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SPPL2A (signal peptide peptidase like 2A)

Identity

Other aliasIMP3
PSL2
HGNC (Hugo) SPPL2A
LocusID (NCBI) 84888
Atlas_Id 56771
Location 15q21.2  [Link to chromosome band 15q21]
Location_base_pair Starts at 50707540 and ends at 50765713 bp from pter ( according to hg38-Dec_2013)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)SPPL2A   30227
Cards
Entrez_Gene (NCBI)SPPL2A  84888  signal peptide peptidase like 2A
AliasesIMP3; PSL2
GeneCards (Weizmann)SPPL2A
Ensembl hg19 (Hinxton) [Gene_View]
Ensembl hg38 (Hinxton) [Gene_View]  chr15:50707540-50765713 [Contig_View]  SPPL2A [Vega]
TCGA cBioPortalSPPL2A
AceView (NCBI)SPPL2A
Genatlas (Paris)SPPL2A
WikiGenes84888
SOURCE (Princeton)SPPL2A
Genetics Home Reference (NIH)SPPL2A
Genomic and cartography
GoldenPath hg38 (UCSC)SPPL2A  -     chr15:50707540-50765713 -  15q21.2   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)SPPL2A  -     15q21.2   [Description]    (hg19-Feb_2009)
EnsemblSPPL2A - 15q21.2 [CytoView hg19]  SPPL2A - 15q21.2 [CytoView hg38]
Mapping of homologs : NCBISPPL2A [Mapview hg19]  SPPL2A [Mapview hg38]
OMIM608238   
Gene and transcription
Genbank (Entrez)AA988423 AJ345028 AJ420896 AK027446 AK075454
RefSeq transcript (Entrez)NM_032802
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)SPPL2A
Cluster EST : UnigeneHs.401537 [ NCBI ]
CGAP (NCI)Hs.401537
Gene ExpressionSPPL2A [ NCBI-GEO ]   SPPL2A [ EBI - ARRAY_EXPRESS ]   SPPL2A [ SEEK ]   SPPL2A [ MEM ]
Gene Expression Viewer (FireBrowse)SPPL2A [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)84888
GTEX Portal (Tissue expression)SPPL2A
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ8TCT8   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ8TCT8  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ8TCT8
Splice isoforms : SwissVarQ8TCT8
Catalytic activity : Enzyme3.4.23.- [ Enzyme-Expasy ]   3.4.23.-3.4.23.- [ IntEnz-EBI ]   3.4.23.- [ BRENDA ]   3.4.23.- [ KEGG ]   
PhosPhoSitePlusQ8TCT8
Domains : Interpro (EBI)PA_domain    Peptidase_A22B_SPP    Preselin/SPP    SPPL2a   
Domain families : Pfam (Sanger)PA (PF02225)    Peptidase_A22B (PF04258)   
Domain families : Pfam (NCBI)pfam02225    pfam04258   
Domain families : Smart (EMBL)PSN (SM00730)  
Conserved Domain (NCBI)SPPL2A
DMDM Disease mutations84888
Blocks (Seattle)SPPL2A
SuperfamilyQ8TCT8
Peptide AtlasQ8TCT8
IPIIPI00154588   
Protein Interaction databases
DIP (DOE-UCLA)Q8TCT8
IntAct (EBI)Q8TCT8
BioGRIDSPPL2A
STRING (EMBL)SPPL2A
ZODIACSPPL2A
Ontologies - Pathways
QuickGOQ8TCT8
Ontology : AmiGOprotein binding  lysosome  lysosomal membrane  late endosome  plasma membrane  plasma membrane  membrane protein ectodomain proteolysis  regulation of tumor necrosis factor-mediated signaling pathway  membrane  Golgi-associated vesicle membrane  membrane protein intracellular domain proteolysis  membrane protein intracellular domain proteolysis  late endosome membrane  membrane protein proteolysis  aspartic endopeptidase activity, intramembrane cleaving  aspartic endopeptidase activity, intramembrane cleaving  protein homodimerization activity  intracellular membrane-bounded organelle  regulation of immune response  extracellular exosome  integral component of cytoplasmic side of endoplasmic reticulum membrane  integral component of lumenal side of endoplasmic reticulum membrane  
Ontology : EGO-EBIprotein binding  lysosome  lysosomal membrane  late endosome  plasma membrane  plasma membrane  membrane protein ectodomain proteolysis  regulation of tumor necrosis factor-mediated signaling pathway  membrane  Golgi-associated vesicle membrane  membrane protein intracellular domain proteolysis  membrane protein intracellular domain proteolysis  late endosome membrane  membrane protein proteolysis  aspartic endopeptidase activity, intramembrane cleaving  aspartic endopeptidase activity, intramembrane cleaving  protein homodimerization activity  intracellular membrane-bounded organelle  regulation of immune response  extracellular exosome  integral component of cytoplasmic side of endoplasmic reticulum membrane  integral component of lumenal side of endoplasmic reticulum membrane  
NDEx NetworkSPPL2A
Atlas of Cancer Signalling NetworkSPPL2A
Wikipedia pathwaysSPPL2A
Orthology - Evolution
OrthoDB84888
Phylogenetic Trees/Animal Genes : TreeFamSPPL2A
HOVERGENQ8TCT8
HOGENOMQ8TCT8
Homologs : HomoloGeneSPPL2A
Homology/Alignments : Family Browser (UCSC)SPPL2A
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerSPPL2A [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)SPPL2A
dbVarSPPL2A
ClinVarSPPL2A
1000_GenomesSPPL2A 
Exome Variant ServerSPPL2A
ExAC (Exome Aggregation Consortium)SPPL2A (select the gene name)
Genetic variants : HAPMAP84888
Genomic Variants (DGV)SPPL2A [DGVbeta]
DECIPHERSPPL2A [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisSPPL2A 
Mutations
ICGC Data PortalSPPL2A 
TCGA Data PortalSPPL2A 
Broad Tumor PortalSPPL2A
OASIS PortalSPPL2A [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICSPPL2A  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDSPPL2A
BioMutasearch SPPL2A
DgiDB (Drug Gene Interaction Database)SPPL2A
DoCM (Curated mutations)SPPL2A (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)SPPL2A (select a term)
intoGenSPPL2A
Cancer3DSPPL2A(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM608238   
Orphanet
MedgenSPPL2A
Genetic Testing Registry SPPL2A
NextProtQ8TCT8 [Medical]
TSGene84888
GENETestsSPPL2A
Target ValidationSPPL2A
Huge Navigator SPPL2A [HugePedia]
snp3D : Map Gene to Disease84888
BioCentury BCIQSPPL2A
ClinGenSPPL2A
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD84888
Chemical/Pharm GKB GenePA166048995
Clinical trialSPPL2A
Miscellaneous
canSAR (ICR)SPPL2A (select the gene name)
Probes
Litterature
PubMed24 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineSPPL2A
EVEXSPPL2A
GoPubMedSPPL2A
iHOPSPPL2A
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Wed Jun 7 12:57:14 CEST 2017

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