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SPRED1 (sprouty related, EVH1 domain containing 1)

Identity

Alias_namesregulatory subunit 147
Alias_symbol (synonym)FLJ33903
PPP1R147
HGNC (Hugo) SPRED1
LocusID (NCBI) 161742
Atlas_Id 46102
Location 15q14  [Link to chromosome band 15q14]
Location_base_pair Starts at 38545052 and ends at 38649450 bp from pter ( according to hg19-Feb_2009)
Fusion genes
(updated 2016)
LARP7 (4q25) / SPRED1 (15q14)MALAT1 (11q13.1) / SPRED1 (15q14)MNT (17p13.3) / SPRED1 (15q14)
SPRED1 (15q14) / MNT (17p13.3)SPRED1 (15q14) / SPRED1 (15q14)SPRED1 (15q14) / TMCO5A (15q14)
SPRED1 15q14 / TMCO5A 15q14

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


Other Leukemias implicated (Data extracted from papers in the Atlas) [ 1 ]
  dic(9;17)(p13;q11) PAX5/TAOK1


External links

Nomenclature
HGNC (Hugo)SPRED1   20249
Cards
Entrez_Gene (NCBI)SPRED1  161742  sprouty related, EVH1 domain containing 1
AliasesNFLS; PPP1R147; hSpred1; spred-1
GeneCards (Weizmann)SPRED1
Ensembl hg19 (Hinxton)ENSG00000166068 [Gene_View]  chr15:38545052-38649450 [Contig_View]  SPRED1 [Vega]
Ensembl hg38 (Hinxton)ENSG00000166068 [Gene_View]  chr15:38545052-38649450 [Contig_View]  SPRED1 [Vega]
ICGC DataPortalENSG00000166068
TCGA cBioPortalSPRED1
AceView (NCBI)SPRED1
Genatlas (Paris)SPRED1
WikiGenes161742
SOURCE (Princeton)SPRED1
Genetics Home Reference (NIH)SPRED1
Genomic and cartography
GoldenPath hg19 (UCSC)SPRED1  -     chr15:38545052-38649450 +  15q14   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)SPRED1  -     15q14   [Description]    (hg38-Dec_2013)
EnsemblSPRED1 - 15q14 [CytoView hg19]  SPRED1 - 15q14 [CytoView hg38]
Mapping of homologs : NCBISPRED1 [Mapview hg19]  SPRED1 [Mapview hg38]
OMIM609291   611431   
Gene and transcription
Genbank (Entrez)AK091222 AK095219 AY299089 BC018015 BC137480
RefSeq transcript (Entrez)NM_152594
RefSeq genomic (Entrez)NC_000015 NC_018926 NG_008980 NT_010194 NW_004929398
Consensus coding sequences : CCDS (NCBI)SPRED1
Cluster EST : UnigeneHs.525781 [ NCBI ]
CGAP (NCI)Hs.525781
Alternative Splicing GalleryENSG00000166068
Gene ExpressionSPRED1 [ NCBI-GEO ]   SPRED1 [ EBI - ARRAY_EXPRESS ]   SPRED1 [ SEEK ]   SPRED1 [ MEM ]
Gene Expression Viewer (FireBrowse)SPRED1 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)161742
GTEX Portal (Tissue expression)SPRED1
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ7Z699   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ7Z699  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ7Z699
Splice isoforms : SwissVarQ7Z699
PhosPhoSitePlusQ7Z699
Domaine pattern : Prosite (Expaxy)KBD (PS51488)    SPR (PS51227)    WH1 (PS50229)   
Domains : Interpro (EBI)KBD    PH_dom-like    Sprouty    WH1/EVH1_dom   
Domain families : Pfam (Sanger)Sprouty (PF05210)    WH1 (PF00568)   
Domain families : Pfam (NCBI)pfam05210    pfam00568   
Conserved Domain (NCBI)SPRED1
DMDM Disease mutations161742
Blocks (Seattle)SPRED1
PDB (SRS)3SYX   
PDB (PDBSum)3SYX   
PDB (IMB)3SYX   
PDB (RSDB)3SYX   
Structural Biology KnowledgeBase3SYX   
SCOP (Structural Classification of Proteins)3SYX   
CATH (Classification of proteins structures)3SYX   
SuperfamilyQ7Z699
Human Protein AtlasENSG00000166068
Peptide AtlasQ7Z699
HPRD11601
IPIIPI00166291   
Protein Interaction databases
DIP (DOE-UCLA)Q7Z699
IntAct (EBI)Q7Z699
FunCoupENSG00000166068
BioGRIDSPRED1
STRING (EMBL)SPRED1
ZODIACSPRED1
Ontologies - Pathways
QuickGOQ7Z699
Ontology : AmiGOMAPK cascade  inactivation of MAPK activity  stem cell factor receptor binding  protein binding  nucleoplasm  cytoplasm  cytosol  plasma membrane  caveola  multicellular organism development  fibroblast growth factor receptor signaling pathway  negative regulation of peptidyl-threonine phosphorylation  negative regulation of phosphatase activity  protein kinase binding  phosphatase binding  protein serine/threonine kinase inhibitor activity  positive regulation of DNA damage response, signal transduction by p53 class mediator  regulation of protein deacetylation  
Ontology : EGO-EBIMAPK cascade  inactivation of MAPK activity  stem cell factor receptor binding  protein binding  nucleoplasm  cytoplasm  cytosol  plasma membrane  caveola  multicellular organism development  fibroblast growth factor receptor signaling pathway  negative regulation of peptidyl-threonine phosphorylation  negative regulation of phosphatase activity  protein kinase binding  phosphatase binding  protein serine/threonine kinase inhibitor activity  positive regulation of DNA damage response, signal transduction by p53 class mediator  regulation of protein deacetylation  
Pathways : KEGGJak-STAT signaling pathway   
NDEx NetworkSPRED1
Atlas of Cancer Signalling NetworkSPRED1
Wikipedia pathwaysSPRED1
Orthology - Evolution
OrthoDB161742
GeneTree (enSembl)ENSG00000166068
Phylogenetic Trees/Animal Genes : TreeFamSPRED1
HOVERGENQ7Z699
HOGENOMQ7Z699
Homologs : HomoloGeneSPRED1
Homology/Alignments : Family Browser (UCSC)SPRED1
Gene fusions - Rearrangements
Fusion: TCGASPRED1 15q14 TMCO5A 15q14 LUAD
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerSPRED1 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)SPRED1
dbVarSPRED1
ClinVarSPRED1
1000_GenomesSPRED1 
Exome Variant ServerSPRED1
ExAC (Exome Aggregation Consortium)SPRED1 (select the gene name)
Genetic variants : HAPMAP161742
Genomic Variants (DGV)SPRED1 [DGVbeta]
DECIPHER (Syndromes)15:38545052-38649450  ENSG00000166068
CONAN: Copy Number AnalysisSPRED1 
Mutations
ICGC Data PortalSPRED1 
TCGA Data PortalSPRED1 
Broad Tumor PortalSPRED1
OASIS PortalSPRED1 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICSPRED1  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDSPRED1
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
LOVD (Leiden Open Variation Database)Mendelian genes
BioMutasearch SPRED1
DgiDB (Drug Gene Interaction Database)SPRED1
DoCM (Curated mutations)SPRED1 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)SPRED1 (select a term)
intoGenSPRED1
Cancer3DSPRED1(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM609291    611431   
Orphanet16684   
MedgenSPRED1
Genetic Testing Registry SPRED1
NextProtQ7Z699 [Medical]
TSGene161742
GENETestsSPRED1
Huge Navigator SPRED1 [HugePedia]
snp3D : Map Gene to Disease161742
BioCentury BCIQSPRED1
ClinGenSPRED1 (curated)
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD161742
Chemical/Pharm GKB GenePA134897382
Clinical trialSPRED1
Miscellaneous
canSAR (ICR)SPRED1 (select the gene name)
Probes
Litterature
PubMed47 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineSPRED1
EVEXSPRED1
GoPubMedSPRED1
iHOPSPRED1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Fri Nov 18 19:52:26 CET 2016

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