SPON1 (spondin 1)

2007-02-01  

Identity

HGNC
LOCATION
11p15.2
LOCUSID
ALIAS
VSGP/F-spondin,f-spondin
FUSION GENES

Other Information

Locus ID:

NCBI: 10418
MIM: 604989
HGNC: 11252
Ensembl: ENSG00000262655

Variants:

dbSNP: 10418
ClinVar: 10418
TCGA: ENSG00000262655
COSMIC: SPON1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000262655ENST00000576479Q9HCB6

Expression (GTEx)

0
50
100
150

Pathways

PathwaySourceExternal ID
Metabolism of proteinsREACTOMER-HSA-392499
Post-translational protein modificationREACTOMER-HSA-597592
O-linked glycosylationREACTOMER-HSA-5173105
O-glycosylation of TSR domain-containing proteinsREACTOMER-HSA-5173214
DiseaseREACTOMER-HSA-1643685
Diseases of glycosylationREACTOMER-HSA-3781865
Diseases associated with O-glycosylation of proteinsREACTOMER-HSA-3906995
Defective B3GALTL causes Peters-plus syndrome (PpS)REACTOMER-HSA-5083635

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
234719852013Genome-wide scan of healthy human connectome discovers SPON1 gene variant influencing dementia severity.63
203796142010Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.62
235350332014Genome-wide association study of the rate of cognitive decline in Alzheimer's disease.49
169657632006Effect of F-spondin on cementoblastic differentiation of human periodontal ligament cells.16
187807632009F-spondin, a neuroregulatory protein, is up-regulated in osteoarthritis and regulates cartilage metabolism via TGF-beta activation.16
270107272016Genome-Wide Pharmacogenomic Study on Methadone Maintenance Treatment Identifies SNP rs17180299 and Multiple Haplotypes on CYP2B6, SPON1, and GSG1L Associated with Plasma Concentrations of Methadone R- and S-enantiomers in Heroin-Dependent Patients.15
241581122013Experimental validation of 5 in-silico predicted glioma biomarkers.14
161037462005VSGP/F-spondin: a new ovarian cancer marker.9
186024042008The crystal structure of the heparin-binding reelin-N domain of f-spondin.8
260324982015Spondin 1 promotes metastatic progression through Fak and Src dependent pathway in human osteosarcoma.7

Citation

Dessen P

SPON1 (spondin 1)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/43886/spon1