Atlas of Genetics and Cytogenetics in Oncology and Haematology


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SPRED1 (sprouty-related, EVH1 domain containing 1)

Identity

Other namesNFLS
PPP1R147
hSpred1
spred-1
HGNC (Hugo) SPRED1
LocusID (NCBI) 161742
Location 15q14
Location_base_pair Starts at 38545052 and ends at 38649450 bp from pter ( according to hg19-Feb_2009)
Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

External links

Nomenclature
HGNC (Hugo)SPRED1   20249
Cards
Entrez_Gene (NCBI)SPRED1  161742  sprouty-related, EVH1 domain containing 1
GeneCards (Weizmann)SPRED1
Ensembl (Hinxton)ENSG00000166068 [Gene_View]  chr15:38545052-38649450 [Contig_View]  SPRED1 [Vega]
ICGC DataPortalENSG00000166068
cBioPortalSPRED1
AceView (NCBI)SPRED1
Genatlas (Paris)SPRED1
WikiGenes161742
SOURCE (Princeton)NM_152594
Genomic and cartography
GoldenPath (UCSC)SPRED1  -  15q14   chr15:38545052-38649450 +  15q14   [Description]    (hg19-Feb_2009)
EnsemblSPRED1 - 15q14 [CytoView]
Mapping of homologs : NCBISPRED1 [Mapview]
OMIM609291   611431   
Gene and transcription
Genbank (Entrez)AK091222 AK095219 AY299089 BC018015 BC137480
RefSeq transcript (Entrez)NM_152594
RefSeq genomic (Entrez)AC_000147 NC_000015 NC_018926 NG_008980 NT_010194 NW_001838214 NW_004929398
Consensus coding sequences : CCDS (NCBI)SPRED1
Cluster EST : UnigeneHs.525781 [ NCBI ]
CGAP (NCI)Hs.525781
Alternative Splicing : Fast-db (Paris)GSHG0009754
Alternative Splicing GalleryENSG00000166068
Gene ExpressionSPRED1 [ NCBI-GEO ]     SPRED1 [ SEEK ]   SPRED1 [ MEM ]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ7Z699 (Uniprot)
NextProtQ7Z699  [Medical]
With graphics : InterProQ7Z699
Splice isoforms : SwissVarQ7Z699 (Swissvar)
Domaine pattern : Prosite (Expaxy)KBD (PS51488)    SPR (PS51227)    WH1 (PS50229)   
Domains : Interpro (EBI)KBD [organisation]   PH_like_dom [organisation]   Sprouty [organisation]   WH1/EVH1 [organisation]  
Related proteins : CluSTrQ7Z699
Domain families : Pfam (Sanger)Sprouty (PF05210)    WH1 (PF00568)   
Domain families : Pfam (NCBI)pfam05210    pfam00568   
DMDM Disease mutations161742
Blocks (Seattle)Q7Z699
PDB (SRS)3SYX   
PDB (PDBSum)3SYX   
PDB (IMB)3SYX   
PDB (RSDB)3SYX   
Human Protein AtlasENSG00000166068 [gene] [tissue] [antibody] [cell] [cancer]
Peptide AtlasQ7Z699
HPRD11601
IPIIPI00166291   
Protein Interaction databases
DIP (DOE-UCLA)Q7Z699
IntAct (EBI)Q7Z699
FunCoupENSG00000166068
BioGRIDSPRED1
InParanoidQ7Z699
Interologous Interaction database Q7Z699
IntegromeDBSPRED1
STRING (EMBL)SPRED1
Ontologies - Pathways
Ontology : AmiGOinactivation of MAPK activity  stem cell factor receptor binding  protein binding  nucleus  nucleolus  cytoplasm  caveola  multicellular organismal development  negative regulation of peptidyl-threonine phosphorylation  negative regulation of phosphatase activity  protein kinase binding  phosphatase binding  protein serine/threonine kinase inhibitor activity  positive regulation of DNA damage response, signal transduction by p53 class mediator  regulation of protein deacetylation  
Ontology : EGO-EBIinactivation of MAPK activity  stem cell factor receptor binding  protein binding  nucleus  nucleolus  cytoplasm  caveola  multicellular organismal development  negative regulation of peptidyl-threonine phosphorylation  negative regulation of phosphatase activity  protein kinase binding  phosphatase binding  protein serine/threonine kinase inhibitor activity  positive regulation of DNA damage response, signal transduction by p53 class mediator  regulation of protein deacetylation  
Pathways : KEGGJak-STAT signaling pathway   
Protein Interaction DatabaseSPRED1
Wikipedia pathwaysSPRED1
Gene fusion - rearrangments
Polymorphisms : SNP, mutations, diseases
SNP Single Nucleotide Polymorphism (NCBI)SPRED1
snp3D : Map Gene to Disease161742
SNP (GeneSNP Utah)SPRED1
SNP : HGBaseSPRED1
Genetic variants : HAPMAPSPRED1
Exome VariantSPRED1
1000_GenomesSPRED1 
ICGC programENSG00000166068 
Somatic Mutations in Cancer : COSMICSPRED1 
CONAN: Copy Number AnalysisSPRED1 
Mutations and Diseases : HGMDSPRED1
Mutations and Diseases : intOGenSPRED1
Genomic VariantsSPRED1  SPRED1 [DGVbeta]
dbVarSPRED1
ClinVarSPRED1
Pred. of missensesPolyPhen-2  SIFT(SG)  SIFT(JCVI)  Align-GVGD  MutAssessor  Mutanalyser  
Pred. splicesGeneSplicer  Human Splicing Finder  MaxEntScan  
Diseases
OMIM609291    611431   
MedgenSPRED1
GENETestsSPRED1
Disease Genetic AssociationSPRED1
Huge Navigator SPRED1 [HugePedia]  SPRED1 [HugeCancerGEM]
General knowledge
Homologs : HomoloGeneSPRED1
Homology/Alignments : Family Browser (UCSC)SPRED1
Phylogenetic Trees/Animal Genes : TreeFamSPRED1
Chemical/Protein Interactions : CTD161742
Chemical/Pharm GKB GenePA134897382
Clinical trialSPRED1
Cancer Resource (Charite)ENSG00000166068
Other databases
Probes
Litterature
PubMed45 Pubmed reference(s) in Entrez
CoreMineSPRED1
iHOPSPRED1
OncoSearchSPRED1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

Contributor(s)

Written09-2002Dessen P, Le Minor S
Updated12-2013Dessen P

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Tue Aug 26 17:06:00 CEST 2014

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