SPPL2B (signal peptide peptidase like 2B)

2007-02-01  

Identity

HGNC
LOCATION
19p13.3
LOCUSID
ALIAS
IMP-4,IMP4,PSH4,PSL1
FUSION GENES

Other Information

Locus ID:

NCBI: 56928
MIM: 608239
HGNC: 30627
Ensembl: ENSG00000005206

Variants:

dbSNP: 56928
ClinVar: 56928
TCGA: ENSG00000005206
COSMIC: SPPL2B

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000005206ENST00000586332A0A087WWL4
ENSG00000005206ENST00000610743Q8TCT7
ENSG00000005206ENST00000612623A0A087WT77
ENSG00000005206ENST00000613503Q8TCT7
ENSG00000005206ENST00000614794A0A087WZ50
ENSG00000005206ENST00000618220Q8TCT7
ENSG00000005206ENST00000621568A0A087WZ93

Expression (GTEx)

0
10
20
30
40
50
60
70
80
90
100

Pathways

PathwaySourceExternal ID
Signal TransductionREACTOMER-HSA-162582
Death Receptor SignallingREACTOMER-HSA-73887
TNF signalingREACTOMER-HSA-75893
Regulation of TNFR1 signalingREACTOMER-HSA-5357905

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
179650142008Regulated intramembrane proteolysis of Bri2 (Itm2b) by ADAM10 and SPPL2a/SPPL2b.56
168299512006A gamma-secretase-like intramembrane cleavage of TNFalpha by the GxGD aspartyl protease SPPL2b.52
153855472004Consensus analysis of signal peptide peptidase and homologous human aspartic proteases reveals opposite topology of catalytic domains compared with presenilins.40
159986422005Differential localization and identification of a critical aspartate suggest non-redundant proteolytic functions of the presenilin homologues SPPL2b and SPPL3.31
221945952012The α-helical content of the transmembrane domain of the British dementia protein-2 (Bri2) determines its processing by signal peptide peptidase-like 2b (SPPL2b).16
187684712008Intramembrane proteolysis of GXGD-type aspartyl proteases is slowed by a familial Alzheimer disease-like mutation.12
233843472013The transferrin receptor-1 membrane stub undergoes intramembrane proteolysis by signal peptide peptidase-like 2b.8
308197242019Atherogenic LOX-1 signaling is controlled by SPPL2-mediated intramembrane proteolysis.7

Citation

Dessen P

SPPL2B (signal peptide peptidase like 2B)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/46149/sppl2b