SPDEF (SAM pointed domain containing ETS transcription factor)

2003-08-01  

Identity

HGNC
LOCATION
6p21.31
LOCUSID
ALIAS
PDEF,bA375E1.3
FUSION GENES

Other Information

Locus ID:

NCBI: 25803
MIM: 608144
HGNC: 17257
Ensembl: ENSG00000124664

Variants:

dbSNP: 25803
ClinVar: 25803
TCGA: ENSG00000124664
COSMIC: SPDEF

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000124664ENST00000374037O95238
ENSG00000124664ENST00000544425O95238

Expression (GTEx)

0
50
100
150
200
250

References

Pubmed IDYearTitleCitations
173476822007SPDEF regulates goblet cell hyperplasia in the airway epithelium.99
127006672003p62 overexpression in breast tumors and regulation by prostate-derived Ets factor in breast cancer cells.74
197860152010SAM pointed domain ETS factor (SPDEF) regulates terminal differentiation and maturation of intestinal goblet cells.71
129076422003Pdef expression in human breast cancer is correlated with invasive potential and altered gene expression.44
163571672005Novel role for PDEF in epithelial cell migration and invasion.34
236652022013Spdef null mice lack conjunctival goblet cells and provide a model of dry eye.33
175217012007Expression characteristics of prostate-derived Ets factor support a role in breast and prostate cancer progression.29
214460142011Mechanisms and functional consequences of PDEF protein expression loss during prostate cancer progression.29
205507082010Loss of PDEF, a prostate-derived Ets factor is associated with aggressive phenotype of prostate cancer: regulation of MMP 9 by PDEF.28
252544942014SPDEF inhibits prostate carcinogenesis by disrupting a positive feedback loop in regulation of the Foxm1 oncogene.28

Citation

Dessen P

SPDEF (SAM pointed domain containing ETS transcription factor)

Atlas Genet Cytogenet Oncol Haematol. 2003-08-01

Online version: http://atlasgeneticsoncology.org/gene/42372/spdef