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SPCS2 (signal peptidase complex subunit 2)

Identity

Alias_namessignal peptidase complex subunit 2 homolog (S. cerevisiae)
Alias_symbol (synonym)KIAA0102
Other alias-
HGNC (Hugo) SPCS2
LocusID (NCBI) 9789
Atlas_Id 74154
Location 11q13.4  [Link to chromosome band 11q13]
Location_base_pair Starts at 74949247 and ends at 74979031 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
SPCS2 (11q13.4) / COL5A1 (9q34.3)SPCS2 (11q13.4) / SUMO1 (2q33.1)XRRA1 (11q13.4) / SPCS2 (11q13.4)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)SPCS2   28962
Cards
Entrez_Gene (NCBI)SPCS2  9789  signal peptidase complex subunit 2
Aliases
GeneCards (Weizmann)SPCS2
Ensembl hg19 (Hinxton)ENSG00000118363 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000118363 [Gene_View]  chr11:74949247-74979031 [Contig_View]  SPCS2 [Vega]
ICGC DataPortalENSG00000118363
TCGA cBioPortalSPCS2
AceView (NCBI)SPCS2
Genatlas (Paris)SPCS2
WikiGenes9789
SOURCE (Princeton)SPCS2
Genetics Home Reference (NIH)SPCS2
Genomic and cartography
GoldenPath hg38 (UCSC)SPCS2  -     chr11:74949247-74979031 +  11q13.4   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)SPCS2  -     11q13.4   [Description]    (hg19-Feb_2009)
EnsemblSPCS2 - 11q13.4 [CytoView hg19]  SPCS2 - 11q13.4 [CytoView hg38]
Mapping of homologs : NCBISPCS2 [Mapview hg19]  SPCS2 [Mapview hg38]
Gene and transcription
Genbank (Entrez)AA921960 AK293128 BC008063 BC064957 BC067821
RefSeq transcript (Entrez)NM_014752
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)SPCS2
Cluster EST : UnigeneHs.719927 [ NCBI ]
CGAP (NCI)Hs.719927
Alternative Splicing GalleryENSG00000118363
Gene ExpressionSPCS2 [ NCBI-GEO ]   SPCS2 [ EBI - ARRAY_EXPRESS ]   SPCS2 [ SEEK ]   SPCS2 [ MEM ]
Gene Expression Viewer (FireBrowse)SPCS2 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)9789
GTEX Portal (Tissue expression)SPCS2
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ15005   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ15005  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ15005
Splice isoforms : SwissVarQ15005
Catalytic activity : Enzyme3.4.-.- [ Enzyme-Expasy ]   3.4.-.-3.4.-.- [ IntEnz-EBI ]   3.4.-.- [ BRENDA ]   3.4.-.- [ KEGG ]   
PhosPhoSitePlusQ15005
Domains : Interpro (EBI)SigPept_cplx_su2   
Domain families : Pfam (Sanger)SPC25 (PF06703)   
Domain families : Pfam (NCBI)pfam06703   
Conserved Domain (NCBI)SPCS2
DMDM Disease mutations9789
Blocks (Seattle)SPCS2
SuperfamilyQ15005
Human Protein AtlasENSG00000118363
Peptide AtlasQ15005
HPRD15435
Protein Interaction databases
DIP (DOE-UCLA)Q15005
IntAct (EBI)Q15005
FunCoupENSG00000118363
BioGRIDSPCS2
STRING (EMBL)SPCS2
ZODIACSPCS2
Ontologies - Pathways
QuickGOQ15005
Ontology : AmiGOsignal peptidase complex  endoplasmic reticulum membrane  signal peptide processing  peptidase activity  integral component of membrane  organelle membrane  protein targeting to ER  
Ontology : EGO-EBIsignal peptidase complex  endoplasmic reticulum membrane  signal peptide processing  peptidase activity  integral component of membrane  organelle membrane  protein targeting to ER  
Pathways : KEGGProtein export   
NDEx NetworkSPCS2
Atlas of Cancer Signalling NetworkSPCS2
Wikipedia pathwaysSPCS2
Orthology - Evolution
OrthoDB9789
GeneTree (enSembl)ENSG00000118363
Phylogenetic Trees/Animal Genes : TreeFamSPCS2
HOVERGENQ15005
HOGENOMQ15005
Homologs : HomoloGeneSPCS2
Homology/Alignments : Family Browser (UCSC)SPCS2
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerSPCS2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)SPCS2
dbVarSPCS2
ClinVarSPCS2
1000_GenomesSPCS2 
Exome Variant ServerSPCS2
ExAC (Exome Aggregation Consortium)SPCS2 (select the gene name)
Genetic variants : HAPMAP9789
Genomic Variants (DGV)SPCS2 [DGVbeta]
DECIPHERSPCS2 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisSPCS2 
Mutations
ICGC Data PortalSPCS2 
TCGA Data PortalSPCS2 
Broad Tumor PortalSPCS2
OASIS PortalSPCS2 [ Somatic mutations - Copy number]
Mutations and Diseases : HGMDSPCS2
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch SPCS2
DgiDB (Drug Gene Interaction Database)SPCS2
DoCM (Curated mutations)SPCS2 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)SPCS2 (select a term)
intoGenSPCS2
Cancer3DSPCS2(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM
Orphanet
MedgenSPCS2
Genetic Testing Registry SPCS2
NextProtQ15005 [Medical]
TSGene9789
GENETestsSPCS2
Target ValidationSPCS2
Huge Navigator SPCS2 [HugePedia]
snp3D : Map Gene to Disease9789
BioCentury BCIQSPCS2
ClinGenSPCS2
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD9789
Chemical/Pharm GKB GenePA128394559
Clinical trialSPCS2
Miscellaneous
canSAR (ICR)SPCS2 (select the gene name)
Probes
Litterature
PubMed19 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineSPCS2
EVEXSPCS2
GoPubMedSPCS2
iHOPSPCS2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Wed May 31 15:43:54 CEST 2017

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