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SPINK4 (serine peptidase inhibitor, Kazal type 4)

Identity

Alias_namesserine protease inhibitor, Kazal type 4
Alias_symbol (synonym)PEC-60
MGC133107
Other aliasHEL136
PEC60
HGNC (Hugo) SPINK4
LocusID (NCBI) 27290
Atlas_Id 74183
Location 9p13.3  [Link to chromosome band 9p13]
Location_base_pair Starts at 33240196 and ends at 33248565 bp from pter ( according to hg19-Feb_2009)
Fusion genes
(updated 2016)
NFX1 (9p13.3) / SPINK4 (9p13.3)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)SPINK4   16646
Cards
Entrez_Gene (NCBI)SPINK4  27290  serine peptidase inhibitor, Kazal type 4
AliasesHEL136; PEC-60; PEC60
GeneCards (Weizmann)SPINK4
Ensembl hg19 (Hinxton)ENSG00000122711 [Gene_View]  chr9:33240196-33248565 [Contig_View]  SPINK4 [Vega]
Ensembl hg38 (Hinxton)ENSG00000122711 [Gene_View]  chr9:33240196-33248565 [Contig_View]  SPINK4 [Vega]
ICGC DataPortalENSG00000122711
TCGA cBioPortalSPINK4
AceView (NCBI)SPINK4
Genatlas (Paris)SPINK4
WikiGenes27290
SOURCE (Princeton)SPINK4
Genetics Home Reference (NIH)SPINK4
Genomic and cartography
GoldenPath hg19 (UCSC)SPINK4  -     chr9:33240196-33248565 +  9p13.3   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)SPINK4  -     9p13.3   [Description]    (hg38-Dec_2013)
EnsemblSPINK4 - 9p13.3 [CytoView hg19]  SPINK4 - 9p13.3 [CytoView hg38]
Mapping of homologs : NCBISPINK4 [Mapview hg19]  SPINK4 [Mapview hg38]
OMIM613929   
Gene and transcription
Genbank (Entrez)AF048700 BC110068 EU794680
RefSeq transcript (Entrez)NM_014471
RefSeq genomic (Entrez)NC_000009 NC_018920 NT_008413 NW_004929342
Consensus coding sequences : CCDS (NCBI)SPINK4
Cluster EST : UnigeneHs.555934 [ NCBI ]
CGAP (NCI)Hs.555934
Alternative Splicing GalleryENSG00000122711
Gene ExpressionSPINK4 [ NCBI-GEO ]   SPINK4 [ EBI - ARRAY_EXPRESS ]   SPINK4 [ SEEK ]   SPINK4 [ MEM ]
Gene Expression Viewer (FireBrowse)SPINK4 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)27290
GTEX Portal (Tissue expression)SPINK4
Protein : pattern, domain, 3D structure
UniProt/SwissProtO60575   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtO60575  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProO60575
Splice isoforms : SwissVarO60575
PhosPhoSitePlusO60575
Domaine pattern : Prosite (Expaxy)KAZAL_1 (PS00282)    KAZAL_2 (PS51465)   
Domains : Interpro (EBI)Kazal_dom   
Domain families : Pfam (Sanger)Kazal_1 (PF00050)   
Domain families : Pfam (NCBI)pfam00050   
Domain families : Smart (EMBL)KAZAL (SM00280)  
Conserved Domain (NCBI)SPINK4
DMDM Disease mutations27290
Blocks (Seattle)SPINK4
SuperfamilyO60575
Human Protein AtlasENSG00000122711
Peptide AtlasO60575
HPRD11598
IPIIPI00030285   IPI00477146   
Protein Interaction databases
DIP (DOE-UCLA)O60575
IntAct (EBI)O60575
FunCoupENSG00000122711
BioGRIDSPINK4
STRING (EMBL)SPINK4
ZODIACSPINK4
Ontologies - Pathways
QuickGOO60575
Ontology : AmiGOserine-type endopeptidase inhibitor activity  extracellular region  negative regulation of endopeptidase activity  response to drug  
Ontology : EGO-EBIserine-type endopeptidase inhibitor activity  extracellular region  negative regulation of endopeptidase activity  response to drug  
NDEx NetworkSPINK4
Atlas of Cancer Signalling NetworkSPINK4
Wikipedia pathwaysSPINK4
Orthology - Evolution
OrthoDB27290
GeneTree (enSembl)ENSG00000122711
Phylogenetic Trees/Animal Genes : TreeFamSPINK4
HOVERGENO60575
HOGENOMO60575
Homologs : HomoloGeneSPINK4
Homology/Alignments : Family Browser (UCSC)SPINK4
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerSPINK4 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)SPINK4
dbVarSPINK4
ClinVarSPINK4
1000_GenomesSPINK4 
Exome Variant ServerSPINK4
ExAC (Exome Aggregation Consortium)SPINK4 (select the gene name)
Genetic variants : HAPMAP27290
Genomic Variants (DGV)SPINK4 [DGVbeta]
DECIPHER (Syndromes)9:33240196-33248565  ENSG00000122711
CONAN: Copy Number AnalysisSPINK4 
Mutations
ICGC Data PortalSPINK4 
TCGA Data PortalSPINK4 
Broad Tumor PortalSPINK4
OASIS PortalSPINK4 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICSPINK4  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDSPINK4
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch SPINK4
DgiDB (Drug Gene Interaction Database)SPINK4
DoCM (Curated mutations)SPINK4 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)SPINK4 (select a term)
intoGenSPINK4
Cancer3DSPINK4(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM613929   
Orphanet
MedgenSPINK4
Genetic Testing Registry SPINK4
NextProtO60575 [Medical]
TSGene27290
GENETestsSPINK4
Huge Navigator SPINK4 [HugePedia]
snp3D : Map Gene to Disease27290
BioCentury BCIQSPINK4
ClinGenSPINK4
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD27290
Chemical/Pharm GKB GenePA38180
Clinical trialSPINK4
Miscellaneous
canSAR (ICR)SPINK4 (select the gene name)
Probes
Litterature
PubMed7 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineSPINK4
EVEXSPINK4
GoPubMedSPINK4
iHOPSPINK4
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Tue Mar 14 12:46:31 CET 2017

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