SPHK2 (sphingosine kinase 2)

2009-06-01  

Identity

HGNC
LOCATION
19q13.33
LOCUSID
ALIAS
SK
FUSION GENES

Other Information

Locus ID:

NCBI: 56848
MIM: 607092
HGNC: 18859
Ensembl: ENSG00000063176

Variants:

dbSNP: 56848
ClinVar: 56848
TCGA: ENSG00000063176
COSMIC: SPHK2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000063176ENST00000245222Q9NRA0
ENSG00000063176ENST00000245222A0A024QZH5
ENSG00000063176ENST00000340932E9PCV4
ENSG00000063176ENST00000426514E7ET12
ENSG00000063176ENST00000593308M0QZP3
ENSG00000063176ENST00000597434A0A075B7A1
ENSG00000063176ENST00000598088Q9NRA0
ENSG00000063176ENST00000598088A0A024QZH5
ENSG00000063176ENST00000599029M0R344
ENSG00000063176ENST00000599748Q9NRA0
ENSG00000063176ENST00000600537Q9NRA0
ENSG00000063176ENST00000601704M0QXX5
ENSG00000063176ENST00000601712M0R0E9

Expression (GTEx)

0
5
10
15
20
25
30
35

Pathways

PathwaySourceExternal ID
Sphingolipid metabolismKEGGko00600
Calcium signaling pathwayKEGGko04020
VEGF signaling pathwayKEGGko04370
Sphingolipid metabolismKEGGhsa00600
Calcium signaling pathwayKEGGhsa04020
VEGF signaling pathwayKEGGhsa04370
Fc gamma R-mediated phagocytosisKEGGko04666
Fc gamma R-mediated phagocytosisKEGGhsa04666
Metabolic pathwaysKEGGhsa01100
TuberculosisKEGGko05152
TuberculosisKEGGhsa05152
Sphingosine degradationKEGGhsa_M00100
Sphingosine degradationKEGGM00100
Sphingolipid signaling pathwayKEGGhsa04071
Sphingolipid signaling pathwayKEGGko04071
MetabolismREACTOMER-HSA-1430728
Metabolism of lipids and lipoproteinsREACTOMER-HSA-556833
Sphingolipid metabolismREACTOMER-HSA-428157
Sphingolipid de novo biosynthesisREACTOMER-HSA-1660661
Phospholipase D signaling pathwayKEGGko04072
Phospholipase D signaling pathwayKEGGhsa04072
Apelin signaling pathwayKEGGhsa04371

References

Pubmed IDYearTitleCitations
145969382003The immunosuppressant FTY720 is phosphorylated by sphingosine kinase type 2.84
173119282007Sphingosine kinase type 2 activation by ERK-mediated phosphorylation.60
213076392011Targeting NFĸB mediated breast cancer chemoresistance through selective inhibition of sphingosine kinase-2.60
159514392005Role of sphingosine kinase 2 in cell migration toward epidermal growth factor.59
161031102005Involvement of N-terminal-extended form of sphingosine kinase 2 in serum-dependent regulation of cell proliferation and apoptosis.59
181788712008Distinct roles of sphingosine kinases 1 and 2 in human mast-cell functions.50
178952502007Recycling of sphingosine is regulated by the concerted actions of sphingosine-1-phosphate phosphohydrolase 1 and sphingosine kinase 2.44
176359162007Protein kinase D-mediated phosphorylation and nuclear export of sphingosine kinase 2.43
192400262009Sphingosine kinase isoforms regulate oxaliplatin sensitivity of human colon cancer cells through ceramide accumulation and Akt activation.34
216209612011(R)-FTY720 methyl ether is a specific sphingosine kinase 2 inhibitor: Effect on sphingosine kinase 2 expression in HEK 293 cells and actin rearrangement and survival of MCF-7 breast cancer cells.31

Citation

Dessen P

SPHK2 (sphingosine kinase 2)

Atlas Genet Cytogenet Oncol Haematol. 2009-06-01

Online version: http://atlasgeneticsoncology.org/gene/50985/sphk2