SPDYA (speedy/RINGO cell cycle regulator family member A)

2009-03-01  

Identity

HGNC
SPDYA
LOCATION
2p23.2
LOCUSID
245711
ALIAS
RINGO3,RINGOA,SPDY1,SPY1
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 245711
MIM: 614029
HGNC: 30613
Ensembl: ENSG00000163806

Variants:

dbSNP: 245711
ClinVar: 245711
TCGA: ENSG00000163806
COSMIC: SPDYA

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000163806ENST00000334056Q5MJ70
ENSG00000163806ENST00000334056A0A384MTT5
ENSG00000163806ENST00000379579Q5MJ70
ENSG00000163806ENST00000379579A0A384MTT5
ENSG00000163806ENST00000439646H7C0J1
ENSG00000163806ENST00000449210E7EPV1

Expression (GTEx)

0
5
10
15
20
25
30
35
40
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Progesterone-mediated oocyte maturationKEGGko04914
Progesterone-mediated oocyte maturationKEGGhsa04914
Oocyte meiosisKEGGko04114
Oocyte meiosisKEGGhsa04114

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
244342102014The cyclin-like protein Spy1 regulates growth and division characteristics of the CD133+ population in human glioma.17
128399622003Human Spy1 promotes survival of mammalian cells following DNA damage.14
176714282007Spy1 enhances phosphorylation and degradation of the cell cycle inhibitor p27.14
169514072006Spy1 expression prevents normal cellular responses to DNA damage: inhibition of apoptosis and checkpoint activation.13
191066032009The atypical CDK activator Spy1 regulates the intrinsic DNA damage response and is dependent upon p53 to inhibit apoptosis.12
196867322009Expression and prognostic role of Spy1 as a novel cell cycle protein in hepatocellular carcinoma.11
196223562009Cell cycle regulation of the mammalian CDK activator RINGO/Speedy A.8
286669952017Structural basis of divergent cyclin-dependent kinase activation by Spy1/RINGO proteins.7
255268602016CRMP1 Interacted with Spy1 During the Collapse of Growth Cones Induced by Sema3A and Acted on Regeneration After Sciatic Nerve Crush.6
224474392012Spy1 is frequently overexpressed in malignant gliomas and critically regulates the proliferation of glioma cells.5

Citation

Dessen P

SPDYA (speedy/RINGO cell cycle regulator family member A)

Atlas Genet Cytogenet Oncol Haematol. 2009-03-01

Online version: http://atlasgeneticsoncology.org/gene/50681/spdya