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SPO11 (SPO11 initiator of meiotic double stranded breaks)

Identity

Alias (NCBI)CT35
SPATA43
TOPOVIA
TOPVIA
HGNC (Hugo) SPO11
HGNC Alias symbCT35
SPATA43
TOPVIA
TOPOVIA
HGNC Alias namecancer/testis antigen 35
 spermatogenesis associated 43
HGNC Previous nameSPO11, meiotic protein covalently bound to DSB (S. cerevisiae)-like
 SPO11 meiotic protein covalently bound to DSB-like (S. cerevisiae)
 SPO11 meiotic protein covalently bound to DSB homolog (S. cerevisiae)
 SPO11 meiotic protein covalently bound to DSB
LocusID (NCBI) 23626
Atlas_Id 56743
Location 20q13.31  [Link to chromosome band 20q13]
Location_base_pair Starts at 57329803 and ends at 57343993 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
RBM38 (20q13.31) / SPO11 (20q13.31)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



External links

 

Nomenclature
HGNC (Hugo)SPO11   11250
Cards
Entrez_Gene (NCBI)SPO11    SPO11 initiator of meiotic double stranded breaks
AliasesCT35; SPATA43; TOPOVIA; TOPVIA
GeneCards (Weizmann)SPO11
Ensembl hg19 (Hinxton)ENSG00000054796 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000054796 [Gene_View]  ENSG00000054796 [Sequence]  chr20:57329803-57343993 [Contig_View]  SPO11 [Vega]
ICGC DataPortalENSG00000054796
TCGA cBioPortalSPO11
AceView (NCBI)SPO11
Genatlas (Paris)SPO11
SOURCE (Princeton)SPO11
Genetics Home Reference (NIH)SPO11
Genomic and cartography
GoldenPath hg38 (UCSC)SPO11  -     chr20:57329803-57343993 +  20q13.31   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)SPO11  -     20q13.31   [Description]    (hg19-Feb_2009)
GoldenPathSPO11 - 20q13.31 [CytoView hg19]  SPO11 - 20q13.31 [CytoView hg38]
ImmunoBaseENSG00000054796
Genome Data Viewer NCBISPO11 [Mapview hg19]  
OMIM605114   
Gene and transcription
Genbank (Entrez)AF149310 AF169385 BC033591
RefSeq transcript (Entrez)NM_012444 NM_198265
Consensus coding sequences : CCDS (NCBI)SPO11
Gene ExpressionSPO11 [ NCBI-GEO ]   SPO11 [ EBI - ARRAY_EXPRESS ]   SPO11 [ SEEK ]   SPO11 [ MEM ]
Gene Expression Viewer (FireBrowse)SPO11 [ Firebrowse - Broad ]
GenevisibleExpression of SPO11 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)23626
GTEX Portal (Tissue expression)SPO11
Human Protein AtlasENSG00000054796-SPO11 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9Y5K1   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9Y5K1  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9Y5K1
PhosPhoSitePlusQ9Y5K1
Domains : Interpro (EBI)Meiosis_Spo11    Meiotic_Spo11    Spo11/TopoVI_A    Spo11/TopoVI_A_N    Spo11/TopoVI_A_sf    TOPRIM_Topo6A/Spo11    WH-like_DNA-bd_sf   
Domain families : Pfam (Sanger)SPO11_like (PF03533)    TP6A_N (PF04406)   
Domain families : Pfam (NCBI)pfam03533    pfam04406   
Conserved Domain (NCBI)SPO11
SuperfamilyQ9Y5K1
AlphaFold pdb e-kbQ9Y5K1   
Human Protein Atlas [tissue]ENSG00000054796-SPO11 [tissue]
Protein Interaction databases
DIP (DOE-UCLA)Q9Y5K1
IntAct (EBI)Q9Y5K1
BioGRIDSPO11
STRING (EMBL)SPO11
ZODIACSPO11
Ontologies - Pathways
QuickGOQ9Y5K1
Ontology : AmiGOnuclear chromosome  meiotic DNA double-strand break processing  chromosome, telomeric region  ovarian follicle development  DNA binding  DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity  protein binding  ATP binding  synaptonemal complex assembly  reciprocal meiotic recombination  male meiosis I  spermatogenesis  spermatid development  female gamete generation  endodeoxyribonuclease activity, producing 3'-phosphomonoesters  protein localization to chromosome  meiotic DNA double-strand break formation  meiotic telomere clustering  metal ion binding  oogenesis  double-strand break repair involved in meiotic recombination  
Ontology : EGO-EBInuclear chromosome  meiotic DNA double-strand break processing  chromosome, telomeric region  ovarian follicle development  DNA binding  DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity  protein binding  ATP binding  synaptonemal complex assembly  reciprocal meiotic recombination  male meiosis I  spermatogenesis  spermatid development  female gamete generation  endodeoxyribonuclease activity, producing 3'-phosphomonoesters  protein localization to chromosome  meiotic DNA double-strand break formation  meiotic telomere clustering  metal ion binding  oogenesis  double-strand break repair involved in meiotic recombination  
NDEx NetworkSPO11
Atlas of Cancer Signalling NetworkSPO11
Wikipedia pathwaysSPO11
Orthology - Evolution
OrthoDB23626
GeneTree (enSembl)ENSG00000054796
Phylogenetic Trees/Animal Genes : TreeFamSPO11
Homologs : HomoloGeneSPO11
Homology/Alignments : Family Browser (UCSC)SPO11
Gene fusions - Rearrangements
Fusion : QuiverSPO11
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerSPO11 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)SPO11
dbVarSPO11
ClinVarSPO11
MonarchSPO11
1000_GenomesSPO11 
Exome Variant ServerSPO11
GNOMAD BrowserENSG00000054796
Varsome BrowserSPO11
ACMGSPO11 variants
VarityQ9Y5K1
Genomic Variants (DGV)SPO11 [DGVbeta]
DECIPHERSPO11 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisSPO11 
Mutations
ICGC Data PortalSPO11 
TCGA Data PortalSPO11 
Broad Tumor PortalSPO11
OASIS PortalSPO11 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICSPO11  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DSPO11
Mutations and Diseases : HGMDSPO11
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaSPO11
DgiDB (Drug Gene Interaction Database)SPO11
DoCM (Curated mutations)SPO11
CIViC (Clinical Interpretations of Variants in Cancer)SPO11
Cancer3DSPO11
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM605114   
Orphanet
DisGeNETSPO11
MedgenSPO11
Genetic Testing Registry SPO11
NextProtQ9Y5K1 [Medical]
GENETestsSPO11
Target ValidationSPO11
Huge Navigator SPO11 [HugePedia]
ClinGenSPO11
Clinical trials, drugs, therapy
MyCancerGenomeSPO11
Protein Interactions : CTDSPO11
Pharm GKB GenePA36080
PharosQ9Y5K1
Clinical trialSPO11
Miscellaneous
canSAR (ICR)SPO11
HarmonizomeSPO11
DataMed IndexSPO11
Probes
Litterature
PubMed19 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXSPO11
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Oct 4 15:32:56 CEST 2021

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