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SPINK1 (serine peptidase inhibitor, Kazal type 1)

Identity

Other namesPCTT
PSTI
Spink3
TATI
TCP
HGNC (Hugo) SPINK1
LocusID (NCBI) 6690
Location 5q32
Location_base_pair Starts at 147204143 and ends at 147211260 bp from pter ( according to hg19-Feb_2009)
Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

External links

Nomenclature
HGNC (Hugo)SPINK1   11244
Cards
Entrez_Gene (NCBI)SPINK1  6690  serine peptidase inhibitor, Kazal type 1
GeneCards (Weizmann)SPINK1
Ensembl (Hinxton)ENSG00000164266 [Gene_View]  chr5:147204143-147211260 [Contig_View]  SPINK1 [Vega]
AceView (NCBI)SPINK1
Genatlas (Paris)SPINK1
WikiGenes6690
SOURCE (Princeton)NM_003122
Genomic and cartography
GoldenPath (UCSC)SPINK1  -  5q32   chr5:147204143-147211260 -  5q32   [Description]    (hg19-Feb_2009)
EnsemblSPINK1 - 5q32 [CytoView]
Mapping of homologs : NCBISPINK1 [Mapview]
OMIM167790   167800   608189   
Gene and transcription
Genbank (Entrez)AI990990 BC025790 BU074107 DQ893613 DQ896842
RefSeq transcript (Entrez)NM_003122
RefSeq genomic (Entrez)AC_000137 NC_000005 NC_018916 NG_008356 NT_029289 NW_001838953 NW_004929324
Consensus coding sequences : CCDS (NCBI)SPINK1
Cluster EST : UnigeneHs.407856 [ NCBI ]
CGAP (NCI)Hs.407856
Alternative Splicing : Fast-db (Paris)GSHG0025158
Alternative Splicing GalleryENSG00000164266
Gene ExpressionSPINK1 [ NCBI-GEO ]     SPINK1 [ SEEK ]   SPINK1 [ MEM ]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP00995 (Uniprot)
NextProtP00995  [Medical]
With graphics : InterProP00995
Splice isoforms : SwissVarP00995 (Swissvar)
Domaine pattern : Prosite (Expaxy)KAZAL_1 (PS00282)    KAZAL_2 (PS51465)   
Domains : Interpro (EBI)Kazal_dom    Prot_inh_Kazal-m   
Related proteins : CluSTrP00995
Domain families : Pfam (Sanger)Kazal_1 (PF00050)   
Domain families : Pfam (NCBI)pfam00050   
Domain families : Smart (EMBL)KAZAL (SM00280)  
DMDM Disease mutations6690
Blocks (Seattle)P00995
PDB (SRS)1CGI    1CGJ    1HPT   
PDB (PDBSum)1CGI    1CGJ    1HPT   
PDB (IMB)1CGI    1CGJ    1HPT   
PDB (RSDB)1CGI    1CGJ    1HPT   
Human Protein AtlasENSG00000164266
Peptide AtlasP00995
HPRD01341
IPIIPI00020687   IPI00966882   
Protein Interaction databases
DIP (DOE-UCLA)P00995
IntAct (EBI)P00995
FunCoupENSG00000164266
BioGRIDSPINK1
InParanoidP00995
Interologous Interaction database P00995
IntegromeDBSPINK1
STRING (EMBL)SPINK1
Ontologies - Pathways
Ontology : AmiGOendopeptidase inhibitor activity  serine-type endopeptidase inhibitor activity  protein binding  extracellular region  negative regulation of nitric oxide mediated signal transduction  negative regulation of peptidyl-tyrosine phosphorylation  regulation of acrosome reaction  negative regulation of calcium ion import  negative regulation of serine-type endopeptidase activity  regulation of store-operated calcium entry  
Ontology : EGO-EBIendopeptidase inhibitor activity  serine-type endopeptidase inhibitor activity  protein binding  extracellular region  negative regulation of nitric oxide mediated signal transduction  negative regulation of peptidyl-tyrosine phosphorylation  regulation of acrosome reaction  negative regulation of calcium ion import  negative regulation of serine-type endopeptidase activity  regulation of store-operated calcium entry  
REACTOMESPINK1
Protein Interaction DatabaseSPINK1
Wikipedia pathwaysSPINK1
Gene fusion - rearrangments
Polymorphisms : SNP, mutations, diseases
SNP Single Nucleotide Polymorphism (NCBI)SPINK1
SNP (GeneSNP Utah)SPINK1
SNP : HGBaseSPINK1
Genetic variants : HAPMAPSPINK1
1000_GenomesSPINK1 
ICGC programENSG00000164266 
Somatic Mutations in Cancer : COSMICSPINK1 
CONAN: Copy Number AnalysisSPINK1 
Mutations and Diseases : HGMDSPINK1
OMIM167790    167800    608189   
GENETestsSPINK1
Disease Genetic AssociationSPINK1
Huge Navigator SPINK1 [HugePedia]  SPINK1 [HugeCancerGEM]
Genomic VariantsSPINK1  SPINK1 [DGVbeta]
Exome VariantSPINK1
dbVarSPINK1
ClinVarSPINK1
snp3D : Map Gene to Disease6690
General knowledge
Homologs : HomoloGeneSPINK1
Homology/Alignments : Family Browser (UCSC)SPINK1
Phylogenetic Trees/Animal Genes : TreeFamSPINK1
Chemical/Protein Interactions : CTD6690
Chemical/Pharm GKB GenePA36074
Clinical trialSPINK1
Cancer Resource (Charite)ENSG00000164266
Other databases
Probes
Litterature
PubMed148 Pubmed reference(s) in Entrez
CoreMineSPINK1
iHOPSPINK1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

Contributor(s)

Written09-2002Dessen P, Le Minor S
Updated12-2013Dessen P

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Fri Apr 18 16:56:50 CEST 2014

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