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SPHK2 (sphingosine kinase 2)

Identity

Other aliasSK 2
SK-2
SPK 2
SPK-2
HGNC (Hugo) SPHK2
LocusID (NCBI) 56848
Atlas_Id 50985
Location 19q13.33  [Link to chromosome band 19q13]
Location_base_pair Starts at 48619291 and ends at 48630406 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
MAP1A (15q15.3) / SPHK2 (19q13.33)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)SPHK2   18859
Cards
Entrez_Gene (NCBI)SPHK2  56848  sphingosine kinase 2
AliasesSK; SK-2; SPK; SPK-2
GeneCards (Weizmann)SPHK2
Ensembl hg19 (Hinxton)ENSG00000063176 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000063176 [Gene_View]  chr19:48619291-48630406 [Contig_View]  SPHK2 [Vega]
ICGC DataPortalENSG00000063176
TCGA cBioPortalSPHK2
AceView (NCBI)SPHK2
Genatlas (Paris)SPHK2
WikiGenes56848
SOURCE (Princeton)SPHK2
Genetics Home Reference (NIH)SPHK2
Genomic and cartography
GoldenPath hg38 (UCSC)SPHK2  -     chr19:48619291-48630406 +  19q13.33   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)SPHK2  -     19q13.33   [Description]    (hg19-Feb_2009)
EnsemblSPHK2 - 19q13.33 [CytoView hg19]  SPHK2 - 19q13.33 [CytoView hg38]
Mapping of homologs : NCBISPHK2 [Mapview hg19]  SPHK2 [Mapview hg38]
OMIM607092   
Gene and transcription
Genbank (Entrez)AB100373 AF245447 AK000599 AK074601 AK122735
RefSeq transcript (Entrez)NM_001204158 NM_001204159 NM_001204160 NM_001243876 NM_020126
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)SPHK2
Cluster EST : UnigeneHs.528006 [ NCBI ]
CGAP (NCI)Hs.528006
Alternative Splicing GalleryENSG00000063176
Gene ExpressionSPHK2 [ NCBI-GEO ]   SPHK2 [ EBI - ARRAY_EXPRESS ]   SPHK2 [ SEEK ]   SPHK2 [ MEM ]
Gene Expression Viewer (FireBrowse)SPHK2 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)56848
GTEX Portal (Tissue expression)SPHK2
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9NRA0   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9NRA0  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9NRA0
Splice isoforms : SwissVarQ9NRA0
PhosPhoSitePlusQ9NRA0
Domaine pattern : Prosite (Expaxy)DAGK (PS50146)   
Domains : Interpro (EBI)Diacylglycerol_kinase_cat_dom    NAD/diacylglycerol_kinase   
Domain families : Pfam (Sanger)DAGK_cat (PF00781)   
Domain families : Pfam (NCBI)pfam00781   
Domain families : Smart (EMBL)DAGKc (SM00046)  
Conserved Domain (NCBI)SPHK2
DMDM Disease mutations56848
Blocks (Seattle)SPHK2
SuperfamilyQ9NRA0
Human Protein AtlasENSG00000063176
Peptide AtlasQ9NRA0
HPRD06157
IPIIPI00939760   IPI00215795   IPI00215796   IPI00024496   IPI00902805   IPI00384784   IPI00749403   
Protein Interaction databases
DIP (DOE-UCLA)Q9NRA0
IntAct (EBI)Q9NRA0
FunCoupENSG00000063176
BioGRIDSPHK2
STRING (EMBL)SPHK2
ZODIACSPHK2
Ontologies - Pathways
QuickGOQ9NRA0
Ontology : AmiGOblood vessel development  sphingosine-1-phosphate signaling pathway  NAD+ kinase activity  protein binding  ATP binding  lysosome  lysosomal membrane  cytosol  cytosol  sphinganine-1-phosphate biosynthetic process  brain development  female pregnancy  cell proliferation  positive regulation of cell proliferation  sphinganine kinase activity  sphinganine kinase activity  membrane  Ras GTPase binding  D-erythro-sphingosine kinase activity  sphingolipid biosynthetic process  sphingosine-1-phosphate receptor activity  negative regulation of apoptotic process  intracellular membrane-bounded organelle  sphingosine biosynthetic process  sphingosine biosynthetic process  lipid phosphorylation  
Ontology : EGO-EBIblood vessel development  sphingosine-1-phosphate signaling pathway  NAD+ kinase activity  protein binding  ATP binding  lysosome  lysosomal membrane  cytosol  cytosol  sphinganine-1-phosphate biosynthetic process  brain development  female pregnancy  cell proliferation  positive regulation of cell proliferation  sphinganine kinase activity  sphinganine kinase activity  membrane  Ras GTPase binding  D-erythro-sphingosine kinase activity  sphingolipid biosynthetic process  sphingosine-1-phosphate receptor activity  negative regulation of apoptotic process  intracellular membrane-bounded organelle  sphingosine biosynthetic process  sphingosine biosynthetic process  lipid phosphorylation  
Pathways : KEGGSphingolipid metabolism    Calcium signaling pathway    VEGF signaling pathway    Fc gamma R-mediated phagocytosis    Tuberculosis   
NDEx NetworkSPHK2
Atlas of Cancer Signalling NetworkSPHK2
Wikipedia pathwaysSPHK2
Orthology - Evolution
OrthoDB56848
GeneTree (enSembl)ENSG00000063176
Phylogenetic Trees/Animal Genes : TreeFamSPHK2
HOVERGENQ9NRA0
HOGENOMQ9NRA0
Homologs : HomoloGeneSPHK2
Homology/Alignments : Family Browser (UCSC)SPHK2
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerSPHK2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)SPHK2
dbVarSPHK2
ClinVarSPHK2
1000_GenomesSPHK2 
Exome Variant ServerSPHK2
ExAC (Exome Aggregation Consortium)SPHK2 (select the gene name)
Genetic variants : HAPMAP56848
Genomic Variants (DGV)SPHK2 [DGVbeta]
DECIPHERSPHK2 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisSPHK2 
Mutations
ICGC Data PortalSPHK2 
TCGA Data PortalSPHK2 
Broad Tumor PortalSPHK2
OASIS PortalSPHK2 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICSPHK2  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDSPHK2
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch SPHK2
DgiDB (Drug Gene Interaction Database)SPHK2
DoCM (Curated mutations)SPHK2 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)SPHK2 (select a term)
intoGenSPHK2
Cancer3DSPHK2(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM607092   
Orphanet
MedgenSPHK2
Genetic Testing Registry SPHK2
NextProtQ9NRA0 [Medical]
TSGene56848
GENETestsSPHK2
Target ValidationSPHK2
Huge Navigator SPHK2 [HugePedia]
snp3D : Map Gene to Disease56848
BioCentury BCIQSPHK2
ClinGenSPHK2
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD56848
Chemical/Pharm GKB GenePA38719
Clinical trialSPHK2
Miscellaneous
canSAR (ICR)SPHK2 (select the gene name)
Probes
Litterature
PubMed56 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineSPHK2
EVEXSPHK2
GoPubMedSPHK2
iHOPSPHK2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Wed Jun 7 12:57:10 CEST 2017

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