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SPHK1 (sphingosine kinase 1)

Identity

Alias_symbol (synonym)SPHK
Other alias
HGNC (Hugo) SPHK1
LocusID (NCBI) 8877
Atlas_Id 45829
Location 17q25.1  [Link to chromosome band 17q25]
Location_base_pair Starts at 76384609 and ends at 76387860 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
SPHK1 (17q25.1) / EP300 (22q13.2)SPHK1 (17q25.1) / SPHK1 (17q25.1)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)SPHK1   11240
Cards
Entrez_Gene (NCBI)SPHK1  8877  sphingosine kinase 1
AliasesSPHK
GeneCards (Weizmann)SPHK1
Ensembl hg19 (Hinxton)ENSG00000176170 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000176170 [Gene_View]  chr17:76384609-76387860 [Contig_View]  SPHK1 [Vega]
ICGC DataPortalENSG00000176170
TCGA cBioPortalSPHK1
AceView (NCBI)SPHK1
Genatlas (Paris)SPHK1
WikiGenes8877
SOURCE (Princeton)SPHK1
Genetics Home Reference (NIH)SPHK1
Genomic and cartography
GoldenPath hg38 (UCSC)SPHK1  -     chr17:76384609-76387860 +  17q25.1   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)SPHK1  -     17q25.1   [Description]    (hg19-Feb_2009)
EnsemblSPHK1 - 17q25.1 [CytoView hg19]  SPHK1 - 17q25.1 [CytoView hg38]
Mapping of homologs : NCBISPHK1 [Mapview hg19]  SPHK1 [Mapview hg38]
OMIM603730   
Gene and transcription
Genbank (Entrez)AF200328 AF238083 AF266756 AJ245504 AK022402
RefSeq transcript (Entrez)NM_001142601 NM_001142602 NM_021972 NM_182965
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)SPHK1
Cluster EST : UnigeneHs.68061 [ NCBI ]
CGAP (NCI)Hs.68061
Alternative Splicing GalleryENSG00000176170
Gene ExpressionSPHK1 [ NCBI-GEO ]   SPHK1 [ EBI - ARRAY_EXPRESS ]   SPHK1 [ SEEK ]   SPHK1 [ MEM ]
Gene Expression Viewer (FireBrowse)SPHK1 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)8877
GTEX Portal (Tissue expression)SPHK1
Human Protein AtlasENSG00000176170-SPHK1 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9NYA1   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9NYA1  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9NYA1
Splice isoforms : SwissVarQ9NYA1
PhosPhoSitePlusQ9NYA1
Domaine pattern : Prosite (Expaxy)DAGK (PS50146)   
Domains : Interpro (EBI)Diacylglycerol_kinase_cat_dom    NAD/diacylglycerol_kinase   
Domain families : Pfam (Sanger)DAGK_cat (PF00781)   
Domain families : Pfam (NCBI)pfam00781   
Domain families : Smart (EMBL)DAGKc (SM00046)  
Conserved Domain (NCBI)SPHK1
DMDM Disease mutations8877
Blocks (Seattle)SPHK1
PDB (SRS)3VZB    3VZC    3VZD    4L02    4V24   
PDB (PDBSum)3VZB    3VZC    3VZD    4L02    4V24   
PDB (IMB)3VZB    3VZC    3VZD    4L02    4V24   
PDB (RSDB)3VZB    3VZC    3VZD    4L02    4V24   
Structural Biology KnowledgeBase3VZB    3VZC    3VZD    4L02    4V24   
SCOP (Structural Classification of Proteins)3VZB    3VZC    3VZD    4L02    4V24   
CATH (Classification of proteins structures)3VZB    3VZC    3VZD    4L02    4V24   
SuperfamilyQ9NYA1
Human Protein Atlas [tissue]ENSG00000176170-SPHK1 [tissue]
Peptide AtlasQ9NYA1
HPRD04768
IPIIPI00182048   IPI00790290   IPI01014444   IPI00398981   
Protein Interaction databases
DIP (DOE-UCLA)Q9NYA1
IntAct (EBI)Q9NYA1
FunCoupENSG00000176170
BioGRIDSPHK1
STRING (EMBL)SPHK1
ZODIACSPHK1
Ontologies - Pathways
QuickGOQ9NYA1
Ontology : AmiGOmagnesium ion binding  magnesium ion binding  blood vessel development  sphingosine-1-phosphate signaling pathway  DNA binding  NAD+ kinase activity  protein binding  calmodulin binding  ATP binding  nucleus  cytoplasm  cytosol  cytosol  plasma membrane  protein folding  sphingosine metabolic process  inflammatory response  signal transduction  brain development  sphinganine kinase activity  sphinganine kinase activity  positive regulation of peptidyl-threonine phosphorylation  regulation of tumor necrosis factor-mediated signaling pathway  D-erythro-sphingosine kinase activity  D-erythro-sphingosine kinase activity  calcium-mediated signaling  sphingolipid biosynthetic process  positive regulation of cell growth  positive regulation of cell migration  positive regulation of protein ubiquitination  regulation of interleukin-1 beta production  intracellular signal transduction  sphingosine-1-phosphate receptor activity  positive regulation of NF-kappaB import into nucleus  negative regulation of apoptotic process  negative regulation of apoptotic process  positive regulation of angiogenesis  positive regulation of mitotic cell cycle  positive regulation of smooth muscle contraction  sphingosine biosynthetic process  sphingosine biosynthetic process  sphingoid catabolic process  lipid phosphorylation  positive regulation of fibroblast proliferation  positive regulation of NF-kappaB transcription factor activity  protein phosphatase 2A binding  
Ontology : EGO-EBImagnesium ion binding  magnesium ion binding  blood vessel development  sphingosine-1-phosphate signaling pathway  DNA binding  NAD+ kinase activity  protein binding  calmodulin binding  ATP binding  nucleus  cytoplasm  cytosol  cytosol  plasma membrane  protein folding  sphingosine metabolic process  inflammatory response  signal transduction  brain development  sphinganine kinase activity  sphinganine kinase activity  positive regulation of peptidyl-threonine phosphorylation  regulation of tumor necrosis factor-mediated signaling pathway  D-erythro-sphingosine kinase activity  D-erythro-sphingosine kinase activity  calcium-mediated signaling  sphingolipid biosynthetic process  positive regulation of cell growth  positive regulation of cell migration  positive regulation of protein ubiquitination  regulation of interleukin-1 beta production  intracellular signal transduction  sphingosine-1-phosphate receptor activity  positive regulation of NF-kappaB import into nucleus  negative regulation of apoptotic process  negative regulation of apoptotic process  positive regulation of angiogenesis  positive regulation of mitotic cell cycle  positive regulation of smooth muscle contraction  sphingosine biosynthetic process  sphingosine biosynthetic process  sphingoid catabolic process  lipid phosphorylation  positive regulation of fibroblast proliferation  positive regulation of NF-kappaB transcription factor activity  protein phosphatase 2A binding  
Pathways : BIOCARTAPhospholipids as signalling intermediaries [Genes]   
Pathways : KEGGSphingolipid metabolism    Calcium signaling pathway    VEGF signaling pathway    Fc gamma R-mediated phagocytosis    Tuberculosis   
NDEx NetworkSPHK1
Atlas of Cancer Signalling NetworkSPHK1
Wikipedia pathwaysSPHK1
Orthology - Evolution
OrthoDB8877
GeneTree (enSembl)ENSG00000176170
Phylogenetic Trees/Animal Genes : TreeFamSPHK1
HOVERGENQ9NYA1
HOGENOMQ9NYA1
Homologs : HomoloGeneSPHK1
Homology/Alignments : Family Browser (UCSC)SPHK1
Gene fusions - Rearrangements
Fusion: Tumor Portal SPHK1
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerSPHK1 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)SPHK1
dbVarSPHK1
ClinVarSPHK1
1000_GenomesSPHK1 
Exome Variant ServerSPHK1
ExAC (Exome Aggregation Consortium)ENSG00000176170
GNOMAD BrowserENSG00000176170
Genetic variants : HAPMAP8877
Genomic Variants (DGV)SPHK1 [DGVbeta]
DECIPHERSPHK1 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisSPHK1 
Mutations
ICGC Data PortalSPHK1 
TCGA Data PortalSPHK1 
Broad Tumor PortalSPHK1
OASIS PortalSPHK1 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICSPHK1  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDSPHK1
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch SPHK1
DgiDB (Drug Gene Interaction Database)SPHK1
DoCM (Curated mutations)SPHK1 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)SPHK1 (select a term)
intoGenSPHK1
Cancer3DSPHK1(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM603730   
Orphanet
MedgenSPHK1
Genetic Testing Registry SPHK1
NextProtQ9NYA1 [Medical]
TSGene8877
GENETestsSPHK1
Target ValidationSPHK1
Huge Navigator SPHK1 [HugePedia]
snp3D : Map Gene to Disease8877
BioCentury BCIQSPHK1
ClinGenSPHK1
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD8877
Chemical/Pharm GKB GenePA36070
Clinical trialSPHK1
Miscellaneous
canSAR (ICR)SPHK1 (select the gene name)
Probes
Litterature
PubMed203 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineSPHK1
EVEXSPHK1
GoPubMedSPHK1
iHOPSPHK1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Thu Nov 9 13:12:24 CET 2017

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