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SPINK5 (serine peptidase inhibitor, Kazal type 5)

Identity

Other namesLEKTI
LETKI
NETS
NS
VAKTI
HGNC (Hugo) SPINK5
LocusID (NCBI) 11005
Location 5q32
Location_base_pair Starts at 147443535 and ends at 147516925 bp from pter ( according to hg19-Feb_2009)
Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

External links

Nomenclature
HGNC (Hugo)SPINK5   15464
Cards
Entrez_Gene (NCBI)SPINK5  11005  serine peptidase inhibitor, Kazal type 5
GeneCards (Weizmann)SPINK5
Ensembl (Hinxton)ENSG00000133710 [Gene_View]  chr5:147443535-147516925 [Contig_View]  SPINK5 [Vega]
AceView (NCBI)SPINK5
Genatlas (Paris)SPINK5
WikiGenes11005
SOURCE (Princeton)NM_001127698 NM_001127699 NM_006846
Genomic and cartography
GoldenPath (UCSC)SPINK5  -  5q32   chr5:147443535-147516925 +  5q32   [Description]    (hg19-Feb_2009)
EnsemblSPINK5 - 5q32 [CytoView]
Mapping of homologs : NCBISPINK5 [Mapview]
OMIM147050   256500   605010   
Gene and transcription
Genbank (Entrez)AF086524 AF147363 AI341060 AJ228139 AK025197
RefSeq transcript (Entrez)NM_001127698 NM_001127699 NM_006846
RefSeq genomic (Entrez)AC_000137 NC_000005 NC_018916 NG_009633 NT_029289 NW_001838953 NW_004929324
Consensus coding sequences : CCDS (NCBI)SPINK5
Cluster EST : UnigeneHs.331555 [ NCBI ]
CGAP (NCI)Hs.331555
Alternative Splicing : Fast-db (Paris)GSHG0024349
Alternative Splicing GalleryENSG00000133710
Gene ExpressionSPINK5 [ NCBI-GEO ]     SPINK5 [ SEEK ]   SPINK5 [ MEM ]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9NQ38 (Uniprot)
NextProtQ9NQ38  [Medical]
With graphics : InterProQ9NQ38
Splice isoforms : SwissVarQ9NQ38 (Swissvar)
Domaine pattern : Prosite (Expaxy)KAZAL_1 (PS00282)    KAZAL_2 (PS51465)   
Domains : Interpro (EBI)Kazal_dom   
Related proteins : CluSTrQ9NQ38
Domain families : Pfam (Sanger)Kazal_1 (PF00050)    Kazal_2 (PF07648)   
Domain families : Pfam (NCBI)pfam00050    pfam07648   
Domain families : Smart (EMBL)KAZAL (SM00280)  
DMDM Disease mutations11005
Blocks (Seattle)Q9NQ38
PDB (SRS)1H0Z    1HDL    1UUC    1UVF    1UVG   
PDB (PDBSum)1H0Z    1HDL    1UUC    1UVF    1UVG   
PDB (IMB)1H0Z    1HDL    1UUC    1UVF    1UVG   
PDB (RSDB)1H0Z    1HDL    1UUC    1UVF    1UVG   
Human Protein AtlasENSG00000133710
Peptide AtlasQ9NQ38
HPRD05423
IPIIPI00478816   IPI00936431   IPI00654656   IPI00968089   IPI00982385   IPI00974061   
Protein Interaction databases
DIP (DOE-UCLA)Q9NQ38
IntAct (EBI)Q9NQ38
FunCoupENSG00000133710
BioGRIDSPINK5
InParanoidQ9NQ38
Interologous Interaction database Q9NQ38
IntegromeDBSPINK5
STRING (EMBL)SPINK5
Ontologies - Pathways
Ontology : AmiGOserine-type endopeptidase inhibitor activity  extracellular region  extracellular region  cytoplasm  endoplasmic reticulum  endoplasmic reticulum membrane  cytosol  cell cortex  epidermal cell differentiation  negative regulation of angiogenesis  regulation of cell adhesion  extracellular matrix organization  epithelial cell differentiation  hair cell differentiation  anagen  regulation of T cell differentiation  negative regulation of proteolysis  perinuclear region of cytoplasm  negative regulation of immune response  epidermal lamellar body  
Ontology : EGO-EBIserine-type endopeptidase inhibitor activity  extracellular region  extracellular region  cytoplasm  endoplasmic reticulum  endoplasmic reticulum membrane  cytosol  cell cortex  epidermal cell differentiation  negative regulation of angiogenesis  regulation of cell adhesion  extracellular matrix organization  epithelial cell differentiation  hair cell differentiation  anagen  regulation of T cell differentiation  negative regulation of proteolysis  perinuclear region of cytoplasm  negative regulation of immune response  epidermal lamellar body  
REACTOMESPINK5
Protein Interaction DatabaseSPINK5
Wikipedia pathwaysSPINK5
Gene fusion - rearrangments
Polymorphisms : SNP, mutations, diseases
SNP Single Nucleotide Polymorphism (NCBI)SPINK5
SNP (GeneSNP Utah)SPINK5
SNP : HGBaseSPINK5
Genetic variants : HAPMAPSPINK5
1000_GenomesSPINK5 
ICGC programENSG00000133710 
Somatic Mutations in Cancer : COSMICSPINK5 
CONAN: Copy Number AnalysisSPINK5 
Mutations and Diseases : HGMDSPINK5
OMIM147050    256500    605010   
GENETestsSPINK5
Disease Genetic AssociationSPINK5
Huge Navigator SPINK5 [HugePedia]  SPINK5 [HugeCancerGEM]
Genomic VariantsSPINK5  SPINK5 [DGVbeta]
Exome VariantSPINK5
dbVarSPINK5
ClinVarSPINK5
snp3D : Map Gene to Disease11005
General knowledge
Homologs : HomoloGeneSPINK5
Homology/Alignments : Family Browser (UCSC)SPINK5
Phylogenetic Trees/Animal Genes : TreeFamSPINK5
Chemical/Protein Interactions : CTD11005
Chemical/Pharm GKB GenePA37962
Clinical trialSPINK5
Cancer Resource (Charite)ENSG00000133710
Other databases
Probes
Litterature
PubMed59 Pubmed reference(s) in Entrez
CoreMineSPINK5
iHOPSPINK5
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

Contributor(s)

Written09-2002Dessen P, Le Minor S
Updated12-2013Dessen P

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Fri Apr 18 16:57:02 CEST 2014

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