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SPPL2C (signal peptide peptidase like 2C)

Identity

Alias_symbol (synonym)IMP5
Other alias
HGNC (Hugo) SPPL2C
LocusID (NCBI) 162540
Atlas_Id 74198
Location 17q21.31  [Link to chromosome band 17q21]
Location_base_pair Starts at 45844890 and ends at 45847072 bp from pter ( according to hg38-Dec_2013)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)SPPL2C   28902
Cards
Entrez_Gene (NCBI)SPPL2C  162540  signal peptide peptidase like 2C
AliasesIMP5
GeneCards (Weizmann)SPPL2C
Ensembl hg19 (Hinxton)ENSG00000185294 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000185294 [Gene_View]  chr17:45844890-45847072 [Contig_View]  SPPL2C [Vega]
ICGC DataPortalENSG00000185294
TCGA cBioPortalSPPL2C
AceView (NCBI)SPPL2C
Genatlas (Paris)SPPL2C
WikiGenes162540
SOURCE (Princeton)SPPL2C
Genetics Home Reference (NIH)SPPL2C
Genomic and cartography
GoldenPath hg38 (UCSC)SPPL2C  -     chr17:45844890-45847072 +  17q21.31   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)SPPL2C  -     17q21.31   [Description]    (hg19-Feb_2009)
EnsemblSPPL2C - 17q21.31 [CytoView hg19]  SPPL2C - 17q21.31 [CytoView hg38]
Mapping of homologs : NCBISPPL2C [Mapview hg19]  SPPL2C [Mapview hg38]
OMIM608284   
Gene and transcription
Genbank (Entrez)BC022041 BC025401
RefSeq transcript (Entrez)NM_175882
RefSeq genomic (Entrez)NC_000017 NC_018928 NT_167251 NT_187663
Consensus coding sequences : CCDS (NCBI)SPPL2C
Cluster EST : UnigeneHs.144491 [ NCBI ]
CGAP (NCI)Hs.144491
Alternative Splicing GalleryENSG00000185294
Gene ExpressionSPPL2C [ NCBI-GEO ]   SPPL2C [ EBI - ARRAY_EXPRESS ]   SPPL2C [ SEEK ]   SPPL2C [ MEM ]
Gene Expression Viewer (FireBrowse)SPPL2C [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)162540
GTEX Portal (Tissue expression)SPPL2C
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ8IUH8   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ8IUH8  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ8IUH8
Splice isoforms : SwissVarQ8IUH8
Catalytic activity : Enzyme3.4.23.- [ Enzyme-Expasy ]   3.4.23.-3.4.23.- [ IntEnz-EBI ]   3.4.23.- [ BRENDA ]   3.4.23.- [ KEGG ]   
PhosPhoSitePlusQ8IUH8
Domains : Interpro (EBI)Peptidase_A22B_SPP    Preselin/SPP    SPPL2C   
Domain families : Pfam (Sanger)Peptidase_A22B (PF04258)   
Domain families : Pfam (NCBI)pfam04258   
Domain families : Smart (EMBL)PSN (SM00730)  
Conserved Domain (NCBI)SPPL2C
DMDM Disease mutations162540
Blocks (Seattle)SPPL2C
SuperfamilyQ8IUH8
Human Protein AtlasENSG00000185294
Peptide AtlasQ8IUH8
HPRD07085
IPIIPI00103286   
Protein Interaction databases
DIP (DOE-UCLA)Q8IUH8
IntAct (EBI)Q8IUH8
FunCoupENSG00000185294
BioGRIDSPPL2C
STRING (EMBL)SPPL2C
ZODIACSPPL2C
Ontologies - Pathways
QuickGOQ8IUH8
Ontology : AmiGOaspartic-type endopeptidase activity  lysosomal membrane  endoplasmic reticulum membrane  membrane protein ectodomain proteolysis  Golgi-associated vesicle membrane  membrane protein intracellular domain proteolysis  protein homodimerization activity  integral component of cytoplasmic side of endoplasmic reticulum membrane  integral component of lumenal side of endoplasmic reticulum membrane  
Ontology : EGO-EBIaspartic-type endopeptidase activity  lysosomal membrane  endoplasmic reticulum membrane  membrane protein ectodomain proteolysis  Golgi-associated vesicle membrane  membrane protein intracellular domain proteolysis  protein homodimerization activity  integral component of cytoplasmic side of endoplasmic reticulum membrane  integral component of lumenal side of endoplasmic reticulum membrane  
NDEx NetworkSPPL2C
Atlas of Cancer Signalling NetworkSPPL2C
Wikipedia pathwaysSPPL2C
Orthology - Evolution
OrthoDB162540
GeneTree (enSembl)ENSG00000185294
Phylogenetic Trees/Animal Genes : TreeFamSPPL2C
HOVERGENQ8IUH8
HOGENOMQ8IUH8
Homologs : HomoloGeneSPPL2C
Homology/Alignments : Family Browser (UCSC)SPPL2C
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerSPPL2C [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)SPPL2C
dbVarSPPL2C
ClinVarSPPL2C
1000_GenomesSPPL2C 
Exome Variant ServerSPPL2C
ExAC (Exome Aggregation Consortium)SPPL2C (select the gene name)
Genetic variants : HAPMAP162540
Genomic Variants (DGV)SPPL2C [DGVbeta]
DECIPHERSPPL2C [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisSPPL2C 
Mutations
ICGC Data PortalSPPL2C 
TCGA Data PortalSPPL2C 
Broad Tumor PortalSPPL2C
OASIS PortalSPPL2C [ Somatic mutations - Copy number]
Mutations and Diseases : HGMDSPPL2C
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch SPPL2C
DgiDB (Drug Gene Interaction Database)SPPL2C
DoCM (Curated mutations)SPPL2C (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)SPPL2C (select a term)
intoGenSPPL2C
Cancer3DSPPL2C(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM608284   
Orphanet
MedgenSPPL2C
Genetic Testing Registry SPPL2C
NextProtQ8IUH8 [Medical]
TSGene162540
GENETestsSPPL2C
Huge Navigator SPPL2C [HugePedia]
snp3D : Map Gene to Disease162540
BioCentury BCIQSPPL2C
ClinGenSPPL2C
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD162540
Chemical/Pharm GKB GenePA166048986
Clinical trialSPPL2C
Miscellaneous
canSAR (ICR)SPPL2C (select the gene name)
Probes
Litterature
PubMed10 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineSPPL2C
EVEXSPPL2C
GoPubMedSPPL2C
iHOPSPPL2C
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Fri May 19 11:56:31 CEST 2017

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