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SPINK5 (serine peptidase inhibitor, Kazal type 5)

Identity

Other namesLEKTI
LETKI
NETS
NS
VAKTI
HGNC (Hugo) SPINK5
LocusID (NCBI) 11005
Atlas_Id 43889
Location 5q32
Location_base_pair Starts at 147443535 and ends at 147516925 bp from pter ( according to hg19-Feb_2009)
Fusion genes
(updated 2016)
SLC25A25 (9q34.11) / SPINK5 (5q32)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)SPINK5   15464
Cards
Entrez_Gene (NCBI)SPINK5  11005  serine peptidase inhibitor, Kazal type 5
AliasesLEKTI; LETKI; NETS; NS; 
VAKTI
GeneCards (Weizmann)SPINK5
Ensembl hg19 (Hinxton)ENSG00000133710 [Gene_View]  chr5:147443535-147516925 [Contig_View]  SPINK5 [Vega]
Ensembl hg38 (Hinxton)ENSG00000133710 [Gene_View]  chr5:147443535-147516925 [Contig_View]  SPINK5 [Vega]
ICGC DataPortalENSG00000133710
TCGA cBioPortalSPINK5
AceView (NCBI)SPINK5
Genatlas (Paris)SPINK5
WikiGenes11005
SOURCE (Princeton)SPINK5
Genomic and cartography
GoldenPath hg19 (UCSC)SPINK5  -     chr5:147443535-147516925 +  5q32   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)SPINK5  -     5q32   [Description]    (hg38-Dec_2013)
EnsemblSPINK5 - 5q32 [CytoView hg19]  SPINK5 - 5q32 [CytoView hg38]
Mapping of homologs : NCBISPINK5 [Mapview hg19]  SPINK5 [Mapview hg38]
OMIM147050   256500   605010   
Gene and transcription
Genbank (Entrez)AF086524 AF147363 AI341060 AJ228139 AK025197
RefSeq transcript (Entrez)NM_001127698 NM_001127699 NM_006846
RefSeq genomic (Entrez)NC_000005 NC_018916 NG_009633 NT_029289 NW_004929324
Consensus coding sequences : CCDS (NCBI)SPINK5
Cluster EST : UnigeneHs.331555 [ NCBI ]
CGAP (NCI)Hs.331555
Alternative Splicing GalleryENSG00000133710
Gene ExpressionSPINK5 [ NCBI-GEO ]   SPINK5 [ EBI - ARRAY_EXPRESS ]   SPINK5 [ SEEK ]   SPINK5 [ MEM ]
Gene Expression Viewer (FireBrowse)SPINK5 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)11005
GTEX Portal (Tissue expression)SPINK5
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9NQ38 (Uniprot)
NextProtQ9NQ38  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9NQ38
Splice isoforms : SwissVarQ9NQ38 (Swissvar)
PhosPhoSitePlusQ9NQ38
Domaine pattern : Prosite (Expaxy)KAZAL_1 (PS00282)    KAZAL_2 (PS51465)   
Domains : Interpro (EBI)Kazal_dom   
Domain families : Pfam (Sanger)Kazal_1 (PF00050)    Kazal_2 (PF07648)   
Domain families : Pfam (NCBI)pfam00050    pfam07648   
Domain families : Smart (EMBL)KAZAL (SM00280)  
DMDM Disease mutations11005
Blocks (Seattle)SPINK5
PDB (SRS)1H0Z    1HDL    1UUC    1UVF    1UVG   
PDB (PDBSum)1H0Z    1HDL    1UUC    1UVF    1UVG   
PDB (IMB)1H0Z    1HDL    1UUC    1UVF    1UVG   
PDB (RSDB)1H0Z    1HDL    1UUC    1UVF    1UVG   
Structural Biology KnowledgeBase1H0Z    1HDL    1UUC    1UVF    1UVG   
SCOP (Structural Classification of Proteins)1H0Z    1HDL    1UUC    1UVF    1UVG   
CATH (Classification of proteins structures)1H0Z    1HDL    1UUC    1UVF    1UVG   
SuperfamilyQ9NQ38
Human Protein AtlasENSG00000133710
Peptide AtlasQ9NQ38
HPRD05423
IPIIPI00478816   IPI00936431   IPI00654656   IPI00968089   IPI00982385   IPI00974061   
Protein Interaction databases
DIP (DOE-UCLA)Q9NQ38
IntAct (EBI)Q9NQ38
FunCoupENSG00000133710
BioGRIDSPINK5
STRING (EMBL)SPINK5
ZODIACSPINK5
Ontologies - Pathways
QuickGOQ9NQ38
Ontology : AmiGOnegative regulation of antibacterial peptide production  serine-type endopeptidase inhibitor activity  extracellular region  extracellular region  cytoplasm  endoplasmic reticulum  endoplasmic reticulum membrane  cytosol  cell cortex  epidermal cell differentiation  negative regulation of angiogenesis  extracellular matrix organization  epithelial cell differentiation  hair cell differentiation  anagen  regulation of T cell differentiation  perinuclear region of cytoplasm  negative regulation of immune response  extracellular exosome  epidermal lamellar body  negative regulation of serine-type endopeptidase activity  
Ontology : EGO-EBInegative regulation of antibacterial peptide production  serine-type endopeptidase inhibitor activity  extracellular region  extracellular region  cytoplasm  endoplasmic reticulum  endoplasmic reticulum membrane  cytosol  cell cortex  epidermal cell differentiation  negative regulation of angiogenesis  extracellular matrix organization  epithelial cell differentiation  hair cell differentiation  anagen  regulation of T cell differentiation  perinuclear region of cytoplasm  negative regulation of immune response  extracellular exosome  epidermal lamellar body  negative regulation of serine-type endopeptidase activity  
NDEx Network
Atlas of Cancer Signalling NetworkSPINK5
Wikipedia pathwaysSPINK5
Orthology - Evolution
OrthoDB11005
GeneTree (enSembl)ENSG00000133710
Phylogenetic Trees/Animal Genes : TreeFamSPINK5
Homologs : HomoloGeneSPINK5
Homology/Alignments : Family Browser (UCSC)SPINK5
Gene fusions - Rearrangements
Polymorphisms : SNP, variants
NCBI Variation ViewerSPINK5 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)SPINK5
dbVarSPINK5
ClinVarSPINK5
1000_GenomesSPINK5 
Exome Variant ServerSPINK5
ExAC (Exome Aggregation Consortium)SPINK5 (select the gene name)
Genetic variants : HAPMAP11005
Genomic Variants (DGV)SPINK5 [DGVbeta]
Mutations
ICGC Data PortalSPINK5 
TCGA Data PortalSPINK5 
Broad Tumor PortalSPINK5
OASIS PortalSPINK5 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICSPINK5 
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
LOVD (Leiden Open Variation Database)**PUBLIC** CCHMC Molecular Genetics Laboratory Mutation Database
BioMutasearch SPINK5
DgiDB (Drug Gene Interaction Database)SPINK5
DoCM (Curated mutations)SPINK5 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)SPINK5 (select a term)
intoGenSPINK5
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] 
Diseases
DECIPHER (Syndromes)5:147443535-147516925  ENSG00000133710
CONAN: Copy Number AnalysisSPINK5 
Mutations and Diseases : HGMDSPINK5
OMIM147050    256500    605010   
MedgenSPINK5
Genetic Testing Registry SPINK5
NextProtQ9NQ38 [Medical]
TSGene11005
GENETestsSPINK5
Huge Navigator SPINK5 [HugePedia]
snp3D : Map Gene to Disease11005
BioCentury BCIQSPINK5
ClinGenSPINK5
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD11005
Chemical/Pharm GKB GenePA37962
Clinical trialSPINK5
Miscellaneous
canSAR (ICR)SPINK5 (select the gene name)
Probes
Litterature
PubMed71 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineSPINK5
EVEXSPINK5
GoPubMedSPINK5
iHOPSPINK5
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Sat May 28 11:22:39 CEST 2016

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