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SPINK8 (serine peptidase inhibitor, Kazal type 8 (putative))

Identity

Other alias-
HGNC (Hugo) SPINK8
LocusID (NCBI) 646424
Atlas_Id 74185
Location 3p21.31  [Link to chromosome band 3p21]
Location_base_pair Starts at 48306846 and ends at 48328341 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
CDC25A (3p21.31) / SPINK8 (3p21.31)MAP4 (3p21.31) / SPINK8 (3p21.31)PRKAR2A (3p21.31) / SPINK8 (3p21.31)
SMARCC1 (3p21.31) / SPINK8 (3p21.31)MAP4 SPINK8CDC25A SPINK8
SMARCC1 SPINK8

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to wrmte a"fell paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

GoldenPath hg19 (UCSC)
Nomenclature
HGNC (Hugo)SPINK8   33160
Cards
Entrez_Gene (NCBI)SPINK8  646424  serine peptidase inhibitor, Kazal type 8 (putative)
Aliases
GeneCards (Weizmann)SPINK8
Ensembl hg19 (Hinxton)ENSG00000229453 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000229453 [Gene_View]  chr3:48306846-48328341 [Contig_View]  SPINK8 [Vega]
ICGC DataPortalENSG00000229453
TCGA cBioPortalSPINK8
AceView (NCBI)SPINK8
Genatlas (Paris)SPINK8
WikiGenes646424
SOURCE (Princeton)SPINK8
Genetics Home Reference (NIH)SPINK8
Genomic and cartography
GoldenPath hg38 (UCSC)SPINK8  -     chr3:48306846-48328341 -  3p21.31   [Description]    (hg38-Dec_2013)
SPINK8  -     3p21.31   [Description]    (hg19-Feb_2009)
EnsemblSPINK8 - 3p21.31 [CytoView hg19]  SPINK8 - 3p21.31 [CytoView hg38]
Mapping of homologs : NCBISPINK8 [Mapview hg19]  SPINK8 [Mapview hg38]
Gene and transcription
Genbank (Entrez)-
RefSeq transcript (Entrez)NM_001080525
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)SPINK8
Cluster EST : UnigeneHs.257687 [ NCBI ]
CGAP (NCI)Hs.257687
Alternative Splicing GalleryENSG00000229453
Gene ExpressionSPINK8 [ NCBI-GEO ]   SPINK8 [ EBI - ARRAY_EXPRESS ]   SPINK8 [ SEEK ]   SPINK8 [ MEM ]
Gene Expression Viewer (FireBrowse)SPINK8 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)646424
GTEX Portal (Tissue expression)SPINK8
Protein : pattern, domain, 3D structure
UniProt/SwissProtP0C7L1   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP0C7L1  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP0C7L1
Splice isoforms : SwissVarP0C7L1
PhosPhoSitePlusP0C7L1
Domaine pattern : Prosite (Expaxy)KAZAL_2 (PS51465)   
Domains : Interpro (EBI)Kazal_dom   
Domain families : Pfam (Sanger)Kazal_1 (PF00050)   
Domain families : Pfam (NCBI)pfam00050   
Domain families : Smart (EMBL)KAZAL (SM00280)  
Conserved Domain (NCBI)SPINK8
DMDM Disease mutations646424
Blocks (Seattle)SPINK8
SuperfamilyP0C7L1
Human Protein AtlasENSG00000229453
Peptide AtlasP0C7L1
IPIIPI00827639   
Protein Interaction databases
DIP (DOE-UCLA)P0C7L1
IntAct (EBI)P0C7L1
FunCoupENSG00000229453
BioGRIDSPINK8
STRING (EMBL)SPINK8
ZODIACSPINK8
Ontologies - Pathways
QuickGOP0C7L1
Ontology : AmiGOacrosomal vesicle  serine-type endopeptidase inhibitor activity  extracellular space  regulation of acrosome reaction  negative regulation of serine-type endopeptidase activity  
Ontology : EGO-EBIacrosomal vesicle  serine-type endopeptidase inhibitor activity  extracellular space  regulation of acrosome reaction  negative regulation of serine-type endopeptidase activity  
NDEx NetworkSPINK8
Atlas of Cancer Signalling NetworkSPINK8
Wikipedia pathwaysSPINK8
Orthology - Evolution
OrthoDB646424
GeneTree (enSembl)ENSG00000229453
Phylogenetic Trees/Animal Genes : TreeFamSPINK8
HOVERGENP0C7L1
HOGENOMP0C7L1
Homologs : HomoloGeneSPINK8
Homology/Alignments : Family Browser (UCSC)SPINK8
Gene fusions - Rearrangements
Fusion: TCGAMAP4 SPINK8
Fusion: TCGACDC25A SPINK8
Fusion: TCGASMARCC1 SPINK8
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerSPINK8 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)SPINK8
dbVarSPINK8
ClinVarSPINK8
1000_GenomesSPINK8 
Exome Variant ServerSPINK8
ExAC (Exome Aggregation Consortium)SPINK8 (select the gene name)
Genetic variants : HAPMAP646424
Genomic Variants (DGV)SPINK8 [DGVbeta]
DECIPHERSPINK8 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisSPINK8 
Mutations
ICGC Data PortalSPINK8 
TCGA Data PortalSPINK8 
Broad Tumor PortalSPINK8
OASIS PortalSPINK8 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICSPINK8  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDSPINK8
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch SPINK8
DgiDB (Drug Gene Interaction Database)SPINK8
DoCM (Curated mutations)SPINK8 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)SPINK8 (select a term)
intoGenSPINK8
Cancer3DSPINK8(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM
Orphanet
MedgenSPINK8
Genetic Testing Registry SPINK8
NextProtP0C7L1 [Medical]
TSGene646424
GENETestsSPINK8
Target ValidationSPINK8
Huge Navigator SPINK8 [HugePedia]
snp3D : Map Gene to Disease646424
BioCentury BCIQSPINK8
ClinGenSPINK8
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD646424
Chemical/Pharm GKB GenePA162404546
Clinical trialSPINK8
Miscellaneous
canSAR (ICR)SPINK8 (select the gene name)
Probes
Litterature
PubMed2 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineSPINK8
EVEXSPINK8
GoPubMedSPINK8
iHOPSPINK8
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

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indexed on : Mon Sep 18 13:40:22 CEST 2017

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