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SPCS3 (signal peptidase complex subunit 3)

Identity

Alias_namessignal peptidase complex subunit 3 homolog (S. cerevisiae)
Alias_symbol (synonym)FLJ22649
SPC22/23
SPC3
YLR066W
PRO3567
Other alias
HGNC (Hugo) SPCS3
LocusID (NCBI) 60559
Atlas_Id 74155
Location 4q34.2  [Link to chromosome band 4q34]
Location_base_pair Starts at 176319939 and ends at 176332245 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
CLDN12 (7q21.13) / SPCS3 (4q34.2)SPCS3 (4q34.2) / P2RX7 (12q24.31)TIMP3 (22q12.3) / SPCS3 (4q34.2)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)SPCS3   26212
Cards
Entrez_Gene (NCBI)SPCS3  60559  signal peptidase complex subunit 3
AliasesPRO3567; SPC22/23; SPC3; YLR066W
GeneCards (Weizmann)SPCS3
Ensembl hg19 (Hinxton)ENSG00000129128 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000129128 [Gene_View]  chr4:176319939-176332245 [Contig_View]  SPCS3 [Vega]
ICGC DataPortalENSG00000129128
TCGA cBioPortalSPCS3
AceView (NCBI)SPCS3
Genatlas (Paris)SPCS3
WikiGenes60559
SOURCE (Princeton)SPCS3
Genetics Home Reference (NIH)SPCS3
Genomic and cartography
GoldenPath hg38 (UCSC)SPCS3  -     chr4:176319939-176332245 +  4q34.2   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)SPCS3  -     4q34.2   [Description]    (hg19-Feb_2009)
EnsemblSPCS3 - 4q34.2 [CytoView hg19]  SPCS3 - 4q34.2 [CytoView hg38]
Mapping of homologs : NCBISPCS3 [Mapview hg19]  SPCS3 [Mapview hg38]
Gene and transcription
Genbank (Entrez)AK026302 AK092634 AL136660 AY359044 BC043490
RefSeq transcript (Entrez)NM_021928
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)SPCS3
Cluster EST : UnigeneHs.42194 [ NCBI ]
CGAP (NCI)Hs.42194
Alternative Splicing GalleryENSG00000129128
Gene ExpressionSPCS3 [ NCBI-GEO ]   SPCS3 [ EBI - ARRAY_EXPRESS ]   SPCS3 [ SEEK ]   SPCS3 [ MEM ]
Gene Expression Viewer (FireBrowse)SPCS3 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)60559
GTEX Portal (Tissue expression)SPCS3
Protein : pattern, domain, 3D structure
UniProt/SwissProtP61009   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP61009  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP61009
Splice isoforms : SwissVarP61009
PhosPhoSitePlusP61009
Domains : Interpro (EBI)SPC3   
Domain families : Pfam (Sanger)SPC22 (PF04573)   
Domain families : Pfam (NCBI)pfam04573   
Conserved Domain (NCBI)SPCS3
DMDM Disease mutations60559
Blocks (Seattle)SPCS3
SuperfamilyP61009
Human Protein AtlasENSG00000129128
Peptide AtlasP61009
HPRD08001
IPIIPI00300299   
Protein Interaction databases
DIP (DOE-UCLA)P61009
IntAct (EBI)P61009
FunCoupENSG00000129128
BioGRIDSPCS3
STRING (EMBL)SPCS3
ZODIACSPCS3
Ontologies - Pathways
QuickGOP61009
Ontology : AmiGOendoplasmic reticulum  signal peptidase complex  endoplasmic reticulum membrane  signal peptide processing  proteolysis  peptidase activity  integral component of membrane  organelle membrane  protein targeting to ER  
Ontology : EGO-EBIendoplasmic reticulum  signal peptidase complex  endoplasmic reticulum membrane  signal peptide processing  proteolysis  peptidase activity  integral component of membrane  organelle membrane  protein targeting to ER  
Pathways : KEGGProtein export   
NDEx NetworkSPCS3
Atlas of Cancer Signalling NetworkSPCS3
Wikipedia pathwaysSPCS3
Orthology - Evolution
OrthoDB60559
GeneTree (enSembl)ENSG00000129128
Phylogenetic Trees/Animal Genes : TreeFamSPCS3
HOVERGENP61009
HOGENOMP61009
Homologs : HomoloGeneSPCS3
Homology/Alignments : Family Browser (UCSC)SPCS3
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerSPCS3 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)SPCS3
dbVarSPCS3
ClinVarSPCS3
1000_GenomesSPCS3 
Exome Variant ServerSPCS3
ExAC (Exome Aggregation Consortium)SPCS3 (select the gene name)
Genetic variants : HAPMAP60559
Genomic Variants (DGV)SPCS3 [DGVbeta]
DECIPHERSPCS3 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisSPCS3 
Mutations
ICGC Data PortalSPCS3 
TCGA Data PortalSPCS3 
Broad Tumor PortalSPCS3
OASIS PortalSPCS3 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICSPCS3  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDSPCS3
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch SPCS3
DgiDB (Drug Gene Interaction Database)SPCS3
DoCM (Curated mutations)SPCS3 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)SPCS3 (select a term)
intoGenSPCS3
Cancer3DSPCS3(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM
Orphanet
MedgenSPCS3
Genetic Testing Registry SPCS3
NextProtP61009 [Medical]
TSGene60559
GENETestsSPCS3
Target ValidationSPCS3
Huge Navigator SPCS3 [HugePedia]
snp3D : Map Gene to Disease60559
BioCentury BCIQSPCS3
ClinGenSPCS3
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD60559
Chemical/Pharm GKB GenePA134910080
Clinical trialSPCS3
Miscellaneous
canSAR (ICR)SPCS3 (select the gene name)
Probes
Litterature
PubMed17 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineSPCS3
EVEXSPCS3
GoPubMedSPCS3
iHOPSPCS3
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Sep 18 13:40:17 CEST 2017

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