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Taking over the Atlas
Dear Colleagues,
The Atlas, once more, is in great danger, and I will have to proceed to a collective economic lay-off of all the team involved in the Atlas before the begining of April 2015 (a foundation having suddenly withdrawn its commitment to support the Atlas). I ask you herein if any Scientific Society (a Society of Cytogenetics, of Clinical Genetics, of Hematology, or a Cancer Society, or any other...), any University and/or Hospital, any Charity, or any database would be interested in taking over the Atlas, in whole or in part. If taking charge of the whole lot is too big, a consortium of various actors could be the solution (I am myself trying to find partners). Could you please spread the information, contact the relevant authorities, and find partners.
Survival of the Atlas will be critically dependant upon your ability to find solutions (and urgently!).
Kind regards.
Jean-Loup Huret
Donations are also welcome

Donate (in Euros)

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SPINK1 (serine peptidase inhibitor, Kazal type 1)

Identity

Other namesPCTT
PSTI
Spink3
TATI
TCP
HGNC (Hugo) SPINK1
LocusID (NCBI) 6690
Location 5q32
Location_base_pair Starts at 147204143 and ends at 147218794 bp from pter ( according to hg19-Feb_2009)
Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

Other Solid tumors implicated (Data extracted from papers in the Atlas)

Solid Tumors AmeloblastomID5945

External links

Nomenclature
HGNC (Hugo)SPINK1   11244
Cards
Entrez_Gene (NCBI)SPINK1  6690  serine peptidase inhibitor, Kazal type 1
GeneCards (Weizmann)SPINK1
Ensembl hg19 (Hinxton)ENSG00000164266 [Gene_View]  chr5:147204143-147218794 [Contig_View]  SPINK1 [Vega]
Ensembl hg38 (Hinxton)ENSG00000164266 [Gene_View]  chr5:147204143-147218794 [Contig_View]  SPINK1 [Vega]
ICGC DataPortalENSG00000164266
cBioPortalSPINK1
AceView (NCBI)SPINK1
Genatlas (Paris)SPINK1
WikiGenes6690
SOURCE (Princeton)SPINK1
Genomic and cartography
GoldenPath hg19 (UCSC)SPINK1  -     chr5:147204143-147218794 -  5q32   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)SPINK1  -     5q32   [Description]    (hg38-Dec_2013)
EnsemblSPINK1 - 5q32 [CytoView hg19]  SPINK1 - 5q32 [CytoView hg38]
Mapping of homologs : NCBISPINK1 [Mapview hg19]  SPINK1 [Mapview hg38]
OMIM167790   167800   608189   
Gene and transcription
Genbank (Entrez)AI990990 BC025790 BU074107 CB159576 DQ893613
RefSeq transcript (Entrez)NM_003122
RefSeq genomic (Entrez)AC_000137 NC_000005 NC_018916 NG_008356 NT_029289 NW_001838953 NW_004929324
Consensus coding sequences : CCDS (NCBI)SPINK1
Cluster EST : UnigeneHs.407856 [ NCBI ]
CGAP (NCI)Hs.407856
Alternative Splicing : Fast-db (Paris)GSHG0025158
Alternative Splicing GalleryENSG00000164266
Gene ExpressionSPINK1 [ NCBI-GEO ]     SPINK1 [ SEEK ]   SPINK1 [ MEM ]
SOURCE (Princeton)Expression in : [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP00995 (Uniprot)
NextProtP00995  [Medical]
With graphics : InterProP00995
Splice isoforms : SwissVarP00995 (Swissvar)
Domaine pattern : Prosite (Expaxy)KAZAL_1 (PS00282)    KAZAL_2 (PS51465)   
Domains : Interpro (EBI)Kazal_dom    Prot_inh_Kazal-m   
Related proteins : CluSTrP00995
Domain families : Pfam (Sanger)Kazal_1 (PF00050)   
Domain families : Pfam (NCBI)pfam00050   
Domain families : Smart (EMBL)KAZAL (SM00280)  
DMDM Disease mutations6690
Blocks (Seattle)P00995
PDB (SRS)1CGI    1CGJ    1HPT   
PDB (PDBSum)1CGI    1CGJ    1HPT   
PDB (IMB)1CGI    1CGJ    1HPT   
PDB (RSDB)1CGI    1CGJ    1HPT   
Human Protein AtlasENSG00000164266
Peptide AtlasP00995
HPRD01341
IPIIPI00020687   IPI00966882   
Protein Interaction databases
DIP (DOE-UCLA)P00995
IntAct (EBI)P00995
FunCoupENSG00000164266
BioGRIDSPINK1
IntegromeDBSPINK1
STRING (EMBL)SPINK1
Ontologies - Pathways
QuickGOP00995
Ontology : AmiGOendopeptidase inhibitor activity  serine-type endopeptidase inhibitor activity  protein binding  extracellular region  negative regulation of nitric oxide mediated signal transduction  negative regulation of peptidyl-tyrosine phosphorylation  regulation of acrosome reaction  negative regulation of calcium ion import  negative regulation of serine-type endopeptidase activity  regulation of store-operated calcium entry  
Ontology : EGO-EBIendopeptidase inhibitor activity  serine-type endopeptidase inhibitor activity  protein binding  extracellular region  negative regulation of nitric oxide mediated signal transduction  negative regulation of peptidyl-tyrosine phosphorylation  regulation of acrosome reaction  negative regulation of calcium ion import  negative regulation of serine-type endopeptidase activity  regulation of store-operated calcium entry  
Protein Interaction DatabaseSPINK1
DoCM (Curated mutations)SPINK1
Wikipedia pathwaysSPINK1
Gene fusion - rearrangements
Polymorphisms : SNP, variants
NCBI Variation ViewerSPINK1 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)SPINK1
dbVarSPINK1
ClinVarSPINK1
1000_GenomesSPINK1 
Exome Variant ServerSPINK1
SNP (GeneSNP Utah)SPINK1
SNP : HGBaseSPINK1
Genetic variants : HAPMAPSPINK1
Genomic Variants (DGV)SPINK1 [DGVbeta]
Mutations
ICGC Data PortalENSG00000164266 
Somatic Mutations in Cancer : COSMICSPINK1 
CONAN: Copy Number AnalysisSPINK1 
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] 
Diseases
DECIPHER (Syndromes)5:147204143-147218794
Mutations and Diseases : HGMDSPINK1
OMIM167790    167800    608189   
MedgenSPINK1
NextProtP00995 [Medical]
GENETestsSPINK1
Disease Genetic AssociationSPINK1
Huge Navigator SPINK1 [HugePedia]  SPINK1 [HugeCancerGEM]
snp3D : Map Gene to Disease6690
DGIdb (Drug Gene Interaction db)SPINK1
General knowledge
Homologs : HomoloGeneSPINK1
Homology/Alignments : Family Browser (UCSC)SPINK1
Phylogenetic Trees/Animal Genes : TreeFamSPINK1
Chemical/Protein Interactions : CTD6690
Chemical/Pharm GKB GenePA36074
Clinical trialSPINK1
Cancer Resource (Charite)ENSG00000164266
Other databases
Probes
Litterature
PubMed161 Pubmed reference(s) in Entrez
CoreMineSPINK1
GoPubMedSPINK1
iHOPSPINK1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

Contributor(s)

Written09-2002Dessen P, Le Minor S
Updated12-2014Dessen P

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Sat Feb 14 18:48:56 CET 2015

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