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SPCS1 (signal peptidase complex subunit 1)

Identity

Alias_namessignal peptidase complex subunit 1 homolog (S. cerevisiae)
Alias_symbol (synonym)SPC12
HSPC033
YJR010C-A
SPC1
Other alias
HGNC (Hugo) SPCS1
LocusID (NCBI) 28972
Atlas_Id 54661
Location 3p21.1  [Link to chromosome band 3p21]
Location_base_pair Starts at 52705841 and ends at 52708181 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
CIB1 (15q26.1) / SPCS1 (3p21.1)SDC4 (20q13.12) / SPCS1 (3p21.1)SPCS1 (3p21.1) / EBNA1BP2 (1p34.2)
SPCS1 (3p21.1) / NTM (11q25)SPCS1 (3p21.1) / RPL4 (15q22.31)SDC4 20q13.12 / SPCS1 3p21.1

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)SPCS1   23401
Cards
Entrez_Gene (NCBI)SPCS1  28972  signal peptidase complex subunit 1
AliasesHSPC033; SPC1; SPC12; YJR010C-A
GeneCards (Weizmann)SPCS1
Ensembl hg19 (Hinxton)ENSG00000114902 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000114902 [Gene_View]  chr3:52705841-52708181 [Contig_View]  SPCS1 [Vega]
ICGC DataPortalENSG00000114902
TCGA cBioPortalSPCS1
AceView (NCBI)SPCS1
Genatlas (Paris)SPCS1
WikiGenes28972
SOURCE (Princeton)SPCS1
Genetics Home Reference (NIH)SPCS1
Genomic and cartography
GoldenPath hg38 (UCSC)SPCS1  -     chr3:52705841-52708181 +  3p21.1   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)SPCS1  -     3p21.1   [Description]    (hg19-Feb_2009)
EnsemblSPCS1 - 3p21.1 [CytoView hg19]  SPCS1 - 3p21.1 [CytoView hg38]
Mapping of homologs : NCBISPCS1 [Mapview hg19]  SPCS1 [Mapview hg38]
OMIM610358   
Gene and transcription
Genbank (Entrez)AF092138 AK027426 AX775783 AX775785 AX775787
RefSeq transcript (Entrez)NM_014041
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)SPCS1
Cluster EST : UnigeneHs.297304 [ NCBI ]
CGAP (NCI)Hs.297304
Alternative Splicing GalleryENSG00000114902
Gene ExpressionSPCS1 [ NCBI-GEO ]   SPCS1 [ EBI - ARRAY_EXPRESS ]   SPCS1 [ SEEK ]   SPCS1 [ MEM ]
Gene Expression Viewer (FireBrowse)SPCS1 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)28972
GTEX Portal (Tissue expression)SPCS1
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9Y6A9   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9Y6A9  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9Y6A9
Splice isoforms : SwissVarQ9Y6A9
Catalytic activity : Enzyme3.4.-.- [ Enzyme-Expasy ]   3.4.-.-3.4.-.- [ IntEnz-EBI ]   3.4.-.- [ BRENDA ]   3.4.-.- [ KEGG ]   
PhosPhoSitePlusQ9Y6A9
Domains : Interpro (EBI)SPC12   
Domain families : Pfam (Sanger)SPC12 (PF06645)   
Domain families : Pfam (NCBI)pfam06645   
Conserved Domain (NCBI)SPCS1
DMDM Disease mutations28972
Blocks (Seattle)SPCS1
SuperfamilyQ9Y6A9
Human Protein AtlasENSG00000114902
Peptide AtlasQ9Y6A9
IPIIPI00924556   IPI00977009   
Protein Interaction databases
DIP (DOE-UCLA)Q9Y6A9
IntAct (EBI)Q9Y6A9
FunCoupENSG00000114902
BioGRIDSPCS1
STRING (EMBL)SPCS1
ZODIACSPCS1
Ontologies - Pathways
QuickGOQ9Y6A9
Ontology : AmiGOmolecular_function  protein binding  signal peptidase complex  endoplasmic reticulum membrane  signal peptide processing  proteolysis  peptidase activity  integral component of endoplasmic reticulum membrane  organelle membrane  protein targeting to ER  
Ontology : EGO-EBImolecular_function  protein binding  signal peptidase complex  endoplasmic reticulum membrane  signal peptide processing  proteolysis  peptidase activity  integral component of endoplasmic reticulum membrane  organelle membrane  protein targeting to ER  
Pathways : KEGGProtein export   
NDEx NetworkSPCS1
Atlas of Cancer Signalling NetworkSPCS1
Wikipedia pathwaysSPCS1
Orthology - Evolution
OrthoDB28972
GeneTree (enSembl)ENSG00000114902
Phylogenetic Trees/Animal Genes : TreeFamSPCS1
HOVERGENQ9Y6A9
HOGENOMQ9Y6A9
Homologs : HomoloGeneSPCS1
Homology/Alignments : Family Browser (UCSC)SPCS1
Gene fusions - Rearrangements
Fusion : MitelmanSDC4/SPCS1 [20q13.12/3p21.1]  [t(3;20)(p21;q12)]  
Fusion: TCGASDC4 20q13.12 SPCS1 3p21.1 GBM
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerSPCS1 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)SPCS1
dbVarSPCS1
ClinVarSPCS1
1000_GenomesSPCS1 
Exome Variant ServerSPCS1
ExAC (Exome Aggregation Consortium)SPCS1 (select the gene name)
Genetic variants : HAPMAP28972
Genomic Variants (DGV)SPCS1 [DGVbeta]
DECIPHERSPCS1 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisSPCS1 
Mutations
ICGC Data PortalSPCS1 
TCGA Data PortalSPCS1 
Broad Tumor PortalSPCS1
OASIS PortalSPCS1 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICSPCS1  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDSPCS1
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch SPCS1
DgiDB (Drug Gene Interaction Database)SPCS1
DoCM (Curated mutations)SPCS1 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)SPCS1 (select a term)
intoGenSPCS1
Cancer3DSPCS1(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM610358   
Orphanet
MedgenSPCS1
Genetic Testing Registry SPCS1
NextProtQ9Y6A9 [Medical]
TSGene28972
GENETestsSPCS1
Target ValidationSPCS1
Huge Navigator SPCS1 [HugePedia]
snp3D : Map Gene to Disease28972
BioCentury BCIQSPCS1
ClinGenSPCS1
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD28972
Chemical/Pharm GKB GenePA134972486
Clinical trialSPCS1
Miscellaneous
canSAR (ICR)SPCS1 (select the gene name)
Probes
Litterature
PubMed13 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineSPCS1
EVEXSPCS1
GoPubMedSPCS1
iHOPSPCS1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Sep 25 19:32:42 CEST 2017

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