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SPOCK1 (sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1)

Identity

Alias_namesTIC1
SPOCK
sparc/osteonectin
Alias_symbol (synonym)testican-1
Other aliasTESTICAN
HGNC (Hugo) SPOCK1
LocusID (NCBI) 6695
Atlas_Id 42376
Location 5q31.2  [Link to chromosome band 5q31]
Location_base_pair Starts at 136310987 and ends at 136835018 bp from pter ( according to hg19-Feb_2009)
Fusion genes
(updated 2016)
KSR2 (12q24.22) / SPOCK1 (5q31.2)SPOCK1 (5q31.2) / ARHGAP26 (5q31.3)SPOCK1 (5q31.2) / COPA (1q23.2)
SPOCK1 (5q31.2) / TBC1D9B (5q35.3)SPOCK1 (5q31.2) / TCTN3 (10q24.1)XPNPEP3 (22q13.2) / SPOCK1 (5q31.2)
SPOCK1 5q31.2 / ARHGAP26 5q31.3

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 1 ]
  Prostate tumors: an overview


External links

Nomenclature
HGNC (Hugo)SPOCK1   11251
Cards
Entrez_Gene (NCBI)SPOCK1  6695  sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1
AliasesSPOCK; TESTICAN; TIC1
GeneCards (Weizmann)SPOCK1
Ensembl hg19 (Hinxton)ENSG00000152377 [Gene_View]  chr5:136310987-136835018 [Contig_View]  SPOCK1 [Vega]
Ensembl hg38 (Hinxton)ENSG00000152377 [Gene_View]  chr5:136310987-136835018 [Contig_View]  SPOCK1 [Vega]
ICGC DataPortalENSG00000152377
TCGA cBioPortalSPOCK1
AceView (NCBI)SPOCK1
Genatlas (Paris)SPOCK1
WikiGenes6695
SOURCE (Princeton)SPOCK1
Genetics Home Reference (NIH)SPOCK1
Genomic and cartography
GoldenPath hg19 (UCSC)SPOCK1  -     chr5:136310987-136835018 -  5q31.2   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)SPOCK1  -     5q31.2   [Description]    (hg38-Dec_2013)
EnsemblSPOCK1 - 5q31.2 [CytoView hg19]  SPOCK1 - 5q31.2 [CytoView hg38]
Mapping of homologs : NCBISPOCK1 [Mapview hg19]  SPOCK1 [Mapview hg38]
OMIM602264   
Gene and transcription
Genbank (Entrez)AB209701 AF231124 AI674088 AK094489 BC030691
RefSeq transcript (Entrez)NM_004598
RefSeq genomic (Entrez)NC_000005 NC_018916 NG_034127 NT_034772 NW_004929323
Consensus coding sequences : CCDS (NCBI)SPOCK1
Cluster EST : UnigeneHs.596136 [ NCBI ]
CGAP (NCI)Hs.596136
Alternative Splicing GalleryENSG00000152377
Gene ExpressionSPOCK1 [ NCBI-GEO ]   SPOCK1 [ EBI - ARRAY_EXPRESS ]   SPOCK1 [ SEEK ]   SPOCK1 [ MEM ]
Gene Expression Viewer (FireBrowse)SPOCK1 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)6695
GTEX Portal (Tissue expression)SPOCK1
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ08629   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ08629  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ08629
Splice isoforms : SwissVarQ08629
PhosPhoSitePlusQ08629
Domaine pattern : Prosite (Expaxy)KAZAL_2 (PS51465)    THYROGLOBULIN_1_1 (PS00484)    THYROGLOBULIN_1_2 (PS51162)   
Domains : Interpro (EBI)EF-hand-dom_pair    Kazal_dom    SPARC/Testican_Ca-bd-dom    Thyroglobulin_1   
Domain families : Pfam (Sanger)Kazal_2 (PF07648)    SPARC_Ca_bdg (PF10591)    Thyroglobulin_1 (PF00086)   
Domain families : Pfam (NCBI)pfam07648    pfam10591    pfam00086   
Domain families : Smart (EMBL)KAZAL (SM00280)  TY (SM00211)  
Conserved Domain (NCBI)SPOCK1
DMDM Disease mutations6695
Blocks (Seattle)SPOCK1
SuperfamilyQ08629
Human Protein AtlasENSG00000152377
Peptide AtlasQ08629
HPRD11887
IPIIPI00005292   IPI00964787   IPI00967801   IPI00967573   
Protein Interaction databases
DIP (DOE-UCLA)Q08629
IntAct (EBI)Q08629
FunCoupENSG00000152377
BioGRIDSPOCK1
STRING (EMBL)SPOCK1
ZODIACSPOCK1
Ontologies - Pathways
QuickGOQ08629
Ontology : AmiGOregulation of cell growth  neuron migration  serine-type endopeptidase inhibitor activity  cysteine-type endopeptidase inhibitor activity  calcium ion binding  proteinaceous extracellular matrix  extracellular space  cytoplasm  cell adhesion  signal transduction  nervous system development  metalloendopeptidase inhibitor activity  negative regulation of cell-substrate adhesion  negative regulation of endopeptidase activity  negative regulation of neuron projection development  postsynaptic density  sarcoplasm  central nervous system neuron differentiation  neurogenesis  neuromuscular junction  node of Ranvier  
Ontology : EGO-EBIregulation of cell growth  neuron migration  serine-type endopeptidase inhibitor activity  cysteine-type endopeptidase inhibitor activity  calcium ion binding  proteinaceous extracellular matrix  extracellular space  cytoplasm  cell adhesion  signal transduction  nervous system development  metalloendopeptidase inhibitor activity  negative regulation of cell-substrate adhesion  negative regulation of endopeptidase activity  negative regulation of neuron projection development  postsynaptic density  sarcoplasm  central nervous system neuron differentiation  neurogenesis  neuromuscular junction  node of Ranvier  
NDEx NetworkSPOCK1
Atlas of Cancer Signalling NetworkSPOCK1
Wikipedia pathwaysSPOCK1
Orthology - Evolution
OrthoDB6695
GeneTree (enSembl)ENSG00000152377
Phylogenetic Trees/Animal Genes : TreeFamSPOCK1
HOVERGENQ08629
HOGENOMQ08629
Homologs : HomoloGeneSPOCK1
Homology/Alignments : Family Browser (UCSC)SPOCK1
Gene fusions - Rearrangements
Fusion : MitelmanSPOCK1/ARHGAP26 [5q31.2/5q31.3]  
Fusion : MitelmanSPOCK1/TBC1D9B [5q31.2/5q35.3]  [t(5;5)(q31;q35)]  
Fusion: TCGASPOCK1 5q31.2 ARHGAP26 5q31.3 LUAD
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerSPOCK1 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)SPOCK1
dbVarSPOCK1
ClinVarSPOCK1
1000_GenomesSPOCK1 
Exome Variant ServerSPOCK1
ExAC (Exome Aggregation Consortium)SPOCK1 (select the gene name)
Genetic variants : HAPMAP6695
Genomic Variants (DGV)SPOCK1 [DGVbeta]
DECIPHER (Syndromes)5:136310987-136835018  ENSG00000152377
CONAN: Copy Number AnalysisSPOCK1 
Mutations
ICGC Data PortalSPOCK1 
TCGA Data PortalSPOCK1 
Broad Tumor PortalSPOCK1
OASIS PortalSPOCK1 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICSPOCK1  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDSPOCK1
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch SPOCK1
DgiDB (Drug Gene Interaction Database)SPOCK1
DoCM (Curated mutations)SPOCK1 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)SPOCK1 (select a term)
intoGenSPOCK1
Cancer3DSPOCK1(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM602264   
Orphanet
MedgenSPOCK1
Genetic Testing Registry SPOCK1
NextProtQ08629 [Medical]
TSGene6695
GENETestsSPOCK1
Huge Navigator SPOCK1 [HugePedia]
snp3D : Map Gene to Disease6695
BioCentury BCIQSPOCK1
ClinGenSPOCK1
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD6695
Chemical/Pharm GKB GenePA36081
Clinical trialSPOCK1
Miscellaneous
canSAR (ICR)SPOCK1 (select the gene name)
Probes
Litterature
PubMed26 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineSPOCK1
EVEXSPOCK1
GoPubMedSPOCK1
iHOPSPOCK1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Thu Mar 30 15:20:40 CEST 2017

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