Atlas of Genetics and Cytogenetics in Oncology and Haematology

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SPON1 (spondin 1)

Identity

Alias_namesspondin 1
Alias_symbol (synonym)KIAA0762
f-spondin
Other aliasVSGP/F-spondin
HGNC (Hugo) SPON1
LocusID (NCBI) 10418
Atlas_Id 43886
Location 11p15.2  [Link to chromosome band 11p15]
Location_base_pair Starts at 13962637 and ends at 14268133 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)		Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
PCF11 (11q14.1) / SPON1 (11p15.2)SPON1 (11p15.2) / SIRT3 (11p15.5)PCF11 11q14.1 / SPON1 11p15.2
SPON1 11p15.2 / SIRT3 11p15.5

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 2 ]
  SPON1/SIRT3 (11p15)
t(11;11)(p15;q14) PCF11/SPON1

External links

Nomenclature
HGNC (Hugo)SPON1   11252
Cards
Entrez_Gene (NCBI)SPON1  10418  spondin 1
AliasesVSGP/F-spondin; f-spondin
GeneCards (Weizmann)SPON1
Ensembl hg19 (Hinxton)ENSG00000262655 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000262655 [Gene_View]  ENSG00000262655 [Sequence]  chr11:13962637-14268133 [Contig_View]  SPON1 [Vega]
ICGC DataPortalENSG00000262655
TCGA cBioPortalSPON1
AceView (NCBI)SPON1
Genatlas (Paris)SPON1
WikiGenes10418
SOURCE (Princeton)SPON1
Genetics Home Reference (NIH)SPON1
Genomic and cartography
GoldenPath hg38 (UCSC)SPON1  -     chr11:13962637-14268133 +  11p15.2   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)SPON1  -     11p15.2   [Description]    (hg19-Feb_2009)
EnsemblSPON1 - 11p15.2 [CytoView hg19]  SPON1 - 11p15.2 [CytoView hg38]
Mapping of homologs : NCBISPON1 [Mapview hg19]  SPON1 [Mapview hg38]
OMIM604989   
Gene and transcription
Genbank (Entrez)AB018305 AB051390 AI424944 AK001584 AK074803
RefSeq transcript (Entrez)NM_006108
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)SPON1
Cluster EST : UnigeneHs.643864 [ NCBI ]
CGAP (NCI)Hs.643864
Alternative Splicing GalleryENSG00000262655
Gene ExpressionSPON1 [ NCBI-GEO ]   SPON1 [ EBI - ARRAY_EXPRESS ]   SPON1 [ SEEK ]   SPON1 [ MEM ]
Gene Expression Viewer (FireBrowse)SPON1 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)10418
GTEX Portal (Tissue expression)SPON1
Human Protein AtlasENSG00000262655-SPON1 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9HCB6   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9HCB6  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9HCB6
Splice isoforms : SwissVarQ9HCB6
PhosPhoSitePlusQ9HCB6
Domaine pattern : Prosite (Expaxy)REELIN (PS51019)    SPONDIN (PS51020)    TSP1 (PS50092)   
Domains : Interpro (EBI)Reeler_dom    Spondin_N    Spondin_N_sf    TSP1_rpt    TSP1_rpt_sf   
Domain families : Pfam (Sanger)Reeler (PF02014)    Spond_N (PF06468)    TSP_1 (PF00090)   
Domain families : Pfam (NCBI)pfam02014    pfam06468    pfam00090   
Domain families : Smart (EMBL)TSP1 (SM00209)  
Conserved Domain (NCBI)SPON1
DMDM Disease mutations10418
Blocks (Seattle)SPON1
PDB (SRS)2ZOT    2ZOU    3COO    3Q13   
PDB (PDBSum)2ZOT    2ZOU    3COO    3Q13   
PDB (IMB)2ZOT    2ZOU    3COO    3Q13   
PDB (RSDB)2ZOT    2ZOU    3COO    3Q13   
Structural Biology KnowledgeBase2ZOT    2ZOU    3COO    3Q13   
SCOP (Structural Classification of Proteins)2ZOT    2ZOU    3COO    3Q13   
CATH (Classification of proteins structures)2ZOT    2ZOU    3COO    3Q13   
SuperfamilyQ9HCB6
Human Protein Atlas [tissue]ENSG00000262655-SPON1 [tissue]
Peptide AtlasQ9HCB6
HPRD16087
IPIIPI00171473   
Protein Interaction databases
DIP (DOE-UCLA)Q9HCB6
IntAct (EBI)Q9HCB6
FunCoupENSG00000262655
BioGRIDSPON1
STRING (EMBL)SPON1
ZODIACSPON1
Ontologies - Pathways
QuickGOQ9HCB6
Ontology : AmiGOextracellular matrix structural constituent  extracellular matrix structural constituent  protein binding  extracellular space  endoplasmic reticulum lumen  cell adhesion  cell adhesion  positive regulation of protein processing  extracellular matrix  positive regulation of protein binding  metal ion binding  LBD domain binding  collagen-containing extracellular matrix  collagen-containing extracellular matrix  negative regulation of amyloid-beta formation  positive regulation of amyloid precursor protein catabolic process  
Ontology : EGO-EBIextracellular matrix structural constituent  extracellular matrix structural constituent  protein binding  extracellular space  endoplasmic reticulum lumen  cell adhesion  cell adhesion  positive regulation of protein processing  extracellular matrix  positive regulation of protein binding  metal ion binding  LBD domain binding  collagen-containing extracellular matrix  collagen-containing extracellular matrix  negative regulation of amyloid-beta formation  positive regulation of amyloid precursor protein catabolic process  
NDEx NetworkSPON1
Atlas of Cancer Signalling NetworkSPON1
Wikipedia pathwaysSPON1
Orthology - Evolution
OrthoDB10418
GeneTree (enSembl)ENSG00000262655
Phylogenetic Trees/Animal Genes : TreeFamSPON1
HOGENOMQ9HCB6
Homologs : HomoloGeneSPON1
Homology/Alignments : Family Browser (UCSC)SPON1
Gene fusions - Rearrangements
Fusion : MitelmanPCF11/SPON1 [11q14.1/11p15.2]  [t(11;11)(p15;q14)]  
Fusion : MitelmanSPON1/SIRT3 [11p15.2/11p15.5]  [t(11;11)(p15;p15)]  
Fusion PortalPCF11 11q14.1 SPON1 11p15.2 BRCA
Fusion PortalSPON1 11p15.2 SIRT3 11p15.5 LGG
Fusion : QuiverSPON1
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerSPON1 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)SPON1
dbVarSPON1
ClinVarSPON1
1000_GenomesSPON1 
Exome Variant ServerSPON1
ExAC (Exome Aggregation Consortium)ENSG00000262655
GNOMAD BrowserENSG00000262655
Varsome BrowserSPON1
Genetic variants : HAPMAP10418
Genomic Variants (DGV)SPON1 [DGVbeta]
DECIPHERSPON1 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisSPON1 
Mutations
ICGC Data PortalSPON1 
TCGA Data PortalSPON1 
Broad Tumor PortalSPON1
OASIS PortalSPON1 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICSPON1  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDSPON1
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch SPON1
DgiDB (Drug Gene Interaction Database)SPON1
DoCM (Curated mutations)SPON1 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)SPON1 (select a term)
intoGenSPON1
Cancer3DSPON1(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM604989   
Orphanet
DisGeNETSPON1
MedgenSPON1
Genetic Testing Registry SPON1
NextProtQ9HCB6 [Medical]
TSGene10418
GENETestsSPON1
Target ValidationSPON1
Huge Navigator SPON1 [HugePedia]
snp3D : Map Gene to Disease10418
BioCentury BCIQSPON1
ClinGenSPON1
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD10418
Chemical/Pharm GKB GenePA36082
Clinical trialSPON1
Miscellaneous
canSAR (ICR)SPON1 (select the gene name)
Probes
Litterature
PubMed31 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineSPON1
EVEXSPON1
GoPubMedSPON1
iHOPSPON1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Fri Dec 21 15:54:00 CET 2018
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