Atlas of Genetics and Cytogenetics in Oncology and Haematology


Home   Genes   Leukemias   Solid Tumors   Cancer-Prone   Deep Insight   Case Reports   Journals  Portal   Teaching   

X Y 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 NA

SPOCK2 (SPARC/osteonectin, cwcv and kazal like domains proteoglycan 2)

Identity

Alias_namessparc/osteonectin
Alias_symbol (synonym)KIAA0275
testican-2
Other alias
HGNC (Hugo) SPOCK2
LocusID (NCBI) 9806
Atlas_Id 53964
Location 10q22.1  [Link to chromosome band 10q22]
Location_base_pair Starts at 72086226 and ends at 72089032 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
CHSY1 (15q26.3) / SPOCK2 (10q22.1)CHSY1 15q26.3 / SPOCK2 10q22.1

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)SPOCK2   13564
Cards
Entrez_Gene (NCBI)SPOCK2  9806  SPARC/osteonectin, cwcv and kazal like domains proteoglycan 2
Aliasestestican-2
GeneCards (Weizmann)SPOCK2
Ensembl hg19 (Hinxton)ENSG00000107742 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000107742 [Gene_View]  chr10:72086226-72089032 [Contig_View]  SPOCK2 [Vega]
ICGC DataPortalENSG00000107742
TCGA cBioPortalSPOCK2
AceView (NCBI)SPOCK2
Genatlas (Paris)SPOCK2
WikiGenes9806
SOURCE (Princeton)SPOCK2
Genetics Home Reference (NIH)SPOCK2
Genomic and cartography
GoldenPath hg38 (UCSC)SPOCK2  -     chr10:72086226-72089032 -  10q22.1   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)SPOCK2  -     10q22.1   [Description]    (hg19-Feb_2009)
EnsemblSPOCK2 - 10q22.1 [CytoView hg19]  SPOCK2 - 10q22.1 [CytoView hg38]
Mapping of homologs : NCBISPOCK2 [Mapview hg19]  SPOCK2 [Mapview hg38]
OMIM607988   
Gene and transcription
Genbank (Entrez)AA922448 AJ001453 AK292328 AK294008 AK307091
RefSeq transcript (Entrez)NM_001134434 NM_001244950 NM_014767
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)SPOCK2
Cluster EST : UnigeneHs.523009 [ NCBI ]
CGAP (NCI)Hs.523009
Alternative Splicing GalleryENSG00000107742
Gene ExpressionSPOCK2 [ NCBI-GEO ]   SPOCK2 [ EBI - ARRAY_EXPRESS ]   SPOCK2 [ SEEK ]   SPOCK2 [ MEM ]
Gene Expression Viewer (FireBrowse)SPOCK2 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)9806
GTEX Portal (Tissue expression)SPOCK2
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ92563   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ92563  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ92563
Splice isoforms : SwissVarQ92563
PhosPhoSitePlusQ92563
Domaine pattern : Prosite (Expaxy)KAZAL_2 (PS51465)    THYROGLOBULIN_1_1 (PS00484)    THYROGLOBULIN_1_2 (PS51162)   
Domains : Interpro (EBI)AB_hydrolase    EF-hand-dom_pair    Kazal_dom    SPARC/Testican_Ca-bd-dom    Thyroglobulin_1   
Domain families : Pfam (Sanger)Kazal_2 (PF07648)    SPARC_Ca_bdg (PF10591)    Thyroglobulin_1 (PF00086)   
Domain families : Pfam (NCBI)pfam07648    pfam10591    pfam00086   
Domain families : Smart (EMBL)KAZAL (SM00280)  TY (SM00211)  
Conserved Domain (NCBI)SPOCK2
DMDM Disease mutations9806
Blocks (Seattle)SPOCK2
SuperfamilyQ92563
Human Protein AtlasENSG00000107742
Peptide AtlasQ92563
HPRD12146
IPIIPI00006128   IPI01011155   IPI00909202   
Protein Interaction databases
DIP (DOE-UCLA)Q92563
IntAct (EBI)Q92563
FunCoupENSG00000107742
BioGRIDSPOCK2
STRING (EMBL)SPOCK2
ZODIACSPOCK2
Ontologies - Pathways
QuickGOQ92563
Ontology : AmiGOcalcium ion binding  glycosaminoglycan binding  proteinaceous extracellular matrix  signal transduction  synapse assembly  metalloendopeptidase inhibitor activity  positive regulation of cell-substrate adhesion  negative regulation of endopeptidase activity  peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan  extracellular matrix organization  regulation of cell differentiation  extracellular matrix binding  positive regulation of cell motility  
Ontology : EGO-EBIcalcium ion binding  glycosaminoglycan binding  proteinaceous extracellular matrix  signal transduction  synapse assembly  metalloendopeptidase inhibitor activity  positive regulation of cell-substrate adhesion  negative regulation of endopeptidase activity  peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan  extracellular matrix organization  regulation of cell differentiation  extracellular matrix binding  positive regulation of cell motility  
NDEx NetworkSPOCK2
Atlas of Cancer Signalling NetworkSPOCK2
Wikipedia pathwaysSPOCK2
Orthology - Evolution
OrthoDB9806
GeneTree (enSembl)ENSG00000107742
Phylogenetic Trees/Animal Genes : TreeFamSPOCK2
HOVERGENQ92563
HOGENOMQ92563
Homologs : HomoloGeneSPOCK2
Homology/Alignments : Family Browser (UCSC)SPOCK2
Gene fusions - Rearrangements
Fusion : MitelmanCHSY1/SPOCK2 [15q26.3/10q22.1]  [t(10;15)(q22;q26)]  
Fusion: TCGACHSY1 15q26.3 SPOCK2 10q22.1 BRCA
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerSPOCK2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)SPOCK2
dbVarSPOCK2
ClinVarSPOCK2
1000_GenomesSPOCK2 
Exome Variant ServerSPOCK2
ExAC (Exome Aggregation Consortium)SPOCK2 (select the gene name)
Genetic variants : HAPMAP9806
Genomic Variants (DGV)SPOCK2 [DGVbeta]
DECIPHERSPOCK2 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisSPOCK2 
Mutations
ICGC Data PortalSPOCK2 
TCGA Data PortalSPOCK2 
Broad Tumor PortalSPOCK2
OASIS PortalSPOCK2 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICSPOCK2  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDSPOCK2
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch SPOCK2
DgiDB (Drug Gene Interaction Database)SPOCK2
DoCM (Curated mutations)SPOCK2 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)SPOCK2 (select a term)
intoGenSPOCK2
Cancer3DSPOCK2(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM607988   
Orphanet
MedgenSPOCK2
Genetic Testing Registry SPOCK2
NextProtQ92563 [Medical]
TSGene9806
GENETestsSPOCK2
Target ValidationSPOCK2
Huge Navigator SPOCK2 [HugePedia]
snp3D : Map Gene to Disease9806
BioCentury BCIQSPOCK2
ClinGenSPOCK2
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD9806
Chemical/Pharm GKB GenePA128394560
Clinical trialSPOCK2
Miscellaneous
canSAR (ICR)SPOCK2 (select the gene name)
Probes
Litterature
PubMed17 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineSPOCK2
EVEXSPOCK2
GoPubMedSPOCK2
iHOPSPOCK2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Mon Sep 25 19:32:48 CEST 2017

Home   Genes   Leukemias   Solid Tumors   Cancer-Prone   Deep Insight   Case Reports   Journals  Portal   Teaching   

For comments and suggestions or contributions, please contact us

jlhuret@AtlasGeneticsOncology.org.