Atlas of Genetics and Cytogenetics in Oncology and Haematology


Home   Genes   Leukemias   Solid Tumors   Cancer-Prone   Deep Insight   Case Reports   Journals  Portal   Teaching   

X Y 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 NA

SPINK8 (serine peptidase inhibitor Kazal type 8 (putative))

Identity

Alias (NCBI)-
HGNC (Hugo) SPINK8
LocusID (NCBI) 646424
Atlas_Id 74185
Location 3p21.31  [Link to chromosome band 3p21]
Location_base_pair Starts at 48306846 and ends at 48328341 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
CDC25A (3p21.31) / SPINK8 (3p21.31)MAP4 (3p21.31) / SPINK8 (3p21.31)PRKAR2A (3p21.31) / SPINK8 (3p21.31)
SMARCC1 (3p21.31) / SPINK8 (3p21.31)MAP4 SPINK8CDC25A SPINK8
SMARCC1 SPINK8

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 4 ]
  CDC25A/SPINK8 (3p21)
MAP4/SPINK8 (3p21)
PRKAR2A/SPINK8 (3p21)
SMARCC1/SPINK8 (3p21)


External links

Nomenclature
HGNC (Hugo)SPINK8   33160
Cards
Entrez_Gene (NCBI)SPINK8  646424  serine peptidase inhibitor Kazal type 8 (putative)
Aliases
GeneCards (Weizmann)SPINK8
Ensembl hg19 (Hinxton)ENSG00000229453 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000229453 [Gene_View]  ENSG00000229453 [Sequence]  chr3:48306846-48328341 [Contig_View]  SPINK8 [Vega]
ICGC DataPortalENSG00000229453
TCGA cBioPortalSPINK8
AceView (NCBI)SPINK8
Genatlas (Paris)SPINK8
WikiGenes646424
SOURCE (Princeton)SPINK8
Genetics Home Reference (NIH)SPINK8
Genomic and cartography
GoldenPath hg38 (UCSC)SPINK8  -     chr3:48306846-48328341 -  3p21.31   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)SPINK8  -     3p21.31   [Description]    (hg19-Feb_2009)
GoldenPathSPINK8 - 3p21.31 [CytoView hg19]  SPINK8 - 3p21.31 [CytoView hg38]
ImmunoBaseENSG00000229453
genome Data Viewer NCBISPINK8 [Mapview hg19]  
Gene and transcription
Genbank (Entrez)AW467501
RefSeq transcript (Entrez)NM_001080525
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)SPINK8
Alternative Splicing GalleryENSG00000229453
Gene ExpressionSPINK8 [ NCBI-GEO ]   SPINK8 [ EBI - ARRAY_EXPRESS ]   SPINK8 [ SEEK ]   SPINK8 [ MEM ]
Gene Expression Viewer (FireBrowse)SPINK8 [ Firebrowse - Broad ]
GenevisibleExpression of SPINK8 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)646424
GTEX Portal (Tissue expression)SPINK8
Human Protein AtlasENSG00000229453-SPINK8 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP0C7L1   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP0C7L1  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP0C7L1
Splice isoforms : SwissVarP0C7L1
PhosPhoSitePlusP0C7L1
Domaine pattern : Prosite (Expaxy)KAZAL_2 (PS51465)   
Domains : Interpro (EBI)Kazal_dom    Kazal_dom_sf   
Domain families : Pfam (Sanger)Kazal_1 (PF00050)   
Domain families : Pfam (NCBI)pfam00050   
Domain families : Smart (EMBL)KAZAL (SM00280)  
Conserved Domain (NCBI)SPINK8
DMDM Disease mutations646424
Blocks (Seattle)SPINK8
SuperfamilyP0C7L1
Human Protein Atlas [tissue]ENSG00000229453-SPINK8 [tissue]
Peptide AtlasP0C7L1
IPIIPI00827639   
Protein Interaction databases
DIP (DOE-UCLA)P0C7L1
IntAct (EBI)P0C7L1
FunCoupENSG00000229453
BioGRIDSPINK8
STRING (EMBL)SPINK8
ZODIACSPINK8
Ontologies - Pathways
QuickGOP0C7L1
Ontology : AmiGOserine-type endopeptidase inhibitor activity  extracellular region  negative regulation of endopeptidase activity  
Ontology : EGO-EBIserine-type endopeptidase inhibitor activity  extracellular region  negative regulation of endopeptidase activity  
NDEx NetworkSPINK8
Atlas of Cancer Signalling NetworkSPINK8
Wikipedia pathwaysSPINK8
Orthology - Evolution
OrthoDB646424
GeneTree (enSembl)ENSG00000229453
Phylogenetic Trees/Animal Genes : TreeFamSPINK8
HOGENOMP0C7L1
Homologs : HomoloGeneSPINK8
Homology/Alignments : Family Browser (UCSC)SPINK8
Gene fusions - Rearrangements
Fusion PortalMAP4 SPINK8
Fusion PortalCDC25A SPINK8
Fusion PortalSMARCC1 SPINK8
Fusion : QuiverSPINK8
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerSPINK8 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)SPINK8
dbVarSPINK8
ClinVarSPINK8
1000_GenomesSPINK8 
Exome Variant ServerSPINK8
GNOMAD BrowserENSG00000229453
Varsome BrowserSPINK8
Genetic variants : HAPMAP646424
Genomic Variants (DGV)SPINK8 [DGVbeta]
DECIPHERSPINK8 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisSPINK8 
Mutations
ICGC Data PortalSPINK8 
TCGA Data PortalSPINK8 
Broad Tumor PortalSPINK8
OASIS PortalSPINK8 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICSPINK8  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DSPINK8
Mutations and Diseases : HGMDSPINK8
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch SPINK8
DgiDB (Drug Gene Interaction Database)SPINK8
DoCM (Curated mutations)SPINK8 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)SPINK8 (select a term)
intoGenSPINK8
Cancer3DSPINK8(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM
Orphanet
DisGeNETSPINK8
MedgenSPINK8
Genetic Testing Registry SPINK8
NextProtP0C7L1 [Medical]
TSGene646424
GENETestsSPINK8
Target ValidationSPINK8
Huge Navigator SPINK8 [HugePedia]
snp3D : Map Gene to Disease646424
BioCentury BCIQSPINK8
ClinGenSPINK8
Clinical trials, drugs, therapy
Protein Interactions : CTD646424
Pharm GKB GenePA162404546
Clinical trialSPINK8
Miscellaneous
canSAR (ICR)SPINK8 (select the gene name)
HarmonizomeSPINK8
DataMed IndexSPINK8
Probes
Litterature
PubMed3 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineSPINK8
EVEXSPINK8
GoPubMedSPINK8
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Sat Aug 22 19:36:48 CEST 2020

Home   Genes   Leukemias   Solid Tumors   Cancer-Prone   Deep Insight   Case Reports   Journals  Portal   Teaching   

For comments and suggestions or contributions, please contact us

jlhuret@AtlasGeneticsOncology.org.