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SPOCK3 (SPARC/osteonectin, cwcv and kazal like domains proteoglycan 3)

Identity

Alias_namessparc/osteonectin
Alias_symbol (synonym)testican-3
Other aliasHSAJ1454
TES-3
TICN3
HGNC (Hugo) SPOCK3
LocusID (NCBI) 50859
Atlas_Id 42377
Location 4q32.3  [Link to chromosome band 4q32]
Location_base_pair Starts at 166733385 and ends at 167234590 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
CNTNAP2 (7q35) / SPOCK3 (4q32.3)SPOCK3 (4q32.3) / ADCY2 (5p15.31)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)SPOCK3   13565
Cards
Entrez_Gene (NCBI)SPOCK3  50859  SPARC/osteonectin, cwcv and kazal like domains proteoglycan 3
AliasesHSAJ1454; TES-3; TICN3
GeneCards (Weizmann)SPOCK3
Ensembl hg19 (Hinxton)ENSG00000196104 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000196104 [Gene_View]  chr4:166733385-167234590 [Contig_View]  SPOCK3 [Vega]
ICGC DataPortalENSG00000196104
TCGA cBioPortalSPOCK3
AceView (NCBI)SPOCK3
Genatlas (Paris)SPOCK3
WikiGenes50859
SOURCE (Princeton)SPOCK3
Genetics Home Reference (NIH)SPOCK3
Genomic and cartography
GoldenPath hg38 (UCSC)SPOCK3  -     chr4:166733385-167234590 -  4q32.3   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)SPOCK3  -     4q32.3   [Description]    (hg19-Feb_2009)
EnsemblSPOCK3 - 4q32.3 [CytoView hg19]  SPOCK3 - 4q32.3 [CytoView hg38]
Mapping of homologs : NCBISPOCK3 [Mapview hg19]  SPOCK3 [Mapview hg38]
OMIM607989   
Gene and transcription
Genbank (Entrez)AB056866 AJ001454 AK091078 AK294293 AK294346
RefSeq transcript (Entrez)NM_001040159 NM_001204352 NM_001204353 NM_001204354 NM_001204355 NM_001204356 NM_001204358 NM_001204359 NM_001251967 NM_016950
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)SPOCK3
Cluster EST : UnigeneHs.481133 [ NCBI ]
CGAP (NCI)Hs.481133
Alternative Splicing GalleryENSG00000196104
Gene ExpressionSPOCK3 [ NCBI-GEO ]   SPOCK3 [ EBI - ARRAY_EXPRESS ]   SPOCK3 [ SEEK ]   SPOCK3 [ MEM ]
Gene Expression Viewer (FireBrowse)SPOCK3 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)50859
GTEX Portal (Tissue expression)SPOCK3
Human Protein AtlasENSG00000196104-SPOCK3 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9BQ16   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9BQ16  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9BQ16
Splice isoforms : SwissVarQ9BQ16
PhosPhoSitePlusQ9BQ16
Domaine pattern : Prosite (Expaxy)KAZAL_2 (PS51465)    THYROGLOBULIN_1_1 (PS00484)    THYROGLOBULIN_1_2 (PS51162)   
Domains : Interpro (EBI)EF-hand-dom_pair    Kazal_dom    SPARC/Testican_Ca-bd-dom    Thyroglobulin_1   
Domain families : Pfam (Sanger)Kazal_2 (PF07648)    SPARC_Ca_bdg (PF10591)    Thyroglobulin_1 (PF00086)   
Domain families : Pfam (NCBI)pfam07648    pfam10591    pfam00086   
Domain families : Smart (EMBL)KAZAL (SM00280)  TY (SM00211)  
Conserved Domain (NCBI)SPOCK3
DMDM Disease mutations50859
Blocks (Seattle)SPOCK3
SuperfamilyQ9BQ16
Human Protein Atlas [tissue]ENSG00000196104-SPOCK3 [tissue]
Peptide AtlasQ9BQ16
HPRD12147
IPIIPI00478890   IPI00419590   IPI00555693   IPI00978156   IPI00977619   IPI00976945   IPI00974268   IPI00964189   IPI00979576   IPI00965608   IPI00968269   IPI00968009   IPI00964235   IPI00964580   IPI00963933   IPI00963957   IPI00964859   IPI00964804   IPI00967735   
Protein Interaction databases
DIP (DOE-UCLA)Q9BQ16
IntAct (EBI)Q9BQ16
FunCoupENSG00000196104
BioGRIDSPOCK3
STRING (EMBL)SPOCK3
ZODIACSPOCK3
Ontologies - Pathways
QuickGOQ9BQ16
Ontology : AmiGOcalcium ion binding  glycosaminoglycan binding  proteinaceous extracellular matrix  signal transduction  metalloendopeptidase inhibitor activity  negative regulation of endopeptidase activity  peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan  negative regulation of cell motility  
Ontology : EGO-EBIcalcium ion binding  glycosaminoglycan binding  proteinaceous extracellular matrix  signal transduction  metalloendopeptidase inhibitor activity  negative regulation of endopeptidase activity  peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan  negative regulation of cell motility  
NDEx NetworkSPOCK3
Atlas of Cancer Signalling NetworkSPOCK3
Wikipedia pathwaysSPOCK3
Orthology - Evolution
OrthoDB50859
GeneTree (enSembl)ENSG00000196104
Phylogenetic Trees/Animal Genes : TreeFamSPOCK3
HOVERGENQ9BQ16
HOGENOMQ9BQ16
Homologs : HomoloGeneSPOCK3
Homology/Alignments : Family Browser (UCSC)SPOCK3
Gene fusions - Rearrangements
Tumor Fusion PortalSPOCK3
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerSPOCK3 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)SPOCK3
dbVarSPOCK3
ClinVarSPOCK3
1000_GenomesSPOCK3 
Exome Variant ServerSPOCK3
ExAC (Exome Aggregation Consortium)ENSG00000196104
GNOMAD BrowserENSG00000196104
Genetic variants : HAPMAP50859
Genomic Variants (DGV)SPOCK3 [DGVbeta]
DECIPHERSPOCK3 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisSPOCK3 
Mutations
ICGC Data PortalSPOCK3 
TCGA Data PortalSPOCK3 
Broad Tumor PortalSPOCK3
OASIS PortalSPOCK3 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICSPOCK3  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDSPOCK3
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch SPOCK3
DgiDB (Drug Gene Interaction Database)SPOCK3
DoCM (Curated mutations)SPOCK3 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)SPOCK3 (select a term)
intoGenSPOCK3
Cancer3DSPOCK3(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM607989   
Orphanet
DisGeNETSPOCK3
MedgenSPOCK3
Genetic Testing Registry SPOCK3
NextProtQ9BQ16 [Medical]
TSGene50859
GENETestsSPOCK3
Target ValidationSPOCK3
Huge Navigator SPOCK3 [HugePedia]
snp3D : Map Gene to Disease50859
BioCentury BCIQSPOCK3
ClinGenSPOCK3
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD50859
Chemical/Pharm GKB GenePA134977377
Clinical trialSPOCK3
Miscellaneous
canSAR (ICR)SPOCK3 (select the gene name)
Probes
Litterature
PubMed14 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineSPOCK3
EVEXSPOCK3
GoPubMedSPOCK3
iHOPSPOCK3
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Tue Nov 21 14:36:18 CET 2017

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