Atlas of Genetics and Cytogenetics in Oncology and Haematology

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SPIRE2 (spire type actin nucleation factor 2)

Identity

Alias (NCBI)Spir-2
HGNC (Hugo) SPIRE2
HGNC Alias symbspir-2
KIAA1832
HGNC Previous namespire homolog 2 (Drosophila)
 spire family actin nucleation factor 2
 spire-type actin nucleation factor 2
LocusID (NCBI) 84501
Atlas_Id 56103
Location 16q24.3  [Link to chromosome band 16q24]
Location_base_pair Starts at 89828475 and ends at 89871319 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)		Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
GAS8 (16q24.3) / SPIRE2 (16q24.3)SPIRE2 (16q24.3) / SPIRE2 (16q24.3)SPIRE2 (16q24.3) / SRC (20q11.23)
TCF25 (16q24.3) / SPIRE2 (16q24.3)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

External links

Nomenclature
HGNC (Hugo)SPIRE2   30623
Cards
Entrez_Gene (NCBI)SPIRE2    spire type actin nucleation factor 2
AliasesSpir-2
GeneCards (Weizmann)SPIRE2
Ensembl hg19 (Hinxton)ENSG00000204991 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000204991 [Gene_View]  ENSG00000204991 [Sequence]  chr16:89828475-89871319 [Contig_View]  SPIRE2 [Vega]
ICGC DataPortalENSG00000204991
TCGA cBioPortalSPIRE2
AceView (NCBI)SPIRE2
Genatlas (Paris)SPIRE2
SOURCE (Princeton)SPIRE2
Genetics Home Reference (NIH)SPIRE2
Genomic and cartography
GoldenPath hg38 (UCSC)SPIRE2  -     chr16:89828475-89871319 +  16q24.3   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)SPIRE2  -     16q24.3   [Description]    (hg19-Feb_2009)
GoldenPathSPIRE2 - 16q24.3 [CytoView hg19]  SPIRE2 - 16q24.3 [CytoView hg38]
ImmunoBaseENSG00000204991
genome Data Viewer NCBISPIRE2 [Mapview hg19]  
OMIM609217   
Gene and transcription
Genbank (Entrez)AB058735 AJ422077 AK094918 AK130680 AK130685
RefSeq transcript (Entrez)NM_032451
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)SPIRE2
Alternative Splicing GalleryENSG00000204991
Gene ExpressionSPIRE2 [ NCBI-GEO ]   SPIRE2 [ EBI - ARRAY_EXPRESS ]   SPIRE2 [ SEEK ]   SPIRE2 [ MEM ]
Gene Expression Viewer (FireBrowse)SPIRE2 [ Firebrowse - Broad ]
GenevisibleExpression of SPIRE2 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)84501
GTEX Portal (Tissue expression)SPIRE2
Human Protein AtlasENSG00000204991-SPIRE2 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ8WWL2   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ8WWL2  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ8WWL2
Splice isoforms : SwissVarQ8WWL2
PhosPhoSitePlusQ8WWL2
Domaine pattern : Prosite (Expaxy)KIND (PS51377)    WH2 (PS51082)   
Domains : Interpro (EBI)KIND_dom    Spire    Spire2    WH2_dom    Znf_FYVE_PHD   
Domain families : Pfam (Sanger)KIND (PF16474)   
Domain families : Pfam (NCBI)pfam16474   
Domain families : Smart (EMBL)KIND (SM00750)  
Conserved Domain (NCBI)SPIRE2
Blocks (Seattle)SPIRE2
PDB (RSDB)5JCY   
PDB Europe5JCY   
PDB (PDBSum)5JCY   
PDB (IMB)5JCY   
Structural Biology KnowledgeBase5JCY   
SCOP (Structural Classification of Proteins)5JCY   
CATH (Classification of proteins structures)5JCY   
SuperfamilyQ8WWL2
Human Protein Atlas [tissue]ENSG00000204991-SPIRE2 [tissue]
Peptide AtlasQ8WWL2
HPRD18099
IPIIPI00783064   IPI00646357   IPI00549652   IPI00646787   
Protein Interaction databases
DIP (DOE-UCLA)Q8WWL2
IntAct (EBI)Q8WWL2
BioGRIDSPIRE2
STRING (EMBL)SPIRE2
ZODIACSPIRE2
Ontologies - Pathways
QuickGOQ8WWL2
Ontology : AmiGOactin binding  cytosol  cytoskeleton  cell cortex  cell cortex  protein transport  vesicle-mediated transport  actin cytoskeleton organization  actin filament polymerization  cytoplasmic vesicle membrane  cytoplasmic vesicle membrane  cleavage furrow  cleavage furrow formation  cleavage furrow formation  polar body extrusion after meiotic divisions  polar body extrusion after meiotic divisions  actin nucleation  intracellular transport  intracellular transport  Golgi vesicle transport  establishment of meiotic spindle localization  establishment of meiotic spindle localization  actin filament network formation  formin-nucleated actin cable assembly  positive regulation of double-strand break repair  
Ontology : EGO-EBIactin binding  cytosol  cytoskeleton  cell cortex  cell cortex  protein transport  vesicle-mediated transport  actin cytoskeleton organization  actin filament polymerization  cytoplasmic vesicle membrane  cytoplasmic vesicle membrane  cleavage furrow  cleavage furrow formation  cleavage furrow formation  polar body extrusion after meiotic divisions  polar body extrusion after meiotic divisions  actin nucleation  intracellular transport  intracellular transport  Golgi vesicle transport  establishment of meiotic spindle localization  establishment of meiotic spindle localization  actin filament network formation  formin-nucleated actin cable assembly  positive regulation of double-strand break repair  
Pathways : KEGGDorso-ventral axis formation   
NDEx NetworkSPIRE2
Atlas of Cancer Signalling NetworkSPIRE2
Wikipedia pathwaysSPIRE2
Orthology - Evolution
OrthoDB84501
GeneTree (enSembl)ENSG00000204991
Phylogenetic Trees/Animal Genes : TreeFamSPIRE2
HOGENOMQ8WWL2
Homologs : HomoloGeneSPIRE2
Homology/Alignments : Family Browser (UCSC)SPIRE2
Gene fusions - Rearrangements
Fusion : QuiverSPIRE2
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerSPIRE2 [hg38]
dbVarSPIRE2
ClinVarSPIRE2
MonarchSPIRE2
1000_GenomesSPIRE2 
Exome Variant ServerSPIRE2
GNOMAD BrowserENSG00000204991
Varsome BrowserSPIRE2
Genomic Variants (DGV)SPIRE2 [DGVbeta]
DECIPHERSPIRE2 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisSPIRE2 
Mutations
ICGC Data PortalSPIRE2 
TCGA Data PortalSPIRE2 
Broad Tumor PortalSPIRE2
OASIS PortalSPIRE2 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICSPIRE2  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DSPIRE2
Mutations and Diseases : HGMDSPIRE2
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch SPIRE2
DgiDB (Drug Gene Interaction Database)SPIRE2
DoCM (Curated mutations)SPIRE2 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)SPIRE2 (select a term)
intoGenSPIRE2
Cancer3DSPIRE2(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM609217   
Orphanet
DisGeNETSPIRE2
MedgenSPIRE2
Genetic Testing Registry SPIRE2
NextProtQ8WWL2 [Medical]
GENETestsSPIRE2
Target ValidationSPIRE2
Huge Navigator SPIRE2 [HugePedia]
ClinGenSPIRE2
Clinical trials, drugs, therapy
MyCancerGenomeSPIRE2
Protein Interactions : CTD
Pharm GKB GenePA134926582
PharosQ8WWL2
Clinical trialSPIRE2
Miscellaneous
canSAR (ICR)SPIRE2 (select the gene name)
HarmonizomeSPIRE2
DataMed IndexSPIRE2
Probes
Litterature
PubMed13 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXSPIRE2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Thu Mar 25 19:47:24 CET 2021
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