SPHK1 (sphingosine kinase 1)

2007-02-01 Affiliation

Identity

HGNC

SPHK1

LOCATION

17q25.1

LOCUSID

8877

ALIAS

SPHK

FUSION GENES

Show Gene Fusions

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 8877
MIM: 603730
HGNC: 11240
Ensembl: ENSG00000176170

Variants:

dbSNP: 8877
ClinVar: 8877
TCGA: ENSG00000176170
COSMIC: SPHK1

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000176170	ENST00000323374	Q9NYA1
ENSG00000176170	ENST00000392496	Q9NYA1
ENSG00000176170	ENST00000392496	Q53ZR5
ENSG00000176170	ENST00000545180	Q9NYA1
ENSG00000176170	ENST00000545180	Q53ZR5
ENSG00000176170	ENST00000588682	K7EMA4
ENSG00000176170	ENST00000590379	K7EJ32
ENSG00000176170	ENST00000590959	Q9NYA1
ENSG00000176170	ENST00000592299	Q9NYA1
ENSG00000176170	ENST00000592299	Q53ZR5

Expression (GTEx)

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
Sphingolipid metabolism	KEGG	ko00600
Calcium signaling pathway	KEGG	ko04020
VEGF signaling pathway	KEGG	ko04370
Sphingolipid metabolism	KEGG	hsa00600
Calcium signaling pathway	KEGG	hsa04020
VEGF signaling pathway	KEGG	hsa04370
Fc gamma R-mediated phagocytosis	KEGG	ko04666
Fc gamma R-mediated phagocytosis	KEGG	hsa04666
Metabolic pathways	KEGG	hsa01100
Tuberculosis	KEGG	ko05152
Tuberculosis	KEGG	hsa05152
Sphingosine degradation	KEGG	hsa_M00100
Sphingosine degradation	KEGG	M00100
Sphingolipid signaling pathway	KEGG	hsa04071
Sphingolipid signaling pathway	KEGG	ko04071
Metabolism of proteins	REACTOME	R-HSA-392499
Protein folding	REACTOME	R-HSA-391251
Chaperonin-mediated protein folding	REACTOME	R-HSA-390466
Association of TriC/CCT with target proteins during biosynthesis	REACTOME	R-HSA-390471
Signal Transduction	REACTOME	R-HSA-162582
Signaling by VEGF	REACTOME	R-HSA-194138
VEGFA-VEGFR2 Pathway	REACTOME	R-HSA-4420097
VEGFR2 mediated cell proliferation	REACTOME	R-HSA-5218921
Metabolism	REACTOME	R-HSA-1430728
Metabolism of lipids and lipoproteins	REACTOME	R-HSA-556833
Sphingolipid metabolism	REACTOME	R-HSA-428157
Sphingolipid de novo biosynthesis	REACTOME	R-HSA-1660661
Phospholipase D signaling pathway	KEGG	ko04072
Phospholipase D signaling pathway	KEGG	hsa04072
Apelin signaling pathway	KEGG	hsa04371

Protein levels (Protein atlas)

Not detected

Low

Medium

High

References

Pubmed ID	Year	Title	Citations
14532121	2003	Activation of sphingosine kinase 1 by ERK1/2-mediated phosphorylation.	175
18058224	2008	Microarray analysis of altered sphingolipid metabolism reveals prognostic significance of sphingosine kinase 1 in breast cancer.	113
18824518	2009	Role for sphingosine kinase 1 in colon carcinogenesis.	103
18362204	2008	Apoptosis induces expression of sphingosine kinase 1 to release sphingosine-1-phosphate as a "come-and-get-me" signal.	97
18849324	2008	Activation of sphingosine kinase-1 reverses the increase in lung vascular permeability through sphingosine-1-phosphate receptor signaling in endothelial cells.	92
11777919	2002	Sphingosine kinase interacts with TRAF2 and dissects tumor necrosis factor-alpha signaling.	88
12124383	2002	PKC-dependent activation of sphingosine kinase 1 and translocation to the plasma membrane. Extracellular release of sphingosine-1-phosphate induced by phorbol 12-myristate 13-acetate (PMA).	88
16194537	2005	Sphingosine kinase 1 is required for migration, proliferation and survival of MCF-7 human breast cancer cells.	85
16623665	2006	Extracellular export of sphingosine kinase-1a contributes to the vascular S1P gradient.	84
26590717	2015	LncRNA Khps1 Regulates Expression of the Proto-oncogene SPHK1 via Triplex-Mediated Changes in Chromatin Structure.	65

Citation

Dessen P

SPHK1 (sphingosine kinase 1)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/45829/sphk1