SPATA2 (spermatogenesis associated 2)

2010-06-01  

Identity

HGNC
LOCATION
20q13.13
LOCUSID
ALIAS
PD1,PPP1R145,tamo

Other Information

Locus ID:

NCBI: 9825
MIM: 607662
HGNC: 14681
Ensembl: ENSG00000158480

Variants:

dbSNP: 9825
ClinVar: 9825
TCGA: ENSG00000158480
COSMIC: SPATA2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000158480ENST00000289431Q9UM82
ENSG00000158480ENST00000422556Q9UM82

Expression (GTEx)

0
5
10
15
20
25
30
35
40

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
203858102010Tumor-infiltrating NY-ESO-1-specific CD8+ T cells are negatively regulated by LAG-3 and PD-1 in human ovarian cancer.243
273074912016SPATA2 links CYLD to the TNF-α receptor signaling complex and modulates the receptor signaling outcomes.40
275458782016SPATA2-Mediated Binding of CYLD to HOIP Enables CYLD Recruitment to Signaling Complexes.35
275910492016SPATA2 Links CYLD to LUBAC, Activates CYLD, and Controls LUBAC Signaling.35
250934962014PD-1(+) CD8(+) T cells are exhausted in tumours and functional in draining lymph nodes of colorectal cancer patients.34
274582372016SPATA2 promotes CYLD activity and regulates TNF-induced NF-κB signaling and cell death.30
196054922009Upregulation of interleukin 7 receptor alpha and programmed death 1 marks an epitope-specific CD8+ T-cell response that disappears following primary Epstein-Barr virus infection.11
252641252014Investigating the genetic association of HCP5, SPATA2, TNIP1, TNFAIP3 and COG6 with psoriasis in Chinese population.7
306978742019Tumor necrosis factor receptor modulator spermatogenesis-associated protein 2 is a novel predictor of outcome in ovarian cancer.3
125314782003Cloning and characterization of the promoter region of human spata2 (spermatogenesis-associated protein 2) gene.1

Citation

Dessen P

SPATA2 (spermatogenesis associated 2)

Atlas Genet Cytogenet Oncol Haematol. 2010-06-01

Online version: http://atlasgeneticsoncology.org/gene/51535/spata2