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SPRED2 (sprouty related EVH1 domain containing 2)

Identity

Alias_symbol (synonym)Spred-2
FLJ21897
FLJ31917
Other alias
HGNC (Hugo) SPRED2
LocusID (NCBI) 200734
Atlas_Id 45535
Location 2p14  [Link to chromosome band 2p14]
Location_base_pair Starts at 65310851 and ends at 65366797 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
NDUFA1 (Xq24) / SPRED2 (2p14)SPRED2 (2p14) / ACTR2 (2p14)SPRED2 (2p14) / G2E3 (14q12)
SPRED2 (2p14) / NAPG (18p11.22)SPRED2 (2p14) / RAB1A (2p14)SPRED2 (2p14) / SPRED2 (2p14)
SPRED2 (2p14) / SYNE2 (14q23.2)SPRED2 2p14 / G2E3 14q12SPRED2 2p14 / NAPG 18p11.22

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)SPRED2   17722
Cards
Entrez_Gene (NCBI)SPRED2  200734  sprouty related EVH1 domain containing 2
AliasesSpred-2
GeneCards (Weizmann)SPRED2
Ensembl hg19 (Hinxton)ENSG00000198369 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000198369 [Gene_View]  chr2:65310851-65366797 [Contig_View]  SPRED2 [Vega]
ICGC DataPortalENSG00000198369
TCGA cBioPortalSPRED2
AceView (NCBI)SPRED2
Genatlas (Paris)SPRED2
WikiGenes200734
SOURCE (Princeton)SPRED2
Genetics Home Reference (NIH)SPRED2
Genomic and cartography
GoldenPath hg38 (UCSC)SPRED2  -     chr2:65310851-65366797 -  2p14   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)SPRED2  -     2p14   [Description]    (hg19-Feb_2009)
EnsemblSPRED2 - 2p14 [CytoView hg19]  SPRED2 - 2p14 [CytoView hg38]
Mapping of homologs : NCBISPRED2 [Mapview hg19]  SPRED2 [Mapview hg38]
OMIM609292   
Gene and transcription
Genbank (Entrez)AF052178 AK025550 AK056479 AK299079 AK307714
RefSeq transcript (Entrez)NM_001128210 NM_181784
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)SPRED2
Cluster EST : UnigeneHs.59332 [ NCBI ]
CGAP (NCI)Hs.59332
Alternative Splicing GalleryENSG00000198369
Gene ExpressionSPRED2 [ NCBI-GEO ]   SPRED2 [ EBI - ARRAY_EXPRESS ]   SPRED2 [ SEEK ]   SPRED2 [ MEM ]
Gene Expression Viewer (FireBrowse)SPRED2 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)200734
GTEX Portal (Tissue expression)SPRED2
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ7Z698   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ7Z698  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ7Z698
Splice isoforms : SwissVarQ7Z698
PhosPhoSitePlusQ7Z698
Domaine pattern : Prosite (Expaxy)KBD (PS51488)    SPR (PS51227)    WH1 (PS50229)   
Domains : Interpro (EBI)KBD    PH_dom-like    Sprouty    WH1/EVH1_dom   
Domain families : Pfam (Sanger)Sprouty (PF05210)    WH1 (PF00568)   
Domain families : Pfam (NCBI)pfam05210    pfam00568   
Domain families : Smart (EMBL)WH1 (SM00461)  
Conserved Domain (NCBI)SPRED2
DMDM Disease mutations200734
Blocks (Seattle)SPRED2
PDB (SRS)2JP2   
PDB (PDBSum)2JP2   
PDB (IMB)2JP2   
PDB (RSDB)2JP2   
Structural Biology KnowledgeBase2JP2   
SCOP (Structural Classification of Proteins)2JP2   
CATH (Classification of proteins structures)2JP2   
SuperfamilyQ7Z698
Human Protein AtlasENSG00000198369
Peptide AtlasQ7Z698
HPRD18100
IPIIPI00375554   IPI00916049   IPI00917942   IPI00917488   IPI00916679   IPI00916856   IPI00896542   
Protein Interaction databases
DIP (DOE-UCLA)Q7Z698
IntAct (EBI)Q7Z698
FunCoupENSG00000198369
BioGRIDSPRED2
STRING (EMBL)SPRED2
ZODIACSPRED2
Ontologies - Pathways
QuickGOQ7Z698
Ontology : AmiGOinactivation of MAPK activity  stem cell factor receptor binding  protein binding  cytosol  plasma membrane  multicellular organism development  fibroblast growth factor receptor signaling pathway  negative regulation of peptidyl-threonine phosphorylation  protein kinase binding  protein serine/threonine kinase inhibitor activity  transport vesicle membrane  positive regulation of DNA damage response, signal transduction by p53 class mediator  regulation of protein deacetylation  
Ontology : EGO-EBIinactivation of MAPK activity  stem cell factor receptor binding  protein binding  cytosol  plasma membrane  multicellular organism development  fibroblast growth factor receptor signaling pathway  negative regulation of peptidyl-threonine phosphorylation  protein kinase binding  protein serine/threonine kinase inhibitor activity  transport vesicle membrane  positive regulation of DNA damage response, signal transduction by p53 class mediator  regulation of protein deacetylation  
Pathways : KEGGJak-STAT signaling pathway   
NDEx NetworkSPRED2
Atlas of Cancer Signalling NetworkSPRED2
Wikipedia pathwaysSPRED2
Orthology - Evolution
OrthoDB200734
GeneTree (enSembl)ENSG00000198369
Phylogenetic Trees/Animal Genes : TreeFamSPRED2
HOVERGENQ7Z698
HOGENOMQ7Z698
Homologs : HomoloGeneSPRED2
Homology/Alignments : Family Browser (UCSC)SPRED2
Gene fusions - Rearrangements
Fusion : MitelmanSPRED2/NAPG [2p14/18p11.22]  
Fusion: TCGASPRED2 2p14 G2E3 14q12 GBM
Fusion: TCGASPRED2 2p14 NAPG 18p11.22 LGG
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerSPRED2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)SPRED2
dbVarSPRED2
ClinVarSPRED2
1000_GenomesSPRED2 
Exome Variant ServerSPRED2
ExAC (Exome Aggregation Consortium)SPRED2 (select the gene name)
Genetic variants : HAPMAP200734
Genomic Variants (DGV)SPRED2 [DGVbeta]
DECIPHERSPRED2 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisSPRED2 
Mutations
ICGC Data PortalSPRED2 
TCGA Data PortalSPRED2 
Broad Tumor PortalSPRED2
OASIS PortalSPRED2 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICSPRED2  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDSPRED2
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch SPRED2
DgiDB (Drug Gene Interaction Database)SPRED2
DoCM (Curated mutations)SPRED2 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)SPRED2 (select a term)
intoGenSPRED2
Cancer3DSPRED2(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM609292   
Orphanet
MedgenSPRED2
Genetic Testing Registry SPRED2
NextProtQ7Z698 [Medical]
TSGene200734
GENETestsSPRED2
Target ValidationSPRED2
Huge Navigator SPRED2 [HugePedia]
snp3D : Map Gene to Disease200734
BioCentury BCIQSPRED2
ClinGenSPRED2
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD200734
Chemical/Pharm GKB GenePA134956365
Clinical trialSPRED2
Miscellaneous
canSAR (ICR)SPRED2 (select the gene name)
Probes
Litterature
PubMed39 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineSPRED2
EVEXSPRED2
GoPubMedSPRED2
iHOPSPRED2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Sep 25 19:32:50 CEST 2017

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