidney aging.27
202374962010New genetic associations detected in a host response study to hepatitis B vaccine.27
168446962006Matricellular hevin regulates decorin production and collagen assembly.25
229273972012Secreted protein, acidic and rich in cysteine-like 1 (SPARCL1) is down regulated in aggressive prostate cancers and is prognostic for poor clinical outcome.24
215280832011SPARCL1, Shp2, MSH2, E-cadherin, p53, ADCY-2 and MAPK are prognosis-related in colorectal cancer.18
228911982012Secreted protein acidic and rich in cysteines-like 1 suppresses aggressiveness and predicts better survival in colorectal cancers.18
239161352013SPARCL1 suppresses metastasis in prostate cancer.15
290842112018SPARCL1 suppresses osteosarcoma metastasis and recruits macrophages by activation of canonical WNT/β-catenin signaling through stabilization of the WNT-receptor complex.15
163166242006Interaction of myocilin with the C-terminal region of hevin.14

Citation

Dessen P

SPARCL1 (SPARC like 1)

Atlas Genet Cytogenet Oncol Haematol. 2003-05-01

Online version: http://atlasgeneticsoncology.org/gene/42370/sparcl1