SPRR1B (small proline rich protein 1B)

2003-08-01  

Identity

HGNC
LOCATION
1q21.3
LOCUSID
ALIAS
CORNIFIN,GADD33,SPR-IB,SPRR1
FUSION GENES

Other Information

Locus ID:

NCBI: 6699
MIM: 182266
HGNC: 11260
Ensembl: ENSG00000169469

Variants:

dbSNP: 6699
ClinVar: 6699
TCGA: ENSG00000169469
COSMIC: SPRR1B

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000169469ENST00000307098P22528

Expression (GTEx)

0
500
1000
1500
2000
2500

Pathways

PathwaySourceExternal ID
Developmental BiologyREACTOMER-HSA-1266738
KeratinizationREACTOMER-HSA-6805567
Formation of the cornified envelopeREACTOMER-HSA-6809371

References

Pubmed IDYearTitleCitations
181720722008Small proline-rich protein 1B (SPRR1B) is a biomarker for squamous metaplasia in dry eye disease.28
186438452009Association of psoriasis to PGLYRP and SPRR genes at PSORS4 locus on 1q shows heterogeneity between Finnish, Swedish and Irish families.16
288597012017RNA sequencing and pathway analysis identify tumor necrosis factor alpha driven small proline-rich protein dysregulation in chronic rhinosinusitis.7
239546382013Small proline-rich protein-1B is overexpressed in human oral squamous cell cancer stem-like cells and is related to their growth through activation of MAP kinase signal.6
273040822017Expression of Cornified Envelope Proteins in Skin and Its Relationship with Atopic Dermatitis Phenotype.6
128322812003SPRR1B overexpression enhances entry of cells into the G0 phase of the cell cycle.5
196019982009Variation in genes of the epidermal differentiation complex in German atopic dermatitis patients.3
120912472002BMK1 (ERK5) regulates squamous differentiation marker SPRR1B transcription in Clara-like H441 cells.2

Citation

Dessen P

SPRR1B (small proline rich protein 1B)

Atlas Genet Cytogenet Oncol Haematol. 2003-08-01

Online version: http://atlasgeneticsoncology.org/gene/42380/sprr1b